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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CREM-MCMBP (FusionGDB2 ID:HG1390TG79892)

Fusion Gene Summary for CREM-MCMBP

check button Fusion gene summary
Fusion gene informationFusion gene name: CREM-MCMBP
Fusion gene ID: hg1390tg79892
HgeneTgene
Gene symbol

CREM

MCMBP

Gene ID

1390

79892

Gene namecAMP responsive element modulatorminichromosome maintenance complex binding protein
SynonymsCREM-2|ICER|hCREM-2C10orf119|MCM-BP
Cytomap('CREM')('MCMBP')

10p11.21

10q26.11

Type of geneprotein-codingprotein-coding
DescriptioncAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICERmini-chromosome maintenance complex-binding proteinMCM-binding protein
Modification date2020031320200313
UniProtAcc

Q03060

.
Ensembl transtripts involved in fusion geneENST00000345491, ENST00000374728, 
ENST00000395895, ENST00000489321, 
ENST00000333809, ENST00000337656, 
ENST00000342105, ENST00000344351, 
ENST00000348787, ENST00000354759, 
ENST00000356917, ENST00000361599, 
ENST00000374721, ENST00000374726, 
ENST00000374734, ENST00000395887, 
ENST00000429130, ENST00000439705, 
ENST00000460270, ENST00000463314, 
ENST00000463960, ENST00000468236, 
ENST00000469949, ENST00000473940, 
ENST00000474362, ENST00000474931, 
ENST00000479070, ENST00000484283, 
ENST00000487763, ENST00000488328, 
ENST00000488741, ENST00000489388, 
ENST00000490511, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 3=75
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREM [Title/Abstract] AND MCMBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREM(35416495)-MCMBP(121609088), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREM

GO:0006355

regulation of transcription, DNA-templated

8206879



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-G7-A8LECREMchr10

35416495

+MCMBPchr10

121609088

-


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Fusion Gene ORF analysis for CREM-MCMBP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000345491ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000345491ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000374728ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000374728ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000395895ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000395895ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000489321ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-3CDSENST00000489321ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-5UTRENST00000345491ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-5UTRENST00000374728ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-5UTRENST00000395895ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
5UTR-5UTRENST00000489321ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000333809ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000333809ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000337656ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000337656ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000342105ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000342105ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000344351ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000344351ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000348787ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000348787ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000354759ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000354759ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000356917ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000356917ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000361599ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000361599ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374721ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374721ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374726ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374726ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374734ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000374734ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000395887ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000395887ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000429130ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000429130ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000439705ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000439705ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000460270ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000460270ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000463314ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000463314ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000463960ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000463960ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000468236ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000468236ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000469949ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000469949ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000473940ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000473940ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000474362ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000474362ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000474931ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000474931ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000479070ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000479070ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000484283ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000484283ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000487763ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000487763ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000488328ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000488328ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000488741ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000488741ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000489388ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000489388ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000490511ENST00000360003CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-3CDSENST00000490511ENST00000369077CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000333809ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000337656ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000342105ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000344351ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000348787ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000354759ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000356917ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000361599ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000374721ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000374726ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000374734ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000395887ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000429130ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000439705ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000460270ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000463314ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000463960ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000468236ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000469949ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000473940ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000474362ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000474931ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000479070ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000484283ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000487763ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000488328ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000488741ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000489388ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-
intron-5UTRENST00000490511ENST00000466047CREMchr10

35416495

+MCMBPchr10

121609088

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CREM-MCMBP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CREM-MCMBP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35416495/:121609088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREM

Q03060

.
FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CREM-MCMBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CREM-MCMBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREM-MCMBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREM-MCMBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREMC0011875Diabetic Angiopathies1CTD_human
HgeneCREMC0020564Hypertrophy1CTD_human
HgeneCREMC0025945Microangiopathy, Diabetic1CTD_human
HgeneCREMC0027051Myocardial Infarction1CTD_human
HgeneCREMC0087031Juvenile-Onset Still Disease1CTD_human
HgeneCREMC0162820Dermatitis, Allergic Contact1CTD_human
HgeneCREMC0263454Chloracne1CTD_human
HgeneCREMC3495559Juvenile arthritis1CTD_human
HgeneCREMC3714758Juvenile psoriatic arthritis1CTD_human
HgeneCREMC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneCREMC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human