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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRI3BP-MARS (FusionGDB2 ID:HG140707TG84174)

Fusion Gene Summary for BRI3BP-MARS

check button Fusion gene summary
Fusion gene informationFusion gene name: BRI3BP-MARS
Fusion gene ID: hg140707tg84174
HgeneTgene
Gene symbol

BRI3BP

MARS

Gene ID

140707

84174

Gene nameBRI3 binding proteinSrc like adaptor 2
SynonymsBNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19C20orf156|MARS|SLAP-2|SLAP2
Cytomap('BRI3BP')('MARS')

12q24.31

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionBRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding proteinsrc-like-adapter 2Src-like adapter protein-2modulator of antigen receptor signaling
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000341446, 
Fusion gene scores* DoF score10 X 4 X 6=24016 X 19 X 8=2432
# samples 1023
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/2432*10)=-3.40243746249921
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRI3BP [Title/Abstract] AND MARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRI3BP(125478549)-MARS(57905480), # samples:1
BRI3BP(125478549)-MARS(57905481), # samples:1
Anticipated loss of major functional domain due to fusion event.BRI3BP-MARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRI3BP-MARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRI3BP-MARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRI3BP-MARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMARS

GO:0000122

negative regulation of transcription by RNA polymerase II

11696592

TgeneMARS

GO:0050849

negative regulation of calcium-mediated signaling

11696592


check buttonFusion gene breakpoints across BRI3BP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-4015BRI3BPchr12

125478549

+MARSchr12

57905480

+
ChimerDB4READTCGA-AG-4015BRI3BPchr12

125478549

+MARSchr12

57905481

+


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Fusion Gene ORF analysis for BRI3BP-MARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000341446ENST00000447721BRI3BPchr12

125478549

+MARSchr12

57905480

+
5CDS-3UTRENST00000341446ENST00000447721BRI3BPchr12

125478549

+MARSchr12

57905481

+
In-frameENST00000341446ENST00000262027BRI3BPchr12

125478549

+MARSchr12

57905480

+
In-frameENST00000341446ENST00000262027BRI3BPchr12

125478549

+MARSchr12

57905481

+
In-frameENST00000341446ENST00000315473BRI3BPchr12

125478549

+MARSchr12

57905480

+
In-frameENST00000341446ENST00000315473BRI3BPchr12

125478549

+MARSchr12

57905481

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000341446BRI3BPchr12125478549+ENST00000262027MARSchr1257905480+1707304911638515
ENST00000341446BRI3BPchr12125478549+ENST00000315473MARSchr1257905480+1689304911545484
ENST00000341446BRI3BPchr12125478549+ENST00000262027MARSchr1257905481+1707304911638515
ENST00000341446BRI3BPchr12125478549+ENST00000315473MARSchr1257905481+1689304911545484

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341446ENST00000262027BRI3BPchr12125478549+MARSchr1257905480+0.0045477050.99545234
ENST00000341446ENST00000315473BRI3BPchr12125478549+MARSchr1257905480+0.0060538850.99394614
ENST00000341446ENST00000262027BRI3BPchr12125478549+MARSchr1257905481+0.0045477050.99545234
ENST00000341446ENST00000315473BRI3BPchr12125478549+MARSchr1257905481+0.0060538850.99394614

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Fusion Genomic Features for BRI3BP-MARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BRI3BPchr12125478549+MARSchr1257905480+5.28E-121
BRI3BPchr12125478549+MARSchr1257905480+5.28E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BRI3BP-MARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:125478549/chr12:57905480)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRI3BPchr12:125478549chr12:57905480ENST00000341446+1313_3371252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905481ENST00000341446+1313_3371252.0TransmembraneHelical
TgeneMARSchr12:125478549chr12:57905480ENST000002620271021841_897456901.0DomainNote=WHEP-TRS
TgeneMARSchr12:125478549chr12:57905481ENST000002620271021841_897456901.0DomainNote=WHEP-TRS
TgeneMARSchr12:125478549chr12:57905480ENST000002620271021593_597456901.0MotifNote='KMSKS' region
TgeneMARSchr12:125478549chr12:57905481ENST000002620271021593_597456901.0MotifNote='KMSKS' region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRI3BPchr12:125478549chr12:57905480ENST00000341446+13217_24771252.0Coiled coilOntology_term=ECO:0000255
HgeneBRI3BPchr12:125478549chr12:57905481ENST00000341446+13217_24771252.0Coiled coilOntology_term=ECO:0000255
HgeneBRI3BPchr12:125478549chr12:57905480ENST00000341446+13125_14571252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905480ENST00000341446+13146_16671252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905480ENST00000341446+13185_20571252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905481ENST00000341446+13125_14571252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905481ENST00000341446+13146_16671252.0TransmembraneHelical
HgeneBRI3BPchr12:125478549chr12:57905481ENST00000341446+13185_20571252.0TransmembraneHelical
TgeneMARSchr12:125478549chr12:57905480ENST00000262027102174_198456901.0DomainNote=GST C-terminal
TgeneMARSchr12:125478549chr12:57905481ENST00000262027102174_198456901.0DomainNote=GST C-terminal
TgeneMARSchr12:125478549chr12:57905480ENST000002620271021273_283456901.0MotifNote='HIGH' region
TgeneMARSchr12:125478549chr12:57905481ENST000002620271021273_283456901.0MotifNote='HIGH' region


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Fusion Gene Sequence for BRI3BP-MARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10264_10264_1_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905480_ENST00000262027_length(transcript)=1707nt_BP=304nt
GAGCGCGCCAACCTTGCCCTAGCCGGAGCCCGCTGCGGCCCAGCGCACGGCCCTCACCCCGCATCGCGACCCCGCGCCCCGCCGGCCGAG
CATGGGCGCGCGCGCCTCAGGCGGGCCCCTGGCCCGGGCCGGGCTCCTGCTGCTGCTGCTGCTGCTGCTGCTGCTCGGGCTGCTGGCCCC
GGGCGCGCAGGGGGCGCGGGGCCGCGGCGGCGCGGAGAAGAACAGCTACCGCCGCACGGTCAACACCTTCTCCCAGAGCGTCAGCAGCCT
GTTCGGCGAGGACAACGTGCGCGCCGCTCAGAAGCTGGAGAAGCGACTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGAC
ACCCAATGCCCAGTTTATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAATGGGGAACCCCTGT
ACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGATGCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCA
GTGGGAGAGATGGTGGAAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCATAGCTTAGTCTTTCC
TTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTC
TAAGAGCCGCGGTGTGGGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTATCTGCTGTACATTCG
GCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTGAAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAA
CAGAGCTGGGATGTTTGTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGCCTGCTGGCCCATGT
CACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGGATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGG
CAACCAATATATTCAGGTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACAGTGACTGGCTTGGC
AGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATGCCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACC
TCCAGCCTGCAGTATCCTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCCTTGTTCCAAAAATT
GGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGCCAGGCAAAAACGTCCCCGAAGCCAGCAGTTGTAGAGACTGTTAC
AACAGCCAAGCCACAGCAGATACAAGCGCTGATGGATGAAGTGACAAAACAAGGAAACATTGTCCGAGAACTGAAAGCACAAAAGGCAGA
CAAGAACGAGGTTGCTGCGGAGGTGGCGAAACTCTTGGATCTAAAGAAACAGTTGGCTGTAGCTGAGGGGAAACCCCCTGAAGCCCCTAA

>10264_10264_1_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905480_ENST00000262027_length(amino acids)=515AA_BP=71
MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFP
CSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFIN
RAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLA
VNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVT

--------------------------------------------------------------
>10264_10264_2_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905480_ENST00000315473_length(transcript)=1689nt_BP=304nt
GAGCGCGCCAACCTTGCCCTAGCCGGAGCCCGCTGCGGCCCAGCGCACGGCCCTCACCCCGCATCGCGACCCCGCGCCCCGCCGGCCGAG
CATGGGCGCGCGCGCCTCAGGCGGGCCCCTGGCCCGGGCCGGGCTCCTGCTGCTGCTGCTGCTGCTGCTGCTGCTCGGGCTGCTGGCCCC
GGGCGCGCAGGGGGCGCGGGGCCGCGGCGGCGCGGAGAAGAACAGCTACCGCCGCACGGTCAACACCTTCTCCCAGAGCGTCAGCAGCCT
GTTCGGCGAGGACAACGTGCGCGCCGCTCAGAAGCTGGAGAAGCGACTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGAC
ACCCAATGCCCAGTTTATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAATGGGGAACCCCTGT
ACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGATGCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCA
GTGGGAGAGATGGTGGAAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCATAGCTTAGTCTTTCC
TTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTC
TAAGAGCCGCGGTGTGGGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTATCTGCTGTACATTCG
GCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTGAAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAA
CAGAGCTGGGATGTTTGTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGCCTGCTGGCCCATGT
CACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGGATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGG
CAACCAATATATTCAGGTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACAGTGACTGGCTTGGC
AGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATGCCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACC
TCCAGCCTGCAGTATCCTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCCTTGTTCCAAAAATT
GGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGCCAGGTGAGAAAGCTAAAGGCTGTGCCCTCGCTCCACAACAGCCA
CAGCATCACTTCCCTAATTTCCCTAAGTAGTCCTCACCCATCACTCTTTCCATCTTTTGGCCCTGCCGCTTCCTCACTTACAGTTTTTCT
TTCCTGTCTTAACTAGAAGAGACCTTCGACTTAAAGGTAACCACTTTCCCTCTGAGATGCTGTATAAAACTGGAGGTTAGGGGATATTTA

>10264_10264_2_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905480_ENST00000315473_length(amino acids)=484AA_BP=71
MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFP
CSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFIN
RAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLA
VNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLKAVPSLHNSH

--------------------------------------------------------------
>10264_10264_3_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905481_ENST00000262027_length(transcript)=1707nt_BP=304nt
GAGCGCGCCAACCTTGCCCTAGCCGGAGCCCGCTGCGGCCCAGCGCACGGCCCTCACCCCGCATCGCGACCCCGCGCCCCGCCGGCCGAG
CATGGGCGCGCGCGCCTCAGGCGGGCCCCTGGCCCGGGCCGGGCTCCTGCTGCTGCTGCTGCTGCTGCTGCTGCTCGGGCTGCTGGCCCC
GGGCGCGCAGGGGGCGCGGGGCCGCGGCGGCGCGGAGAAGAACAGCTACCGCCGCACGGTCAACACCTTCTCCCAGAGCGTCAGCAGCCT
GTTCGGCGAGGACAACGTGCGCGCCGCTCAGAAGCTGGAGAAGCGACTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGAC
ACCCAATGCCCAGTTTATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAATGGGGAACCCCTGT
ACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGATGCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCA
GTGGGAGAGATGGTGGAAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCATAGCTTAGTCTTTCC
TTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTC
TAAGAGCCGCGGTGTGGGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTATCTGCTGTACATTCG
GCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTGAAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAA
CAGAGCTGGGATGTTTGTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGCCTGCTGGCCCATGT
CACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGGATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGG
CAACCAATATATTCAGGTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACAGTGACTGGCTTGGC
AGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATGCCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACC
TCCAGCCTGCAGTATCCTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCCTTGTTCCAAAAATT
GGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGCCAGGCAAAAACGTCCCCGAAGCCAGCAGTTGTAGAGACTGTTAC
AACAGCCAAGCCACAGCAGATACAAGCGCTGATGGATGAAGTGACAAAACAAGGAAACATTGTCCGAGAACTGAAAGCACAAAAGGCAGA
CAAGAACGAGGTTGCTGCGGAGGTGGCGAAACTCTTGGATCTAAAGAAACAGTTGGCTGTAGCTGAGGGGAAACCCCCTGAAGCCCCTAA

>10264_10264_3_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905481_ENST00000262027_length(amino acids)=515AA_BP=71
MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFP
CSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFIN
RAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLA
VNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVT

--------------------------------------------------------------
>10264_10264_4_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905481_ENST00000315473_length(transcript)=1689nt_BP=304nt
GAGCGCGCCAACCTTGCCCTAGCCGGAGCCCGCTGCGGCCCAGCGCACGGCCCTCACCCCGCATCGCGACCCCGCGCCCCGCCGGCCGAG
CATGGGCGCGCGCGCCTCAGGCGGGCCCCTGGCCCGGGCCGGGCTCCTGCTGCTGCTGCTGCTGCTGCTGCTGCTCGGGCTGCTGGCCCC
GGGCGCGCAGGGGGCGCGGGGCCGCGGCGGCGCGGAGAAGAACAGCTACCGCCGCACGGTCAACACCTTCTCCCAGAGCGTCAGCAGCCT
GTTCGGCGAGGACAACGTGCGCGCCGCTCAGAAGCTGGAGAAGCGACTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGAC
ACCCAATGCCCAGTTTATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAATGGGGAACCCCTGT
ACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGATGCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCA
GTGGGAGAGATGGTGGAAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCATAGCTTAGTCTTTCC
TTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCACCTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTC
TAAGAGCCGCGGTGTGGGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTATCTGCTGTACATTCG
GCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTGAAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAA
CAGAGCTGGGATGTTTGTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGCCTGCTGGCCCATGT
CACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGGATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGG
CAACCAATATATTCAGGTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACAGTGACTGGCTTGGC
AGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATGCCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACC
TCCAGCCTGCAGTATCCTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCCTTGTTCCAAAAATT
GGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGCCAGGTGAGAAAGCTAAAGGCTGTGCCCTCGCTCCACAACAGCCA
CAGCATCACTTCCCTAATTTCCCTAAGTAGTCCTCACCCATCACTCTTTCCATCTTTTGGCCCTGCCGCTTCCTCACTTACAGTTTTTCT
TTCCTGTCTTAACTAGAAGAGACCTTCGACTTAAAGGTAACCACTTTCCCTCTGAGATGCTGTATAAAACTGGAGGTTAGGGGATATTTA

>10264_10264_4_BRI3BP-MARS_BRI3BP_chr12_125478549_ENST00000341446_MARS_chr12_57905481_ENST00000315473_length(amino acids)=484AA_BP=71
MGARASGGPLARAGLLLLLLLLLLLGLLAPGAQGARGRGGAEKNSYRRTVNTFSQSVSSLFGEDNVRAAQKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFP
CSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFIN
RAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLA
VNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLKAVPSLHNSH

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Fusion Gene PPI Analysis for BRI3BP-MARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRI3BP-MARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRI3BP-MARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource