|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MBOAT2-NCOA1 (FusionGDB2 ID:HG129642TG8648) |
Fusion Gene Summary for MBOAT2-NCOA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MBOAT2-NCOA1 | Fusion gene ID: hg129642tg8648 | Hgene | Tgene | Gene symbol | MBOAT2 | NCOA1 | Gene ID | 129642 | 8648 |
| Gene name | membrane bound O-acyltransferase domain containing 2 | nuclear receptor coactivator 1 | |
| Synonyms | LPAAT|LPCAT4|LPEAT|LPLAT 2|OACT2 | F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74 | |
| Cytomap | ('MBOAT2')('NCOA1') 2p25.1 | 2p23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophospholipid acyltransferase 21-acylglycerophosphate O-acyltransferase1-acylglycerophosphoethanolamine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 2lyso-PA acyltransferaselyso-PE acyltransferaselysophosphatidic acid acy | nuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | Q6ZWT7 | Q15788 | |
| Ensembl transtripts involved in fusion gene | ENST00000305997, ENST00000486484, | ||
| Fusion gene scores | * DoF score | 11 X 7 X 9=693 | 11 X 13 X 7=1001 |
| # samples | 13 | 13 | |
| ** MAII score | log2(13/693*10)=-2.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MBOAT2 [Title/Abstract] AND NCOA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MBOAT2(9143669)-NCOA1(24787164), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NCOA1 | GO:0000435 | positive regulation of transcription from RNA polymerase II promoter by galactose | 10207113 |
| Tgene | NCOA1 | GO:0006351 | transcription, DNA-templated | 9223431 |
| Tgene | NCOA1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11891224|15367689 |
| Tgene | NCOA1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15919756 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-IN-8462-11A | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
Top |
Fusion Gene ORF analysis for MBOAT2-NCOA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000305997 | ENST00000469850 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-5UTR | ENST00000305997 | ENST00000405141 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-5UTR | ENST00000305997 | ENST00000406961 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-intron | ENST00000305997 | ENST00000288599 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-intron | ENST00000305997 | ENST00000348332 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-intron | ENST00000305997 | ENST00000395856 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-intron | ENST00000305997 | ENST00000407230 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5CDS-intron | ENST00000305997 | ENST00000538539 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-3UTR | ENST00000486484 | ENST00000469850 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-5UTR | ENST00000486484 | ENST00000405141 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-5UTR | ENST00000486484 | ENST00000406961 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-intron | ENST00000486484 | ENST00000288599 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-intron | ENST00000486484 | ENST00000348332 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-intron | ENST00000486484 | ENST00000395856 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-intron | ENST00000486484 | ENST00000407230 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| 5UTR-intron | ENST00000486484 | ENST00000538539 | MBOAT2 | chr2 | 9143669 | - | NCOA1 | chr2 | 24787164 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for MBOAT2-NCOA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for MBOAT2-NCOA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:9143669/:24787164) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MBOAT2 | NCOA1 |
| FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R3I2, ECO:0000269|PubMed:18772128}. | FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for MBOAT2-NCOA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for MBOAT2-NCOA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for MBOAT2-NCOA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for MBOAT2-NCOA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MBOAT2 | C0019209 | Hepatomegaly | 1 | CTD_human |
| Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
| Tgene | C0014175 | Endometriosis | 1 | CTD_human | |
| Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
| Tgene | C0027627 | Neoplasm Metastasis | 1 | CTD_human | |
| Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
| Tgene | C0269102 | Endometrioma | 1 | CTD_human | |
| Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
| Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
| Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
| Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
| Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies