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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRP-SEPHS2 (FusionGDB2 ID:HG1401TG22928)

Fusion Gene Summary for CRP-SEPHS2

check button Fusion gene summary
Fusion gene informationFusion gene name: CRP-SEPHS2
Fusion gene ID: hg1401tg22928
HgeneTgene
Gene symbol

CRP

SEPHS2

Gene ID

1401

22928

Gene nameC-reactive proteinselenophosphate synthetase 2
SynonymsPTX1SPS2
Cytomap('CRP')('SEPHS2')

1q23.2

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionC-reactive proteinC-reactive protein, pentraxin-relatedpentraxin 1selenide, water dikinase 2selenium donor protein 2selenophosphate synthase 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000255030, ENST00000343919, 
ENST00000368110, ENST00000368111, 
ENST00000368112, ENST00000437342, 
ENST00000473196, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: CRP [Title/Abstract] AND SEPHS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRP(159683023)-SEPHS2(30456377), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRP

GO:0010628

positive regulation of gene expression

24141169

HgeneCRP

GO:0010745

negative regulation of macrophage derived foam cell differentiation

18322245

HgeneCRP

GO:0010888

negative regulation of lipid storage

18322245

HgeneCRP

GO:0032930

positive regulation of superoxide anion generation

24141169

HgeneCRP

GO:0032945

negative regulation of mononuclear cell proliferation

29202702

HgeneCRP

GO:0097756

negative regulation of blood vessel diameter

24141169

HgeneCRP

GO:2000482

regulation of interleukin-8 secretion

21037097



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CRP-SEPHS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CRP-SEPHS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CRP-SEPHS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:159683023/:30456377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CRP-SEPHS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CRP-SEPHS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRP-SEPHS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CRP-SEPHS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRPC0020538Hypertensive disease4CTD_human
HgeneCRPC0021368Inflammation3CTD_human
HgeneCRPC0036341Schizophrenia3PSYGENET
HgeneCRPC0007222Cardiovascular Diseases2CTD_human
HgeneCRPC0041696Unipolar Depression2PSYGENET
HgeneCRPC0344315Depressed mood2PSYGENET
HgeneCRPC0948089Acute Coronary Syndrome2CTD_human
HgeneCRPC1269683Major Depressive Disorder2PSYGENET
HgeneCRPC0003469Anxiety Disorders1CTD_human
HgeneCRPC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneCRPC0003873Rheumatoid Arthritis1CTD_human
HgeneCRPC0004153Atherosclerosis1CTD_human
HgeneCRPC0010054Coronary Arteriosclerosis1CTD_human
HgeneCRPC0010346Crohn Disease1CTD_human
HgeneCRPC0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
HgeneCRPC0011884Diabetic Retinopathy1CTD_human
HgeneCRPC0018799Heart Diseases1CTD_human
HgeneCRPC0018801Heart failure1CTD_human
HgeneCRPC0018802Congestive heart failure1CTD_human
HgeneCRPC0019193Hepatitis, Toxic1CTD_human
HgeneCRPC0020503Hyperparathyroidism, Secondary1CTD_human
HgeneCRPC0020557Hypertriglyceridemia1CTD_human
HgeneCRPC0022661Kidney Failure, Chronic1CTD_human
HgeneCRPC0023212Left-Sided Heart Failure1CTD_human
HgeneCRPC0023281Leishmaniasis1CTD_human
HgeneCRPC0023290Leishmaniasis, Visceral1CTD_human
HgeneCRPC0024121Lung Neoplasms1CTD_human
HgeneCRPC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCRPC0024530Malaria1CTD_human
HgeneCRPC0025289Meningitis1CTD_human
HgeneCRPC0025517Metabolic Diseases1CTD_human
HgeneCRPC0027059Myocarditis1CTD_human
HgeneCRPC0027707Nephritis, Interstitial1CTD_human
HgeneCRPC0028754Obesity1CTD_human
HgeneCRPC0030167Pachymeningitis1CTD_human
HgeneCRPC0030246Pustulosis of Palms and Soles1CTD_human
HgeneCRPC0031051Pericementitis1CTD_human
HgeneCRPC0031099Periodontitis1CTD_human
HgeneCRPC0033860Psoriasis1CTD_human
HgeneCRPC0038587Substance Withdrawal Syndrome1CTD_human
HgeneCRPC0040053Thrombosis1CTD_human
HgeneCRPC0041349Nephritis, Tubulointerstitial1CTD_human
HgeneCRPC0085397Pasteurellaceae Infections1CTD_human
HgeneCRPC0086189Drug Withdrawal Symptoms1CTD_human
HgeneCRPC0087086Thrombus1CTD_human
HgeneCRPC0087169Withdrawal Symptoms1CTD_human
HgeneCRPC0151744Myocardial Ischemia1CTD_human
HgeneCRPC0156147Crohn's disease of large bowel1CTD_human
HgeneCRPC0205734Diabetes, Autoimmune1CTD_human
HgeneCRPC0235527Heart Failure, Right-Sided1CTD_human
HgeneCRPC0242379Malignant neoplasm of lung1CTD_human
HgeneCRPC0242380Libman-Sacks Disease1CTD_human
HgeneCRPC0267380Crohn's disease of the ileum1CTD_human
HgeneCRPC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneCRPC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneCRPC0311375Arsenic Poisoning1CTD_human
HgeneCRPC0342302Brittle diabetes1CTD_human
HgeneCRPC0376280Anxiety States, Neurotic1CTD_human
HgeneCRPC0524620Metabolic Syndrome X1CTD_human
HgeneCRPC0678202Regional enteritis1CTD_human
HgeneCRPC0751851Arsenic Encephalopathy1CTD_human
HgeneCRPC0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneCRPC0860207Drug-Induced Liver Disease1CTD_human
HgeneCRPC0869523Carditis1CTD_human
HgeneCRPC0949272IIeocolitis1CTD_human
HgeneCRPC0971858Arthritis, Collagen-Induced1CTD_human
HgeneCRPC0993582Arthritis, Experimental1CTD_human
HgeneCRPC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCRPC1279420Anxiety neurosis (finding)1CTD_human
HgeneCRPC1563937Atherogenesis1CTD_human
HgeneCRPC1956346Coronary Artery Disease1CTD_human
HgeneCRPC1959583Myocardial Failure1CTD_human
HgeneCRPC1961112Heart Decompensation1CTD_human
HgeneCRPC2239176Liver carcinoma1CTD_human
HgeneCRPC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCRPC3714514Infection1CTD_human
HgeneCRPC3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
HgeneCRPC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCRPC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneCRPC4554117Diabetes Mellitus, Sudden-Onset1CTD_human