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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPK14-MICU2 (FusionGDB2 ID:HG1432TG221154)

Fusion Gene Summary for MAPK14-MICU2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK14-MICU2
Fusion gene ID: hg1432tg221154
HgeneTgene
Gene symbol

MAPK14

MICU2

Gene ID

1432

221154

Gene namemitogen-activated protein kinase 14mitochondrial calcium uptake 2
SynonymsCSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA1110008L20Rik|EFHA1
Cytomap('MAPK14','MAPK14')('EFHA1','MICU2')

6p21.31

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 14CSAID-binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 alphap38 MAP kinasep3calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000229794, ENST00000229795, 
ENST00000310795, ENST00000468133, 
Fusion gene scores* DoF score7 X 6 X 5=21013 X 13 X 6=1014
# samples 713
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1014*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK14 [Title/Abstract] AND MICU2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPK14(36044376)-EFHA1(22113827), # samples:1
MAPK14(36043739)-EFHA1(22113827), # samples:1
MAPK14(36044376)-MICU2(22113827), # samples:1
Anticipated loss of major functional domain due to fusion event.MAPK14-MICU2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK14-MICU2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK14-MICU2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAPK14-MICU2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK14

GO:0035556

intracellular signal transduction

10838079

HgeneMAPK14

GO:0071222

cellular response to lipopolysaccharide

23776175

HgeneMAPK14

GO:1900015

regulation of cytokine production involved in inflammatory response

15251176

TgeneMICU2

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU2

GO:0051562

negative regulation of mitochondrial calcium ion concentration

24560927


check buttonFusion gene breakpoints across MAPK14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MICU2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A129-01AMAPK14chr6

36043739

-EFHA1chr13

22113827

-
ChimerDB4BRCATCGA-AO-A129-01AMAPK14chr6

36044376

+EFHA1chr13

22113827

-
ChimerDB4BRCATCGA-AO-A129-01AMAPK14chr6

36044376

+MICU2chr13

22113827

-


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Fusion Gene ORF analysis for MAPK14-MICU2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000229794ENST00000479790MAPK14chr6

36044376

+MICU2chr13

22113827

-
5CDS-intronENST00000229795ENST00000479790MAPK14chr6

36044376

+MICU2chr13

22113827

-
5CDS-intronENST00000310795ENST00000479790MAPK14chr6

36044376

+MICU2chr13

22113827

-
5CDS-intronENST00000468133ENST00000479790MAPK14chr6

36044376

+MICU2chr13

22113827

-
In-frameENST00000229794ENST00000382374MAPK14chr6

36044376

+MICU2chr13

22113827

-
In-frameENST00000229795ENST00000382374MAPK14chr6

36044376

+MICU2chr13

22113827

-
In-frameENST00000310795ENST00000382374MAPK14chr6

36044376

+MICU2chr13

22113827

-
In-frameENST00000468133ENST00000382374MAPK14chr6

36044376

+MICU2chr13

22113827

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229795MAPK14chr636044376+ENST00000382374MICU2chr1322113827-2562106632012669
ENST00000229794MAPK14chr636044376+ENST00000382374MICU2chr1322113827-250310071631953596
ENST00000468133MAPK14chr636044376+ENST00000382374MICU2chr1322113827-21856891061635509
ENST00000310795MAPK14chr636044376+ENST00000382374MICU2chr1322113827-211561901565521

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229795ENST00000382374MAPK14chr636044376+MICU2chr1322113827-0.0005669090.9994331
ENST00000229794ENST00000382374MAPK14chr636044376+MICU2chr1322113827-0.0005659530.99943405
ENST00000468133ENST00000382374MAPK14chr636044376+MICU2chr1322113827-0.0004227620.9995772
ENST00000310795ENST00000382374MAPK14chr636044376+MICU2chr1322113827-0.0005538910.9994461

