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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COMT-TPM3 (FusionGDB2 ID:HG1312TG7170)

Fusion Gene Summary for COMT-TPM3

check button Fusion gene summary
Fusion gene informationFusion gene name: COMT-TPM3
Fusion gene ID: hg1312tg7170
HgeneTgene
Gene symbol

COMT

TPM3

Gene ID

1312

7170

Gene namecatechol-O-methyltransferasetropomyosin 3
SynonymsHEL-S-98nCAPM1|CFTD|HEL-189|HEL-S-82p|NEM1|OK/SW-cl.5|TM-5|TM3|TM30|TM30nm|TM5|TPM3nu|TPMsk3|TRK|hscp30
Cytomap('COMT')('TPM3')

22q11.21

1q21.3

Type of geneprotein-codingprotein-coding
Descriptioncatechol O-methyltransferasecatechol-O-methyltransferase isoformepididymis secretory sperm binding protein Li 98ntesticular tissue protein Li 42tropomyosin alpha-3 chainalpha-tropomyosin, slow skeletalcytoskeletal tropomyosin TM30epididymis luminal protein 189epididymis secretory sperm binding protein Li 82pheat-stable cytoskeletal protein 30 kDatropomyosin 3 nutropomyosin gammatropomyosi
Modification date2020032920200328
UniProtAcc

P21964

P06753

Ensembl transtripts involved in fusion geneENST00000361682, ENST00000449653, 
ENST00000403184, ENST00000403710, 
ENST00000406520, ENST00000407537, 
ENST00000493893, 
Fusion gene scores* DoF score13 X 12 X 5=7809 X 10 X 5=450
# samples 1512
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COMT [Title/Abstract] AND TPM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOMT(19956547)-TPM3(154144671), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOMT

GO:0042424

catecholamine catabolic process

15645182|21846718



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for COMT-TPM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for COMT-TPM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for COMT-TPM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19956547/:154144671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COMT

P21964

TPM3

P06753

FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. {ECO:0000269|PubMed:11559542, ECO:0000269|PubMed:21846718}.FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for COMT-TPM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for COMT-TPM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COMT-TPM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCOMTP21964DB00494EntacaponeInhibitorSmall moleculeApproved|Investigational
HgeneCOMTP21964DB11632OpicaponeAntagonistSmall moleculeApproved|Investigational
HgeneCOMTP21964DB00118AdemetionineCofactorSmall moleculeApproved|Investigational|Nutraceutical
HgeneCOMTP21964DB00323TolcaponeInhibitorSmall moleculeApproved|Withdrawn
HgeneCOMTP21964DB04820NialamideSmall moleculeApproved|Withdrawn

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Related Diseases for COMT-TPM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOMTC0005586Bipolar Disorder6CTD_human;PSYGENET
HgeneCOMTC0001723Affective Disorders, Psychotic5PSYGENET
HgeneCOMTC0011570Mental Depression5PSYGENET
HgeneCOMTC0011581Depressive disorder5PSYGENET
HgeneCOMTC0041696Unipolar Depression5PSYGENET
HgeneCOMTC0525045Mood Disorders5PSYGENET
HgeneCOMTC1269683Major Depressive Disorder5PSYGENET
HgeneCOMTC0036341Schizophrenia4CTD_human
HgeneCOMTC0005587Depression, Bipolar3CTD_human;PSYGENET
HgeneCOMTC0006142Malignant neoplasm of breast3CTD_human
HgeneCOMTC0024809Marijuana Abuse3PSYGENET
HgeneCOMTC0600427Cocaine Dependence3CTD_human;PSYGENET
HgeneCOMTC0678222Breast Carcinoma3CTD_human
HgeneCOMTC1257931Mammary Neoplasms, Human3CTD_human
HgeneCOMTC1458155Mammary Neoplasms3CTD_human
HgeneCOMTC4704874Mammary Carcinoma, Human3CTD_human
HgeneCOMTC0233477Dysphoric mood2PSYGENET
HgeneCOMTC3160814Cannabis use2PSYGENET
HgeneCOMTC0001956Alcohol Use Disorder1CTD_human
HgeneCOMTC0001973Alcoholic Intoxication, Chronic1CTD_human
HgeneCOMTC0004352Autistic Disorder1CTD_human
HgeneCOMTC0004930Behavior Disorders1CTD_human
HgeneCOMTC0004936Mental disorders1CTD_human
HgeneCOMTC0009171Cocaine Abuse1CTD_human
HgeneCOMTC0009241Cognition Disorders1CTD_human
HgeneCOMTC0012236DiGeorge Syndrome1CTD_human;ORPHANET
HgeneCOMTC0015934Fetal Growth Retardation1CTD_human
HgeneCOMTC0020429Hyperalgesia1CTD_human
HgeneCOMTC0024667Animal Mammary Neoplasms1CTD_human
HgeneCOMTC0024713Manic Disorder1CTD_human
HgeneCOMTC0025261Memory Disorders1CTD_human
HgeneCOMTC0026858Musculoskeletal Pain1CTD_human
HgeneCOMTC0030193Pain1CTD_human
HgeneCOMTC0031511Pheochromocytoma1CTD_human
HgeneCOMTC0033578Prostatic Neoplasms1CTD_human
HgeneCOMTC0039494Temporomandibular Joint Disorders1CTD_human
HgeneCOMTC0041671Attention Deficit Disorder1CTD_human
HgeneCOMTC0085762Alcohol abuse1CTD_human
HgeneCOMTC0086133Depressive Syndrome1PSYGENET
HgeneCOMTC0178417Anhedonia1PSYGENET
HgeneCOMTC0220704Shprintzen syndrome1CTD_human;ORPHANET
HgeneCOMTC0233794Memory impairment1CTD_human
HgeneCOMTC0234230Pain, Burning1CTD_human
HgeneCOMTC0234238Ache1CTD_human
HgeneCOMTC0234254Radiating pain1CTD_human
HgeneCOMTC0236733Amphetamine-Related Disorders1CTD_human
HgeneCOMTC0236736Cocaine-Related Disorders1CTD_human
HgeneCOMTC0236804Amphetamine Addiction1CTD_human
HgeneCOMTC0236807Amphetamine Abuse1CTD_human
HgeneCOMTC0338831Manic1CTD_human
HgeneCOMTC0376338Diagnosis, Psychiatric1CTD_human
HgeneCOMTC0376358Malignant neoplasm of prostate1CTD_human
HgeneCOMTC0458247Allodynia1CTD_human
HgeneCOMTC0458257Pain, Splitting1CTD_human
HgeneCOMTC0458259Pain, Crushing1CTD_human
HgeneCOMTC0525046Schizophrenia Spectrum and Other Psychotic Disorders1CTD_human
HgeneCOMTC0751211Hyperalgesia, Primary1CTD_human
HgeneCOMTC0751212Hyperalgesia, Secondary1CTD_human
HgeneCOMTC0751213Tactile Allodynia1CTD_human
HgeneCOMTC0751214Hyperalgesia, Thermal1CTD_human
HgeneCOMTC0751292Age-Related Memory Disorders1CTD_human
HgeneCOMTC0751293Memory Disorder, Semantic1CTD_human
HgeneCOMTC0751294Memory Disorder, Spatial1CTD_human
HgeneCOMTC0751295Memory Loss1CTD_human
HgeneCOMTC0751407Pain, Migratory1CTD_human
HgeneCOMTC0751408Suffering, Physical1CTD_human
HgeneCOMTC0795907CONOTRUNCAL ANOMALY FACE SYNDROME1CTD_human;ORPHANET
HgeneCOMTC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneCOMTC1257925Mammary Carcinoma, Animal1CTD_human
HgeneCOMTC1263846Attention deficit hyperactivity disorder1CTD_human
HgeneCOMTC1306067Drug-induced paranoid state1PSYGENET
HgeneCOMTC1321905Minimal Brain Dysfunction1CTD_human
HgeneCOMTC2239176Liver carcinoma1CTD_human
HgeneCOMTC2750088HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO1CTD_human
HgeneCOMTC2936719Mechanical Allodynia1CTD_human
HgeneCOMTC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 11GENOMICS_ENGLAND
HgeneCOMTC4046029Mental Disorders, Severe1CTD_human
TgeneC1836448Nemaline myopathy 19CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0546264Congenital Fiber Type Disproportion4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0007097Carcinoma2CTD_human
TgeneC0024667Animal Mammary Neoplasms2CTD_human
TgeneC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneC0205696Anaplastic carcinoma2CTD_human
TgeneC0205697Carcinoma, Spindle-Cell2CTD_human
TgeneC0205698Undifferentiated carcinoma2CTD_human
TgeneC0205699Carcinomatosis2CTD_human
TgeneC0206157Myopathies, Nemaline2GENOMICS_ENGLAND
TgeneC1257925Mammary Carcinoma, Animal2CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0024623Malignant neoplasm of stomach1CTD_human
TgeneC0038356Stomach Neoplasms1CTD_human
TgeneC0040136Thyroid Neoplasm1CTD_human
TgeneC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0270960Congenital myopathy (disorder)1GENOMICS_ENGLAND
TgeneC0334121Inflammatory Myofibroblastic Tumor1ORPHANET
TgeneC0546125Nemaline Myopathy, Childhood Onset1ORPHANET
TgeneC0549473Thyroid carcinoma1CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC3710589Cap Myopathy1ORPHANET