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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACVR1C-ACVR1B (FusionGDB2 ID:HG130399TG91)

Fusion Gene Summary for ACVR1C-ACVR1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ACVR1C-ACVR1B
Fusion gene ID: hg130399tg91
HgeneTgene
Gene symbol

ACVR1C

ACVR1B

Gene ID

130399

91

Gene nameactivin A receptor type 1Cactivin A receptor type 1B
SynonymsACVRLK7|ALK7ACTRIB|ACVRLK4|ALK4|SKR2
Cytomap('ACVR1C')('ACVR1B')

2q24.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionactivin receptor type-1CACTR-ICALK-7activin A receptor, type ICactivin receptor type ICactivin receptor-like kinase 7activin receptor type-1Bactivin A receptor, type IBactivin A receptor, type II-like kinase 4activin receptor-like kinase 4serine/threonine-protein kinase receptor R2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000243349, ENST00000335450, 
ENST00000409680, ENST00000348328, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 5 X 6=180
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACVR1C [Title/Abstract] AND ACVR1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACVR1C(158406673)-ACVR1B(52377782), # samples:1
Anticipated loss of major functional domain due to fusion event.ACVR1C-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR1C-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR1C-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACVR1C-ACVR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACVR1C

GO:0001834

trophectodermal cell proliferation

15150278

HgeneACVR1C

GO:0030154

cell differentiation

15531507

HgeneACVR1C

GO:0030262

apoptotic nuclear changes

15531507

HgeneACVR1C

GO:0043065

positive regulation of apoptotic process

15150278

HgeneACVR1C

GO:1901164

negative regulation of trophoblast cell migration

21356369

TgeneACVR1B

GO:0000082

G1/S transition of mitotic cell cycle

11117535

TgeneACVR1B

GO:0006355

regulation of transcription, DNA-templated

8622651|12665502

TgeneACVR1B

GO:0006468

protein phosphorylation

12065756

TgeneACVR1B

GO:0007165

signal transduction

8622651|12665502

TgeneACVR1B

GO:0018107

peptidyl-threonine phosphorylation

18039968

TgeneACVR1B

GO:0030308

negative regulation of cell growth

11117535

TgeneACVR1B

GO:0032924

activin receptor signaling pathway

9892009

TgeneACVR1B

GO:0032927

positive regulation of activin receptor signaling pathway

16720724

TgeneACVR1B

GO:0045648

positive regulation of erythrocyte differentiation

9032295

TgeneACVR1B

GO:0046777

protein autophosphorylation

18039968

TgeneACVR1B

GO:1901165

positive regulation of trophoblast cell migration

21356369


check buttonFusion gene breakpoints across ACVR1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACVR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer203NACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+


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Fusion Gene ORF analysis for ACVR1C-ACVR1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000243349ENST00000563121ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
5CDS-intronENST00000335450ENST00000563121ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
5CDS-intronENST00000409680ENST00000563121ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000243349ENST00000257963ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000243349ENST00000415850ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000243349ENST00000426655ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000243349ENST00000541224ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000243349ENST00000542485ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000335450ENST00000257963ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000335450ENST00000415850ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000335450ENST00000426655ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000335450ENST00000541224ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000335450ENST00000542485ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000409680ENST00000257963ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000409680ENST00000415850ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000409680ENST00000426655ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000409680ENST00000541224ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
In-frameENST00000409680ENST00000542485ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-3CDSENST00000348328ENST00000257963ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-3CDSENST00000348328ENST00000415850ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-3CDSENST00000348328ENST00000426655ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-3CDSENST00000348328ENST00000541224ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-3CDSENST00000348328ENST00000542485ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+
intron-intronENST00000348328ENST00000563121ACVR1Cchr2

158406673

-ACVR1Bchr12

52377782

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000243349ACVR1Cchr2158406673-ENST00000257963ACVR1Bchr1252377782+481111363521842496
ENST00000243349ACVR1Cchr2158406673-ENST00000541224ACVR1Bchr1252377782+195011363521842496
ENST00000243349ACVR1Cchr2158406673-ENST00000426655ACVR1Bchr1252377782+206511363521755467
ENST00000243349ACVR1Cchr2158406673-ENST00000415850ACVR1Bchr1252377782+199011363521788478
ENST00000243349ACVR1Cchr2158406673-ENST00000542485ACVR1Bchr1252377782+265811363521842496
ENST00000335450ACVR1Cchr2158406673-ENST00000257963ACVR1Bchr1252377782+4293618741324416
ENST00000335450ACVR1Cchr2158406673-ENST00000541224ACVR1Bchr1252377782+1432618741324416
ENST00000335450ACVR1Cchr2158406673-ENST00000426655ACVR1Bchr1252377782+1547618741237387
ENST00000335450ACVR1Cchr2158406673-ENST00000415850ACVR1Bchr1252377782+1472618741270398
ENST00000335450ACVR1Cchr2158406673-ENST00000542485ACVR1Bchr1252377782+2140618741324416
ENST00000409680ACVR1Cchr2158406673-ENST00000257963ACVR1Bchr1252377782+45789031521609485
ENST00000409680ACVR1Cchr2158406673-ENST00000541224ACVR1Bchr1252377782+17179031521609485
ENST00000409680ACVR1Cchr2158406673-ENST00000426655ACVR1Bchr1252377782+18329031521522456
ENST00000409680ACVR1Cchr2158406673-ENST00000415850ACVR1Bchr1252377782+17579031521555467
ENST00000409680ACVR1Cchr2158406673-ENST00000542485ACVR1Bchr1252377782+24259031521609485

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000243349ENST00000257963ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0012663780.9987336
ENST00000243349ENST00000541224ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0046369930.995363
ENST00000243349ENST00000426655ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0031717240.99682826
ENST00000243349ENST00000415850ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0027635820.9972364
ENST00000243349ENST00000542485ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0041078710.99589217
ENST00000335450ENST00000257963ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0006180140.999382
ENST00000335450ENST00000541224ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0016092060.9983908
ENST00000335450ENST00000426655ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0012137520.9987863
ENST00000335450ENST00000415850ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0005807320.99941933
ENST00000335450ENST00000542485ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0020914410.9979086
ENST00000409680ENST00000257963ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0039036640.9960963
ENST00000409680ENST00000541224ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.005934360.99406564
ENST00000409680ENST00000426655ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0038270690.99617296
ENST00000409680ENST00000415850ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0031980250.996802
ENST00000409680ENST00000542485ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.0068506550.99314934

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Fusion Genomic Features for ACVR1C-ACVR1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.51668490.4833151
ACVR1Cchr2158406673-ACVR1Bchr1252377782+0.51668490.4833151

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACVR1C-ACVR1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:158406673/chr12:52377782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-49165_194258494.0DomainGS
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-49165_194208444.0DomainGS
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-49201_209258494.0Nucleotide bindingATP
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-49201_209208444.0Nucleotide bindingATP
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-4922_113258494.0Topological domainExtracellular
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-3822_113178414.0Topological domainExtracellular
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-4922_113208444.0Topological domainExtracellular
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-49114_134258494.0TransmembraneHelical
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-38114_134178414.0TransmembraneHelical
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-49114_134208444.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-49195_485258494.0DomainProtein kinase
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-38165_194178414.0DomainGS
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-38195_485178414.0DomainProtein kinase
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-17165_1940337.0DomainGS
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-17195_4850337.0DomainProtein kinase
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-49195_485208444.0DomainProtein kinase
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-38201_209178414.0Nucleotide bindingATP
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-17201_2090337.0Nucleotide bindingATP
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000243349-49135_493258494.0Topological domainCytoplasmic
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000335450-38135_493178414.0Topological domainCytoplasmic
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-17135_4930337.0Topological domainCytoplasmic
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-1722_1130337.0Topological domainExtracellular
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000409680-49135_493208444.0Topological domainCytoplasmic
HgeneACVR1Cchr2:158406673chr12:52377782ENST00000348328-17114_1340337.0TransmembraneHelical
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000025796339177_206270506.0DomainGS
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000025796339207_497270506.0DomainProtein kinase
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000041585037177_206270488.0DomainGS
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000041585037207_497270488.0DomainProtein kinase
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000042665538177_206270477.0DomainGS
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000042665538207_497270477.0DomainProtein kinase
TgeneACVR1Bchr2:158406673chr12:52377782ENST00000541224410177_206311547.0DomainGS
TgeneACVR1Bchr2:158406673chr12:52377782ENST00000541224410207_497311547.0DomainProtein kinase
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054248539177_206218454.0DomainGS
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054248539207_497218454.0DomainProtein kinase
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000025796339213_221270506.0Nucleotide bindingATP
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000041585037213_221270488.0Nucleotide bindingATP
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000042665538213_221270477.0Nucleotide bindingATP
TgeneACVR1Bchr2:158406673chr12:52377782ENST00000541224410213_221311547.0Nucleotide bindingATP
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054248539213_221218454.0Nucleotide bindingATP
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000025796339150_505270506.0Topological domainCytoplasmic
TgeneACVR1Bchr2:158406673chr12:52377782ENST000002579633924_126270506.0Topological domainExtracellular
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000041585037150_505270488.0Topological domainCytoplasmic
TgeneACVR1Bchr2:158406673chr12:52377782ENST000004158503724_126270488.0Topological domainExtracellular
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000042665538150_505270477.0Topological domainCytoplasmic
TgeneACVR1Bchr2:158406673chr12:52377782ENST000004266553824_126270477.0Topological domainExtracellular
TgeneACVR1Bchr2:158406673chr12:52377782ENST00000541224410150_505311547.0Topological domainCytoplasmic
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054122441024_126311547.0Topological domainExtracellular
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054248539150_505218454.0Topological domainCytoplasmic
TgeneACVR1Bchr2:158406673chr12:52377782ENST000005424853924_126218454.0Topological domainExtracellular
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000025796339127_149270506.0TransmembraneHelical
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000041585037127_149270488.0TransmembraneHelical
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000042665538127_149270477.0TransmembraneHelical
TgeneACVR1Bchr2:158406673chr12:52377782ENST00000541224410127_149311547.0TransmembraneHelical
TgeneACVR1Bchr2:158406673chr12:52377782ENST0000054248539127_149218454.0TransmembraneHelical


