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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ZNF786-ABCF2 (FusionGDB2 ID:HG136051TG10061) |
Fusion Gene Summary for ZNF786-ABCF2 |
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Fusion gene information | Fusion gene name: ZNF786-ABCF2 | Fusion gene ID: hg136051tg10061 | Hgene | Tgene | Gene symbol | ZNF786 | ABCF2 | Gene ID | 136051 | 10061 |
Gene name | zinc finger protein 786 | ATP binding cassette subfamily F member 2 | |
Synonyms | - | ABC28|EST133090|HUSSY-18|HUSSY18 | |
Cytomap | ('ZNF786')('ABCF2') 7q36.1 | 7q36.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 786 | ATP-binding cassette sub-family F member 2ABC-type transport proteinATP-binding cassette, sub-family F (GCN20), member 2iron-inhibited ABC transporter 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000491431, ENST00000316286, ENST00000451334, | ||
Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 5 X 4 X 3=60 |
# samples | 6 | 6 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: ZNF786 [Title/Abstract] AND ABCF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ZNF786(148787715)-ABCF2(150913115), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ZNF786-ABCF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF786-ABCF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-25-1323-01A | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
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Fusion Gene ORF analysis for ZNF786-ABCF2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000491431 | ENST00000473874 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-3CDS | ENST00000316286 | ENST00000222388 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-3CDS | ENST00000316286 | ENST00000287844 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-3CDS | ENST00000451334 | ENST00000222388 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-3CDS | ENST00000451334 | ENST00000287844 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-intron | ENST00000316286 | ENST00000473874 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
5UTR-intron | ENST00000451334 | ENST00000473874 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
In-frame | ENST00000491431 | ENST00000222388 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
In-frame | ENST00000491431 | ENST00000287844 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000491431 | ZNF786 | chr7 | 148787715 | - | ENST00000222388 | ABCF2 | chr7 | 150913115 | - | 884 | 83 | 8 | 649 | 213 |
ENST00000491431 | ZNF786 | chr7 | 148787715 | - | ENST00000287844 | ABCF2 | chr7 | 150913115 | - | 2181 | 83 | 8 | 616 | 202 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000491431 | ENST00000222388 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - | 0.011093374 | 0.9889066 |
ENST00000491431 | ENST00000287844 | ZNF786 | chr7 | 148787715 | - | ABCF2 | chr7 | 150913115 | - | 0.010905912 | 0.9890941 |
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Fusion Genomic Features for ZNF786-ABCF2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ZNF786-ABCF2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:148787715/chr7:150913115) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 9_80 | 6 | 783.0 | Domain | KRAB |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 192_209 | 6 | 783.0 | Zinc finger | C2H2-type 1%3B degenerate |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 240_262 | 6 | 783.0 | Zinc finger | C2H2-type 2 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 369_391 | 6 | 783.0 | Zinc finger | C2H2-type 3%3B degenerate |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 397_419 | 6 | 783.0 | Zinc finger | C2H2-type 4 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 425_447 | 6 | 783.0 | Zinc finger | C2H2-type 5 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 453_475 | 6 | 783.0 | Zinc finger | C2H2-type 6 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 481_503 | 6 | 783.0 | Zinc finger | C2H2-type 7%3B degenerate |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 509_531 | 6 | 783.0 | Zinc finger | C2H2-type 8 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 537_559 | 6 | 783.0 | Zinc finger | C2H2-type 9 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 565_587 | 6 | 783.0 | Zinc finger | C2H2-type 10 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 593_615 | 6 | 783.0 | Zinc finger | C2H2-type 11 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 621_643 | 6 | 783.0 | Zinc finger | C2H2-type 12 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 649_670 | 6 | 783.0 | Zinc finger | C2H2-type 13 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 676_698 | 6 | 783.0 | Zinc finger | C2H2-type 14 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 704_726 | 6 | 783.0 | Zinc finger | C2H2-type 15 |
Hgene | ZNF786 | chr7:148787715 | chr7:150913115 | ENST00000491431 | - | 1 | 4 | 732_754 | 6 | 783.0 | Zinc finger | C2H2-type 16 |
Tgene | ABCF2 | chr7:148787715 | chr7:150913115 | ENST00000287844 | 10 | 15 | 396_613 | 446 | 624.0 | Domain | ABC transporter 2 | |
Tgene | ABCF2 | chr7:148787715 | chr7:150913115 | ENST00000287844 | 10 | 15 | 86_325 | 446 | 624.0 | Domain | ABC transporter 1 | |
Tgene | ABCF2 | chr7:148787715 | chr7:150913115 | ENST00000287844 | 10 | 15 | 118_125 | 446 | 624.0 | Nucleotide binding | ATP 1 | |
Tgene | ABCF2 | chr7:148787715 | chr7:150913115 | ENST00000287844 | 10 | 15 | 430_437 | 446 | 624.0 | Nucleotide binding | ATP 2 |
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Fusion Gene Sequence for ZNF786-ABCF2 |
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>102927_102927_1_ZNF786-ABCF2_ZNF786_chr7_148787715_ENST00000491431_ABCF2_chr7_150913115_ENST00000222388_length(transcript)=884nt_BP=83nt GCAGGTTCCTGCGGAGCCGCCGGAGACGGTCGGGTTTGCCAGGGCCGGGCGGGACCGCGGGGACCATGGCGGAGCCGCCTCGGCTACTAC CCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCAC CTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAAC AACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCT TCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGG TCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCC TGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGCACCCTGACATTGG CATCTCTGCCAAGGCCATGAGCATCATGAACTCGTTTGTAAACGACGTGTTTGAGCAGCTGGCGTGTGAGGCTGCCCGGCTGGCCCAGTA CTCGGGCCGGACCACCCTGACATCCCGAGAAGTCCAGACGGCTGTGCGTCTGCTGCTGCCTGGGGAGCTGGCCAAGCACGCTGTGTCTGA >102927_102927_1_ZNF786-ABCF2_ZNF786_chr7_148787715_ENST00000491431_ABCF2_chr7_150913115_ENST00000222388_length(amino acids)=213AA_BP=18 MRSRRRRSGLPGPGGTAGTMAEPPRLLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAY -------------------------------------------------------------- >102927_102927_2_ZNF786-ABCF2_ZNF786_chr7_148787715_ENST00000491431_ABCF2_chr7_150913115_ENST00000287844_length(transcript)=2181nt_BP=83nt GCAGGTTCCTGCGGAGCCGCCGGAGACGGTCGGGTTTGCCAGGGCCGGGCGGGACCGCGGGGACCATGGCGGAGCCGCCTCGGCTACTAC CCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCAC CTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAAC AACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCT TCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGG TCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCC TGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGAGCCCTCTACCTGG GTTCGGGTCAGGAGCTCCATCTGGGAACTAACAGCTGCTAACCTGACCAGCCGCTCAGGACAGGACCCTGGGGCTACACTCCTGCATTGC TGCAATACTGCTCCCCCAGCCTCTCCCCTGCCCCTCAACCTGCCTTAGCTGCACTCTCTTACCTACAGCTGGACAGTACCTGTCTGTTTC CTGTCCTCCTTCCAGTTACATCTGTCCATGTCTGGACTCGGCTGGCCGTTCCCTCCAGCCCCTTGCTGGTTATCTTACTCTGAGTGTGAT GCAGTCAGAGGCACCTGCGGGTTAGCCCAGGGGCCCAAGCCCTGGATTTGGCCTGCGGAGGAGCTTAGGATCCTCGTTTTCTGGGTTTTG GTGATGTTGGAGGAGTACCCCCCAGCCCACCGCCCCGATTCCTTTTTGCTTCTGGTTTGGAGCTCCGGACCAGGACCTTCGTCCTGGTCA GTTTTTAAATAATTATTTAGCAGTGTAACTTTTAGACCTGCGTGACATCTACAAAGCGCCCAATAAAGAAAGAGGAAGCCACGGTCCCTA CCTTCCTTCTCGGGTCTCTGGGGCCTTCTCCTCCCTGCAGTGCCAACATGCACTGCCCACAGCAGGAGCTGGATCCAGCGTCAGTGTGTC GATGGGAACTGAAGACTAGTCCATAGGAGCTGGAAGAACTTTGTCCCTTTACTTCTGATTTGAAATTGTACCTTTTCTCAGGCCTGTGAT TCACAGACTTTAACATGAATCAGAATCACCTGGAGGGCTCATGCAATCAGATTGCCAGATCTCGCCTCAGCGTTTCTGGTTCAATAGGTT TTGGGGGAGACCAAGAACGTTAACATTTCTAGCAAGTTTCCAGGTGATGCTGTTGTTGCTGGTCTAGAGACTATTTTGAGAACCACTGTC CAGGAGCGTGGTTTTCTGATTGTGATCTGAGGTTCTGCCCCAACTGCACAGCAGTTGGGCTGCTTGTTAAAAATGCAGGCCAGGTGCGGT GGCTCACACCTGTAATCCCAGCGCTTTGGGAGGCTGAGGCAGGTGGATCACTTGAGCTCAGGAGTTCAAGACCAGCTTGGGAAACATGGC AAAACCCGTCTTTATGTGCCTGGAATCCCACCTGCTCAGGTGGCTAGGGTGGATGGATCGCTTGAGCCCAGGAGGTGGAGGTTGCAGTGA GCTGAGATTGCACCACTGCATTCCAGCCTGGATGACAGAGCAAAACCCTGTCTCAAAAAAATGCAGACTGGCCAGGCACAGTGGCTCACA CCTGTAATCCGACTGTAAGCTCATCACCTTGGGAGGCCACTGTAGGAGGATCAATTGAGCCTAGAAGTTCAAGACCAGCCTGGGCAAAGT AGGGAGACCCCTTCTCTACAAATAGTAATAAAATGAACCGGGCATAGTAGCATGTGCCTGCGGTCCCAGCTGCTCTGATAAGAGGAGGCT CACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCAGAGCGTGCCGCTACACTCCAGCCTGATGACAGACCGAGACACTGTCTCAAAAAAA >102927_102927_2_ZNF786-ABCF2_ZNF786_chr7_148787715_ENST00000491431_ABCF2_chr7_150913115_ENST00000287844_length(amino acids)=202AA_BP=18 MRSRRRRSGLPGPGGTAGTMAEPPRLLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ZNF786-ABCF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZNF786-ABCF2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZNF786-ABCF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human |