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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP42-HIBCH (FusionGDB2 ID:HG143872TG26275)

Fusion Gene Summary for ARHGAP42-HIBCH

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP42-HIBCH
Fusion gene ID: hg143872tg26275
HgeneTgene
Gene symbol

ARHGAP42

HIBCH

Gene ID

143872

26275

Gene nameRho GTPase activating protein 423-hydroxyisobutyryl-CoA hydrolase
SynonymsAD031|GRAF3|TMEM133HIBYLCOAH
Cytomap('ARHGAP42')('HIBCH')

11q22.1

2q32.2

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 1333-hydroxyisobutyryl-CoA hydrolase, mitochondrial3-hydroxyisobutyryl-Coenzyme A hydrolaseHIB-CoA hydrolaseHIBYL-CoA-Htesticular tissue protein Li 86
Modification date2020031320200313
UniProtAcc.

Q6NVY1

Ensembl transtripts involved in fusion geneENST00000534060, ENST00000298815, 
ENST00000524892, 
Fusion gene scores* DoF score11 X 7 X 7=5394 X 3 X 4=48
# samples 124
** MAII scorelog2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP42 [Title/Abstract] AND HIBCH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP42(100665897)-HIBCH(191077801), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGAP42-HIBCH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP42-HIBCH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP42

GO:0090630

activation of GTPase activity

24335996


check buttonFusion gene breakpoints across ARHGAP42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HIBCH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2281-01AARHGAP42chr11

100665897

+HIBCHchr2

191077801

-


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Fusion Gene ORF analysis for ARHGAP42-HIBCH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000534060ENST00000359678ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
3UTR-3CDSENST00000534060ENST00000392332ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
3UTR-3CDSENST00000534060ENST00000410045ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
3UTR-5UTRENST00000534060ENST00000486981ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
5CDS-5UTRENST00000298815ENST00000486981ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
5CDS-5UTRENST00000524892ENST00000486981ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000298815ENST00000359678ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000298815ENST00000392332ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000298815ENST00000410045ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000524892ENST00000359678ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000524892ENST00000392332ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-
In-frameENST00000524892ENST00000410045ARHGAP42chr11

100665897

+HIBCHchr2

191077801

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524892ARHGAP42chr11100665897+ENST00000392332HIBCHchr2191077801-177033826463145
ENST00000524892ARHGAP42chr11100665897+ENST00000359678HIBCHchr2191077801-109133826607193
ENST00000524892ARHGAP42chr11100665897+ENST00000410045HIBCHchr2191077801-71033826607193
ENST00000298815ARHGAP42chr11100665897+ENST00000392332HIBCHchr2191077801-17473153440145
ENST00000298815ARHGAP42chr11100665897+ENST00000359678HIBCHchr2191077801-10683153584193
ENST00000298815ARHGAP42chr11100665897+ENST00000410045HIBCHchr2191077801-6873153584193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524892ENST00000392332ARHGAP42chr11100665897+HIBCHchr2191077801-0.0219221970.97807777
ENST00000524892ENST00000359678ARHGAP42chr11100665897+HIBCHchr2191077801-0.0015586050.9984414
ENST00000524892ENST00000410045ARHGAP42chr11100665897+HIBCHchr2191077801-0.0028076240.99719244
ENST00000298815ENST00000392332ARHGAP42chr11100665897+HIBCHchr2191077801-0.0106706980.9893293
ENST00000298815ENST00000359678ARHGAP42chr11100665897+HIBCHchr2191077801-0.0012925250.9987074
ENST00000298815ENST00000410045ARHGAP42chr11100665897+HIBCHchr2191077801-0.0024286940.9975713

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Fusion Genomic Features for ARHGAP42-HIBCH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGAP42-HIBCH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:100665897/chr2:191077801)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HIBCH

Q6NVY1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+324225_261104875.0Coiled coilOntology_term=ECO:0000255
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+324619_762104875.0Compositional biasNote=Ser-rich
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+324265_374104875.0DomainPH
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+324376_572104875.0DomainRho-GAP
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+3247_262104875.0DomainNote=BAR
HgeneARHGAP42chr11:100665897chr2:191077801ENST00000298815+324816_874104875.0DomainSH3