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Fusion Gene Sequence for ACVR1C-ACVR1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1894_1894_1_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000257963_length(transcript)=4811nt_BP=1136nt
GCCGGGCACAGGGCCGCCTTTGCCTGCCTGCCCTGCAGCAGCAGGCCCGGGCGGCTGCGAGAGGGCGCAGGGGGCGGAGGCGCGGCAGGG
GCGGGCTCTGCCGCCCGCCCCACCACCCGCTCCCCGCCCGGCTGCGGGGCCAGTGGCAGGAGCGCCGCGCACCGCCAGCCGCAGGGGGCG
TGGGATGGGGGCGGCCGGGGAGGGGGGCGCCCACACTGACTAGAGCCAACCGCGCACTTCAAAAGGGTGTCGGTGCCGCGCTCCCCTCCC
GCGGCCCGGGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGC
GATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATG
TCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGAT
CAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGA
TTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGT
GCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAA
TGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGG
CTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTG
GCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCA
GACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTC
TGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGC
TAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCT
GGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTGACACCATTGACATTGCCCCGAA
TCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACTTTGACTCCTTTAAATGTGCTGA
TATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAGAATATCAGCTGCCATATTACGA
CTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAG
TTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAA
GACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCAC
AGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCCTCTGTGGCCAGGAGCCCTGGCCCGCAAGAGGGACAGA
GCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTCTATTTACCTCCTAATGGCATGGAGACTCTGAGAGCGA
ATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCCGCGAAACCCGGTGCATCTGGCACGTGGCCAGGAGCCA
TGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAGCTGCCCTGAGGGTTTCCTTCGGGGACCAGCCCACAGC
ACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTCTGAGCCGCGCTTTCCCCTCCTCCCTGGGATGGACGCT
GCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTGTGTGCATGTGCCGAGGTGCGTCCCCCGTTGTGCCTGG
TTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTGCGCACTTACCTGCTTGAGCTTTCTGTGCATGTGCAGG
TCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAGTGAGCAGCATCTAGTTTCCCTGGTGCCCTTCCCTGGA
GGTCTCTCCCTCCCCCAGAGCCCCTCATGCCACAGTGGTACTCTGTGTCTGGCAGGCTACTCTGCCCACCCCAGCATCAGCACAGCTCTC
CTCCTCCATCTCAGACTGTGGAACCAAAGCTGGCCCAGTTGTCCATGACAAAAGAGGCTTTTGGGCCAAAATGTGAGGGTGGTGGGTGGG
ATGGGCAGGGAAGGAATCCTGGTGGAAGTCTTGGGTGTTAGTGTCAGCCATGGGAAATGAGCCAGCCCAAGGGCATCATCCTCAGCAGCA
TCGAGGAAGGGCCGAGGAATGTGAAGCCAGATCTCGGGACTCAGATTGGAATGTTACATCTGTCTTTCATCTCCCAGATCCTGGAAACAG
CAGTGTATATTTTTGGTGGTGGTGGGTTTGGGGTGGGGAAGGGAAGGGCGGGCAAGGAGTGGGGAGGGAGTCTGGGGTGGGAGGGAGGCA
TCTGCATGGGTCTTCTTTTACTGGACTGTCTGATCAGGGTGGAGGGAAGGTGAGAGGTTTGCATCCACTTCAGGAGCCCTACTGAAGGGA
ACAGCCTGAGCCGAACATGTTATTTAACCTGAGTATAGTATTTAACGAAGCCTAGAAGCACGGCTGTGGGTGGTGATTTGGTCAGCATAT
CTTAGGTATATAATAACTTTGAAGCCATAACTTTTAACTGGAGTGGTTTGATTTCTTTTTTTAATTTTATTGGGAGGGTTTGGATTTTAA
CTTTTTTTAATGTTGTTAAATATTAAGTTTTTGTAAAAGGAAAACCATCTCTGTGATTACCTCTCAATCTATTTGTTTTTAAAGAAATCC
CTAAAAAAAAAAATTATCCAATTGAACGCACATAGCTCAATCACACTGGAAATGTTTGTCCTTGCACCTGAGCCTGTTCCCACTCAGCAG
TGAGAGTTCCTCTTTGCCCTGAGGCTCAGTCTCTCTCGTATTTTGTCCCCACCCCCAATTCCTTGAGTGGTTTTTGCTCTAGGGCCCTTT
CTTGCACTGTCCAGCTGGTTGTACCCTCTCCAGGCATTTATTCAACAAATGTGGGTGAAGTGCCTGCTGGGTGCCAGGTGCTGGGAATAC
ATCTGTGGACAAGACATGCTTGGGTCCTACTCCTGGAGCACTGTAAAAAGAGCTGATTCAAGTAAGTAGATGCCTGTTTTGAGACCAGAA
GGTTTCATAATTGGTTCTACGACCCTTTTGAGCCTAGAATTATTGTTCTTATATAAGATCACTGAAGAAAGAGGAACCCCCACAACCCCC
TCCACAAAGAGACCAGGGGCGGGTGATGAGACCTGGGGTTTAGAACCCCAGGTGAGACCTCAAATCACTGCATTCATTCTGAGCCCCCTT
CCTGTCCCCAGGGGAGGTGTATTGTGTATGTAGCCTTAGAGCATCTCTGCCTCCAACCCAGCAGTTCTCTGCCAAAGCTTGTGGAGGAGG
GAGAGCCCTGTCCCTGCCCTCAGGCTCCCCAGTGCTCCTGGCCCTTCTATTTATTTGACTGATTATTGCTTCTTTCCTTGCATTAAAGGA
GATCTTCCCCTAACCTTTGGGCCAATTTACTGGCCACTAATTTCGTTTAAATACCATTGTGTCATTGGGGGGACCGTCTTTACCCCTGCT
GACCTCCCACCTATCCGCCCTGCAGCAGAACCTTGGCGGTTTATAGGTAATGATGGAACTTAGACTCCTCTTCCCAGAGTCACAAGTAGC
CTCTGGGATCTGCCAACACACGTCCACTCCCAAGCCACTAGCCCACTCCCCAGTTGGCCCTTCTGCCCTTACCCCACACACAGTCCAACT
CTTCCACCTCTGGGGAAGATGGAGCAGGTCTTTGGGAAGCTCCCACACCCACCTCTGCCACTCTTAACACTAAGTGAGAGTTGGGGAGAA
ACTGAAGCCGTGTTTTTGGCCCCCCGAGGCTAACCCTGATCCATAGTGCTACCTGCACCTCTGGATTCTGGATTCACAGACCAAGTCCAA
GCCCGTTCTTACGTCGCCATAAAGGCCCCCGAACGGCATTCTCGGTACTTCTGTTTGTTTTTGTACATTTTATTAGAAAGGACTGTAAAA
TAGCCACTTAGACACTTTACCTCTTCAGTATGCAAATGTAAATAAATTGTAATATAGGAAATCTTTTGTTTTAATATAAGAATGAGCCTG

>1894_1894_1_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000257963_length(amino acids)=496AA_BP=184
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTAS
GSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDI
APNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNW

--------------------------------------------------------------
>1894_1894_2_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000415850_length(transcript)=1990nt_BP=1136nt
GCCGGGCACAGGGCCGCCTTTGCCTGCCTGCCCTGCAGCAGCAGGCCCGGGCGGCTGCGAGAGGGCGCAGGGGGCGGAGGCGCGGCAGGG
GCGGGCTCTGCCGCCCGCCCCACCACCCGCTCCCCGCCCGGCTGCGGGGCCAGTGGCAGGAGCGCCGCGCACCGCCAGCCGCAGGGGGCG
TGGGATGGGGGCGGCCGGGGAGGGGGGCGCCCACACTGACTAGAGCCAACCGCGCACTTCAAAAGGGTGTCGGTGCCGCGCTCCCCTCCC
GCGGCCCGGGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGC
GATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATG
TCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGAT
CAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGA
TTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGT
GCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAA
TGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGG
CTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTG
GCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCA
GACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTC
TGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGC
TAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCT
GGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTGACACCATTGACATTGCCCCGAA
TCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACTTTGACTCCTTTAAATGTGCTGA
TATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGTACCTTTCTTTTTTGCCTTTGCTCCTACCTCCC
ATTCCAGGATGCTGGATCACCCAAAGCTGTTTTACTGCCCCCTTTCTTTTTACAACCTGTTGGATGCCTGTTGCCAGAGCCTGAATCATC
GTTTAAGGTTGCCATCAAAGGTGTGGAGGTAGCTGTGCTTAGGGTGCGTTTATTCTTCAGGGATCAGTTTGTTGAATAGCGTTGTGTGTT
ATGGTAACCATTCTGAAGGCTCGTTTGGCTTTATAAACAAACAAACATTGTTTTATTAGTCCGTGGCGGGGAGTGCCCCGGTGCGCATAG
CACGGGATTCATGCAGTGGTCTCCTTCACATCAGAAGCAGTATATTCTAACGCGGTGGCTCCCAAGCCACATTCATGGGAAACCCTGCTG

>1894_1894_2_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000415850_length(amino acids)=478AA_BP=184
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTAS
GSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDI
APNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGTFLFCLCSYLPFQDAGSPKAVLLPPFFLQPVGCLLPEP

--------------------------------------------------------------
>1894_1894_3_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000426655_length(transcript)=2065nt_BP=1136nt
GCCGGGCACAGGGCCGCCTTTGCCTGCCTGCCCTGCAGCAGCAGGCCCGGGCGGCTGCGAGAGGGCGCAGGGGGCGGAGGCGCGGCAGGG
GCGGGCTCTGCCGCCCGCCCCACCACCCGCTCCCCGCCCGGCTGCGGGGCCAGTGGCAGGAGCGCCGCGCACCGCCAGCCGCAGGGGGCG
TGGGATGGGGGCGGCCGGGGAGGGGGGCGCCCACACTGACTAGAGCCAACCGCGCACTTCAAAAGGGTGTCGGTGCCGCGCTCCCCTCCC
GCGGCCCGGGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGC
GATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATG
TCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGAT
CAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGA
TTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGT
GCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAA
TGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGG
CTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTG
GCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCA
GACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTC
TGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGC
TAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCT
GGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTGACACCATTGACATTGCCCCGAA
TCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACTTTGACTCCTTTAAATGTGCTGA
TATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAGAATATCAGCTGCCATATTACGA
CTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAG
TTATGAGGTAAGAAGCTGGCCTCCTGCGGCTTTCCCATCAGCCTGATTTCTCCACCTTAGAAAAGGGTTTCTTGACAATGGGGTCAGGCC
CCAGAGGAGCCCCCTGAGAGTGTCAGTTATTATTTACTATTACGTGCTATTTTACATATCCCAAGCCCTTTAGGGCTACAGTCTCTTGTC
CTGGACCCTGTAGGGTGCCATTTGGAGTTCACAGCCTAGAAGAAGAAAAGGCTTTGGGCCTGGTGTGGTGGCATAGGCCTGTAATCGTAG

>1894_1894_3_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000426655_length(amino acids)=467AA_BP=184
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTAS
GSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDI
APNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNW

--------------------------------------------------------------
>1894_1894_4_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000541224_length(transcript)=1950nt_BP=1136nt
GCCGGGCACAGGGCCGCCTTTGCCTGCCTGCCCTGCAGCAGCAGGCCCGGGCGGCTGCGAGAGGGCGCAGGGGGCGGAGGCGCGGCAGGG
GCGGGCTCTGCCGCCCGCCCCACCACCCGCTCCCCGCCCGGCTGCGGGGCCAGTGGCAGGAGCGCCGCGCACCGCCAGCCGCAGGGGGCG
TGGGATGGGGGCGGCCGGGGAGGGGGGCGCCCACACTGACTAGAGCCAACCGCGCACTTCAAAAGGGTGTCGGTGCCGCGCTCCCCTCCC
GCGGCCCGGGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGC
GATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATG
TCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGAT
CAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGA
TTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGT
GCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAA
TGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGG
CTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTG
GCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCA
GACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTC
TGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGC
TAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCT
GGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTGACACCATTGACATTGCCCCGAA
TCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACTTTGACTCCTTTAAATGTGCTGA
TATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAGAATATCAGCTGCCATATTACGA
CTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAG
TTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAA
GACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCAC

>1894_1894_4_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000541224_length(amino acids)=496AA_BP=184
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTAS
GSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDI
APNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNW

--------------------------------------------------------------
>1894_1894_5_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000542485_length(transcript)=2658nt_BP=1136nt
GCCGGGCACAGGGCCGCCTTTGCCTGCCTGCCCTGCAGCAGCAGGCCCGGGCGGCTGCGAGAGGGCGCAGGGGGCGGAGGCGCGGCAGGG
GCGGGCTCTGCCGCCCGCCCCACCACCCGCTCCCCGCCCGGCTGCGGGGCCAGTGGCAGGAGCGCCGCGCACCGCCAGCCGCAGGGGGCG
TGGGATGGGGGCGGCCGGGGAGGGGGGCGCCCACACTGACTAGAGCCAACCGCGCACTTCAAAAGGGTGTCGGTGCCGCGCTCCCCTCCC
GCGGCCCGGGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGC
GATGACCCGGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATG
TCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGAT
CAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGA
TTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAAAACTTGGACCCATGGAGCTGGCCATCATTATTACTGT
GCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGGGTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAA
TGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGAAAGATCTGATTTATGATGTGACCGCCTCTGGATCTGG
CTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTG
GCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCA
GACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTC
TGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGC
TAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCT
GGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTGACACCATTGACATTGCCCCGAA
TCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACTTTGACTCCTTTAAATGTGCTGA
TATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAGAATATCAGCTGCCATATTACGA
CTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAG
TTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAA
GACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCAC
AGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCCTCTGTGGCCAGGAGCCCTGGCCCGCAAGAGGGACAGA
GCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTCTATTTACCTCCTAATGGCATGGAGACTCTGAGAGCGA
ATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCCGCGAAACCCGGTGCATCTGGCACGTGGCCAGGAGCCA
TGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAGCTGCCCTGAGGGTTTCCTTCGGGGACCAGCCCACAGC
ACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTCTGAGCCGCGCTTTCCCCTCCTCCCTGGGATGGACGCT
GCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTGTGTGCATGTGCCGAGGTGCGTCCCCCGTTGTGCCTGG
TTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTGCGCACTTACCTGCTTGAGCTTTCTGTGCATGTGCAGG
TCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAGTGAGCAGCATCTAGTTTCCCTGGTGCCCTTCCCTGGA

>1894_1894_5_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000243349_ACVR1B_chr12_52377782_ENST00000542485_length(amino acids)=496AA_BP=184
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTAS
GSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLW
LVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDI
APNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNW

--------------------------------------------------------------
>1894_1894_6_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000257963_length(transcript)=4293nt_BP=618nt
GGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGCGATGACCC
GGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATGTCTTTTGT
GTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCT
GTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCA
ACAACATAACACTGCACCTTCCAACAGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAA
AAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGT
TTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCT
GGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGA
TTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAG
ACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTG
ACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACT
TTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAG
AATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCA
ACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCC
TGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCT
CCTGGCAGCGAGAACTACGCACAGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCCTCTGTGGCCAGGAGC
CCTGGCCCGCAAGAGGGACAGAGCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTCTATTTACCTCCTAAT
GGCATGGAGACTCTGAGAGCGAATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCCGCGAAACCCGGTGCA
TCTGGCACGTGGCCAGGAGCCATGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAGCTGCCCTGAGGGTTT
CCTTCGGGGACCAGCCCACAGCACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTCTGAGCCGCGCTTTCC
CCTCCTCCCTGGGATGGACGCTGCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTGTGTGCATGTGCCGAG
GTGCGTCCCCCGTTGTGCCTGGTTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTGCGCACTTACCTGCTT
GAGCTTTCTGTGCATGTGCAGGTCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAGTGAGCAGCATCTAGT
TTCCCTGGTGCCCTTCCCTGGAGGTCTCTCCCTCCCCCAGAGCCCCTCATGCCACAGTGGTACTCTGTGTCTGGCAGGCTACTCTGCCCA
CCCCAGCATCAGCACAGCTCTCCTCCTCCATCTCAGACTGTGGAACCAAAGCTGGCCCAGTTGTCCATGACAAAAGAGGCTTTTGGGCCA
AAATGTGAGGGTGGTGGGTGGGATGGGCAGGGAAGGAATCCTGGTGGAAGTCTTGGGTGTTAGTGTCAGCCATGGGAAATGAGCCAGCCC
AAGGGCATCATCCTCAGCAGCATCGAGGAAGGGCCGAGGAATGTGAAGCCAGATCTCGGGACTCAGATTGGAATGTTACATCTGTCTTTC
ATCTCCCAGATCCTGGAAACAGCAGTGTATATTTTTGGTGGTGGTGGGTTTGGGGTGGGGAAGGGAAGGGCGGGCAAGGAGTGGGGAGGG
AGTCTGGGGTGGGAGGGAGGCATCTGCATGGGTCTTCTTTTACTGGACTGTCTGATCAGGGTGGAGGGAAGGTGAGAGGTTTGCATCCAC
TTCAGGAGCCCTACTGAAGGGAACAGCCTGAGCCGAACATGTTATTTAACCTGAGTATAGTATTTAACGAAGCCTAGAAGCACGGCTGTG
GGTGGTGATTTGGTCAGCATATCTTAGGTATATAATAACTTTGAAGCCATAACTTTTAACTGGAGTGGTTTGATTTCTTTTTTTAATTTT
ATTGGGAGGGTTTGGATTTTAACTTTTTTTAATGTTGTTAAATATTAAGTTTTTGTAAAAGGAAAACCATCTCTGTGATTACCTCTCAAT
CTATTTGTTTTTAAAGAAATCCCTAAAAAAAAAAATTATCCAATTGAACGCACATAGCTCAATCACACTGGAAATGTTTGTCCTTGCACC
TGAGCCTGTTCCCACTCAGCAGTGAGAGTTCCTCTTTGCCCTGAGGCTCAGTCTCTCTCGTATTTTGTCCCCACCCCCAATTCCTTGAGT
GGTTTTTGCTCTAGGGCCCTTTCTTGCACTGTCCAGCTGGTTGTACCCTCTCCAGGCATTTATTCAACAAATGTGGGTGAAGTGCCTGCT
GGGTGCCAGGTGCTGGGAATACATCTGTGGACAAGACATGCTTGGGTCCTACTCCTGGAGCACTGTAAAAAGAGCTGATTCAAGTAAGTA
GATGCCTGTTTTGAGACCAGAAGGTTTCATAATTGGTTCTACGACCCTTTTGAGCCTAGAATTATTGTTCTTATATAAGATCACTGAAGA
AAGAGGAACCCCCACAACCCCCTCCACAAAGAGACCAGGGGCGGGTGATGAGACCTGGGGTTTAGAACCCCAGGTGAGACCTCAAATCAC
TGCATTCATTCTGAGCCCCCTTCCTGTCCCCAGGGGAGGTGTATTGTGTATGTAGCCTTAGAGCATCTCTGCCTCCAACCCAGCAGTTCT
CTGCCAAAGCTTGTGGAGGAGGGAGAGCCCTGTCCCTGCCCTCAGGCTCCCCAGTGCTCCTGGCCCTTCTATTTATTTGACTGATTATTG
CTTCTTTCCTTGCATTAAAGGAGATCTTCCCCTAACCTTTGGGCCAATTTACTGGCCACTAATTTCGTTTAAATACCATTGTGTCATTGG
GGGGACCGTCTTTACCCCTGCTGACCTCCCACCTATCCGCCCTGCAGCAGAACCTTGGCGGTTTATAGGTAATGATGGAACTTAGACTCC
TCTTCCCAGAGTCACAAGTAGCCTCTGGGATCTGCCAACACACGTCCACTCCCAAGCCACTAGCCCACTCCCCAGTTGGCCCTTCTGCCC
TTACCCCACACACAGTCCAACTCTTCCACCTCTGGGGAAGATGGAGCAGGTCTTTGGGAAGCTCCCACACCCACCTCTGCCACTCTTAAC
ACTAAGTGAGAGTTGGGGAGAAACTGAAGCCGTGTTTTTGGCCCCCCGAGGCTAACCCTGATCCATAGTGCTACCTGCACCTCTGGATTC
TGGATTCACAGACCAAGTCCAAGCCCGTTCTTACGTCGCCATAAAGGCCCCCGAACGGCATTCTCGGTACTTCTGTTTGTTTTTGTACAT
TTTATTAGAAAGGACTGTAAAATAGCCACTTAGACACTTTACCTCTTCAGTATGCAAATGTAAATAAATTGTAATATAGGAAATCTTTTG

>1894_1894_6_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000257963_length(amino acids)=416AA_BP=103
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN
KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD

--------------------------------------------------------------
>1894_1894_7_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000415850_length(transcript)=1472nt_BP=618nt
GGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGCGATGACCC
GGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATGTCTTTTGT
GTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCT
GTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCA
ACAACATAACACTGCACCTTCCAACAGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAA
AAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGT
TTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCT
GGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGA
TTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAG
ACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTG
ACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACT
TTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGTACCTTTCTTT
TTTGCCTTTGCTCCTACCTCCCATTCCAGGATGCTGGATCACCCAAAGCTGTTTTACTGCCCCCTTTCTTTTTACAACCTGTTGGATGCC
TGTTGCCAGAGCCTGAATCATCGTTTAAGGTTGCCATCAAAGGTGTGGAGGTAGCTGTGCTTAGGGTGCGTTTATTCTTCAGGGATCAGT
TTGTTGAATAGCGTTGTGTGTTATGGTAACCATTCTGAAGGCTCGTTTGGCTTTATAAACAAACAAACATTGTTTTATTAGTCCGTGGCG
GGGAGTGCCCCGGTGCGCATAGCACGGGATTCATGCAGTGGTCTCCTTCACATCAGAAGCAGTATATTCTAACGCGGTGGCTCCCAAGCC

>1894_1894_7_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000415850_length(amino acids)=398AA_BP=103
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN
KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGTFLFCLCSYLPFQDAGSPKAVLLPPFFL

--------------------------------------------------------------
>1894_1894_8_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000426655_length(transcript)=1547nt_BP=618nt
GGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGCGATGACCC
GGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATGTCTTTTGT
GTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCT
GTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCA
ACAACATAACACTGCACCTTCCAACAGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAA
AAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGT
TTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCT
GGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGA
TTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAG
ACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTG
ACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACT
TTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAG
AATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCA
ACATCCCCAACTGGTGGCAGAGTTATGAGGTAAGAAGCTGGCCTCCTGCGGCTTTCCCATCAGCCTGATTTCTCCACCTTAGAAAAGGGT
TTCTTGACAATGGGGTCAGGCCCCAGAGGAGCCCCCTGAGAGTGTCAGTTATTATTTACTATTACGTGCTATTTTACATATCCCAAGCCC
TTTAGGGCTACAGTCTCTTGTCCTGGACCCTGTAGGGTGCCATTTGGAGTTCACAGCCTAGAAGAAGAAAAGGCTTTGGGCCTGGTGTGG
TGGCATAGGCCTGTAATCGTAGCGCTTTGAGAGGCTGAGGCAGGAAGATAGCTTGAGCTCAGAAGTTCGAGACAAACCTGGGCAATGTGG

