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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CPS1-PRDX3 (FusionGDB2 ID:HG1373TG10935) |
Fusion Gene Summary for CPS1-PRDX3 |
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Fusion gene information | Fusion gene name: CPS1-PRDX3 | Fusion gene ID: hg1373tg10935 | Hgene | Tgene | Gene symbol | CPS1 | PRDX3 | Gene ID | 1373 | 10935 |
Gene name | carbamoyl-phosphate synthase 1 | peroxiredoxin 3 | |
Synonyms | CPSASE1|PHN | AOP-1|AOP1|HBC189|MER5|PRO1748|SP-22|prx-III | |
Cytomap | ('CPS1')('PRDX3') 2q34 | 10q26.11 | |
Type of gene | protein-coding | protein-coding | |
Description | carbamoyl-phosphate synthase [ammonia], mitochondrialcarbamoyl-phosphate synthase (ammonia)carbamoyl-phosphate synthase 1, mitochondrialcarbamoylphosphate synthetase I | thioredoxin-dependent peroxide reductase, mitochondrialantioxidant protein 1epididymis secretory sperm binding proteinperoxiredoxin IIIprotein MER5 homolog | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | P31327 | . | |
Ensembl transtripts involved in fusion gene | ENST00000233072, ENST00000430249, ENST00000451903, ENST00000497121, | ||
Fusion gene scores | * DoF score | 10 X 11 X 4=440 | 4 X 4 X 2=32 |
# samples | 11 | 5 | |
** MAII score | log2(11/440*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CPS1 [Title/Abstract] AND PRDX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CPS1(211421447)-PRDX3(120931984), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CPS1 | GO:0032496 | response to lipopolysaccharide | 15897806 |
Hgene | CPS1 | GO:0050667 | homocysteine metabolic process | 20031578 |
Tgene | PRDX3 | GO:0008284 | positive regulation of cell proliferation | 12011429 |
Tgene | PRDX3 | GO:0018171 | peptidyl-cysteine oxidation | 21850687 |
Tgene | PRDX3 | GO:0033673 | negative regulation of kinase activity | 18205602 |
Tgene | PRDX3 | GO:0034599 | cellular response to oxidative stress | 21850687 |
Tgene | PRDX3 | GO:0042542 | response to hydrogen peroxide | 17893648 |
Tgene | PRDX3 | GO:0042744 | hydrogen peroxide catabolic process | 7733872 |
Tgene | PRDX3 | GO:0043066 | negative regulation of apoptotic process | 21850687 |
Tgene | PRDX3 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12492477 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CPS1-PRDX3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CPS1-PRDX3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CPS1-PRDX3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:211421447/:120931984) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CPS1 | . |
FUNCTION: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CPS1-PRDX3 |
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Fusion Gene PPI Analysis for CPS1-PRDX3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CPS1-PRDX3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CPS1 | P31327 | DB06775 | Carglumic acid | Allosteric modulator | Small molecule | Approved |
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Related Diseases for CPS1-PRDX3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CPS1 | C4082171 | Hyperammonemia Due to Carbamoyl Phosphate Synthetase 1 Deficiency | 19 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CPS1 | C0751753 | Carbamoyl-Phosphate Synthase I Deficiency Disease | 13 | CLINGEN;CTD_human;ORPHANET |
Hgene | CPS1 | C0220994 | Hyperammonemia | 2 | CTD_human |
Hgene | CPS1 | C4085580 | Carbamoyl Phosphate Synthase 1 Deficiency | 2 | CTD_human |
Hgene | CPS1 | C0009421 | Comatose | 1 | CTD_human |
Hgene | CPS1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | CPS1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CPS1 | C0031190 | Persistent Fetal Circulation Syndrome | 1 | CTD_human |
Hgene | CPS1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Hgene | CPS1 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
Hgene | CPS1 | C0376618 | Endotoxemia | 1 | CTD_human |
Hgene | CPS1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | CPS1 | C0860634 | Psychogenic coma | 1 | CTD_human |
Hgene | CPS1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | CPS1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | CPS1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | CPS1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Tgene | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human | |
Tgene | C0029456 | Osteoporosis | 1 | CTD_human | |
Tgene | C0029459 | Osteoporosis, Senile | 1 | CTD_human | |
Tgene | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human | |
Tgene | C0085084 | Motor Neuron Disease | 1 | CTD_human | |
Tgene | C0154681 | Anterior Horn Cell Disease | 1 | CTD_human | |
Tgene | C0154682 | Lateral Sclerosis | 1 | CTD_human | |
Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human | |
Tgene | C0270763 | Familial Motor Neuron Disease | 1 | CTD_human | |
Tgene | C0270764 | Motor Neuron Disease, Lower | 1 | CTD_human | |
Tgene | C0521659 | Motor Neuron Disease, Upper | 1 | CTD_human | |
Tgene | C0543858 | Motor Neuron Disease, Secondary | 1 | CTD_human | |
Tgene | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |