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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREBBP-ADCY9 (FusionGDB2 ID:HG1387TG115)

Fusion Gene Summary for CREBBP-ADCY9

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP-ADCY9
Fusion gene ID: hg1387tg115
HgeneTgene
Gene symbol

CREBBP

ADCY9

Gene ID

1387

115

Gene nameCREB binding proteinadenylate cyclase 9
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1AC9|ACIX
Cytomap('CREBBP')('ADCY9')

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase
Modification date2020032920200313
UniProtAcc

Q92793

.
Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000262367, ENST00000382070, 
Fusion gene scores* DoF score43 X 38 X 17=277788 X 7 X 6=336
# samples 619
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREBBP [Title/Abstract] AND ADCY9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREBBP(3929833)-ADCY9(4016967), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930

TgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

TgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADCY9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-UY-A9PB-01ACREBBPchr16

3929833

-ADCY9chr16

4016967

-
ChimerDB4ESCATCGA-L5-A43M-01ACREBBPchr16

3929833

-ADCY9chr16

4043511

-


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Fusion Gene ORF analysis for CREBBP-ADCY9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262367ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4043511

-
5CDS-5UTRENST00000382070ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4043511

-
5CDS-intronENST00000262367ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4016967

-
5CDS-intronENST00000382070ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4016967

-
In-frameENST00000262367ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4016967

-
In-frameENST00000262367ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4043511

-
In-frameENST00000382070ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4016967

-
In-frameENST00000382070ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4043511

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163929833-ENST00000294016ADCY9chr164043511-61978958143072752
ENST00000382070CREBBPchr163929833-ENST00000294016ADCY9chr164043511-55912892082466752

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000294016CREBBPchr163929833-ADCY9chr164043511-0.00178650.9982135
ENST00000382070ENST00000294016CREBBPchr163929833-ADCY9chr164043511-0.0014755050.9985245

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Fusion Genomic Features for CREBBP-ADCY9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CREBBP-ADCY9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3929833/chr16:4016967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

.
FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111058_11989561354.0DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111058_11986281354.0DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111185_11879561354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111192_11969561354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111185_11876281354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111192_11966281354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911997_13539561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211808_8186281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211840_8676281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211889_8916281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211913_9206281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211942_9756281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211997_13536281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911976_9969561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211787_8076281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211819_8396281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211868_8886281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211892_9126281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211921_9416281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211976_9966281354.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311061_1064282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311199_1487282443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311555_1562282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311943_1948282443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311967_1970282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312081_2085282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312199_2216282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312245_2248282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312297_2300282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301061_1064282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301199_1487282405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301555_1562282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301943_1948282405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301967_1970282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302081_2085282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302199_2216282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302245_2248282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302297_2300282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311061_1064282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311199_1487282443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311555_1562282443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311943_1948282443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311967_1970282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312081_2085282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312199_2216282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312245_2248282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312297_2300282443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301061_1064282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301199_1487282405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301555_1562282405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301943_1948282405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301967_1970282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302081_2085282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302199_2216282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302245_2248282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302297_2300282405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311103_1175282443.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311323_1700282443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131587_666282443.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301103_1175282405.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301323_1700282405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130587_666282405.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311103_1175282443.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311323_1700282443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131587_666282443.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301103_1175282405.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301323_1700282405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130587_666282405.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311434_1436282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311446_1447282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301434_1436282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301446_1447282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311434_1436282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311446_1447282443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301434_1436282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301446_1447282405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311701_1744282443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311765_1846282443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131347_433282443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301701_1744282405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301765_1846282405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130347_433282405.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311701_1744282443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311765_1846282443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131347_433282443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301701_1744282405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301765_1846282405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130347_433282405.0Zinc fingerTAZ-type 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911394_5219561354.0DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211394_5216281354.0DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911399_4049561354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911441_4439561354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211399_4046281354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211441_4436281354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911139_1419561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911163_1719561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911193_2159561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111_1179561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911236_2419561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911260_2809561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911302_7869561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911808_8189561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911840_8679561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911889_8919561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911913_9209561354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911942_9759561354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211139_1416281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211163_1716281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211193_2156281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111_1176281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211236_2416281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211260_2806281354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211302_7866281354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911118_1389561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911142_1629561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911172_1929561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911216_2359561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911242_2599561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911281_3019561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911787_8079561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911819_8399561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911868_8889561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911892_9129561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911921_9419561354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211118_1386281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211142_1626281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211172_1926281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211216_2356281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211242_2596281354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211281_3016281354.0TransmembraneHelical


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Fusion Gene Sequence for CREBBP-ADCY9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19349_19349_1_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000262367_ADCY9_chr16_4043511_ENST00000294016_length(transcript)=6197nt_BP=895nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACCTG
CCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAA
CAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGAC
TTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACAT
CCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTT
CAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCATAAAGAACTCCCCCGTGAAGACGTT
TGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTCCACCACCTGCTTCCTGAAGTACGA
GGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGTGCTGTCCCTCGCGGTGTCCATCAG
GATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGC
CATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTC
GGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGG
GCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAG
GAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCT
CTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAA
GATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTA
CTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGA
GTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCAT
CGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGA
GTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGG
GCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCAC
CGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAA
TGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCC
AGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAA
GACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGA
AAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTC
AAAGAGTGTGTGAGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATATTTGTATTTGGCTGTTGTGCTTTCC
AAGCGCCACAGTTGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGGATCACAGTTATTCAGGGTTCATTT
TCATCCATTCTTCCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCACGTGGTGGAGAACAAGTGCCTTCA
GGGCTGGCCTCGGCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTATTTGACTTTTAGAACAAAAGCTGTG
GTTAAGATCTCATTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTAATACCCTGTTTTTGAGTTTATTTT
GTTTCTGTCTATGTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACACACACTTGCATTCATGAATCTGATA
TAAAGTGCCAGTAATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCCCATTGCCCACCCGCACTTTCCCGA
GCACCGCGCCCCGTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCCACATGCATGCAGGCCAAGACAGCA
AATGCCAGCCGGGCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCCGACCCTCCACCCAGGGGTCTCCCC
ATCGGGAGTGGAGGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCCGAGGTTGCATTTATTTATTTATTT
ATTTACCCGGAAGCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCACAGGGGAGGGCAGTTCCCAGGAAG
GTAACCAGATGTCTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGGGGTCTGAGTGGGACCTCAAAGCAT
GGCCAGTGCAATTCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGGGCTCCTCCCTGCCGGGGTCCAGCT
CAGAACCACGGGGGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTTCTTGGCTGCCTCCCGCTCTCAGAT
GGCACAGGGCCTATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCTCACACCGTATCTAGGGACAGAGGC
ATCTGGATGCAAACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCCGGGCAGTTGGCTGCTGGTCCTGTC
TGATTATGTTTTGCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTCGGAGTTGTAGCCAGTCTTTCAGGG
GACCCCGGGACGCTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCATTTTGCTTTCCGCTGTCAAATCTCA
CTGTCTCGTTTTCACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGCCCTCCCCGGCATGAAGAAGTCACA
ATTCTGACCCGCCACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCAGGGTCCCGGCGTCCTGAGAGTCCA
GGGCACCTCCCCCCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCAATACCGAAGAAAGGGTGGTTGTGA
CAATACCTCTTGCTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAACACTACCTGATGCTTTCCTTGTTCG
TGGGGATTGTGGTCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCCCTCCCCTTTCCCCTCCAGGCTGTG
TAGCTTTGAGGGGCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGTTCTCCGCACACACTTCTTCCCCAT
CAAGCCCATTTCCTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCTGCAAAGTGGAGTCTGGTTCAGCCC
CGTGCAGACTCACCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTGCAGACGTTCTCTCTGGGCCACGAA
GCCCCTCGGGTCCTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGCAGCGGAAACGCCGTGCATCTCTTG
TCTGTTGGCAGCGAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTGACGGCATGGGTCGTGCTTCAGGGT
GGCAATACCTCTTAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTGCTTTGAGTTGCAATTGCTATTTTC
TTCTCAGTCCCAGCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATATATATATATATATATGGTAAACAAG
CACACACAATTTTATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGAGAGCCCCACAGGCTCTGCCACACC
CGTGACTTCATCCACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAGAGCCGAAGGCCGCGTGCTTCCTGT
CACATGGGCTGTAATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAGGTAAGGAGTTTTTTTTAATTGGTT
GTTTGGAAAATCACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTTCCATATATCCTTTTATCTGCTCTT

>19349_19349_1_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000262367_ADCY9_chr16_4043511_ENST00000294016_length(amino acids)=752AA_BP=27
MRTCWTDRPTPKEPNSARPVSRRMTAQTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTS
LCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFA
SPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAI
LVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERN
PCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYS
KNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEF
AKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNV
KGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEER

--------------------------------------------------------------
>19349_19349_2_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000382070_ADCY9_chr16_4043511_ENST00000294016_length(transcript)=5591nt_BP=289nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGACCTGCCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAA
CGGCTGCCAAGACGAGCATAAAAACAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGA
GGAGAAGCTCACCAACAGTCAGACTTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCT
CCTTCCGCTGAGGTTCAAGAACATCCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTT
TTTTAAGCCGCCCATTAATCAGTTCAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCAT
AAAGAACTCCCCCGTGAAGACGTTTGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTC
CACCACCTGCTTCCTGAAGTACGAGGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGT
GCTGTCCCTCGCGGTGTCCATCAGGATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTG
GCTACCACGTCACTGCATCGGGGCCATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACAT
ACACTTCCCAGTGTTCACAGGCTCGGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTC
CCTCGCCACCGTCGTGGGGGCCGGGCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGC
AGTACAGAATTTCAGTTCCGAGAGGAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGT
GGTTCTCGTCTTCTTTCTCCTGCTCTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGT
GGAAGCGGATCTTCACCGCACCAAGATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGA
GCAGCTGAAGGTGTCCCAGACCTACTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGA
GGAGAACTACGAGGGCGGCAAGGAGTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAG
CAGCATCGAGAAGATCAAGACCATCGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCA
GGAGCACCTGCAGATCCTGTTCGAGTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAA
GCTCCGCGTCGGCTTCAACCATGGGCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAA
CATCGCCAGCAGGATGGACACCACCGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGA
CTTCGACTACAGAGGGACCGTGAATGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCC
ACAGCACCAGCTGTCCATCTCCCCAGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGT
GCCTTCTGTCCAGTATGTGGACAAGACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTG
GAAGGAGCCCGTCAAAGCCGAAGAAAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAA
CGAACTCACCAAGCTCAACGTTTCAAAGAGTGTGTGAGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATAT
TTGTATTTGGCTGTTGTGCTTTCCAAGCGCCACAGTTGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGG
ATCACAGTTATTCAGGGTTCATTTTCATCCATTCTTCCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCA
CGTGGTGGAGAACAAGTGCCTTCAGGGCTGGCCTCGGCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTAT
TTGACTTTTAGAACAAAAGCTGTGGTTAAGATCTCATTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTA
ATACCCTGTTTTTGAGTTTATTTTGTTTCTGTCTATGTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACAC
ACACTTGCATTCATGAATCTGATATAAAGTGCCAGTAATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCC
CATTGCCCACCCGCACTTTCCCGAGCACCGCGCCCCGTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCC
ACATGCATGCAGGCCAAGACAGCAAATGCCAGCCGGGCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCC
GACCCTCCACCCAGGGGTCTCCCCATCGGGAGTGGAGGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCC
GAGGTTGCATTTATTTATTTATTTATTTACCCGGAAGCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCA
CAGGGGAGGGCAGTTCCCAGGAAGGTAACCAGATGTCTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGG
GGTCTGAGTGGGACCTCAAAGCATGGCCAGTGCAATTCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGG
GCTCCTCCCTGCCGGGGTCCAGCTCAGAACCACGGGGGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTT
CTTGGCTGCCTCCCGCTCTCAGATGGCACAGGGCCTATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCT
CACACCGTATCTAGGGACAGAGGCATCTGGATGCAAACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCC
GGGCAGTTGGCTGCTGGTCCTGTCTGATTATGTTTTGCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTC
GGAGTTGTAGCCAGTCTTTCAGGGGACCCCGGGACGCTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCAT
TTTGCTTTCCGCTGTCAAATCTCACTGTCTCGTTTTCACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGC
CCTCCCCGGCATGAAGAAGTCACAATTCTGACCCGCCACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCA
GGGTCCCGGCGTCCTGAGAGTCCAGGGCACCTCCCCCCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCA
ATACCGAAGAAAGGGTGGTTGTGACAATACCTCTTGCTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAAC
ACTACCTGATGCTTTCCTTGTTCGTGGGGATTGTGGTCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCC
CTCCCCTTTCCCCTCCAGGCTGTGTAGCTTTGAGGGGCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGT
TCTCCGCACACACTTCTTCCCCATCAAGCCCATTTCCTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCT
GCAAAGTGGAGTCTGGTTCAGCCCCGTGCAGACTCACCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTG
CAGACGTTCTCTCTGGGCCACGAAGCCCCTCGGGTCCTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGC
AGCGGAAACGCCGTGCATCTCTTGTCTGTTGGCAGCGAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTG
ACGGCATGGGTCGTGCTTCAGGGTGGCAATACCTCTTAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTG
CTTTGAGTTGCAATTGCTATTTTCTTCTCAGTCCCAGCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATAT
ATATATATATATATGGTAAACAAGCACACACAATTTTATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGA
GAGCCCCACAGGCTCTGCCACACCCGTGACTTCATCCACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAG
AGCCGAAGGCCGCGTGCTTCCTGTCACATGGGCTGTAATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAG
GTAAGGAGTTTTTTTTAATTGGTTGTTTGGAAAATCACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTT
CCATATATCCTTTTATCTGCTCTTTTTAAATTGTTAATTCTAATAATTTCAAAATGCATTCACTGAAGAAATGGACATTAAAATATTCTA

>19349_19349_2_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000382070_ADCY9_chr16_4043511_ENST00000294016_length(amino acids)=752AA_BP=27
MRTCWTDRPTPKEPNSARPVSRRMTAQTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTS
LCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFA
SPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAI
LVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERN
PCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYS
KNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEF
AKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNV
KGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEER

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Fusion Gene PPI Analysis for CREBBP-ADCY9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311162_118028.3333333333333322443.0ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301162_118028.3333333333333322405.0ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311162_118028.3333333333333322443.0ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301162_118028.3333333333333322405.0ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311433_143528.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301433_143528.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311433_143528.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301433_143528.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311124_117028.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301124_117028.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311124_117028.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301124_117028.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131227_41028.3333333333333322443.0SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130227_41028.3333333333333322405.0SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131227_41028.3333333333333322443.0SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130227_41028.3333333333333322405.0SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311460_189128.3333333333333322443.0TRERF1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301460_189128.3333333333333322405.0TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311460_189128.3333333333333322443.0TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301460_189128.3333333333333322405.0TRERF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREBBP-ADCY9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREBBP-ADCY9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
HgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
HgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
HgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
HgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneCREBBPC0005695Bladder Neoplasm1CTD_human
HgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
HgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
HgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCREBBPC0011573Endogenous depression1PSYGENET
HgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
HgeneCREBBPC0036920Sezary Syndrome1CTD_human
HgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
HgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
HgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
HgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
HgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
HgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
HgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
HgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human