>1894_1894_8_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000426655_length(amino acids)=387AA_BP=103
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN
KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD

--------------------------------------------------------------
>1894_1894_9_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000541224_length(transcript)=1432nt_BP=618nt
GGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGCGATGACCC
GGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATGTCTTTTGT
GTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCT
GTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCA
ACAACATAACACTGCACCTTCCAACAGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAA
AAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGT
TTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCT
GGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGA
TTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAG
ACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTG
ACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACT
TTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAG
AATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCA
ACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCC
TGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCT

>1894_1894_9_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000541224_length(amino acids)=416AA_BP=103
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN
KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD

--------------------------------------------------------------
>1894_1894_10_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000542485_length(transcript)=2140nt_BP=618nt
GGAACTTCAAAGCGGGCCGTGCTGCCCCGGCTGCCTCGCTCTGCTCTGGGGCCTCGCAGCCCCGGCGCGGCCGCCTGGTGGCGATGACCC
GGGCGCTCTGCTCAGCGCTCCGCCAGGCTCTCCTGCTGCTCGCAGCGGCCGCCGAGCTCTCGCCAGGACTGAAGTGTGTATGTCTTTTGT
GTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGGCATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCT
GTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTTCCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCA
ACAACATAACACTGCACCTTCCAACAGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTCAGGAAATAGTAGGAA
AAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAGATGAAAGATCTTGGT
TTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACAAAGATAATGGCACCT
GGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGACAATTGAGGGGATGA
TTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTGGAATTGCTCATCGAG
ACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTCATGATGCAGTCACTG
ACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCATTAATATGAAACACT
TTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTGGAGGAGTCCATGAAG
AATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATCAGAAGCTGCGTCCCA
ACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCAACGGCGCAGCCCGCC
TGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTCTCTCCACACGGAGCT
CCTGGCAGCGAGAACTACGCACAGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCCTCTGTGGCCAGGAGC
CCTGGCCCGCAAGAGGGACAGAGCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTCTATTTACCTCCTAAT
GGCATGGAGACTCTGAGAGCGAATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCCGCGAAACCCGGTGCA
TCTGGCACGTGGCCAGGAGCCATGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAGCTGCCCTGAGGGTTT
CCTTCGGGGACCAGCCCACAGCACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTCTGAGCCGCGCTTTCC
CCTCCTCCCTGGGATGGACGCTGCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTGTGTGCATGTGCCGAG
GTGCGTCCCCCGTTGTGCCTGGTTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTGCGCACTTACCTGCTT
GAGCTTTCTGTGCATGTGCAGGTCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAGTGAGCAGCATCTAGT

>1894_1894_10_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000335450_ACVR1B_chr12_52377782_ENST00000542485_length(amino acids)=416AA_BP=103
MVAMTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECC
FTDFCNNITLHLPTGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN
KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCD

--------------------------------------------------------------
>1894_1894_11_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000257963_length(transcript)=4578nt_BP=903nt
GTTGCGCTGCCGTCGGGCAGGTGGCCGAGCCCCGCGGGAGCTGTCGTCGGGGCCGAATTCACTGCGCCAAGGTCCAGCGGAAAGCTGGGG
CATCCCGGCGACCGCAGGGTGTCCCTTCGCAAATTCATCAGGCGAAGGGGAGGCGGAAGCTCCTGGCCGCTGCTCTGGGGGAGGGCTCCG
AGCTCCAACCTGCAAGTCCAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGG
CATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTT
CCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAA
AACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGG
GTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGA
AAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTC
AGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAG
ATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACA
AAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGA
CAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTG
GAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTC
ATGATGCAGTCACTGACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCA
TTAATATGAAACACTTTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTG
GAGGAGTCCATGAAGAATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATC
AGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCA
ACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTC
TCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCACAGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCC
TCTGTGGCCAGGAGCCCTGGCCCGCAAGAGGGACAGAGCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTC
TATTTACCTCCTAATGGCATGGAGACTCTGAGAGCGAATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCC
GCGAAACCCGGTGCATCTGGCACGTGGCCAGGAGCCATGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAG
CTGCCCTGAGGGTTTCCTTCGGGGACCAGCCCACAGCACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTC
TGAGCCGCGCTTTCCCCTCCTCCCTGGGATGGACGCTGCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTG
TGTGCATGTGCCGAGGTGCGTCCCCCGTTGTGCCTGGTTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTG
CGCACTTACCTGCTTGAGCTTTCTGTGCATGTGCAGGTCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAG
TGAGCAGCATCTAGTTTCCCTGGTGCCCTTCCCTGGAGGTCTCTCCCTCCCCCAGAGCCCCTCATGCCACAGTGGTACTCTGTGTCTGGC
AGGCTACTCTGCCCACCCCAGCATCAGCACAGCTCTCCTCCTCCATCTCAGACTGTGGAACCAAAGCTGGCCCAGTTGTCCATGACAAAA
GAGGCTTTTGGGCCAAAATGTGAGGGTGGTGGGTGGGATGGGCAGGGAAGGAATCCTGGTGGAAGTCTTGGGTGTTAGTGTCAGCCATGG
GAAATGAGCCAGCCCAAGGGCATCATCCTCAGCAGCATCGAGGAAGGGCCGAGGAATGTGAAGCCAGATCTCGGGACTCAGATTGGAATG
TTACATCTGTCTTTCATCTCCCAGATCCTGGAAACAGCAGTGTATATTTTTGGTGGTGGTGGGTTTGGGGTGGGGAAGGGAAGGGCGGGC
AAGGAGTGGGGAGGGAGTCTGGGGTGGGAGGGAGGCATCTGCATGGGTCTTCTTTTACTGGACTGTCTGATCAGGGTGGAGGGAAGGTGA
GAGGTTTGCATCCACTTCAGGAGCCCTACTGAAGGGAACAGCCTGAGCCGAACATGTTATTTAACCTGAGTATAGTATTTAACGAAGCCT
AGAAGCACGGCTGTGGGTGGTGATTTGGTCAGCATATCTTAGGTATATAATAACTTTGAAGCCATAACTTTTAACTGGAGTGGTTTGATT
TCTTTTTTTAATTTTATTGGGAGGGTTTGGATTTTAACTTTTTTTAATGTTGTTAAATATTAAGTTTTTGTAAAAGGAAAACCATCTCTG
TGATTACCTCTCAATCTATTTGTTTTTAAAGAAATCCCTAAAAAAAAAAATTATCCAATTGAACGCACATAGCTCAATCACACTGGAAAT
GTTTGTCCTTGCACCTGAGCCTGTTCCCACTCAGCAGTGAGAGTTCCTCTTTGCCCTGAGGCTCAGTCTCTCTCGTATTTTGTCCCCACC
CCCAATTCCTTGAGTGGTTTTTGCTCTAGGGCCCTTTCTTGCACTGTCCAGCTGGTTGTACCCTCTCCAGGCATTTATTCAACAAATGTG
GGTGAAGTGCCTGCTGGGTGCCAGGTGCTGGGAATACATCTGTGGACAAGACATGCTTGGGTCCTACTCCTGGAGCACTGTAAAAAGAGC
TGATTCAAGTAAGTAGATGCCTGTTTTGAGACCAGAAGGTTTCATAATTGGTTCTACGACCCTTTTGAGCCTAGAATTATTGTTCTTATA
TAAGATCACTGAAGAAAGAGGAACCCCCACAACCCCCTCCACAAAGAGACCAGGGGCGGGTGATGAGACCTGGGGTTTAGAACCCCAGGT
GAGACCTCAAATCACTGCATTCATTCTGAGCCCCCTTCCTGTCCCCAGGGGAGGTGTATTGTGTATGTAGCCTTAGAGCATCTCTGCCTC
CAACCCAGCAGTTCTCTGCCAAAGCTTGTGGAGGAGGGAGAGCCCTGTCCCTGCCCTCAGGCTCCCCAGTGCTCCTGGCCCTTCTATTTA
TTTGACTGATTATTGCTTCTTTCCTTGCATTAAAGGAGATCTTCCCCTAACCTTTGGGCCAATTTACTGGCCACTAATTTCGTTTAAATA
CCATTGTGTCATTGGGGGGACCGTCTTTACCCCTGCTGACCTCCCACCTATCCGCCCTGCAGCAGAACCTTGGCGGTTTATAGGTAATGA
TGGAACTTAGACTCCTCTTCCCAGAGTCACAAGTAGCCTCTGGGATCTGCCAACACACGTCCACTCCCAAGCCACTAGCCCACTCCCCAG
TTGGCCCTTCTGCCCTTACCCCACACACAGTCCAACTCTTCCACCTCTGGGGAAGATGGAGCAGGTCTTTGGGAAGCTCCCACACCCACC
TCTGCCACTCTTAACACTAAGTGAGAGTTGGGGAGAAACTGAAGCCGTGTTTTTGGCCCCCCGAGGCTAACCCTGATCCATAGTGCTACC
TGCACCTCTGGATTCTGGATTCACAGACCAAGTCCAAGCCCGTTCTTACGTCGCCATAAAGGCCCCCGAACGGCATTCTCGGTACTTCTG
TTTGTTTTTGTACATTTTATTAGAAAGGACTGTAAAATAGCCACTTAGACACTTTACCTCTTCAGTATGCAAATGTAAATAAATTGTAAT

>1894_1894_11_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000257963_length(amino acids)=485AA_BP=173
MAAALGEGSELQPASPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLH
LPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQ
RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSL
FDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRY
MAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMG

--------------------------------------------------------------
>1894_1894_12_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000415850_length(transcript)=1757nt_BP=903nt
GTTGCGCTGCCGTCGGGCAGGTGGCCGAGCCCCGCGGGAGCTGTCGTCGGGGCCGAATTCACTGCGCCAAGGTCCAGCGGAAAGCTGGGG
CATCCCGGCGACCGCAGGGTGTCCCTTCGCAAATTCATCAGGCGAAGGGGAGGCGGAAGCTCCTGGCCGCTGCTCTGGGGGAGGGCTCCG
AGCTCCAACCTGCAAGTCCAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGG
CATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTT
CCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAA
AACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGG
GTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGA
AAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTC
AGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAG
ATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACA
AAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGA
CAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTG
GAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTC
ATGATGCAGTCACTGACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCA
TTAATATGAAACACTTTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTG
GAGGTACCTTTCTTTTTTGCCTTTGCTCCTACCTCCCATTCCAGGATGCTGGATCACCCAAAGCTGTTTTACTGCCCCCTTTCTTTTTAC
AACCTGTTGGATGCCTGTTGCCAGAGCCTGAATCATCGTTTAAGGTTGCCATCAAAGGTGTGGAGGTAGCTGTGCTTAGGGTGCGTTTAT
TCTTCAGGGATCAGTTTGTTGAATAGCGTTGTGTGTTATGGTAACCATTCTGAAGGCTCGTTTGGCTTTATAAACAAACAAACATTGTTT
TATTAGTCCGTGGCGGGGAGTGCCCCGGTGCGCATAGCACGGGATTCATGCAGTGGTCTCCTTCACATCAGAAGCAGTATATTCTAACGC

>1894_1894_12_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000415850_length(amino acids)=467AA_BP=173
MAAALGEGSELQPASPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLH
LPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQ
RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSL
FDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRY
MAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGTFLFCLCSYLPFQDAGSPKAVLLPPFFLQPVGCLLPEPESSFKVAIKGV

--------------------------------------------------------------
>1894_1894_13_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000426655_length(transcript)=1832nt_BP=903nt
GTTGCGCTGCCGTCGGGCAGGTGGCCGAGCCCCGCGGGAGCTGTCGTCGGGGCCGAATTCACTGCGCCAAGGTCCAGCGGAAAGCTGGGG
CATCCCGGCGACCGCAGGGTGTCCCTTCGCAAATTCATCAGGCGAAGGGGAGGCGGAAGCTCCTGGCCGCTGCTCTGGGGGAGGGCTCCG
AGCTCCAACCTGCAAGTCCAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGG
CATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTT
CCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAA
AACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGG
GTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGA
AAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTC
AGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAG
ATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACA
AAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGA
CAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTG
GAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTC
ATGATGCAGTCACTGACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCA
TTAATATGAAACACTTTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTG
GAGGAGTCCATGAAGAATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATC
AGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAGTTATGAGGTAAGAAGCTGGCCTCCTGCGGCTTTCCCATCAGCCTGATTTCTCC
ACCTTAGAAAAGGGTTTCTTGACAATGGGGTCAGGCCCCAGAGGAGCCCCCTGAGAGTGTCAGTTATTATTTACTATTACGTGCTATTTT
ACATATCCCAAGCCCTTTAGGGCTACAGTCTCTTGTCCTGGACCCTGTAGGGTGCCATTTGGAGTTCACAGCCTAGAAGAAGAAAAGGCT
TTGGGCCTGGTGTGGTGGCATAGGCCTGTAATCGTAGCGCTTTGAGAGGCTGAGGCAGGAAGATAGCTTGAGCTCAGAAGTTCGAGACAA

>1894_1894_13_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000426655_length(amino acids)=456AA_BP=173
MAAALGEGSELQPASPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLH
LPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQ
RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSL
FDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRY
MAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEVRSWPP

--------------------------------------------------------------
>1894_1894_14_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000541224_length(transcript)=1717nt_BP=903nt
GTTGCGCTGCCGTCGGGCAGGTGGCCGAGCCCCGCGGGAGCTGTCGTCGGGGCCGAATTCACTGCGCCAAGGTCCAGCGGAAAGCTGGGG
CATCCCGGCGACCGCAGGGTGTCCCTTCGCAAATTCATCAGGCGAAGGGGAGGCGGAAGCTCCTGGCCGCTGCTCTGGGGGAGGGCTCCG
AGCTCCAACCTGCAAGTCCAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGG
CATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTT
CCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAA
AACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGG
GTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGA
AAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTC
AGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAG
ATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACA
AAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGA
CAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTG
GAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTC
ATGATGCAGTCACTGACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCA
TTAATATGAAACACTTTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTG
GAGGAGTCCATGAAGAATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATC
AGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCA
ACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTC
TCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCACAGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCC

>1894_1894_14_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000541224_length(amino acids)=485AA_BP=173
MAAALGEGSELQPASPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLH
LPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQ
RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSL
FDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRY
MAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMG

--------------------------------------------------------------
>1894_1894_15_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000542485_length(transcript)=2425nt_BP=903nt
GTTGCGCTGCCGTCGGGCAGGTGGCCGAGCCCCGCGGGAGCTGTCGTCGGGGCCGAATTCACTGCGCCAAGGTCCAGCGGAAAGCTGGGG
CATCCCGGCGACCGCAGGGTGTCCCTTCGCAAATTCATCAGGCGAAGGGGAGGCGGAAGCTCCTGGCCGCTGCTCTGGGGGAGGGCTCCG
AGCTCCAACCTGCAAGTCCAGGACTGAAGTGTGTATGTCTTTTGTGTGATTCTTCAAACTTCACCTGCCAAACAGAAGGAGCATGTTGGG
CATCAGTCATGCTAACCAATGGAAAAGAGCAGGTGATCAAATCCTGTGTCTCCCTTCCAGAACTGAATGCTCAAGTCTTCTGTCATAGTT
CCAACAATGTTACCAAAACCGAATGCTGCTTCACAGATTTTTGCAACAACATAACACTGCACCTTCCAACAGCATCACCAAATGCCCCAA
AACTTGGACCCATGGAGCTGGCCATCATTATTACTGTGCCTGTTTGCCTCCTGTCCATAGCTGCGATGCTGACAGTATGGGCATGCCAGG
GTCGACAGTGCTCCTACAGGAAGAAAAAGAGACCAAATGTGGAGGAACCACTCTCTGAGTGCAATCTGGTAAATGCTGGAAAAACTCTGA
AAGATCTGATTTATGATGTGACCGCCTCTGGATCTGGCTCTGGTCTACCTCTGTTGGTTCAAAGGACAATTGCAAGGACGATTGTGCTTC
AGGAAATAGTAGGAAAAGGTAGATTTGGTGAGGTGTGGCATGGAAGATGGTGTGGGGAAGATGTGGCTGTGAAAATATTCTCCTCCAGAG
ATGAAAGATCTTGGTTTCGTGAGGCAGAAATTTACCAGACGGTCATGCTGCGACATGAAAACATCCTTGGTTTCATTGCTGCTGACAACA
AAGATAATGGCACCTGGACACAGCTGTGGCTTGTTTCTGACTATCATGAGCACGGGTCCCTGTTTGATTATCTGAACCGGTACACAGTGA
CAATTGAGGGGATGATTAAGCTGGCCTTGTCTGCTGCTAGTGGGCTGGCACACCTGCACATGGAGATCGTGGGCACCCAAGGGAAGCCTG
GAATTGCTCATCGAGACTTAAAGTCAAAGAACATTCTGGTGAAGAAAAATGGCATGTGTGCCATAGCAGACCTGGGCCTGGCTGTCCGTC
ATGATGCAGTCACTGACACCATTGACATTGCCCCGAATCAGAGGGTGGGGACCAAACGATACATGGCCCCTGAAGTACTTGATGAAACCA
TTAATATGAAACACTTTGACTCCTTTAAATGTGCTGATATTTATGCCCTCGGGCTTGTATATTGGGAGATTGCTCGAAGATGCAATTCTG
GAGGAGTCCATGAAGAATATCAGCTGCCATATTACGACTTAGTGCCCTCTGACCCTTCCATTGAGGAAATGCGAAAGGTTGTATGTGATC
AGAAGCTGCGTCCCAACATCCCCAACTGGTGGCAGAGTTATGAGGCACTGCGGGTGATGGGGAAGATGATGCGAGAGTGTTGGTATGCCA
ACGGCGCAGCCCGCCTGACGGCCCTGCGCATCAAGAAGACCCTCTCCCAGCTCAGCGTGCAGGAAGACGTGAAGATCTAACTGCTCCCTC
TCTCCACACGGAGCTCCTGGCAGCGAGAACTACGCACAGCTGCCGCGTTGAGCGTACGATGGAGGCCTACCTCTCGTTTCTGCCCAGCCC
TCTGTGGCCAGGAGCCCTGGCCCGCAAGAGGGACAGAGCCCGGGAGAGACTCGCTCACTCCCATGTTGGGTTTGAGACAGACACCTTTTC
TATTTACCTCCTAATGGCATGGAGACTCTGAGAGCGAATTGTGTGGAGAACTCAGTGCCACACCTCGAACTGGTTGTAGTGGGAAGTCCC
GCGAAACCCGGTGCATCTGGCACGTGGCCAGGAGCCATGACAGGGGCGCTTGGGAGGGGCCGGAGGAACCGAGGTGTTGCCAGTGCTAAG
CTGCCCTGAGGGTTTCCTTCGGGGACCAGCCCACAGCACACCAAGGTGGCCCGGAAGAACCAGAAGTGCAGCCCCTCTCACAGGCAGCTC
TGAGCCGCGCTTTCCCCTCCTCCCTGGGATGGACGCTGCCGGGAGACTGCCAGTGGAGACGGAATCTGCCGCTTTGTCTGTCCAGCCGTG
TGTGCATGTGCCGAGGTGCGTCCCCCGTTGTGCCTGGTTCGTGCCATGCCCTTACACGTGCGTGTGAGTGTGTGTGTGTGTCTGTAGGTG
CGCACTTACCTGCTTGAGCTTTCTGTGCATGTGCAGGTCGGGGGTGTGGTCGTCATGCTGTCCGTGCTTGCTGGTGCCTCTTTTCAGTAG

>1894_1894_15_ACVR1C-ACVR1B_ACVR1C_chr2_158406673_ENST00000409680_ACVR1B_chr12_52377782_ENST00000542485_length(amino acids)=485AA_BP=173
MAAALGEGSELQPASPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLH
LPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQ
RTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSL
FDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRY
MAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACVR1C-ACVR1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACVR1C-ACVR1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACVR1C-ACVR1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource