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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C22orf39-MAPK1 (FusionGDB2 ID:HG128977TG5594)

Fusion Gene Summary for C22orf39-MAPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: C22orf39-MAPK1
Fusion gene ID: hg128977tg5594
HgeneTgene
Gene symbol

C22orf39

MAPK1

Gene ID

128977

5594

Gene namechromosome 22 open reading frame 39mitogen-activated protein kinase 1
Synonyms-ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
Cytomap('C22orf39')('MAPK1')

22q11.21

22q11.22

Type of geneprotein-codingprotein-coding
DescriptionUPF0545 protein C22orf39mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
Modification date2020031320200327
UniProtAcc

Q6P5X5

.
Ensembl transtripts involved in fusion geneENST00000333059, ENST00000399562, 
ENST00000399568, ENST00000542103, 
Fusion gene scores* DoF score15 X 10 X 10=150015 X 8 X 9=1080
# samples 1616
** MAII scorelog2(16/1500*10)=-3.22881869049588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C22orf39 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC22orf39(19434900)-MAPK1(22162135), # samples:2
Anticipated loss of major functional domain due to fusion event.C22orf39-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
C22orf39-MAPK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPK1

GO:0006468

protein phosphorylation

23184662

TgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

TgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

TgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

TgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

TgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

TgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

TgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356


check buttonFusion gene breakpoints across C22orf39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MAPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A939C22orf39chr22

19434900

-MAPK1chr22

22162135

-


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Fusion Gene ORF analysis for C22orf39-MAPK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000333059ENST00000491588C22orf39chr22

19434900

-MAPK1chr22

22162135

-
5CDS-intronENST00000399562ENST00000491588C22orf39chr22

19434900

-MAPK1chr22

22162135

-
5CDS-intronENST00000399568ENST00000491588C22orf39chr22

19434900

-MAPK1chr22

22162135

-
5CDS-intronENST00000542103ENST00000491588C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000333059ENST00000398822C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000333059ENST00000544786C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000399562ENST00000398822C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000399562ENST00000544786C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000399568ENST00000398822C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000399568ENST00000544786C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000542103ENST00000398822C22orf39chr22

19434900

-MAPK1chr22

22162135

-
Frame-shiftENST00000542103ENST00000544786C22orf39chr22

19434900

-MAPK1chr22

22162135

-
In-frameENST00000333059ENST00000215832C22orf39chr22

19434900

-MAPK1chr22

22162135

-
In-frameENST00000399562ENST00000215832C22orf39chr22

19434900

-MAPK1chr22

22162135

-
In-frameENST00000399568ENST00000215832C22orf39chr22

19434900

-MAPK1chr22

22162135

-
In-frameENST00000542103ENST00000215832C22orf39chr22

19434900

-MAPK1chr22

22162135

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399568C22orf39chr2219434900-ENST00000215832MAPK1chr2222162135-109101962811159292
ENST00000542103C22orf39chr2219434900-ENST00000215832MAPK1chr2222162135-114507364971699400
ENST00000399562C22orf39chr2219434900-ENST00000215832MAPK1chr2222162135-114507364971699400
ENST00000333059C22orf39chr2219434900-ENST00000215832MAPK1chr2222162135-109152012861164292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399568ENST00000215832C22orf39chr2219434900-MAPK1chr2222162135-0.0011228560.9988771
ENST00000542103ENST00000215832C22orf39chr2219434900-MAPK1chr2222162135-0.001181340.9988186
ENST00000399562ENST00000215832C22orf39chr2219434900-MAPK1chr2222162135-0.001181340.9988186
ENST00000333059ENST00000215832C22orf39chr2219434900-MAPK1chr2222162135-0.0011201190.99887985

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Fusion Genomic Features for C22orf39-MAPK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C22orf39-MAPK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19434900/chr22:22162135)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C22orf39

Q6P5X5

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209259_277393486.3333333333335DNA binding.
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208259_27739361.0DNA binding.
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607259_27739317.0DNA binding.
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209185_187393486.3333333333335MotifTXY
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209318_322393486.3333333333335MotifCytoplasmic retention motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209327_333393486.3333333333335MotifNuclear translocation motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208185_18739361.0MotifTXY
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208318_32239361.0MotifCytoplasmic retention motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208327_33339361.0MotifNuclear translocation motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607185_18739317.0MotifTXY
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607318_32239317.0MotifCytoplasmic retention motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607327_33339317.0MotifNuclear translocation motif
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209105_108393486.3333333333335RegionNote=Inhibitor-binding
TgeneMAPK1chr22:19434900chr22:22162135ENST0000021583209153_154393486.3333333333335RegionNote=Inhibitor-binding
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208105_10839361.0RegionNote=Inhibitor-binding
TgeneMAPK1chr22:19434900chr22:22162135ENST0000039882208153_15439361.0RegionNote=Inhibitor-binding
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607105_10839317.0RegionNote=Inhibitor-binding
TgeneMAPK1chr22:19434900chr22:22162135ENST0000054478607153_15439317.0RegionNote=Inhibitor-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPK1chr22:19434900chr22:22162135ENST00000215832092_9393486.3333333333335Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:19434900chr22:22162135ENST00000398822082_939361.0Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:19434900chr22:22162135ENST00000544786072_939317.0Compositional biasNote=Poly-Ala
TgeneMAPK1chr22:19434900chr22:22162135ENST000002158320925_313393486.3333333333335DomainProtein kinase
TgeneMAPK1chr22:19434900chr22:22162135ENST000003988220825_31339361.0DomainProtein kinase
TgeneMAPK1chr22:19434900chr22:22162135ENST000005447860725_31339317.0DomainProtein kinase
TgeneMAPK1chr22:19434900chr22:22162135ENST000002158320931_39393486.3333333333335Nucleotide bindingATP
TgeneMAPK1chr22:19434900chr22:22162135ENST000003988220831_3939361.0Nucleotide bindingATP
TgeneMAPK1chr22:19434900chr22:22162135ENST000005447860731_3939317.0Nucleotide bindingATP


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Fusion Gene Sequence for C22orf39-MAPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11585_11585_1_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000333059_MAPK1_chr22_22162135_ENST00000215832_length(transcript)=10915nt_BP=201nt
CGCCCAGACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGG
CACTTCCTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAG
CGCCGGAACGCCGAGGCCCAGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCACCAGAC
CTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCGAGCACC
AACCATCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCTCAGCAA
TGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTC
CAACCTGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTT
CCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTC
TGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTAT
TCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGT
GCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGA
AGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACAT
GGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTG
TCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCT
TGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCC
AGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTT
TAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGC
CGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGT
CAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCA
GCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAG
GTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTA
CTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGAT
TTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGT
GGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAG
AGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACA
GTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAG
TCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGT
GTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTT
CAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAAC
TCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCT
CAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTG
TAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGA
CAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAG
ATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGG
TCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGC
CCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTC
ACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCAC
TTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGT
TTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCT
TCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTG
GCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAG
AGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAAT
GTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCT
TTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTG
GGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGG
TAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAG
AGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCAC
GTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTAT
GGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAG
CAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTG
TGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTAC
GTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGC
CTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTA
TTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTAT
TCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTA
TATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAA
AAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTT
TCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGG
GCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGG
GTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGA
GCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATAC
TGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGC
GGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTT
GTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATG
CTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACT
AATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCA
CTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCAT
CTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGT
TTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAA
ACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAG
TGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGT
GGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGG
TGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCA
GAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTT
AGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGT
GGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACA
ATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGC
TATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATA
CCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCAC
TGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTG
CTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTT
TTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTC
CTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTA
GAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAG
CCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTA
GCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACC
CTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTT
GTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACAT
CGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTG
TCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAA
TACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTA
GTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAA
GGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGG
AGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCA
GGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAAT
ACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAG
GAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGG
CTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTG
GGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTA
CTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCG
ACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCC
TTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCT
GCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCA
CAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCC
TCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAG
GGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAAC
TCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCA
GGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGT
GGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGAT
GGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTC
AGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAG
GGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAG
CACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCAC
AGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAA
AAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCA
CAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCAT
TGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGG
CTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGA
TGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTG
AGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCC
CTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGC

>11585_11585_1_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000333059_MAPK1_chr22_22162135_ENST00000215832_length(amino acids)=292AA_BP=
MREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN
TTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS
QEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL

--------------------------------------------------------------
>11585_11585_2_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000399562_MAPK1_chr22_22162135_ENST00000215832_length(transcript)=11450nt_BP=736nt
ATATGTCATGCCCAACCAATCTCAGTTACTTTGCGAGTTCACCTCCATCCTGAGTGGACGCTCAAGCAAGACTGCTGGAGCTGCAGATCT
GGGAGGTTCGCTGCACCACCTTGATGCTCAGTATGTACTTTTGAAAATATACCGGATTGTTGAGATTTGAGAAAATCTCATAAAGCTGCT
GAAAAGAACTGGCCAGAGCCGTGTGATTTGAGAGGCGGCTGACGTAAGGTAGCTGCGCGGCCCAGGATGCCCGCCTGGCCCGGGGTGAAT
GGCGCTGTCGTCGCGGTGGTCGCGTAGGCTTCGCGCCAGGTCTCGCCCCGGATTTACCCTGCGACCCCGGCCCTCCGCGCGCGCCGCAGC
CGCCCTCGGTTGCTATTGGTTGCTCGTCCTGTTTGTCGGCGCTTCTCGAAGAAGGGGGCGAAGACGTGATTGAATGTGTCGGTGCTCATT
AGTTCTTCTGTCAGTCGATCACGAGGTGCCGTTTTCTTCATTTTTCATTGGCTGGCGGACTGAGGGGCGGGCTTGGCGCGCCGGTCGCCC
AGACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTT
CCTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCG
GAACGCCGAGGCCCAGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCACCAGACCTACT
GCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCA
TCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCTCAGCAATGACC
ATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACC
TGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGA
CAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAG
GCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTG
GATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCAT
GGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAG
AACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAAT
TGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGG
ACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCT
TATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGA
ATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTC
ACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCAC
CAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTG
ACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTG
CAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATG
TGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTG
GTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAA
GTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAAC
TCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGG
AACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATA
ACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGA
CTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACT
GTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATA
ATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTAT
TGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCT
GTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATT
CATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTC
AGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAG
TTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCA
AATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAG
AGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCAC
TCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCG
TGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCA
TTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAA
ATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATG
AAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAAT
GGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACA
GATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTT
GGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATG
GAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAA
GAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTA
ACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAAT
ATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAA
CAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATC
CCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTT
TAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCAT
CCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTT
CTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTA
CCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATT
ATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTT
CATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACT
ACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATC
TGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGT
GAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGG
CGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAG
AAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAA
AATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTG
GCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATA
TGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCT
TTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCA
GAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTG
GGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCC
TTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGA
CCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACC
CCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAG
GGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCAT
TGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAG
AGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCC
ACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTG
GGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCAC
GTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGAT
ATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATAT
CACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAA
TGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGT
TCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGT
CCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTAT
TTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGG
GTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGAC
GGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACT
GCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGT
TTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGT
ACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTC
CCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGC
CTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCA
AGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTA
GGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAG
ACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAA
GCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAA
GATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAG
TGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAA
ATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGA
AGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGG
TGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAA
CATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAG
GAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAAT
TTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTA
TGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCAT
AGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGAT
GACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCT
AGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCA
GGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGC
AGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAAT
GAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGG
CGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGC
CACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTA
AGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGAT
TAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAG
GGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAAC
ACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAG
GGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTG
TGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTT
TTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCC
TGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACA
AGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATA
AGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCT
GCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATT

>11585_11585_2_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000399562_MAPK1_chr22_22162135_ENST00000215832_length(amino acids)=400AA_BP=79
MAGGLRGGLGAPVAQTWRTAAAGSRRAPARPTAPSGSSAAAPGTSYTTTTSTASGRPANSGSATWPAAATGRSAGTPRPSSAYDNVNKVR
VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYI
HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG
KHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS

--------------------------------------------------------------
>11585_11585_3_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000399568_MAPK1_chr22_22162135_ENST00000215832_length(transcript)=10910nt_BP=196nt
AGACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTT
CCTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCG
GAACGCCGAGGCCCAGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCACCAGACCTACT
GCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCA
TCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCTCAGCAATGACC
ATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACC
TGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGA
CAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAG
GCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTG
GATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCAT
GGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAG
AACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAAT
TGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGG
ACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCT
TATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGA
ATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTC
ACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCAC
CAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTG
ACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTG
CAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATG
TGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTG
GTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAA
GTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAAC
TCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGG
AACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATA
ACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGA
CTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACT
GTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATA
ATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTAT
TGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCT
GTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATT
CATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTC
AGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAG
TTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCA
AATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAG
AGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCAC
TCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCG
TGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCA
TTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAA
ATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATG
AAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAAT
GGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACA
GATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTT
GGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATG
GAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAA
GAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTA
ACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAAT
ATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAA
CAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATC
CCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTT
TAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCAT
CCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTT
CTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTA
CCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATT
ATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTT
CATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACT
ACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATC
TGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGT
GAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGG
CGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAG
AAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAA
AATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTG
GCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATA
TGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCT
TTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCA
GAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTG
GGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCC
TTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGA
CCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACC
CCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAG
GGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCAT
TGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAG
AGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCC
ACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTG
GGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCAC
GTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGAT
ATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATAT
CACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAA
TGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGT
TCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGT
CCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTAT
TTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGG
GTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGAC
GGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACT
GCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGT
TTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGT
ACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTC
CCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGC
CTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCA
AGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTA
GGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAG
ACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAA
GCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAA
GATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAG
TGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAA
ATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGA
AGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGG
TGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAA
CATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAG
GAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAAT
TTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTA
TGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCAT
AGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGAT
GACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCT
AGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCA
GGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGC
AGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAAT
GAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGG
CGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGC
CACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTA
AGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGAT
TAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAG
GGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAAC
ACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAG
GGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTG
TGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTT
TTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCC
TGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACA
AGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATA
AGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCT
GCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATT

>11585_11585_3_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000399568_MAPK1_chr22_22162135_ENST00000215832_length(amino acids)=292AA_BP=
MREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN
TTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS
QEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL

--------------------------------------------------------------
>11585_11585_4_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000542103_MAPK1_chr22_22162135_ENST00000215832_length(transcript)=11450nt_BP=736nt
ATATGTCATGCCCAACCAATCTCAGTTACTTTGCGAGTTCACCTCCATCCTGAGTGGACGCTCAAGCAAGACTGCTGGAGCTGCAGATCT
GGGAGGTTCGCTGCACCACCTTGATGCTCAGTATGTACTTTTGAAAATATACCGGATTGTTGAGATTTGAGAAAATCTCATAAAGCTGCT
GAAAAGAACTGGCCAGAGCCGTGTGATTTGAGAGGCGGCTGACGTAAGGTAGCTGCGCGGCCCAGGATGCCCGCCTGGCCCGGGGTGAAT
GGCGCTGTCGTCGCGGTGGTCGCGTAGGCTTCGCGCCAGGTCTCGCCCCGGATTTACCCTGCGACCCCGGCCCTCCGCGCGCGCCGCAGC
CGCCCTCGGTTGCTATTGGTTGCTCGTCCTGTTTGTCGGCGCTTCTCGAAGAAGGGGGCGAAGACGTGATTGAATGTGTCGGTGCTCATT
AGTTCTTCTGTCAGTCGATCACGAGGTGCCGTTTTCTTCATTTTTCATTGGCTGGCGGACTGAGGGGCGGGCTTGGCGCGCCGGTCGCCC
AGACATGGCGGACGGCAGCGGCTGGCAGCCGCCGCGCCCCTGCGAGGCCTACCGCGCCGAGTGGAAGCTCTGCCGCAGCGCCAGGCACTT
CCTACACCACTACTACGTCCACGGCGAGCGGCCGGCCTGCGAACAGTGGCAGCGCGACCTGGCCAGCTGCCGCGACTGGGAGGAGCGCCG
GAACGCCGAGGCCCAGCTCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAGCACCAGACCTACT
GCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACATGAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCA
TCGAGCAAATGAAAGATGTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACACCTCAGCAATGACC
ATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATCCATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACC
TGCTGCTCAACACCACCTGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGA
CAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAG
GCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTG
GATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCAT
GGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAG
AACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAAT
TGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGG
ACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCT
TATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGA
ATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTC
ACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCAC
CAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTG
ACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTG
CAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATG
TGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTG
GTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAA
GTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAAC
TCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGG
AACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATA
ACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGA
CTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACT
GTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATA
ATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTAT
TGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCT
GTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATT
CATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTC
AGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAG
TTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCA
AATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAG
AGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCAC
TCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCG
TGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCA
TTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAA
ATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATG
AAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAAT
GGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACA
GATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTT
GGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATG
GAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAA
GAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTA
ACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAAT
ATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAA
CAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATC
CCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTT
TAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCAT
CCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTT
CTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTA
CCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATT
ATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTT
CATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACT
ACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATC
TGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGT
GAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGG
CGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAG
AAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAA
AATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTG
GCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATA
TGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCT
TTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCA
GAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTG
GGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCC
TTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGA
CCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACC
CCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAG
GGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCAT
TGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAG
AGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCC
ACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTG
GGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCAC
GTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGAT
ATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATAT
CACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAA
TGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGT
TCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGT
CCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTAT
TTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGG
GTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGAC
GGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACT
GCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGT
TTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGT
ACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTC
CCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGC
CTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCA
AGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTA
GGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAG
ACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAA
GCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAA
GATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAG
TGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAA
ATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGA
AGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGG
TGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAA
CATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAG
GAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAAT
TTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTA
TGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCAT
AGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGAT
GACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCT
AGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCA
GGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGC
AGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAAT
GAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGG
CGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGC
CACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTA
AGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGAT
TAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAG
GGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAAC
ACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAG
GGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTG
TGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTT
TTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCC
TGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACA
AGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATA
AGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCT
GCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATT

>11585_11585_4_C22orf39-MAPK1_C22orf39_chr22_19434900_ENST00000542103_MAPK1_chr22_22162135_ENST00000215832_length(amino acids)=400AA_BP=79
MAGGLRGGLGAPVAQTWRTAAAGSRRAPARPTAPSGSSAAAPGTSYTTTTSTASGRPANSGSATWPAAATGRSAGTPRPSSAYDNVNKVR
VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYI
HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG
KHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS

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Fusion Gene PPI Analysis for C22orf39-MAPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C22orf39-MAPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C22orf39-MAPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0009171Cocaine Abuse2CTD_human
TgeneC0020429Hyperalgesia2CTD_human
TgeneC0024121Lung Neoplasms2CTD_human
TgeneC0236736Cocaine-Related Disorders2CTD_human
TgeneC0242379Malignant neoplasm of lung2CTD_human
TgeneC0458247Allodynia2CTD_human
TgeneC0600427Cocaine Dependence2CTD_human
TgeneC0751211Hyperalgesia, Primary2CTD_human
TgeneC0751212Hyperalgesia, Secondary2CTD_human
TgeneC0751213Tactile Allodynia2CTD_human
TgeneC0751214Hyperalgesia, Thermal2CTD_human
TgeneC2936719Mechanical Allodynia2CTD_human
TgeneC0005398Cholestasis, Extrahepatic1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007786Brain Ischemia1CTD_human
TgeneC0017639Gliosis1CTD_human
TgeneC0018671Head and Neck Neoplasms1CTD_human
TgeneC0018675Head Neoplasms1CTD_human
TgeneC0019207Hepatoma, Morris1CTD_human
TgeneC0019208Hepatoma, Novikoff1CTD_human
TgeneC0020564Hypertrophy1CTD_human
TgeneC0021361Female infertility1CTD_human
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0023904Liver Neoplasms, Experimental1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0027533Neck Neoplasms1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0027746Nerve Degeneration1CTD_human
TgeneC0033141Cardiomyopathies, Primary1CTD_human
TgeneC0034189Pyemia1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0036529Myocardial Diseases, Secondary1CTD_human
TgeneC0036690Septicemia1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0038279Sterility, Postpartum1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0038587Substance Withdrawal Syndrome1CTD_human
TgeneC0040997Trigeminal Neuralgia1CTD_human
TgeneC0086189Drug Withdrawal Symptoms1CTD_human
TgeneC0086404Experimental Hepatoma1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0087169Withdrawal Symptoms1CTD_human
TgeneC0155862Streptococcal pneumonia1CTD_human
TgeneC0178417Anhedonia1PSYGENET
TgeneC0243026Sepsis1CTD_human
TgeneC0278996Malignant Head and Neck Neoplasm1CTD_human
TgeneC0341869Subfertility, Female1CTD_human
TgeneC0393786Trigeminal Neuralgia, Idiopathic1CTD_human
TgeneC0393787Secondary Trigeminal Neuralgia1CTD_human
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC0746787Cancer of Neck1CTD_human
TgeneC0751177Cancer of Head1CTD_human
TgeneC0878544Cardiomyopathies1CTD_human
TgeneC0887900Upper Aerodigestive Tract Neoplasms1CTD_human
TgeneC0917730Female sterility1CTD_human
TgeneC0917798Cerebral Ischemia1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC1719672Severe Sepsis1CTD_human
TgeneC1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC3887640Astrocytosis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human