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Fusion Gene Sequence for ARHGAP42-HIBCH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6111_6111_1_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000359678_length(transcript)=1068nt_BP=315nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG
CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTT
CATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTG
AATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATC
TACAGCATGTGGGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAA
AGAAATCAAAGACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATA
TATTATCTGTGGCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGA
AAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGAT

>6111_6111_1_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000359678_length(amino acids)=193AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN

--------------------------------------------------------------
>6111_6111_2_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000392332_length(transcript)=1747nt_BP=315nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG
CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGTTTTAATTGATAAAG
ACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATT
TGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATCTACAGCATGTGGGCCAAATCCAGCCTGCTGCCTG
TTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAAAGAAATCAAAGACTAATAATTCATGACGTGAAAA
TTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATATATTATCTGTGGCTGCTTTGAAATGAGTAGTTGC
AATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGA
AAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGATCTTCGTTTGGCTTGTATGTTGATGAAATCAACTT
AGGTATACAATATAAAAAATAAAGACCCTGAAAATTGTTTTGGATACTGTGTTAATGCCTCATAGAATTTTTGTTTTGGATACTGTGTTA
ATGCCTCATAGAATTTTCTCCATATATGAGTGTGTTTTAAAGTAACTGAGTTACTGTAGCAGAAGAGCTCCTTTTATAAACATTAGAAAC
CTTGGGCAGAGAGAAAAGATTTTTATTAACGTCCCTCTTCAGTATTAACTCAGACTTGGTCTTCCCTAAAATAATCAGAATACCATCCCA
TGGTGAAACTGAAAGGATTATTTTCTTGTTATTTGTGATATTTGTTAATCTGGTAGAATGAGAAATTAGGAAACTCCAATCTCTTAGATA
GAGACACTCTGTTTTTTTATAATTTACGTAAGACTTTTGTGTGATAATTATCCTTACAAACAAGGTTCAAGTCAGGAGAAAAAAATTAAT
TGAAAGCAAGAAGACTTTTGTTCAAAAGATATATTCAATAATTGATATTGTTAATGAAGTAAGTACTTTTTAAGGTATGAAAGAACTAAA
AGGTATTCCAGACTCAGAACCTTAAAGTTCTAGGCAAGAATAATTTTTAAACTAAAGGTAAGTTTATAAATTAACAAAGTAAACAAAATT
TATGATTTTGTTTTTTGTTTGTAATTTTTGTTTAATTTTAAAGGTAAGTTTATAAATTAACAAACAAAATTTATAATTTTTTGTTTGTAA

>6111_6111_2_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000392332_length(amino acids)=145AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF

--------------------------------------------------------------
>6111_6111_3_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000410045_length(transcript)=687nt_BP=315nt
GCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCTTGCAGTGTCACGAGATTGAGCTG
GAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGAATCTGTCTATGGCAGTGCAGAAA
TTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTAGTATTGCTCAGTCACTAAAAGAA
TTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAACATCTCTAAAGATCACACTAAGG
CAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAGCTTGTATGAGAGGTCATGACTTT
CATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTG
AATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATC

>6111_6111_3_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000298815_HIBCH_chr2_191077801_ENST00000410045_length(amino acids)=193AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN

--------------------------------------------------------------
>6111_6111_4_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000359678_length(transcript)=1091nt_BP=338nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA
CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG
CTTGTATGAGAGGTCATGACTTTCATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAA
AAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATA
TTTTGTAGCATGGGTTGGCAATCTACAGCATGTGGGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTC
CGCATTTTTAAATGGTTGGGAAAAGAAATCAAAGACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAA
CTAGCTATACTCATCTGTTTATATATTATCTGTGGCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTA
TTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGTCAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGT
GGTATATCTAATTGAAATGGGATCTTCGTTTGGCTTGTATGTTGATGAAATCAACTTAGGTATACAATATAAAAAATAAAGACCCTGAAA

>6111_6111_4_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000359678_length(amino acids)=193AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN

--------------------------------------------------------------
>6111_6111_5_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000392332_length(transcript)=1770nt_BP=338nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA
CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG
CTTGTATGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAAAAGAAGTTACTGAGGAAGATTTGAATAATCACTT
TAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATATTTTGTAGCATGGGTTGGCAATCTACAGCATGTG
GGCCAAATCCAGCCTGCTGCCTGTTTTTATATACCCTGTAAGCTAAGAATGGTTTCCGCATTTTTAAATGGTTGGGAAAAGAAATCAAAG
ACTAATAATTCATGACGTGAAAATTATCAGAATTCACAAATAAAGCTTTATTGGAACTAGCTATACTCATCTGTTTATATATTATCTGTG
GCTGCTTTGAAATGAGTAGTTGCAATAGAGATGGTAAAGCCTACAAAGCCTAATTATTTACTGTCTGGTTTTTGTCAGAAAAAAGTTTGT
CAATCCTTGTTTTAGAAGATGGAAAAATGTGAAGATCTTTGGAGATTCTCTTGAGTGGTATATCTAATTGAAATGGGATCTTCGTTTGGC
TTGTATGTTGATGAAATCAACTTAGGTATACAATATAAAAAATAAAGACCCTGAAAATTGTTTTGGATACTGTGTTAATGCCTCATAGAA
TTTTTGTTTTGGATACTGTGTTAATGCCTCATAGAATTTTCTCCATATATGAGTGTGTTTTAAAGTAACTGAGTTACTGTAGCAGAAGAG
CTCCTTTTATAAACATTAGAAACCTTGGGCAGAGAGAAAAGATTTTTATTAACGTCCCTCTTCAGTATTAACTCAGACTTGGTCTTCCCT
AAAATAATCAGAATACCATCCCATGGTGAAACTGAAAGGATTATTTTCTTGTTATTTGTGATATTTGTTAATCTGGTAGAATGAGAAATT
AGGAAACTCCAATCTCTTAGATAGAGACACTCTGTTTTTTTATAATTTACGTAAGACTTTTGTGTGATAATTATCCTTACAAACAAGGTT
CAAGTCAGGAGAAAAAAATTAATTGAAAGCAAGAAGACTTTTGTTCAAAAGATATATTCAATAATTGATATTGTTAATGAAGTAAGTACT
TTTTAAGGTATGAAAGAACTAAAAGGTATTCCAGACTCAGAACCTTAAAGTTCTAGGCAAGAATAATTTTTAAACTAAAGGTAAGTTTAT
AAATTAACAAAGTAAACAAAATTTATGATTTTGTTTTTTGTTTGTAATTTTTGTTTAATTTTAAAGGTAAGTTTATAAATTAACAAACAA

>6111_6111_5_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000392332_length(amino acids)=145AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF

--------------------------------------------------------------
>6111_6111_6_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000410045_length(transcript)=710nt_BP=338nt
CGGCCGCCGCTGGCAGCGCCTGTGCCATGGGGCTGCCCACTCTGGAGTTCAGCGATTCCTACTTGGACAGCCCAGATTTCAGGGAGCGCT
TGCAGTGTCACGAGATTGAGCTGGAGCGAACCAACAAGTTCATCAAGGAGCTCATTAAGGACGGCTCTCTGCTCATTGGGGCGTTGAGGA
ATCTGTCTATGGCAGTGCAGAAATTTTCCCAGTCATTGCAAGATTTCCAGTTTGAATGTATTGGTGATGCTGAAACAGATGATGAAATTA
GTATTGCTCAGTCACTAAAAGAATTTGCAAGACTACTCATTGCAGTAGAAGAAGAAAGGCGAAGACTGGTAATTAATAAAATGTCTCCAA
CATCTCTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAGACCTTGCAAGAAGTACTAACTATGGAGTATCGGCTAAGTCAAG
CTTGTATGAGAGGTCATGACTTTCATGAAGGCGTTAGAGCTGTTTTAATTGATAAAGACCAGAGTCCAAAATGGAAACCAGCTGATCTAA
AAGAAGTTACTGAGGAAGATTTGAATAATCACTTTAAGTCTTTGGGAAGCAGTGATTTGAAATTTTGAGGTGACAGGCTTTTAAGGTATA

>6111_6111_6_ARHGAP42-HIBCH_ARHGAP42_chr11_100665897_ENST00000524892_HIBCH_chr2_191077801_ENST00000410045_length(amino acids)=193AA_BP=104
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEF
ARLLIAVEEERRRLVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLN

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Fusion Gene PPI Analysis for ARHGAP42-HIBCH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP42-HIBCH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP42-HIBCH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0342738Beta-Hydroxyisobutyryl CoA Deacylase Deficiency9CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human