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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATF2-CYTIP (FusionGDB2 ID:HG1386TG9595)

Fusion Gene Summary for ATF2-CYTIP

check button Fusion gene summary
Fusion gene informationFusion gene name: ATF2-CYTIP
Fusion gene ID: hg1386tg9595
HgeneTgene
Gene symbol

ATF2

CYTIP

Gene ID

1386

9595

Gene nameactivating transcription factor 2cytohesin 1 interacting protein
SynonymsCRE-BP1|CREB-2|CREB2|HB16|TREB7B3-1|CASP|CYBR|CYTHIP|HE|PSCDBP
Cytomap('ATF2')('CYTIP')

2q31.1

2q24.1

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-2activating transcription factor 2 splice variant ATF2-var2cAMP response element-binding protein CRE-BP1cAMP responsive element binding protein 2, formerlycAMP-dependent transcription factor ATF-2cyclic Acytohesin-interacting proteincbp HEcytohesin binder and regulatorcytohesin binding protein HEcytohesin-associated scaffolding proteinpleckstrin homology Sec7 and coiled-coil domains-binding protein
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264110, ENST00000345739, 
ENST00000392543, ENST00000392544, 
ENST00000409437, ENST00000409499, 
ENST00000409635, ENST00000409833, 
ENST00000426833, ENST00000487334, 
ENST00000538946, ENST00000413123, 
Fusion gene scores* DoF score12 X 11 X 9=11883 X 3 X 3=27
# samples 133
** MAII scorelog2(13/1188*10)=-3.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATF2 [Title/Abstract] AND CYTIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATF2(175994865)-CYTIP(158283932), # samples:1
Anticipated loss of major functional domain due to fusion event.ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ATF2-CYTIP seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ATF2-CYTIP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF2

GO:0006357

regulation of transcription by RNA polymerase II

19861239

HgeneATF2

GO:0006970

response to osmotic stress

21098032

HgeneATF2

GO:0006974

cellular response to DNA damage stimulus

22304920

HgeneATF2

GO:0045944

positive regulation of transcription by RNA polymerase II

16300731|18671972

HgeneATF2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

22982025

TgeneCYTIP

GO:0030155

regulation of cell adhesion

12606567


check buttonFusion gene breakpoints across ATF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CYTIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PFATF2chr2

175994865

-CYTIPchr2

158283932

-


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Fusion Gene ORF analysis for ATF2-CYTIP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264110ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000264110ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000345739ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000345739ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000392543ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000392543ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000392544ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000392544ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409437ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409437ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409499ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409499ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409635ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409635ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409833ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000409833ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000426833ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000426833ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000487334ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000487334ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000538946ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5CDS-intronENST00000538946ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
5UTR-3CDSENST00000413123ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
5UTR-intronENST00000413123ENST00000264192ATF2chr2

175994865

-CYTIPchr2

158283932

-
5UTR-intronENST00000413123ENST00000497432ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000264110ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000345739ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000392543ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000409437ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000409499ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000409635ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000409833ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
Frame-shiftENST00000487334ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
In-frameENST00000392544ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
In-frameENST00000426833ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-
In-frameENST00000538946ENST00000540637ATF2chr2

175994865

-CYTIPchr2

158283932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392544ATF2chr2175994865-ENST00000540637CYTIPchr2158283932-12223993581002214
ENST00000426833ATF2chr2175994865-ENST00000540637CYTIPchr2158283932-12223993581002214
ENST00000538946ATF2chr2175994865-ENST00000540637CYTIPchr2158283932-12223993581002214

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392544ENST00000540637ATF2chr2175994865-CYTIPchr2158283932-0.0112567980.9887432
ENST00000426833ENST00000540637ATF2chr2175994865-CYTIPchr2158283932-0.0112567980.9887432
ENST00000538946ENST00000540637ATF2chr2175994865-CYTIPchr2158283932-0.0112567980.9887432

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Fusion Genomic Features for ATF2-CYTIP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATF2-CYTIP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:175994865/chr2:158283932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-4141_734506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-4131_78448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-461_716127.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-5151_734506.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-461_734145.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-5141_78448.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-481_734210.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-5151_716488.0MotifNote=Nuclear export signal 1 (N-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-5161_716373.3333333333333MotifNote=Nuclear export signal 1 (N-NES)
TgeneCYTIPchr2:175994865chr2:158283932ENST0000026419248166_188158360.0Coiled coilOntology_term=ECO:0000255
TgeneCYTIPchr2:175994865chr2:158283932ENST0000026419248241_323158360.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-414352_41534506.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-413352_4158448.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-46352_41516127.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-515352_41534506.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-46352_41534145.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-514352_4158448.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-48352_41534210.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-515352_41516488.0DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-516352_41516373.3333333333333DomainbZIP
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-414405_41434506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-413405_4148448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-46405_41416127.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-515405_41434506.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-46405_41434145.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-514405_4148448.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-48405_41434210.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-515405_41416488.0MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-516405_41416373.3333333333333MotifNote=Nuclear export signal 2 (C-NES)
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-414296_29934506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-414354_37434506.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-414380_40834506.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-413296_2998448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-413354_3748448.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-413380_4088448.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-46296_29916127.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-46354_37416127.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-46380_40816127.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-515296_29934506.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-515354_37434506.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-515380_40834506.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-46296_29934145.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-46354_37434145.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-46380_40834145.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-514296_2998448.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-514354_3748448.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-514380_4088448.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-48296_29934210.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-48354_37434210.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-48380_40834210.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-515296_29916488.0RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-515354_37416488.0RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-515380_40816488.0RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-516296_29916373.3333333333333RegionNote=Essential for its histone acetyltransferase activity
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-516354_37416373.3333333333333RegionBasic motif
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-516380_40816373.3333333333333RegionLeucine-zipper
HgeneATF2chr2:175994865chr2:158283932ENST00000264110-41425_4934506.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000345739-41325_498448.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000392543-4625_4916127.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000392544-51525_4934506.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000409499-4625_4934145.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000409635-51425_498448.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000409833-4825_4934210.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000426833-51525_4916488.0Zinc fingerC2H2-type
HgeneATF2chr2:175994865chr2:158283932ENST00000487334-51625_4916373.3333333333333Zinc fingerC2H2-type
TgeneCYTIPchr2:175994865chr2:158283932ENST000002641924877_166158360.0DomainPDZ


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Fusion Gene Sequence for ATF2-CYTIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7410_7410_1_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000392544_CYTIP_chr2_158283932_ENST00000540637_length(transcript)=1222nt_BP=399nt
GTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCTTTGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACC
GAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAAAGGACTGCTTATTGATAACAGCTAAGGTATTCCTGGA
AGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGATTTCCTGAAGAGGTAGTCTGATTGGCTTAACTCGTATTCTTGCCATGAGA
AAAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGGCAATACAAGGACCTGTGGAATATGAGTGAT
GACAAACCCTTTCTATGTACTGCGCCTGGATGTGGCCAGGATAGAGACTCTTAATGGAACAATGATTCTGAAAAGAACGGAGCTTGAAGC
AAAGCTGCAGGTTTTAAAGCAAACTTTGAAACAAAAATGGGTGGAGTACAGATCTCTGCAGTTACAGGAACATCGTCTGCTTCATGGTGA
TGCAGCTAATTGCCCCAGTTTGGAAAACATGGACTTGGATGAATTGTCTTTGTTTGGACCCCTGCCTGGGCCAGGCCCAGCCCTTGTGGA
CCGGAATCGATTATCCAGTGAGAGCAGCTGTAAGAGCTGGCTGAGCTCCATGACGATGGACAGTGAAGATGGCTACCAGACGTGTGTGTC
TGAGGACTCCAGCAGGGGTGCCTTCAGTCGGCAGACGAGTACAGATGATGAGTGCTTTATCCCCAAGGAGGGGGATGATTTTCTGAGGAG
GTCATCTTCAAGGAGGAACCGGAGCATCAGTAACACCAGCAGCGGATCCATGTCTCCCTTGTGGGAGGGCAACTTATCAAGCATGTTTGG
GACCCTGCCCCGGAAGAGCAGAAAGGGAAGTGTCCGAAAGCAACTCTTGAAATTTATCCCTGGCCTTCATCGTGCTGTGGAAGAGGAAGA
AAGTCGCTTTTGACGGATTGTGGTGTCCTTTCAAATTAGCTTATTTCACAAATATCTCTAGACTCACCCAGATCCCAGCTTGGTGGGAAA
GTGCAGAAGAATTGCAAAACTGACATCCCATTTCACAGCAATAGTGACCTTTATTTAAATTGTTGTGTTATAGTTTATGCTTCTTAAATC
ATTTTTCAACCTAAACAGCCAATTTCTAAGCAGACAGGAAAACTAAATAATA

>7410_7410_1_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000392544_CYTIP_chr2_158283932_ENST00000540637_length(amino acids)=214AA_BP=13
MTNPFYVLRLDVARIETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALV
DRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMF
GTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

--------------------------------------------------------------
>7410_7410_2_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000426833_CYTIP_chr2_158283932_ENST00000540637_length(transcript)=1222nt_BP=399nt
GTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCTTTGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACC
GAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAAAGGACTGCTTATTGATAACAGCTAAGGTATTCCTGGA
AGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGATTTCCTGAAGAGGTAGTCTGATTGGCTTAACTCGTATTCTTGCCATGAGA
AAAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGGCAATACAAGGACCTGTGGAATATGAGTGAT
GACAAACCCTTTCTATGTACTGCGCCTGGATGTGGCCAGGATAGAGACTCTTAATGGAACAATGATTCTGAAAAGAACGGAGCTTGAAGC
AAAGCTGCAGGTTTTAAAGCAAACTTTGAAACAAAAATGGGTGGAGTACAGATCTCTGCAGTTACAGGAACATCGTCTGCTTCATGGTGA
TGCAGCTAATTGCCCCAGTTTGGAAAACATGGACTTGGATGAATTGTCTTTGTTTGGACCCCTGCCTGGGCCAGGCCCAGCCCTTGTGGA
CCGGAATCGATTATCCAGTGAGAGCAGCTGTAAGAGCTGGCTGAGCTCCATGACGATGGACAGTGAAGATGGCTACCAGACGTGTGTGTC
TGAGGACTCCAGCAGGGGTGCCTTCAGTCGGCAGACGAGTACAGATGATGAGTGCTTTATCCCCAAGGAGGGGGATGATTTTCTGAGGAG
GTCATCTTCAAGGAGGAACCGGAGCATCAGTAACACCAGCAGCGGATCCATGTCTCCCTTGTGGGAGGGCAACTTATCAAGCATGTTTGG
GACCCTGCCCCGGAAGAGCAGAAAGGGAAGTGTCCGAAAGCAACTCTTGAAATTTATCCCTGGCCTTCATCGTGCTGTGGAAGAGGAAGA
AAGTCGCTTTTGACGGATTGTGGTGTCCTTTCAAATTAGCTTATTTCACAAATATCTCTAGACTCACCCAGATCCCAGCTTGGTGGGAAA
GTGCAGAAGAATTGCAAAACTGACATCCCATTTCACAGCAATAGTGACCTTTATTTAAATTGTTGTGTTATAGTTTATGCTTCTTAAATC
ATTTTTCAACCTAAACAGCCAATTTCTAAGCAGACAGGAAAACTAAATAATA

>7410_7410_2_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000426833_CYTIP_chr2_158283932_ENST00000540637_length(amino acids)=214AA_BP=13
MTNPFYVLRLDVARIETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALV
DRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMF
GTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

--------------------------------------------------------------
>7410_7410_3_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000538946_CYTIP_chr2_158283932_ENST00000540637_length(transcript)=1222nt_BP=399nt
GTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCTTTGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACC
GAAAGGATCATGAACTAGTGACCTGGAAAGGGTACTAGATGGAAACTTGAGAAAGGACTGCTTATTGATAACAGCTAAGGTATTCCTGGA
AGCAGAGTAAATAAAGCTCATGGCCCACCAGCTAGAAAGATTTCCTGAAGAGGTAGTCTGATTGGCTTAACTCGTATTCTTGCCATGAGA
AAAAGAATGTGATAAGTTATTCAACTTATGAAATTCAAGTTACATGTGAATTCTGCCAGGCAATACAAGGACCTGTGGAATATGAGTGAT
GACAAACCCTTTCTATGTACTGCGCCTGGATGTGGCCAGGATAGAGACTCTTAATGGAACAATGATTCTGAAAAGAACGGAGCTTGAAGC
AAAGCTGCAGGTTTTAAAGCAAACTTTGAAACAAAAATGGGTGGAGTACAGATCTCTGCAGTTACAGGAACATCGTCTGCTTCATGGTGA
TGCAGCTAATTGCCCCAGTTTGGAAAACATGGACTTGGATGAATTGTCTTTGTTTGGACCCCTGCCTGGGCCAGGCCCAGCCCTTGTGGA
CCGGAATCGATTATCCAGTGAGAGCAGCTGTAAGAGCTGGCTGAGCTCCATGACGATGGACAGTGAAGATGGCTACCAGACGTGTGTGTC
TGAGGACTCCAGCAGGGGTGCCTTCAGTCGGCAGACGAGTACAGATGATGAGTGCTTTATCCCCAAGGAGGGGGATGATTTTCTGAGGAG
GTCATCTTCAAGGAGGAACCGGAGCATCAGTAACACCAGCAGCGGATCCATGTCTCCCTTGTGGGAGGGCAACTTATCAAGCATGTTTGG
GACCCTGCCCCGGAAGAGCAGAAAGGGAAGTGTCCGAAAGCAACTCTTGAAATTTATCCCTGGCCTTCATCGTGCTGTGGAAGAGGAAGA
AAGTCGCTTTTGACGGATTGTGGTGTCCTTTCAAATTAGCTTATTTCACAAATATCTCTAGACTCACCCAGATCCCAGCTTGGTGGGAAA
GTGCAGAAGAATTGCAAAACTGACATCCCATTTCACAGCAATAGTGACCTTTATTTAAATTGTTGTGTTATAGTTTATGCTTCTTAAATC
ATTTTTCAACCTAAACAGCCAATTTCTAAGCAGACAGGAAAACTAAATAATA

>7410_7410_3_ATF2-CYTIP_ATF2_chr2_175994865_ENST00000538946_CYTIP_chr2_158283932_ENST00000540637_length(amino acids)=214AA_BP=13
MTNPFYVLRLDVARIETLNGTMILKRTELEAKLQVLKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALV
DRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSRRNRSISNTSSGSMSPLWEGNLSSMF
GTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATF2-CYTIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATF2-CYTIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATF2-CYTIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATF2C0006826Malignant Neoplasms1CTD_human
HgeneATF2C0027651Neoplasms1CTD_human
HgeneATF2C0086692Benign Neoplasm1CTD_human
HgeneATF2C0235874Disease Exacerbation1CTD_human