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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NADK2-CDH1 (FusionGDB2 ID:HG133686TG999)

Fusion Gene Summary for NADK2-CDH1

check button Fusion gene summary
Fusion gene informationFusion gene name: NADK2-CDH1
Fusion gene ID: hg133686tg999
HgeneTgene
Gene symbol

NADK2

CDH1

Gene ID

133686

999

Gene nameNAD kinase 2, mitochondrialcadherin 1
SynonymsC5orf33|DECRD|MNADK|NADKD1Arc-1|BCDS1|CD324|CDHE|ECAD|LCAM|UVO
Cytomap('NADK2')('CDH1')

5p13.2

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionNAD kinase 2, mitochondrialNAD kinase domain-containing protein 1, mitochondrialcadherin-1CAM 120/80E-cadherin 1cadherin 1, E-cadherin (epithelial)cadherin 1, type 1, E-cadherin (epithelial)calcium-dependent adhesion protein, epithelialcell-CAM 120/80epididymis secretory sperm binding proteinepithelial cadherinuvomorulin
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000282512, ENST00000381937, 
ENST00000397338, ENST00000506945, 
ENST00000511613, ENST00000514504, 
ENST00000506945, ENST00000511613, 
ENST00000514504, ENST00000282512, 
ENST00000381937, ENST00000397338, 
Fusion gene scores* DoF score7 X 8 X 4=22419 X 20 X 5=1900
# samples 823
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1900*10)=-3.04629365227394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NADK2 [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNADK2(36207272)-CDH1(68835573), # samples:1
Anticipated loss of major functional domain due to fusion event.NADK2-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NADK2-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NADK2-CDH1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NADK2-CDH1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CDH1-NADK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CDH1-NADK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CDH1-NADK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNADK2

GO:0019674

NAD metabolic process

23212377

TgeneCDH1

GO:0042307

positive regulation of protein import into nucleus

16338932

TgeneCDH1

GO:0045893

positive regulation of transcription, DNA-templated

16338932

TgeneCDH1

GO:0071285

cellular response to lithium ion

12937339

TgeneCDH1

GO:0071681

cellular response to indole-3-methanol

10868478

TgeneCDH1

GO:0072659

protein localization to plasma membrane

17620337

TgeneCDH1

GO:0098609

cell-cell adhesion

16338932|18593713


check buttonFusion gene breakpoints across NADK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A4RW-01ANADK2chr5

36207272

-CDH1chr16

68835573

+


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Fusion Gene ORF analysis for NADK2-CDH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000282512ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+
5CDS-3UTRENST00000381937ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+
5CDS-3UTRENST00000397338ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+
5CDS-3UTRENST00000506945ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+
5UTR-3CDSENST00000511613ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
5UTR-3CDSENST00000511613ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
5UTR-3UTRENST00000511613ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+
Frame-shiftENST00000381937ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
Frame-shiftENST00000381937ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
Frame-shiftENST00000397338ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
Frame-shiftENST00000397338ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
In-frameENST00000282512ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
In-frameENST00000282512ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
In-frameENST00000506945ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
In-frameENST00000506945ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
intron-3CDSENST00000514504ENST00000261769NADK2chr5

36207272

-CDH1chr16

68835573

+
intron-3CDSENST00000514504ENST00000422392NADK2chr5

36207272

-CDH1chr16

68835573

+
intron-3UTRENST00000514504ENST00000562836NADK2chr5

36207272

-CDH1chr16

68835573

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000282512NADK2chr536207272-ENST00000261769CDH1chr1668835573+52387035733188871
ENST00000282512NADK2chr536207272-ENST00000422392CDH1chr1668835573+30437035733005810
ENST00000506945NADK2chr536207272-ENST00000261769CDH1chr1668835573+54419068213391856
ENST00000506945NADK2chr536207272-ENST00000422392CDH1chr1668835573+32469068213208795

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000282512ENST00000261769NADK2chr536207272-CDH1chr1668835573+0.0003917710.9996082
ENST00000282512ENST00000422392NADK2chr536207272-CDH1chr1668835573+0.0014203220.99857974
ENST00000506945ENST00000261769NADK2chr536207272-CDH1chr1668835573+0.0004604390.9995396
ENST00000506945ENST00000422392NADK2chr536207272-CDH1chr1668835573+0.0013000450.9986999

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Fusion Genomic Features for NADK2-CDH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NADK2chr536207271-CDH1chr1668835572+1.36E-070.9999999
NADK2chr536207271-CDH1chr1668835572+1.36E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NADK2-CDH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36207272/chr16:68835573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116838_85154883.0Compositional biasNote=Ser-rich
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116155_26254883.0DomainCadherin 1
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116263_37554883.0DomainCadherin 2
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116376_48654883.0DomainCadherin 3
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116487_59354883.0DomainCadherin 4
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116594_69754883.0DomainCadherin 5
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116758_76954883.0RegionNote=Required for binding CTNND1 and PSEN1
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116811_88254883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116155_70954883.0Topological domainExtracellular
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116731_88254883.0Topological domainCytoplasmic
TgeneCDH1chr5:36207272chr16:68835573ENST00000261769116710_73054883.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NADK2-CDH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57101_57101_1_NADK2-CDH1_NADK2_chr5_36207272_ENST00000282512_CDH1_chr16_68835573_ENST00000261769_length(transcript)=5238nt_BP=703nt
GGTGCGGGGAGGTCGCCCCCGGGCGGCGAAGCAGCCATTATGCAGGCCTTGCATTGAAAGGCTCTAGTTACAGTGGACTTCTTGAACGAC
ATCATATTCACACCAAAAATGTAGAACATATTATAGATAGTTTACGGAATGAGGGAATTGAGGTTCGTCTAGTAAAGAGGAGAGAATATG
ATGAAGAGACTGTTCGATGGGCAGATGCTGTCATAGCTGCAGGAGGTGATGGCACAATGCTGCTGGCAGCGAGTAAAGTCTTGGACAGAC
TTAAACCAGTTATAGGGGTAAACACTGATCCAGAACGGTCTGAGGGTCATTTATGCCTGCCCGTTCGATATACACATTCCTTTCCAGAAG
CCTTACAGAAGTTCTATCGTGGTGAGTTCAGGTGGTTGTGGAGGCAGAGAATCAGGTTATACCTTGAAGGGACTGGCATAAACCCTGTAC
CTGTGGACCTTCACGAGCAGCAGCTAAGCTTGAATCAGCACAATAGAGCCCTTAACATTGAAAGAGCTCATGATGAAAGGTCTGAGGCTT
CAGGACCCCAACTTCTGCCAGTGAGAGCACTAAATGAAGTCTTCATTGGGGAGAGTCTGTCATCCAGGGCTTCCTACTATGAGATTTCAG
TTGATGATGGTCCATGGGAAAAACAGAAGAGTTCAGGGCTCAATTTGTGTACTGGAACAGGATCAAAGGCCTGTGAATTTTGAAGATTGC
ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG
TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG
CACCACCACCGCCCCCCGCCCCATCAGGCCTCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGA
AGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTAAAAACCTGGTTCAGATCAAATCC
AACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTGGTGTCTTTATTATTGAAAGAGAA
ACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACGCATTGCCACATACACTCTCTTCTCTCACGCTGTGTCATCCAACGGGAAT
GCAGTTGAGGATCCAATGGAGATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCACCCAGGAGGTCTTTAAGGGGTCT
GTCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATGTGAACACCTACAATGCCGCCATC
GCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTCACCATTAACAGGAACACAGGAGTCATCAGTGTGGTCACC
ACTGGGCTGGACCGAGAGAGTTTCCCTACGTATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACA
GCTGTGATCACAGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGTACAAGGGTCAGGTGCCTGAGAACGAGGCTAAC
GTCGTAATCACCACACTGAAAGTGACTGATGCTGATGCCCCCAATACCCCAGCGTGGGAGGCTGTATACACCATATTGAATGATGATGGT
GGACAATTTGTCGTCACCACAAATCCAGTGAACAACGATGGCATTTTGAAAACAGCAAAGGGCTTGGATTTTGAGGCCAAGCAGCAGTAC
ATTCTACACGTAGCAGTGACGAATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTG
AATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGGAAATCACATCCTACACTGCC
CAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGAGACACTGCCAACTGGCTGGAGATTAATCCGGACACTGGT
GCCATTTCCACTCGGGCTGAGCTGGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCCTAATCATAGCTACAGACAAT
GGTTCTCCAGTTGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCATACCAGAACCTCGAACTATA
TTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTCCCAATACATCTCCCTTCACAGCAGAACTA
ACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGACCCAACCCAAGAATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTG
GGTGACTACAAAATCAATCTCAAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCAGCGTGTGTGACTGTGAAGGG
GCCGCTGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTCTTGGAGGAATTCTTGCTTTG
CTAATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCCTTACTGCCCCCAGAGGATGACACCCGGGAC
AACGTTTATTACTATGATGAAGAAGGAGGCGGAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCT
GAAGTGACTCGTAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATCCCGATGAAATTGGAAATTTT
ATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGCTCGTGTTTGACTATGAAGGAAGCGGTTCC
GAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGACAAAGACCAGGACTATGACTACTTGAACGAATGGGGCAATCGCTTCAAG
AAGCTGGCTGACATGTACGGAGGCGGCGAGGACGACTAGGGGACTCGAGAGAGGCGGGCCCCAGACCCATGTGCTGGGAAATGCAGAAAT
CACGTTGCTGGTGGTTTTTCAGCTCCCTTCCCTTGAGATGAGTTTCTGGGGAAAAAAAAGAGACTGGTTAGTGATGCAGTTAGTATAGCT
TTATACTCTCTCCACTTTATAGCTCTAATAAGTTTGTGTTAGAAAAGTTTCGACTTATTTCTTAAAGCTTTTTTTTTTTTCCCATCACTC
TTTACATGGTGGTGATGTCCAAAAGATACCCAAATTTTAATATTCCAGAAGAACAACTTTAGCATCAGAAGGTTCACCCAGCACCTTGCA
GATTTTCTTAAGGAATTTTGTCTCACTTTTAAAAAGAAGGGGAGAAGTCAGCTACTCTAGTTCTGTTGTTTTGTGTATATAATTTTTTAA
AAAAAATTTGTGTGCTTCTGCTCATTACTACACTGGTGTGTCCCTCTGCCTTTTTTTTTTTTTTAAGACAGGGTCTCATTCTATCGGCCA
GGCTGGAGTGCAGTGGTGCAATCACAGCTCACTGCAGCCTTGTCCTCCCAGGCTCAAGCTATCCTTGCACCTCAGCCTCCCAAGTAGCTG
GGACCACAGGCATGCACCACTACGCATGACTAATTTTTTAAATATTTGAGACGGGGTCTCCCTGTGTTACCCAGGCTGGTCTCAAACTCC
TGGGCTCAAGTGATCCTCCCATCTTGGCCTCCCAGAGTATTGGGATTACAGACATGAGCCACTGCACCTGCCCAGCTCCCCAACTCCCTG
CCATTTTTTAAGAGACAGTTTCGCTCCATCGCCCAGGCCTGGGATGCAGTGATGTGATCATAGCTCACTGTAACCTCAAACTCTGGGGCT
CAAGCAGTTCTCCCACCAGCCTCCTTTTTATTTTTTTGTACAGATGGGGTCTTGCTATGTTGCCCAAGCTGGTCTTAAACTCCTGGCCTC
AAGCAATCCTTCTGCCTTGGCCCCCCAAAGTGCTGGGATTGTGGGCATGAGCTGCTGTGCCCAGCCTCCATGTTTTAATATCAACTCTCA
CTCCTGAATTCAGTTGCTTTGCCCAAGATAGGAGTTCTCTGATGCAGAAATTATTGGGCTCTTTTAGGGTAAGAAGTTTGTGTCTTTGTC
TGGCCACATCTTGACTAGGTATTGTCTACTCTGAAGACCTTTAATGGCTTCCCTCTTTCATCTCCTGAGTATGTAACTTGCAATGGGCAG
CTATCCAGTGACTTGTTCTGAGTAAGTGTGTTCATTAATGTTTATTTAGCTCTGAAGCAAGAGTGATATACTCCAGGACTTAGAATAGTG
CCTAAAGTGCTGCAGCCAAAGACAGAGCGGAACTATGAAAAGTGGGCTTGGAGATGGCAGGAGAGCTTGTCATTGAGCCTGGCAATTTAG
CAAACTGATGCTGAGGATGATTGAGGTGGGTCTACCTCATCTCTGAAAATTCTGGAAGGAATGGAGGAGTCTCAACATGTGTTTCTGACA
CAAGATCCGTGGTTTGTACTCAAAGCCCAGAATCCCCAAGTGCCTGCTTTTGATGATGTCTACAGAAAATGCTGGCTGAGCTGAACACAT
TTGCCCAATTCCAGGTGTGCACAGAAAACCGAGAATATTCAAAATTCCAAATTTTTTTCTTAGGAGCAAGAAGAAAATGTGGCCCTAAAG
GGGGTTAGTTGAGGGGTAGGGGGTAGTGAGGATCTTGATTTGGATCTCTTTTTATTTAAATGTGAATTTCAACTTTTGACAATCAAAGAA
AAGACTTTTGTTGAAATAGCTTTACTGTTTCTCAAGTGTTTTGGAGAAAAAAATCAACCCTGCAATCACTTTTTGGAATTGTCTTGATTT
TTCGGCAGTTCAAGCTATATCGAATATAGTTCTGTGTAGAGAATGTCACTGTAGTTTTGAGTGTATACATGTGTGGGTGCTGATAATTGT
GTATTTTCTTTGGGGGTGGAAAAGGAAAACAATTCAAGCTGAGAAAAGTATTCTCAAAGATGCATTTTTATAAATTTTATTAAACAATTT

>57101_57101_1_NADK2-CDH1_NADK2_chr5_36207272_ENST00000282512_CDH1_chr16_68835573_ENST00000261769_length(amino acids)=871AA_BP=43
MKSSLGRVCHPGLPTMRFQLMMVHGKNRRVQGSICVLEQDQRPVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVY
AWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYS
ITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSV
MEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDN
PPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVP
FEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDRE
DFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQ
YNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFL
RRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTD

--------------------------------------------------------------
>57101_57101_2_NADK2-CDH1_NADK2_chr5_36207272_ENST00000282512_CDH1_chr16_68835573_ENST00000422392_length(transcript)=3043nt_BP=703nt
GGTGCGGGGAGGTCGCCCCCGGGCGGCGAAGCAGCCATTATGCAGGCCTTGCATTGAAAGGCTCTAGTTACAGTGGACTTCTTGAACGAC
ATCATATTCACACCAAAAATGTAGAACATATTATAGATAGTTTACGGAATGAGGGAATTGAGGTTCGTCTAGTAAAGAGGAGAGAATATG
ATGAAGAGACTGTTCGATGGGCAGATGCTGTCATAGCTGCAGGAGGTGATGGCACAATGCTGCTGGCAGCGAGTAAAGTCTTGGACAGAC
TTAAACCAGTTATAGGGGTAAACACTGATCCAGAACGGTCTGAGGGTCATTTATGCCTGCCCGTTCGATATACACATTCCTTTCCAGAAG
CCTTACAGAAGTTCTATCGTGGTGAGTTCAGGTGGTTGTGGAGGCAGAGAATCAGGTTATACCTTGAAGGGACTGGCATAAACCCTGTAC
CTGTGGACCTTCACGAGCAGCAGCTAAGCTTGAATCAGCACAATAGAGCCCTTAACATTGAAAGAGCTCATGATGAAAGGTCTGAGGCTT
CAGGACCCCAACTTCTGCCAGTGAGAGCACTAAATGAAGTCTTCATTGGGGAGAGTCTGTCATCCAGGGCTTCCTACTATGAGATTTCAG
TTGATGATGGTCCATGGGAAAAACAGAAGAGTTCAGGGCTCAATTTGTGTACTGGAACAGGATCAAAGGCCTGTGAATTTTGAAGATTGC
ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGG
TTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG
CACCACCACCGCCCCCCGCCCCATCAGGCCTCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGGCCTCAGA
AGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTAAAAACCTGGTTCAGATCAAATCC
AACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTGGTGTCTTTATTATTGAAAGAGAA
ACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACGCATTGCCACATACACTCTCTTCTCTCACGCTGTGTCATCCAACGGGAAT
GCAGTTGAGGATCCAATGGAGATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCACCCAGGAGGTCTTTAAGGGGTCT
GTCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATGTGAACACCTACAATGCCGCCATC
GCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTCACCATTAACAGGAACACAGGAGTCATCAGTGTGGTCACC
ACTGGGCTGGACCGAGAGAGTTTCCCTACGTATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACA
GCTGTGATCACAGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGGGCTTGGATTTTGAGGCCAAGCAGCAGTACATT
CTACACGTAGCAGTGACGAATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTGAAT
GAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGGAAATCACATCCTACACTGCCCAG
GAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGAGACACTGCCAACTGGCTGGAGATTAATCCGGACACTGGTGCC
ATTTCCACTCGGGCTGAGCTGGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCCTAATCATAGCTACAGACAATGGT
TCTCCAGTTGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCATACCAGAACCTCGAACTATATTC
TTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTCCCAATACATCTCCCTTCACAGCAGAACTAACA
CACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGACCCAACCCAAGAATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTGGGT
GACTACAAAATCAATCTCAAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCAGCGTGTGTGACTGTGAAGGGGCC
GCTGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTCTTGGAGGAATTCTTGCTTTGCTA
ATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCCTTACTGCCCCCAGAGGATGACACCCGGGACAAC
GTTTATTACTATGATGAAGAAGGAGGCGGAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCTGAA
GTGACTCGTAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATCCCGATGAAATTGGAAATTTTATT
GATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGCTCGTGTTTGACTATGAAGGAAGCGGTTCCGAA
GCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGACAAAGACCAGGACTATGACTACTTGAACGAATGGGGCAATCGCTTCAAGAAG

>57101_57101_2_NADK2-CDH1_NADK2_chr5_36207272_ENST00000282512_CDH1_chr16_68835573_ENST00000422392_length(amino acids)=810AA_BP=43
MKSSLGRVCHPGLPTMRFQLMMVHGKNRRVQGSICVLEQDQRPVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVY
AWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYS
ITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSV
MEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDN
PPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKIT
YRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVI
NIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVE
AGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLM
SVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD

--------------------------------------------------------------
>57101_57101_3_NADK2-CDH1_NADK2_chr5_36207272_ENST00000506945_CDH1_chr16_68835573_ENST00000261769_length(transcript)=5441nt_BP=906nt
ATCGCCTAACAGAATTCTACCTCTTTCTCAGGCCGCAGCCAATGGCGCGGCCCCTCGGATCCGGAGCCGCCGCGGGCTCTGATTGGCCGA
TAGAGTTAGCCTGGGGGCGGGAGAAGAGCGACCTCGGGGAAGCGTGTGGTGCGGGGAGGTCGCCCCCGGGCGGCGAAGCAGCCATTATGC
AGGCCTTGCATTGAAAGGCTCTAGTTACAGTGGACTTCTTGAACGACATCATATTCACACCAAAAATGTAGAACATATTATAGATAGTTT
ACGGAATGAGGGAATTGAGGTTCGTCTAGTAAAGAGGAGAGAATATGATGAAGAGACTGTTCGATGGGCAGATGCTGTCATAGCTGCAGG
AGGTGATGGCACAATGCTGCTGGCAGCGAGTAAAGTCTTGGACAGACTTAAACCAGTTATAGGGGTAAACACTGATCCAGAACGGTCTGA
GGGTCATTTATGCCTGCCCGTTCGATATACACATTCCTTTCCAGAAGCCTTACAGAAGTTCTATCGTGGTGAGTTCAGGTGGTTGTGGAG
GCAGAGAATCAGGTTATACCTTGAAGGGACTGGCATAAACCCTGTACCTGTGGACCTTCACGAGCAGCAGCTAAGCTTGAATCAGCACAA
TAGAGCCCTTAACATTGAAAGAGCTCATGATGAAAGGTCTGAGGCTTCAGGACCCCAACTTCTGCCAGTGAGAGCACTAAATGAAGTCTT
CATTGGGGAGAGTCTGTCATCCAGAATGTCTTATTCTTGGGCTGTAGCAGTGGACAATTTAAGAAGAAGTATACCCACTCTAAAGGGACT
GGCTTCCTACTATGAGATTTCAGTTGATGATGGTCCATGGGAAAAACAGAAGAGTTCAGGGCTCAATTTGTGTACTGGAACAGGATCAAA
GGCCTGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGA
TTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCA
AAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCCTCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTC
CCAACTCCTCTCCTGGCCTCAGAAGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTA
AAAACCTGGTTCAGATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTG
GTGTCTTTATTATTGAAAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACGCATTGCCACATACACTCTCTTCTCTC
ACGCTGTGTCATCCAACGGGAATGCAGTTGAGGATCCAATGGAGATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCA
CCCAGGAGGTCTTTAAGGGGTCTGTCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATG
TGAACACCTACAATGCCGCCATCGCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTCACCATTAACAGGAACA
CAGGAGTCATCAGTGTGGTCACCACTGGGCTGGACCGAGAGAGTTTCCCTACGTATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTG
AGGGGTTAAGCACAACAGCAACAGCTGTGATCACAGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGTACAAGGGTC
AGGTGCCTGAGAACGAGGCTAACGTCGTAATCACCACACTGAAAGTGACTGATGCTGATGCCCCCAATACCCCAGCGTGGGAGGCTGTAT
ACACCATATTGAATGATGATGGTGGACAATTTGTCGTCACCACAAATCCAGTGAACAACGATGGCATTTTGAAAACAGCAAAGGGCTTGG
ATTTTGAGGCCAAGCAGCAGTACATTCTACACGTAGCAGTGACGAATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCG
TCACCGTGGATGTGCTGGATGTGAATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCC
AGGAAATCACATCCTACACTGCCCAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGAGACACTGCCAACTGGC
TGGAGATTAATCCGGACACTGGTGCCATTTCCACTCGGGCTGAGCTGGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACGTACACAG
CCCTAATCATAGCTACAGACAATGGTTCTCCAGTTGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCC
CCATACCAGAACCTCGAACTATATTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTCCCAATA
CATCTCCCTTCACAGCAGAACTAACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGACCCAACCCAAGAATCTATCATTTTGA
AGCCAAAGATGGCCTTAGAGGTGGGTGACTACAAAATCAATCTCAAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGG
TCAGCGTGTGTGACTGTGAAGGGGCCGCTGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGA
TTCTTGGAGGAATTCTTGCTTTGCTAATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCCTTACTGC
CCCCAGAGGATGACACCCGGGACAACGTTTATTACTATGATGAAGAAGGAGGCGGAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGC
ACAGGGGCCTGGACGCTCGGCCTGAAGTGACTCGTAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCA
ATCCCGATGAAATTGGAAATTTTATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGCTCGTGT
TTGACTATGAAGGAAGCGGTTCCGAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGACAAAGACCAGGACTATGACTACTTGA
ACGAATGGGGCAATCGCTTCAAGAAGCTGGCTGACATGTACGGAGGCGGCGAGGACGACTAGGGGACTCGAGAGAGGCGGGCCCCAGACC
CATGTGCTGGGAAATGCAGAAATCACGTTGCTGGTGGTTTTTCAGCTCCCTTCCCTTGAGATGAGTTTCTGGGGAAAAAAAAGAGACTGG
TTAGTGATGCAGTTAGTATAGCTTTATACTCTCTCCACTTTATAGCTCTAATAAGTTTGTGTTAGAAAAGTTTCGACTTATTTCTTAAAG
CTTTTTTTTTTTTCCCATCACTCTTTACATGGTGGTGATGTCCAAAAGATACCCAAATTTTAATATTCCAGAAGAACAACTTTAGCATCA
GAAGGTTCACCCAGCACCTTGCAGATTTTCTTAAGGAATTTTGTCTCACTTTTAAAAAGAAGGGGAGAAGTCAGCTACTCTAGTTCTGTT
GTTTTGTGTATATAATTTTTTAAAAAAAATTTGTGTGCTTCTGCTCATTACTACACTGGTGTGTCCCTCTGCCTTTTTTTTTTTTTTAAG
ACAGGGTCTCATTCTATCGGCCAGGCTGGAGTGCAGTGGTGCAATCACAGCTCACTGCAGCCTTGTCCTCCCAGGCTCAAGCTATCCTTG
CACCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGCACCACTACGCATGACTAATTTTTTAAATATTTGAGACGGGGTCTCCCTGTGT
TACCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCCTCCCATCTTGGCCTCCCAGAGTATTGGGATTACAGACATGAGCCACTGCAC
CTGCCCAGCTCCCCAACTCCCTGCCATTTTTTAAGAGACAGTTTCGCTCCATCGCCCAGGCCTGGGATGCAGTGATGTGATCATAGCTCA
CTGTAACCTCAAACTCTGGGGCTCAAGCAGTTCTCCCACCAGCCTCCTTTTTATTTTTTTGTACAGATGGGGTCTTGCTATGTTGCCCAA
GCTGGTCTTAAACTCCTGGCCTCAAGCAATCCTTCTGCCTTGGCCCCCCAAAGTGCTGGGATTGTGGGCATGAGCTGCTGTGCCCAGCCT
CCATGTTTTAATATCAACTCTCACTCCTGAATTCAGTTGCTTTGCCCAAGATAGGAGTTCTCTGATGCAGAAATTATTGGGCTCTTTTAG
GGTAAGAAGTTTGTGTCTTTGTCTGGCCACATCTTGACTAGGTATTGTCTACTCTGAAGACCTTTAATGGCTTCCCTCTTTCATCTCCTG
AGTATGTAACTTGCAATGGGCAGCTATCCAGTGACTTGTTCTGAGTAAGTGTGTTCATTAATGTTTATTTAGCTCTGAAGCAAGAGTGAT
ATACTCCAGGACTTAGAATAGTGCCTAAAGTGCTGCAGCCAAAGACAGAGCGGAACTATGAAAAGTGGGCTTGGAGATGGCAGGAGAGCT
TGTCATTGAGCCTGGCAATTTAGCAAACTGATGCTGAGGATGATTGAGGTGGGTCTACCTCATCTCTGAAAATTCTGGAAGGAATGGAGG
AGTCTCAACATGTGTTTCTGACACAAGATCCGTGGTTTGTACTCAAAGCCCAGAATCCCCAAGTGCCTGCTTTTGATGATGTCTACAGAA
AATGCTGGCTGAGCTGAACACATTTGCCCAATTCCAGGTGTGCACAGAAAACCGAGAATATTCAAAATTCCAAATTTTTTTCTTAGGAGC
AAGAAGAAAATGTGGCCCTAAAGGGGGTTAGTTGAGGGGTAGGGGGTAGTGAGGATCTTGATTTGGATCTCTTTTTATTTAAATGTGAAT
TTCAACTTTTGACAATCAAAGAAAAGACTTTTGTTGAAATAGCTTTACTGTTTCTCAAGTGTTTTGGAGAAAAAAATCAACCCTGCAATC
ACTTTTTGGAATTGTCTTGATTTTTCGGCAGTTCAAGCTATATCGAATATAGTTCTGTGTAGAGAATGTCACTGTAGTTTTGAGTGTATA
CATGTGTGGGTGCTGATAATTGTGTATTTTCTTTGGGGGTGGAAAAGGAAAACAATTCAAGCTGAGAAAAGTATTCTCAAAGATGCATTT

>57101_57101_3_NADK2-CDH1_NADK2_chr5_36207272_ENST00000506945_CDH1_chr16_68835573_ENST00000261769_length(amino acids)=856AA_BP=28
MRFQLMMVHGKNRRVQGSICVLEQDQRPVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTL
NTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFI
IERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTY
NAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPE
NEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVD
VLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALII
ATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKM
ALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPED
DTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYE

--------------------------------------------------------------
>57101_57101_4_NADK2-CDH1_NADK2_chr5_36207272_ENST00000506945_CDH1_chr16_68835573_ENST00000422392_length(transcript)=3246nt_BP=906nt
ATCGCCTAACAGAATTCTACCTCTTTCTCAGGCCGCAGCCAATGGCGCGGCCCCTCGGATCCGGAGCCGCCGCGGGCTCTGATTGGCCGA
TAGAGTTAGCCTGGGGGCGGGAGAAGAGCGACCTCGGGGAAGCGTGTGGTGCGGGGAGGTCGCCCCCGGGCGGCGAAGCAGCCATTATGC
AGGCCTTGCATTGAAAGGCTCTAGTTACAGTGGACTTCTTGAACGACATCATATTCACACCAAAAATGTAGAACATATTATAGATAGTTT
ACGGAATGAGGGAATTGAGGTTCGTCTAGTAAAGAGGAGAGAATATGATGAAGAGACTGTTCGATGGGCAGATGCTGTCATAGCTGCAGG
AGGTGATGGCACAATGCTGCTGGCAGCGAGTAAAGTCTTGGACAGACTTAAACCAGTTATAGGGGTAAACACTGATCCAGAACGGTCTGA
GGGTCATTTATGCCTGCCCGTTCGATATACACATTCCTTTCCAGAAGCCTTACAGAAGTTCTATCGTGGTGAGTTCAGGTGGTTGTGGAG
GCAGAGAATCAGGTTATACCTTGAAGGGACTGGCATAAACCCTGTACCTGTGGACCTTCACGAGCAGCAGCTAAGCTTGAATCAGCACAA
TAGAGCCCTTAACATTGAAAGAGCTCATGATGAAAGGTCTGAGGCTTCAGGACCCCAACTTCTGCCAGTGAGAGCACTAAATGAAGTCTT
CATTGGGGAGAGTCTGTCATCCAGAATGTCTTATTCTTGGGCTGTAGCAGTGGACAATTTAAGAAGAAGTATACCCACTCTAAAGGGACT
GGCTTCCTACTATGAGATTTCAGTTGATGATGGTCCATGGGAAAAACAGAAGAGTTCAGGGCTCAATTTGTGTACTGGAACAGGATCAAA
GGCCTGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGA
TTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCA
AAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGCCTCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTC
CCAACTCCTCTCCTGGCCTCAGAAGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTA
AAAACCTGGTTCAGATCAAATCCAACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTG
GTGTCTTTATTATTGAAAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACGCATTGCCACATACACTCTCTTCTCTC
ACGCTGTGTCATCCAACGGGAATGCAGTTGAGGATCCAATGGAGATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCA
CCCAGGAGGTCTTTAAGGGGTCTGTCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGACGCGGACGATGATG
TGAACACCTACAATGCCGCCATCGCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTCACCATTAACAGGAACA
CAGGAGTCATCAGTGTGGTCACCACTGGGCTGGACCGAGAGAGTTTCCCTACGTATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTG
AGGGGTTAAGCACAACAGCAACAGCTGTGATCACAGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACGGGCTTGGATT
TTGAGGCCAAGCAGCAGTACATTCTACACGTAGCAGTGACGAATGTGGTACCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCA
CCGTGGATGTGCTGGATGTGAATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGG
AAATCACATCCTACACTGCCCAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGAGACACTGCCAACTGGCTGG
AGATTAATCCGGACACTGGTGCCATTTCCACTCGGGCTGAGCTGGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCC
TAATCATAGCTACAGACAATGGTTCTCCAGTTGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCA
TACCAGAACCTCGAACTATATTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTCCCAATACAT
CTCCCTTCACAGCAGAACTAACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGACCCAACCCAAGAATCTATCATTTTGAAGC
CAAAGATGGCCTTAGAGGTGGGTGACTACAAAATCAATCTCAAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCA
GCGTGTGTGACTGTGAAGGGGCCGCTGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTC
TTGGAGGAATTCTTGCTTTGCTAATTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCCTTACTGCCCC
CAGAGGATGACACCCGGGACAACGTTTATTACTATGATGAAGAAGGAGGCGGAGAAGAGGACCAGGACTTTGACTTGAGCCAGCTGCACA
GGGGCCTGGACGCTCGGCCTGAAGTGACTCGTAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATC
CCGATGAAATTGGAAATTTTATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGATTCTCTGCTCGTGTTTG
ACTATGAAGGAAGCGGTTCCGAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGACAAAGACCAGGACTATGACTACTTGAACG
AATGGGGCAATCGCTTCAAGAAGCTGGCTGACATGTACGGAGGCGGCGAGGACGACTAGGGGACTCGAGAGAGGCGGGCCCCAGACCCAT

>57101_57101_4_NADK2-CDH1_NADK2_chr5_36207272_ENST00000506945_CDH1_chr16_68835573_ENST00000422392_length(amino acids)=795AA_BP=28
MRFQLMMVHGKNRRVQGSICVLEQDQRPVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTL
NTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFI
IERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTY
NAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTGLDFEAK
QQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINP
DTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFT
AELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGI
LALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NADK2-CDH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NADK2-CDH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NADK2-CDH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNADK2C18572522,4-Dienoyl-CoA Reductase Deficiency5CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC1708349Hereditary Diffuse Gastric Cancer15CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0346153Breast Cancer, Familial12CLINGEN
TgeneC0009405Hereditary Nonpolyposis Colorectal Neoplasms6CLINGEN
TgeneC0024623Malignant neoplasm of stomach6CGI;CTD_human;UNIPROT
TgeneC0038356Stomach Neoplasms6CGI;CTD_human
TgeneC1112155Hereditary non-polyposis colorectal cancer syndrome6CLINGEN
TgeneC1333990Hereditary Nonpolyposis Colorectal Cancer6CLINGEN
TgeneC1333991Hereditary Non-Polyposis Colon Cancer Type 26CLINGEN
TgeneC2936783Colorectal cancer, hereditary nonpolyposis, type 16CLINGEN
TgeneC0006142Malignant neoplasm of breast4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0033578Prostatic Neoplasms4CTD_human
TgeneC0376358Malignant neoplasm of prostate4CTD_human;GENOMICS_ENGLAND
TgeneC0678222Breast Carcinoma4CTD_human
TgeneC1257931Mammary Neoplasms, Human4CTD_human
TgeneC1458155Mammary Neoplasms4CTD_human
TgeneC4704874Mammary Carcinoma, Human4CTD_human
TgeneC0007097Carcinoma3CTD_human
TgeneC0205696Anaplastic carcinoma3CTD_human
TgeneC0205697Carcinoma, Spindle-Cell3CTD_human
TgeneC0205698Undifferentiated carcinoma3CTD_human
TgeneC0205699Carcinomatosis3CTD_human
TgeneC0005684Malignant neoplasm of urinary bladder2CTD_human
TgeneC0005695Bladder Neoplasm2CTD_human
TgeneC0009402Colorectal Carcinoma2CTD_human
TgeneC0009404Colorectal Neoplasms2CTD_human
TgeneC0019207Hepatoma, Morris2CTD_human
TgeneC0019208Hepatoma, Novikoff2CTD_human
TgeneC0021367Mammary Ductal Carcinoma2CTD_human
TgeneC0023904Liver Neoplasms, Experimental2CTD_human
TgeneC0027626Neoplasm Invasiveness2CTD_human
TgeneC0027627Neoplasm Metastasis2CTD_human
TgeneC0086404Experimental Hepatoma2CTD_human
TgeneC0206692Carcinoma, Lobular2CGI;CTD_human;UNIPROT
TgeneC1134719Invasive Ductal Breast Carcinoma2CTD_human
TgeneC2931456Prostate cancer, familial2CTD_human
TgeneC4551988BLEPHAROCHEILODONTIC SYNDROME 12GENOMICS_ENGLAND;UNIPROT
TgeneC4722327PROSTATE CANCER, HEREDITARY, 12CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0009324Ulcerative Colitis1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0014170Endometrial Neoplasms1CTD_human
TgeneC0014476Eperythrozoonosis1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0025500Mesothelioma1CTD_human
TgeneC0026936Mycoplasma Infections1CTD_human
TgeneC0027645Neoplasm Seeding1CTD_human
TgeneC0027659Neoplasms, Experimental1CTD_human
TgeneC0027746Nerve Degeneration1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0036095Salivary Gland Neoplasms1CTD_human
TgeneC0079487Helicobacter Infections1CTD_human
TgeneC0158646Cleft palate with cleft lip1ORPHANET
TgeneC0220636Malignant neoplasm of salivary gland1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0476089Endometrial Carcinoma1CTD_human;GENOMICS_ENGLAND
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1176475Ductal Carcinoma1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC1861536Blepharo-cheilo-dontic syndrome1ORPHANET