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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:COL5A1-DDX21 (FusionGDB2 ID:HG1289TG9188) |
Fusion Gene Summary for COL5A1-DDX21 |
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Fusion gene information | Fusion gene name: COL5A1-DDX21 | Fusion gene ID: hg1289tg9188 | Hgene | Tgene | Gene symbol | COL5A1 | DDX21 | Gene ID | 1289 | 9188 |
Gene name | collagen type V alpha 1 chain | DExD-box helicase 21 | |
Synonyms | EDSC|EDSCL1 | GUA|GURDB|RH-II/GU|RH-II/GuA | |
Cytomap | ('COL5A1')('DDX21') 9q34.3 | 10q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | collagen alpha-1(V) chaincollagen, type V, alpha 1 | nucleolar RNA helicase 2DEAD (Asp-Glu-Ala-Asp) box helicase 21DEAD (Asp-Glu-Ala-Asp) box polypeptide 21DEAD box protein 21DEAD-box helicase 21DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21Gu proteinRH II/GuRNA helicase II/Gu alphagu-alphanucleo | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P20908 | Q9NR30 | |
Ensembl transtripts involved in fusion gene | ENST00000371817, ENST00000464187, | ||
Fusion gene scores | * DoF score | 11 X 10 X 8=880 | 36 X 11 X 14=5544 |
# samples | 12 | 37 | |
** MAII score | log2(12/880*10)=-2.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/5544*10)=-3.9053300816209 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COL5A1 [Title/Abstract] AND DDX21 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | COL5A1(137736686)-DDX21(70723858), # samples:1 COL5A1(137734719)-DDX21(70723858), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COL5A1 | GO:1903225 | negative regulation of endodermal cell differentiation | 23154389 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ACC | TCGA-P6-A5OG-01A | COL5A1 | chr9 | 137734719 | - | DDX21 | chr10 | 70723858 | + |
ChimerDB4 | UCS | TCGA-N6-A4VG-01A | COL5A1 | chr9 | 137736686 | - | DDX21 | chr10 | 70723858 | + |
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Fusion Gene ORF analysis for COL5A1-DDX21 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000371817 | ENST00000354185 | COL5A1 | chr9 | 137734719 | - | DDX21 | chr10 | 70723858 | + |
5CDS-intron | ENST00000371817 | ENST00000354185 | COL5A1 | chr9 | 137736686 | - | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000464187 | ENST00000354185 | COL5A1 | chr9 | 137734719 | - | DDX21 | chr10 | 70723858 | + |
intron-intron | ENST00000464187 | ENST00000354185 | COL5A1 | chr9 | 137736686 | - | DDX21 | chr10 | 70723858 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for COL5A1-DDX21 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for COL5A1-DDX21 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:137736686/:70723858) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
COL5A1 | DDX21 |
FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. | FUNCTION: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for COL5A1-DDX21 |
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Fusion Gene PPI Analysis for COL5A1-DDX21 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COL5A1-DDX21 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COL5A1-DDX21 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COL5A1 | C4552122 | EHLERS-DANLOS SYNDROME, CLASSIC TYPE, 1 | 7 | GENOMICS_ENGLAND;UNIPROT |
Hgene | COL5A1 | C0268335 | Ehlers-Danlos syndrome type 1 | 3 | CTD_human;GENOMICS_ENGLAND |
Hgene | COL5A1 | C0220679 | Ehlers-Danlos Syndrome, Autosomal Dominant, Type Unspecified | 2 | ORPHANET |
Hgene | COL5A1 | C0268336 | Ehlers-Danlos syndrome type 2 | 2 | CTD_human;GENOMICS_ENGLAND |
Hgene | COL5A1 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | COL5A1 | C0000822 | Abortion, Tubal | 1 | CTD_human |
Hgene | COL5A1 | C0005779 | Blood Coagulation Disorders | 1 | GENOMICS_ENGLAND |
Hgene | COL5A1 | C0007097 | Carcinoma | 1 | CTD_human |
Hgene | COL5A1 | C0022548 | Keloid | 1 | CTD_human |
Hgene | COL5A1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | COL5A1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | COL5A1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | COL5A1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | COL5A1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
Hgene | COL5A1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
Hgene | COL5A1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
Hgene | COL5A1 | C0205699 | Carcinomatosis | 1 | CTD_human |
Hgene | COL5A1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | COL5A1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
Hgene | COL5A1 | C1458140 | Bleeding tendency | 1 | GENOMICS_ENGLAND |
Hgene | COL5A1 | C1846545 | Autoimmune Lymphoproliferative Syndrome Type 2B | 1 | GENOMICS_ENGLAND |
Hgene | COL5A1 | C3830362 | Early Pregnancy Loss | 1 | CTD_human |
Hgene | COL5A1 | C4225429 | Ehlers-Danlos syndrome classic type | 1 | GENOMICS_ENGLAND |
Hgene | COL5A1 | C4552766 | Miscarriage | 1 | CTD_human |