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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSF1-GSTM5 (FusionGDB2 ID:HG1435TG2949)

Fusion Gene Summary for CSF1-GSTM5

check button Fusion gene summary
Fusion gene informationFusion gene name: CSF1-GSTM5
Fusion gene ID: hg1435tg2949
HgeneTgene
Gene symbol

CSF1

GSTM5

Gene ID

1435

2949

Gene namecolony stimulating factor 1glutathione S-transferase mu 5
SynonymsCSF-1|MCSFGSTM5-5|GTM5
Cytomap('CSF1')('GSTM5')

1p13.3

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionmacrophage colony-stimulating factor 1colony stimulating factor 1 (macrophage)lanimostimmacrophage colony stimulating factor 1glutathione S-transferase Mu 5GST class-mu 5S-(hydroxyalkyl)glutathione lyase M5epididymis secretory sperm binding proteinglutathione S-alkyltransferase M5glutathione S-aralkyltransferase M5glutathione S-aryltransferase M5glutathione S-transferase
Modification date2020031320200313
UniProtAcc

P09603

.
Ensembl transtripts involved in fusion geneENST00000329608, ENST00000344188, 
ENST00000369802, ENST00000420111, 
ENST00000369801, ENST00000526001, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 3 X 2=12
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSF1 [Title/Abstract] AND GSTM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSF1(110467824)-GSTM5(110317694), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSF1

GO:0002931

response to ischemia

8922060

HgeneCSF1

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

19100238

HgeneCSF1

GO:0008284

positive regulation of cell proliferation

10652277

HgeneCSF1

GO:0010628

positive regulation of gene expression

1739124|10666185

HgeneCSF1

GO:0010744

positive regulation of macrophage derived foam cell differentiation

17244792

HgeneCSF1

GO:0010759

positive regulation of macrophage chemotaxis

19100238

HgeneCSF1

GO:0030316

osteoclast differentiation

18606301

HgeneCSF1

GO:0032270

positive regulation of cellular protein metabolic process

1739124

HgeneCSF1

GO:0032946

positive regulation of mononuclear cell proliferation

2460758

HgeneCSF1

GO:0045651

positive regulation of macrophage differentiation

2460758

HgeneCSF1

GO:0045672

positive regulation of osteoclast differentiation

15304486

HgeneCSF1

GO:1901215

negative regulation of neuron death

8922060

HgeneCSF1

GO:1902228

positive regulation of macrophage colony-stimulating factor signaling pathway

19100238

HgeneCSF1

GO:1904141

positive regulation of microglial cell migration

19100238

TgeneGSTM5

GO:0006749

glutathione metabolic process

10587441



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1695-01ACSF1chr1

110467824

+GSTM5chr1

110317694

+


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Fusion Gene ORF analysis for CSF1-GSTM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000329608ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000329608ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000329608ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000329608ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000344188ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000344188ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000344188ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000344188ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000369802ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000369802ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000369802ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000369802ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000420111ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000420111ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000420111ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
3UTR-intronENST00000420111ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+
5CDS-intronENST00000369801ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
5CDS-intronENST00000369801ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
5CDS-intronENST00000369801ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
5CDS-intronENST00000369801ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+
intron-intronENST00000526001ENST00000256593CSF1chr1

110467824

+GSTM5chr1

110317694

+
intron-intronENST00000526001ENST00000369812CSF1chr1

110467824

+GSTM5chr1

110317694

+
intron-intronENST00000526001ENST00000369813CSF1chr1

110467824

+GSTM5chr1

110317694

+
intron-intronENST00000526001ENST00000492718CSF1chr1

110467824

+GSTM5chr1

110317694

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CSF1-GSTM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for CSF1-GSTM5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:110467824/:110317694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSF1

P09603

.
FUNCTION: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CSF1-GSTM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CSF1-GSTM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSF1-GSTM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSF1-GSTM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSF1C0006142Malignant neoplasm of breast1CTD_human
HgeneCSF1C0029401Osteitis Deformans1CTD_human
HgeneCSF1C0345967Malignant mesothelioma1CTD_human
HgeneCSF1C0678222Breast Carcinoma1CTD_human
HgeneCSF1C1257931Mammary Neoplasms, Human1CTD_human
HgeneCSF1C1458155Mammary Neoplasms1CTD_human
HgeneCSF1C4704874Mammary Carcinoma, Human1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneC0524851Neurodegenerative Disorders1CTD_human
TgeneC0751733Degenerative Diseases, Spinal Cord1CTD_human