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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CPM-AVIL (FusionGDB2 ID:HG1368TG10677) |
Fusion Gene Summary for CPM-AVIL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPM-AVIL | Fusion gene ID: hg1368tg10677 | Hgene | Tgene | Gene symbol | CPM | AVIL | Gene ID | 1368 | 10677 |
| Gene name | carboxypeptidase M | advillin | |
| Synonyms | - | ADVIL|DOC6|NPHS21|p92 | |
| Cytomap | ('CPM')('AVIL') 12q15 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | advillin | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P14384 | O75366 | |
| Ensembl transtripts involved in fusion gene | ENST00000338356, ENST00000546373, ENST00000551568, ENST00000549691, | ||
| Fusion gene scores | * DoF score | 15 X 8 X 7=840 | 20 X 12 X 9=2160 |
| # samples | 17 | 20 | |
| ** MAII score | log2(17/840*10)=-2.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/2160*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CPM [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CPM(69326458)-AVIL(58194995), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CPM-AVIL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPM-AVIL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPM-AVIL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CPM-AVIL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across CPM (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across AVIL (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A1L0-01A | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
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Fusion Gene ORF analysis for CPM-AVIL |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000338356 | ENST00000550083 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| 5CDS-intron | ENST00000546373 | ENST00000550083 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| 5CDS-intron | ENST00000551568 | ENST00000550083 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000338356 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000338356 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000546373 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000546373 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000551568 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| In-frame | ENST00000551568 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| intron-3CDS | ENST00000549691 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| intron-3CDS | ENST00000549691 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| intron-intron | ENST00000549691 | ENST00000550083 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000546373 | CPM | chr12 | 69326458 | - | ENST00000537081 | AVIL | chr12 | 58194995 | - | 1073 | 264 | 665 | 285 | 126 |
| ENST00000546373 | CPM | chr12 | 69326458 | - | ENST00000257861 | AVIL | chr12 | 58194995 | - | 573 | 264 | 297 | 572 | 91 |
| ENST00000551568 | CPM | chr12 | 69326458 | - | ENST00000537081 | AVIL | chr12 | 58194995 | - | 1030 | 221 | 254 | 529 | 91 |
| ENST00000551568 | CPM | chr12 | 69326458 | - | ENST00000257861 | AVIL | chr12 | 58194995 | - | 530 | 221 | 254 | 529 | 92 |
| ENST00000338356 | CPM | chr12 | 69326458 | - | ENST00000537081 | AVIL | chr12 | 58194995 | - | 1016 | 207 | 240 | 515 | 91 |
| ENST00000338356 | CPM | chr12 | 69326458 | - | ENST00000257861 | AVIL | chr12 | 58194995 | - | 516 | 207 | 240 | 515 | 91 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000546373 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.06953608 | 0.93046397 |
| ENST00000546373 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.024823463 | 0.9751765 |
| ENST00000551568 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.09690333 | 0.90309674 |
| ENST00000551568 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.03542984 | 0.96457016 |
| ENST00000338356 | ENST00000537081 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.09761046 | 0.9023896 |
| ENST00000338356 | ENST00000257861 | CPM | chr12 | 69326458 | - | AVIL | chr12 | 58194995 | - | 0.054485846 | 0.94551414 |
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Fusion Genomic Features for CPM-AVIL |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for CPM-AVIL |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69326458/chr12:58194995) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPM | AVIL |
| FUNCTION: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269|PubMed:12457462}. | FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 753_819 | 717 | 820.0 | Domain | HP | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 753_819 | 710 | 813.0 | Domain | HP | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 731_819 | 717 | 820.0 | Region | Headpiece | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 731_819 | 710 | 813.0 | Region | Headpiece |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 109_116 | 717 | 820.0 | Region | Polyphosphoinositide binding | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 135_143 | 717 | 820.0 | Region | Polyphosphoinositide binding | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 1_731 | 717 | 820.0 | Region | Core | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 109_116 | 710 | 813.0 | Region | Polyphosphoinositide binding | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 135_143 | 710 | 813.0 | Region | Polyphosphoinositide binding | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 1_731 | 710 | 813.0 | Region | Core | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 145_185 | 717 | 820.0 | Repeat | Note=Gelsolin-like 2 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 24_73 | 717 | 820.0 | Repeat | Note=Gelsolin-like 1 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 262_306 | 717 | 820.0 | Repeat | Note=Gelsolin-like 3 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 403_454 | 717 | 820.0 | Repeat | Note=Gelsolin-like 4 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 525_565 | 717 | 820.0 | Repeat | Note=Gelsolin-like 5 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000257861 | 15 | 19 | 628_669 | 717 | 820.0 | Repeat | Note=Gelsolin-like 6 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 145_185 | 710 | 813.0 | Repeat | Note=Gelsolin-like 2 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 24_73 | 710 | 813.0 | Repeat | Note=Gelsolin-like 1 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 262_306 | 710 | 813.0 | Repeat | Note=Gelsolin-like 3 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 403_454 | 710 | 813.0 | Repeat | Note=Gelsolin-like 4 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 525_565 | 710 | 813.0 | Repeat | Note=Gelsolin-like 5 | |
| Tgene | AVIL | chr12:69326458 | chr12:58194995 | ENST00000537081 | 15 | 19 | 628_669 | 710 | 813.0 | Repeat | Note=Gelsolin-like 6 |
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Fusion Gene Sequence for CPM-AVIL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >18983_18983_1_CPM-AVIL_CPM_chr12_69326458_ENST00000338356_AVIL_chr12_58194995_ENST00000257861_length(transcript)=516nt_BP=207nt CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT TACACAGTATTGGGAAATCTGTGAAAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATC ACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAG AATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGA GGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAA >18983_18983_1_CPM-AVIL_CPM_chr12_69326458_ENST00000338356_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=91AA_BP= MGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL F -------------------------------------------------------------- >18983_18983_2_CPM-AVIL_CPM_chr12_69326458_ENST00000338356_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1016nt_BP=207nt CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT TACACAGTATTGGGAAATCTGTGAAAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATC ACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAG AATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGA GGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGC AAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATAT AATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGT TTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAA AACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAAT CTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATTTTTCA CTTTTCAAATAAAGATACCTATAATG >18983_18983_2_CPM-AVIL_CPM_chr12_69326458_ENST00000338356_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=91AA_BP= MGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL F -------------------------------------------------------------- >18983_18983_3_CPM-AVIL_CPM_chr12_69326458_ENST00000546373_AVIL_chr12_58194995_ENST00000257861_length(transcript)=573nt_BP=264nt GTCTAGATTCTTCTTGGCCTCTCTGAGCAGCATTTCTTCCTTCTGCGTATGGGACAGGACCCTTTCTGGAATGGGGGTCTTATGACCTAC AATCAAACAAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGG AAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGCAGGA AAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTG AATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCC AAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAG CTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAA >18983_18983_3_CPM-AVIL_CPM_chr12_69326458_ENST00000546373_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=91AA_BP= MGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL F -------------------------------------------------------------- >18983_18983_4_CPM-AVIL_CPM_chr12_69326458_ENST00000546373_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1073nt_BP=264nt GTCTAGATTCTTCTTGGCCTCTCTGAGCAGCATTTCTTCCTTCTGCGTATGGGACAGGACCCTTTCTGGAATGGGGGTCTTATGACCTAC AATCAAACAAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGG AAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGCAGGA AAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTG AATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCC AAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAG CTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATAT CAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCAT TTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTC AGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTT TAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATAT GCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATTTTTCACTTTTCAAATAAAGATACCTATAATG >18983_18983_4_CPM-AVIL_CPM_chr12_69326458_ENST00000546373_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=126AA_BP= MSGRNWWINYFLILALSALFCGLAIGIGLLALEKPLFFLHLELFPARQSCKLPSCDAKHRHKVLFREVILLFGRVYILRQLLILVFQQNC YRVIFWLTVIRIQGEGCILHVSSDSHDSSSISQLFF -------------------------------------------------------------- >18983_18983_5_CPM-AVIL_CPM_chr12_69326458_ENST00000551568_AVIL_chr12_58194995_ENST00000257861_length(transcript)=530nt_BP=221nt ATAACACCCGGCCCCGCCGGGCGGCCGCGGGTGGGTAGAGGTGCGCGCCTGGGACCTGAACATGGACTTCCCGTGCCTCTGGCTAGGGCT GTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAG TTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTG CTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTC TGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGT TTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAA >18983_18983_5_CPM-AVIL_CPM_chr12_69326458_ENST00000551568_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=92AA_BP= MGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL FX -------------------------------------------------------------- >18983_18983_6_CPM-AVIL_CPM_chr12_69326458_ENST00000551568_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1030nt_BP=221nt ATAACACCCGGCCCCGCCGGGCGGCCGCGGGTGGGTAGAGGTGCGCGCCTGGGACCTGAACATGGACTTCCCGTGCCTCTGGCTAGGGCT GTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAG TTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTG CTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTC TGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGT TTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGG CCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTA CTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAAT GTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAG AAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATG ATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGT CAAAGCATTTTTCACTTTTCAAATAAAGATACCTATAATG >18983_18983_6_CPM-AVIL_CPM_chr12_69326458_ENST00000551568_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=91AA_BP= MGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL F -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CPM-AVIL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CPM-AVIL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CPM-AVIL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CPM | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | CPM | C0037116 | Silicosis | 1 | CTD_human |
| Hgene | CPM | C0269102 | Endometrioma | 1 | CTD_human |
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