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Fusion Genomic Features for MAPK14-MICU2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MAPK14-MICU2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:36044376/chr13:22113827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICU2chr6:36044376chr13:22113827ENST00000382374112172_207119435.0DomainEF-hand 1
TgeneMICU2chr6:36044376chr13:22113827ENST00000382374112227_262119435.0DomainEF-hand 2
TgeneMICU2chr6:36044376chr13:22113827ENST00000382374112293_328119435.0DomainEF-hand 3
TgeneMICU2chr6:36044376chr13:22113827ENST00000382374112362_397119435.0DomainEF-hand 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229794+11224_3080361.0DomainProtein kinase
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229795+11224_3080361.0DomainProtein kinase
HgeneMAPK14chr6:36044376chr13:22113827ENST00000310795+11124_3080312.6666666666667DomainProtein kinase
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229794+11230_380361.0Nucleotide bindingNote=ATP
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229795+11230_380361.0Nucleotide bindingNote=ATP
HgeneMAPK14chr6:36044376chr13:22113827ENST00000310795+11130_380312.6666666666667Nucleotide bindingNote=ATP
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229794+112106_1100361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229794+112168_1690361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229794+11270_710361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229795+112106_1100361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229795+112168_1690361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000229795+11270_710361.0RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000310795+111106_1100312.6666666666667RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000310795+111168_1690312.6666666666667RegionNote=Inhibitor-binding
HgeneMAPK14chr6:36044376chr13:22113827ENST00000310795+11170_710312.6666666666667RegionNote=Inhibitor-binding
TgeneMICU2chr6:36044376chr13:22113827ENST000003823741122_50119435.0Compositional biasNote=Ala-rich


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Fusion Gene Sequence for MAPK14-MICU2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51520_51520_1_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000229794_MICU2_chr13_22113827_ENST00000382374_length(transcript)=2503nt_BP=1007nt
CGGGAGGCTCCCGTTTGCTGGCTCTTGGAACCGCGACCACTGGAGCCTTAGCGGGCGCAGCAGCTGGAACGGGAGTACTGCGACGCAGCC
CGGAGTCGGCCTTGTAGGGGCGAAGGTGCAGGGAGATCGCGGCGGGCGCAGTCTTGAGCGCCGGAGCGCGTCCCTGCCCTTAGCGGGGCT
TGCCCCAGTCGCAGGGGCACATCCAGCCGCTGCGGCTGACAGCAGCCGCGCGCGCGGGAGTCTGCGGGGTCGCGGCAGCCGCACCTGCGC
GGGCGACCAGCGCAAGGTCCCCGCCCGGCTGGGCGGGCAGCAAGGGCCGGGGAGAGGGTGCGGGTGCAGGCGGGGGCCCCACAGGGCCAC
CTTCTTGCCCGGCGGCTGCCGCTGGAAAATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTGCC
CGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCTGCTTTTGACACAAAAACGGGGTTACGTGTGGC
AGTGAAGAAGCTCTCCAGACCATTTCAGTCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACATGA
AAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAATGATGTGTATCTGGTGACCCATCTCATGGGGGC
AGATCTGAACAACATTGTGAAATGTCAGAAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTATAT
ACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAAGACTGTGAGCTGAAGATTCTGGATTTTGGACT
GGCTCGGCACACAGATGATGAAATGACAGGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTACAA
CCAGACAGGTACAGACCGTAAAACTTCAGTCAAGAAGCTGACAAAAAAGGACATCGAGGATACACTGTCAGGGATCCAAACAGCTGGCTG
TGGATCAACTTTTTTCAGAGACCTTGGCGATAAAGGGCTAATTTCATATACCGAGTATCTTTTCTTGCTTACAATCCTCACTAAACCCCA
TTCTGGATTTCATGTTGCTTTTAAAATGCTGGATACAGATGGTAATGAGATGATTGAAAAAAGGGAATTTTTTAAGCTGCAGAAGATCAT
AAGTAAACAAGATGACTTGATGACAGTGAAAACTAATGAAACTGGATATCAGGAAGCAATAGTGAAAGAACCTGAAATTAACACAACTCT
TCAGATGCGTTTCTTTGGAAAAAGAGGACAAAGAAAACTTCATTATAAAGAATTTCGAAGATTTATGGAAAATTTACAAACAGAGATTCA
AGAAATGGAATTCCTTCAGTTTTCTAAAGGTTTGAGTTTCATGAGAAAAGAAGACTTTGCAGAGTGGCTACTTTTTTTCACTAACACTGA
AAATAAAGATATTTATTGGAAAAATGTGAGAGAGAAGTTGTCAGCAGGAGAGAGCATTAGTTTGGATGAATTCAAGTCATTTTGCCATTT
TACAACCCACTTGGAAGACTTTGCTATTGCCATGCAGATGTTCAGTTTAGCTCATCGTCCTGTCAGACTAGCGGAGTTTAAGAGAGCTGT
GAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCA
TGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGT
GAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTA
TATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGC
ATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCA
GAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATG
CTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAG
GCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAG

>51520_51520_1_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000229794_MICU2_chr13_22113827_ENST00000382374_length(amino acids)=596AA_BP=282
MPLAGLAPVAGAHPAAAADSSRARGSLRGRGSRTCAGDQRKVPARLGGQQGPGRGCGCRRGPHRATFLPGGCRWKMSQERPTFYRQELNK
TIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLV
THLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIML
NWMHYNQTGTDRKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFF
KLQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLL
FFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDG

--------------------------------------------------------------
>51520_51520_2_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000229795_MICU2_chr13_22113827_ENST00000382374_length(transcript)=2562nt_BP=1066nt
ATATTGGGTAAAATCTCGGCTCTCGGAGAGTCCCGGGAGCTGTTCTCGCGAGAGTACTGCGGGAGGCTCCCGTTTGCTGGCTCTTGGAAC
CGCGACCACTGGAGCCTTAGCGGGCGCAGCAGCTGGAACGGGAGTACTGCGACGCAGCCCGGAGTCGGCCTTGTAGGGGCGAAGGTGCAG
GGAGATCGCGGCGGGCGCAGTCTTGAGCGCCGGAGCGCGTCCCTGCCCTTAGCGGGGCTTGCCCCAGTCGCAGGGGCACATCCAGCCGCT
GCGGCTGACAGCAGCCGCGCGCGCGGGAGTCTGCGGGGTCGCGGCAGCCGCACCTGCGCGGGCGACCAGCGCAAGGTCCCCGCCCGGCTG
GGCGGGCAGCAAGGGCCGGGGAGAGGGTGCGGGTGCAGGCGGGGGCCCCACAGGGCCACCTTCTTGCCCGGCGGCTGCCGCTGGAAAATG
TCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTGCCCGAGCGTTACCAGAACCTGTCTCCAGTGGGC
TCTGGCGCCTATGGCTCTGTGTGTGCTGCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAGTCC
ATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACATGAAAATGTGATTGGTCTGTTGGACGTTTTTACA
CCTGCAAGGTCTCTGGAGGAATTCAATGATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAGAAG
CTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTATATACATTCAGCTGACATAATTCACAGGGACCTA
AAACCTAGTAATCTAGCTGTGAATGAAGACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACAGGC
TACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTACAACCAGACAGGTACAGACCGTAAAACTTCAGTC
AAGAAGCTGACAAAAAAGGACATCGAGGATACACTGTCAGGGATCCAAACAGCTGGCTGTGGATCAACTTTTTTCAGAGACCTTGGCGAT
AAAGGGCTAATTTCATATACCGAGTATCTTTTCTTGCTTACAATCCTCACTAAACCCCATTCTGGATTTCATGTTGCTTTTAAAATGCTG
GATACAGATGGTAATGAGATGATTGAAAAAAGGGAATTTTTTAAGCTGCAGAAGATCATAAGTAAACAAGATGACTTGATGACAGTGAAA
ACTAATGAAACTGGATATCAGGAAGCAATAGTGAAAGAACCTGAAATTAACACAACTCTTCAGATGCGTTTCTTTGGAAAAAGAGGACAA
AGAAAACTTCATTATAAAGAATTTCGAAGATTTATGGAAAATTTACAAACAGAGATTCAAGAAATGGAATTCCTTCAGTTTTCTAAAGGT
TTGAGTTTCATGAGAAAAGAAGACTTTGCAGAGTGGCTACTTTTTTTCACTAACACTGAAAATAAAGATATTTATTGGAAAAATGTGAGA
GAGAAGTTGTCAGCAGGAGAGAGCATTAGTTTGGATGAATTCAAGTCATTTTGCCATTTTACAACCCACTTGGAAGACTTTGCTATTGCC
ATGCAGATGTTCAGTTTAGCTCATCGTCCTGTCAGACTAGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAAC
AATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGA
ATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAA
GTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTT
TTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATT
TTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTAC
TTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGG
GAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATT
TTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAAC

>51520_51520_2_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000229795_MICU2_chr13_22113827_ENST00000382374_length(amino acids)=669AA_BP=355
MGKISALGESRELFSREYCGRLPFAGSWNRDHWSLSGRSSWNGSTATQPGVGLVGAKVQGDRGGRSLERRSASLPLAGLAPVAGAHPAAA
ADSSRARGSLRGRGSRTCAGDQRKVPARLGGQQGPGRGCGCRRGPHRATFLPGGCRWKMSQERPTFYRQELNKTIWEVPERYQNLSPVGS
GAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL
TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTGTDRKTSVK
KLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKREFFKLQKIISKQDDLMTVKT
NETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTENKDIYWKNVRE
KLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRM

--------------------------------------------------------------
>51520_51520_3_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000310795_MICU2_chr13_22113827_ENST00000382374_length(transcript)=2115nt_BP=619nt
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTGCCCGAGCGTTACCAGAACCTGTCTCCAGTG
GGCTCTGGCGCCTATGGCTCTGTGTGTGCTGCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACATGAAAATGTGATTGGTCTGTTGGACGTTTTT
ACACCTGCAAGGTCTCTGGAGGAATTCAATGATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTATATACATTCAGCTGACATAATTCACAGGGAC
CTAAAACCTAGTAATCTAGCTGTGAATGAAGACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTACAACCAGACAGGTACAGACCGTAAAACTTCA
GTCAAGAAGCTGACAAAAAAGGACATCGAGGATACACTGTCAGGGATCCAAACAGCTGGCTGTGGATCAACTTTTTTCAGAGACCTTGGC
GATAAAGGGCTAATTTCATATACCGAGTATCTTTTCTTGCTTACAATCCTCACTAAACCCCATTCTGGATTTCATGTTGCTTTTAAAATG
CTGGATACAGATGGTAATGAGATGATTGAAAAAAGGGAATTTTTTAAGCTGCAGAAGATCATAAGTAAACAAGATGACTTGATGACAGTG
AAAACTAATGAAACTGGATATCAGGAAGCAATAGTGAAAGAACCTGAAATTAACACAACTCTTCAGATGCGTTTCTTTGGAAAAAGAGGA
CAAAGAAAACTTCATTATAAAGAATTTCGAAGATTTATGGAAAATTTACAAACAGAGATTCAAGAAATGGAATTCCTTCAGTTTTCTAAA
GGTTTGAGTTTCATGAGAAAAGAAGACTTTGCAGAGTGGCTACTTTTTTTCACTAACACTGAAAATAAAGATATTTATTGGAAAAATGTG
AGAGAGAAGTTGTCAGCAGGAGAGAGCATTAGTTTGGATGAATTCAAGTCATTTTGCCATTTTACAACCCACTTGGAAGACTTTGCTATT
GCCATGCAGATGTTCAGTTTAGCTCATCGTCCTGTCAGACTAGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCA
AACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAAC
AGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAA
GAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGAT
TTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATA
ATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTG
TACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATA
TGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAG
ATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTA

>51520_51520_3_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000310795_MICU2_chr13_22113827_ENST00000382374_length(amino acids)=521AA_BP=207
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVF
TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTGTDRKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKM
LDTDGNEMIEKREFFKLQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSK
GLSFMRKEDFAEWLLFFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELS

--------------------------------------------------------------
>51520_51520_4_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000468133_MICU2_chr13_22113827_ENST00000382374_length(transcript)=2185nt_BP=689nt
GTTTGCTGGCTCTTGGAACCGCGACCACTGGAGCCTTAGCGGGCGCAGCAGCTGGAACGGGAGTACTGCGACGCAGCCCGGAGTCGGCCT
TGTAGGGGCGAAGGAGCTGAACAAGACAATCTGGGAGGTGCCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTC
TGTGTGTGCTGCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAGTCCATCATTCATGCGAAAAG
AACCTACAGAGAACTGCGGTTACTTAAACATATGAAACATGAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGA
GGAATTCAATGATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAGAAGCTTACAGATGACCATGT
TCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTATATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGC
TGTGAATGAAGACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACAGGCTACGTGGCCACTAGGTG
GTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTACAACCAGACAGGTACAGACCGTAAAACTTCAGTCAAGAAGCTGACAAAAAA
GGACATCGAGGATACACTGTCAGGGATCCAAACAGCTGGCTGTGGATCAACTTTTTTCAGAGACCTTGGCGATAAAGGGCTAATTTCATA
TACCGAGTATCTTTTCTTGCTTACAATCCTCACTAAACCCCATTCTGGATTTCATGTTGCTTTTAAAATGCTGGATACAGATGGTAATGA
GATGATTGAAAAAAGGGAATTTTTTAAGCTGCAGAAGATCATAAGTAAACAAGATGACTTGATGACAGTGAAAACTAATGAAACTGGATA
TCAGGAAGCAATAGTGAAAGAACCTGAAATTAACACAACTCTTCAGATGCGTTTCTTTGGAAAAAGAGGACAAAGAAAACTTCATTATAA
AGAATTTCGAAGATTTATGGAAAATTTACAAACAGAGATTCAAGAAATGGAATTCCTTCAGTTTTCTAAAGGTTTGAGTTTCATGAGAAA
AGAAGACTTTGCAGAGTGGCTACTTTTTTTCACTAACACTGAAAATAAAGATATTTATTGGAAAAATGTGAGAGAGAAGTTGTCAGCAGG
AGAGAGCATTAGTTTGGATGAATTCAAGTCATTTTGCCATTTTACAACCCACTTGGAAGACTTTGCTATTGCCATGCAGATGTTCAGTTT
AGCTCATCGTCCTGTCAGACTAGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGT
CTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATG
GGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGG
AAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTAT
TTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGT
AGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAA
CTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGAC
CAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTT
ATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAATGTTCTATCTGG

>51520_51520_4_MAPK14-MICU2_MAPK14_chr6_36044376_ENST00000468133_MICU2_chr13_22113827_ENST00000382374_length(amino acids)=509AA_BP=195
MNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV
YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE
IMLNWMHYNQTGTDRKTSVKKLTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDTDGNEMIEKR
EFFKLQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAE
WLLFFTNTENKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFD

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Fusion Gene PPI Analysis for MAPK14-MICU2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPK14-MICU2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAPK14-MICU2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK14C0005398Cholestasis, Extrahepatic1CTD_human
HgeneMAPK14C0008312Primary biliary cirrhosis1CTD_human
HgeneMAPK14C0008370Cholestasis1CTD_human
HgeneMAPK14C0019209Hepatomegaly1CTD_human
HgeneMAPK14C0023473Myeloid Leukemia, Chronic1CTD_human
HgeneMAPK14C0023892Biliary cirrhosis1CTD_human
HgeneMAPK14C0023903Liver neoplasms1CTD_human
HgeneMAPK14C0024121Lung Neoplasms1CTD_human
HgeneMAPK14C0024809Marijuana Abuse1PSYGENET
HgeneMAPK14C0033141Cardiomyopathies, Primary1CTD_human
HgeneMAPK14C0036341Schizophrenia1PSYGENET
HgeneMAPK14C0036529Myocardial Diseases, Secondary1CTD_human
HgeneMAPK14C0086132Depressive Symptoms1PSYGENET
HgeneMAPK14C0151744Myocardial Ischemia1CTD_human
HgeneMAPK14C0233477Dysphoric mood1PSYGENET
HgeneMAPK14C0238065Secondary Biliary Cholangitis1CTD_human
HgeneMAPK14C0242379Malignant neoplasm of lung1CTD_human
HgeneMAPK14C0338715Drug-induced depressive state1PSYGENET
HgeneMAPK14C0345904Malignant neoplasm of liver1CTD_human
HgeneMAPK14C0878544Cardiomyopathies1CTD_human
HgeneMAPK14C1306571Hepatic Insufficiency1CTD_human
HgeneMAPK14C4551595Biliary Cirrhosis, Primary, 11CTD_human