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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C20orf112-ASXL1 (FusionGDB2 ID:HG140688TG171023)

Fusion Gene Summary for C20orf112-ASXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: C20orf112-ASXL1
Fusion gene ID: hg140688tg171023
HgeneTgene
Gene symbol

C20orf112

ASXL1

Gene ID

140688

171023

Gene namenucleolar protein 4 likeASXL transcriptional regulator 1
SynonymsC20orf112|C20orf113BOPS|MDS
Cytomap('C20orf112')('ASXL1')

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 4-likepolycomb group protein ASXL1additional sex combs like 1, transcriptional regulatoradditional sex combs like transcriptional regulator 1putative Polycomb group protein ASXL1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000475781, ENST00000326071, 
ENST00000359676, ENST00000375677, 
ENST00000375678, ENST00000201961, 
Fusion gene scores* DoF score4 X 7 X 4=11210 X 7 X 6=420
# samples 510
** MAII scorelog2(5/112*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C20orf112 [Title/Abstract] AND ASXL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC20orf112(31062404)-ASXL1(30954187), # samples:1
Anticipated loss of major functional domain due to fusion event.C20orf112-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
C20orf112-ASXL1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASXL1

GO:0035522

monoubiquitinated histone H2A deubiquitination

20436459


check buttonFusion gene breakpoints across C20orf112 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ASXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315395C20orf112chr20

31062404

-ASXL1chr20

30954187

+


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Fusion Gene ORF analysis for C20orf112-ASXL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000475781ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
5UTR-3CDSENST00000475781ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
5UTR-3CDSENST00000475781ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
5UTR-3CDSENST00000475781ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
5UTR-3CDSENST00000475781ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000326071ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000326071ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000326071ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000326071ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000359676ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000359676ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000359676ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000359676ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375677ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375677ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375677ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375677ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375678ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375678ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375678ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
Frame-shiftENST00000375678ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+
In-frameENST00000326071ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
In-frameENST00000359676ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
In-frameENST00000375677ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
In-frameENST00000375678ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
intron-3CDSENST00000201961ENST00000306058C20orf112chr20

31062404

-ASXL1chr20

30954187

+
intron-3CDSENST00000201961ENST00000375687C20orf112chr20

31062404

-ASXL1chr20

30954187

+
intron-3CDSENST00000201961ENST00000375689C20orf112chr20

31062404

-ASXL1chr20

30954187

+
intron-3CDSENST00000201961ENST00000470145C20orf112chr20

31062404

-ASXL1chr20

30954187

+
intron-3CDSENST00000201961ENST00000542461C20orf112chr20

31062404

-ASXL1chr20

30954187

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000359676C20orf112chr2031062404-ENST00000470145ASXL1chr2030954187+132525241412123
ENST00000326071C20orf112chr2031062404-ENST00000470145ASXL1chr2030954187+1436363152523123
ENST00000375677C20orf112chr2031062404-ENST00000470145ASXL1chr2030954187+127620319363114
ENST00000375678C20orf112chr2031062404-ENST00000470145ASXL1chr2030954187+2760168711791847222

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359676ENST00000470145C20orf112chr2031062404-ASXL1chr2030954187+0.0444360080.955564
ENST00000326071ENST00000470145C20orf112chr2031062404-ASXL1chr2030954187+0.094843110.90515685
ENST00000375677ENST00000470145C20orf112chr2031062404-ASXL1chr2030954187+0.137980220.86201984
ENST00000375678ENST00000470145C20orf112chr2031062404-ASXL1chr2030954187+0.015409360.98459065

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Fusion Genomic Features for C20orf112-ASXL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C20orf112chr2031062403-ASXL1chr2030954186+0.0013327810.99866724
C20orf112chr2031062403-ASXL1chr2030954186+0.0013327810.99866724

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C20orf112-ASXL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31062404/chr20:30954187)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASXL1chr20:31062404chr20:30954187ENST000003756870131457_1460191542.0Compositional biasNote=Poly-Ser
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013199_209191542.0Compositional biasNote=Poly-Ser
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013641_684191542.0Compositional biasNote=Gly-rich
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013255_364191542.0DomainDEUBAD
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013160_164191542.0MotifNuclear localization signal 1
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013284_288191542.0MotifNote=LXXLL motif
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013409_413191542.0MotifNuclear localization signal 2
TgeneASXL1chr20:31062404chr20:30954187ENST000003756870131503_1540191542.0Zinc fingerNote=PHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC20orf112chr20:31062404chr20:30954187ENST00000359676-28161_16936437.0Compositional biasNote=Poly-Asp
TgeneASXL1chr20:31062404chr20:30954187ENST000003756870132_9191542.0Compositional biasNote=Poly-Lys
TgeneASXL1chr20:31062404chr20:30954187ENST0000037568701311_86191542.0DomainHTH HARE-type


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Fusion Gene Sequence for C20orf112-ASXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11459_11459_1_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000326071_ASXL1_chr20_30954187_ENST00000470145_length(transcript)=1436nt_BP=363nt
GGCGCCGCCGCCGCTGCCGCCGCTGCTCGCCTGGGCCCTCCTCCTGGCCACCCCCGCCCCCGGGCCGGGCAGTGACGCGCCGCGGTGGTG
CCAGCCCCTCTCCCCGGGCAGCCGCGGCGGCAGCAGCAGCAGCAGCAGCTGGAGCTGTGGGGCTGTCACCGCCGCCCGCCCCGCTCACTC
GCGGATCCCGACCGCCCATCTCCGCCTCGCTTCCAGCCCAGGATGAGACTTCTGTGAGCAGCGAGGATTTTGATATGAGCGACTCCACAT
GGATGTCAGCTGACCCGCACCTGGCCTCCAGCCTGAGCCCCAGCCAGGACGAGAGGATGCGGAGCCCGCAGAACCTCCACAGTCAAGAGG
ACGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGT
GGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATC
AGCCTTTTCACGCTCAAGAAGGATGCCCTGCAGTGGTCTCGCCATCCAGCTACAGTGGAGGGAGAGGAGCCAGAGGACACGGCTGATGTG
GAGAGCTGTGGGTCTAATGAAGCCAGCACTGTGAGTGGTGAAAACGATGGTAAGGACCCTTTAATGGATGGGTGAGGGAGCCACAGCAGG
CACTAGGGACTAACCTTTATTTTCCTCTCTTCCAGTATCTCTTGATGAAACATCTTCGAACGCATCCTGTTCTACAGAATCTCAGAGTCG
ACCTCTTTCCAATCCCAGGGACAGCTACAGAGCTTCCTCACAGGCGAACAAACAAAAGAAAAAGACTGGGGTGATGCTGCCTCGAGTTGT
CCTGACTCCTCTGAAGGTAAACGGGGCCCACGTGGAATCTGCATCAGGTATGTGTAAACTCATGGTTGTGATGCTTTTTCCTCAGGTCCT
GGGGACCTGGCCTCCCTCTGTCAGCAGTTTCTGACCTAATAGTGCGATACTAGGAGAGCTGTCGGGCCACAGGCAAGAGCCCTGCCAATG
GATGAGGCCTGCCATAGGTTCTAGTGCTGGGCTCTGCTGTGTGCCTTCCTCTTTGTCTCCCAGGGCAGTCGTGAGGATCCAACGGAGGAT
TTGATTATGCCAGTGCTTTGTAAAAGGTGTAGTGCTATACAAATAAAGATGGCAGTTTGGCACCTGTAAGGTGATATTTTAAAGCCAGAC
CATGAAGTGGTGGTTTCTCTCAGCCTAAGGCTGGGAGATGGAAGCATCCCAGTATTGCTGGCAGCATCTCAGGGAGAGCTGGGAGAAATG

>11459_11459_1_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000326071_ASXL1_chr20_30954187_ENST00000470145_length(amino acids)=123AA_BP=70
MSPPPAPLTRGSRPPISASLPAQDETSVSSEDFDMSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDGIRKLLGCSNDTKTDSAGHR

--------------------------------------------------------------
>11459_11459_2_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000359676_ASXL1_chr20_30954187_ENST00000470145_length(transcript)=1325nt_BP=252nt
CCGCGGCGGCAGCAGCAGCAGCAGCAGCTGGAGCTGTGGGGCTGTCACCGCCGCCCGCCCCGCTCACTCGCGGATCCCGACCGCCCATCT
CCGCCTCGCTTCCAGCCCAGGATGAGACTTCTGTGAGCAGCGAGGATTTTGATATGAGCGACTCCACATGGATGTCAGCTGACCCGCACC
TGGCCTCCAGCCTGAGCCCCAGCCAGGACGAGAGGATGCGGAGCCCGCAGAACCTCCACAGTCAAGAGGACGGTATTAGAAAACTACTCG
GATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGC
CTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGAAG
GATGCCCTGCAGTGGTCTCGCCATCCAGCTACAGTGGAGGGAGAGGAGCCAGAGGACACGGCTGATGTGGAGAGCTGTGGGTCTAATGAA
GCCAGCACTGTGAGTGGTGAAAACGATGGTAAGGACCCTTTAATGGATGGGTGAGGGAGCCACAGCAGGCACTAGGGACTAACCTTTATT
TTCCTCTCTTCCAGTATCTCTTGATGAAACATCTTCGAACGCATCCTGTTCTACAGAATCTCAGAGTCGACCTCTTTCCAATCCCAGGGA
CAGCTACAGAGCTTCCTCACAGGCGAACAAACAAAAGAAAAAGACTGGGGTGATGCTGCCTCGAGTTGTCCTGACTCCTCTGAAGGTAAA
CGGGGCCCACGTGGAATCTGCATCAGGTATGTGTAAACTCATGGTTGTGATGCTTTTTCCTCAGGTCCTGGGGACCTGGCCTCCCTCTGT
CAGCAGTTTCTGACCTAATAGTGCGATACTAGGAGAGCTGTCGGGCCACAGGCAAGAGCCCTGCCAATGGATGAGGCCTGCCATAGGTTC
TAGTGCTGGGCTCTGCTGTGTGCCTTCCTCTTTGTCTCCCAGGGCAGTCGTGAGGATCCAACGGAGGATTTGATTATGCCAGTGCTTTGT
AAAAGGTGTAGTGCTATACAAATAAAGATGGCAGTTTGGCACCTGTAAGGTGATATTTTAAAGCCAGACCATGAAGTGGTGGTTTCTCTC
AGCCTAAGGCTGGGAGATGGAAGCATCCCAGTATTGCTGGCAGCATCTCAGGGAGAGCTGGGAGAAATGAGCTTGTCTGAGAGCCATGGG

>11459_11459_2_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000359676_ASXL1_chr20_30954187_ENST00000470145_length(amino acids)=123AA_BP=70
MSPPPAPLTRGSRPPISASLPAQDETSVSSEDFDMSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDGIRKLLGCSNDTKTDSAGHR

--------------------------------------------------------------
>11459_11459_3_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000375677_ASXL1_chr20_30954187_ENST00000470145_length(transcript)=1276nt_BP=203nt
GCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATGAATTCCCAGGAGCAGGATGAGACTTCTGTGAGCAGCGAGGATTT
TGATATGAGCGACTCCACATGGATGTCAGCTGACCCGCACCTGGCCTCCAGCCTGAGCCCCAGCCAGGACGAGAGGATGCGGAGCCCGCA
GAACCTCCACAGTCAAGAGGACGGTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAG
GACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTT
ATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGAAGGATGCCCTGCAGTGGTCTCGCCATCCAGCTACAGTGGAGGGAGAGGAGC
CAGAGGACACGGCTGATGTGGAGAGCTGTGGGTCTAATGAAGCCAGCACTGTGAGTGGTGAAAACGATGGTAAGGACCCTTTAATGGATG
GGTGAGGGAGCCACAGCAGGCACTAGGGACTAACCTTTATTTTCCTCTCTTCCAGTATCTCTTGATGAAACATCTTCGAACGCATCCTGT
TCTACAGAATCTCAGAGTCGACCTCTTTCCAATCCCAGGGACAGCTACAGAGCTTCCTCACAGGCGAACAAACAAAAGAAAAAGACTGGG
GTGATGCTGCCTCGAGTTGTCCTGACTCCTCTGAAGGTAAACGGGGCCCACGTGGAATCTGCATCAGGTATGTGTAAACTCATGGTTGTG
ATGCTTTTTCCTCAGGTCCTGGGGACCTGGCCTCCCTCTGTCAGCAGTTTCTGACCTAATAGTGCGATACTAGGAGAGCTGTCGGGCCAC
AGGCAAGAGCCCTGCCAATGGATGAGGCCTGCCATAGGTTCTAGTGCTGGGCTCTGCTGTGTGCCTTCCTCTTTGTCTCCCAGGGCAGTC
GTGAGGATCCAACGGAGGATTTGATTATGCCAGTGCTTTGTAAAAGGTGTAGTGCTATACAAATAAAGATGGCAGTTTGGCACCTGTAAG
GTGATATTTTAAAGCCAGACCATGAAGTGGTGGTTTCTCTCAGCCTAAGGCTGGGAGATGGAAGCATCCCAGTATTGCTGGCAGCATCTC
AGGGAGAGCTGGGAGAAATGAGCTTGTCTGAGAGCCATGGGCGCGGCTTGGTGATACTTTTGACCAGTGGAATGCTGTGCCTTCAGGGTT

>11459_11459_3_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000375677_ASXL1_chr20_30954187_ENST00000470145_length(amino acids)=114AA_BP=61
MKQMKLRVMNSQEQDETSVSSEDFDMSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDGIRKLLGCSNDTKTDSAGHRGRRTKGNEK

--------------------------------------------------------------
>11459_11459_4_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000375678_ASXL1_chr20_30954187_ENST00000470145_length(transcript)=2760nt_BP=1687nt
CCCCCTCCAGCCCCACCTCTTCCCCCGGCCCTGGGTGGGGCCCGCACCTGGGGCTCTCCGCTCGTTAGCGCGCCCAGGGCGCCTCCTCGG
CCCGAGAGGGACCCGCCCGCGGGGCCTGGCTGGCTCAGGGCTACCTCCTTCCGCCTAGGACCCCCCCTTCGGTGACTCCCGATTCCCTGT
CCTAGGCTGCGGTGCCCCGGGAGGCGGGTCGCCAGAGTAGCAGACAGAGCTCTTTAATGGGTGTCTTCTAGGGCGGGTGCTGTTTGTGCA
TCATTTGGGTTCCCACACACTTCCTATGAGGTGGCGAAAGCCATTATGCCTATGGTGTCTGCTCACACAGGGGGAAACTGAGGCCCAGGC
AGGACAGCCCCTTGCCTGGGGTGGGGGCTGGGTTGTCCTTAGGCCTGTGACTTCACCTCTACAGCACCCTCCTGTGGACCCTCTCCCTGC
CCCCGCCAGGCCAGAGTCCTGCAGCCAGGCCCAGACCCTGGCCTGTCCGTCCGGGGATGCTGGACAGTACTCCTCCCTCCAGCCCTCATA
AGTCATTGTCATTCGGATCTGCATTTCCCCAGCCCCTCTCCTTCTAACTGGGGGGCACTGTGGCCCACTGTGCCCCTTTCTCTTCCCATT
CCTTCCCCCTACACCCATTCCAGACATCCCAGAGTTAACAAAACCCAAAAGAAAGAGAAAAAAGACTCAGAGCTGCTTGGAGGAGATGAC
ATCCTCAAATGTAGCGCCGTTGTTTGAGGGGCTGGTCCCAGGCACCTTTCTCTGTGGCCTGGGGTGTGCGTTTTGGTCCCCAGCGTGATT
TGAAAGAAGATGGAGGTTCAGCGAAGCAGAAAGGAGGTCTTGGAATATGTGAGGCCTGTTCCAGATGGCAGGTGCGACTCGGTGGTGGCG
GTGGCGGCGGCAGCTACGCGCTAACAGTTGGAGATTGTGCACAAGGGTGGAGAAGAGTTACCTCCCTGGCTCAATCATGGAGACATTCTG
ATCAGCAGTTCTCAAAATCTGTCTTGCATCAGAATCATCTGGGGGGGCCTGTTAAAACCCCCAGCACATCAGATTTGGGTTCTCCTTGAA
GGCCACGTAGACATCCTGGCGTTCTTCCCCTAGGGTGTAGCACACATGGAATCCAGGTGGCCCTAGCTCACCAGAGGACAGTTCAAGGGG
GCAGATGGCCTGTCGGAGCCAGAGGGCATCTCTCTGAAGCGGGTCGCTGTGGTGGAAGATTTCTTTGACATCATCTACTCGATGCATGTG
GAGAGCTCAGCGGAGCCAGGCAAAGCCCCCAAGCACGCTGGGCAGAAGAAAACCTACCGAGCGATCGCAGAGACCTATGCCTTCCTCCCG
AGAGAGGCCGTGACCCGGTTCCTGATGAGCTGTACGGAGTGTCAGAAGAGGATGCACTTTAACTCCAATGGCCTGGAACCCAAAGAAAAC
GAGCCTCCATCTCCACTGGTCTCTGGGATTATTGATTACAACATGCCCCTCACCTCCACCTACCTGAAGCAGATGAAGCTTCGAGTGATG
AATTCCCAGGAGCAGGATGAGACTTCTGTGAGCAGCGAGGATTTTGATATGAGCGACTCCACATGGATGTCAGCTGACCCGCACCTGGCC
TCCAGCCTGAGCCCCAGCCAGGACGAGAGGATGCGGAGCCCGCAGAACCTCCACAGTCAAGAGGACGGTATTAGAAAACTACTCGGATGC
TCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGAAGTGGGACTTCCCCTCTCGCATGCCTCAA
TGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAGAAGGATGC
CCTGCAGTGGTCTCGCCATCCAGCTACAGTGGAGGGAGAGGAGCCAGAGGACACGGCTGATGTGGAGAGCTGTGGGTCTAATGAAGCCAG
CACTGTGAGTGGTGAAAACGATGGTAAGGACCCTTTAATGGATGGGTGAGGGAGCCACAGCAGGCACTAGGGACTAACCTTTATTTTCCT
CTCTTCCAGTATCTCTTGATGAAACATCTTCGAACGCATCCTGTTCTACAGAATCTCAGAGTCGACCTCTTTCCAATCCCAGGGACAGCT
ACAGAGCTTCCTCACAGGCGAACAAACAAAAGAAAAAGACTGGGGTGATGCTGCCTCGAGTTGTCCTGACTCCTCTGAAGGTAAACGGGG
CCCACGTGGAATCTGCATCAGGTATGTGTAAACTCATGGTTGTGATGCTTTTTCCTCAGGTCCTGGGGACCTGGCCTCCCTCTGTCAGCA
GTTTCTGACCTAATAGTGCGATACTAGGAGAGCTGTCGGGCCACAGGCAAGAGCCCTGCCAATGGATGAGGCCTGCCATAGGTTCTAGTG
CTGGGCTCTGCTGTGTGCCTTCCTCTTTGTCTCCCAGGGCAGTCGTGAGGATCCAACGGAGGATTTGATTATGCCAGTGCTTTGTAAAAG
GTGTAGTGCTATACAAATAAAGATGGCAGTTTGGCACCTGTAAGGTGATATTTTAAAGCCAGACCATGAAGTGGTGGTTTCTCTCAGCCT
AAGGCTGGGAGATGGAAGCATCCCAGTATTGCTGGCAGCATCTCAGGGAGAGCTGGGAGAAATGAGCTTGTCTGAGAGCCATGGGCGCGG

>11459_11459_4_C20orf112-ASXL1_C20orf112_chr20_31062404_ENST00000375678_ASXL1_chr20_30954187_ENST00000470145_length(amino acids)=222AA_BP=169
MSEPEGISLKRVAVVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRMHFNSNGLEPKENEPP
SPLVSGIIDYNMPLTSTYLKQMKLRVMNSQEQDETSVSSEDFDMSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDGIRKLLGCSND

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Fusion Gene PPI Analysis for C20orf112-ASXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneASXL1chr20:31062404chr20:30954187ENST00000375687013300_65819.01542.0NCOA1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C20orf112-ASXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C20orf112-ASXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0796232Bohring syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0349639Juvenile Myelomonocytic Leukemia2CTD_human;GENOMICS_ENGLAND
TgeneC3463824MYELODYSPLASTIC SYNDROME2CGI;CTD_human;GENOMICS_ENGLAND
TgeneC0023487Acute Promyelocytic Leukemia1CTD_human
TgeneC0027643Neoplasm Recurrence, Local1CTD_human
TgeneC0027708Nephroblastoma1CTD_human
TgeneC1301365Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease1ORPHANET
TgeneC2713368Hematopoetic Myelodysplasia1CTD_human
TgeneC2930471Bilateral Wilms Tumor1CTD_human