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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:B3GLCT-MRPS35 (FusionGDB2 ID:HG145173TG60488)

Fusion Gene Summary for B3GLCT-MRPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: B3GLCT-MRPS35
Fusion gene ID: hg145173tg60488
HgeneTgene
Gene symbol

B3GLCT

MRPS35

Gene ID

145173

60488

Gene namebeta 3-glucosyltransferasemitochondrial ribosomal protein S35
SynonymsB3GALTL|B3GTL|B3Glc-T|Gal-T|beta3Glc-THDCMD11P|MDS023|MRP-S28|MRPS28
Cytomap('B3GALTL','B3GLCT')('MRPS35','MRPS35')

13q12.3

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,3-glucosyltransferaseUDP-GAL:beta-GlcNAc beta-1,3-galactosyltransferase-likebeta 1,3-galactosyltransferase-likebeta 3-glycosyltransferase-like28S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000343307, ENST00000461652, 
Fusion gene scores* DoF score7 X 4 X 5=14015 X 8 X 7=840
# samples 1020
** MAII scorelog2(10/140*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/840*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B3GLCT [Title/Abstract] AND MRPS35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointB3GALTL(31789237)-MRPS35(27872740), # samples:1
B3GALTL(31789237)-MRPS35(27872741), # samples:1
B3GLCT(31789237)-MRPS35(27872741), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across B3GALTL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MRPS35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8524-01AB3GALTLchr13

31789237

+MRPS35chr12

27872741

+
ChimerDB4STADTCGA-CD-8524B3GALTLchr13

31789237

+MRPS35chr12

27872740

+
ChimerDB4STADTCGA-CD-8524-01AB3GLCTchr13

31789237

+MRPS35chr12

27872741

+


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Fusion Gene ORF analysis for B3GLCT-MRPS35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000343307ENST00000081029B3GALTLchr13

31789237

+MRPS35chr12

27872741

+
In-frameENST00000343307ENST00000081029B3GALTLchr13

31789237

+MRPS35chr12

27872740

+
In-frameENST00000343307ENST00000538315B3GALTLchr13

31789237

+MRPS35chr12

27872741

+
In-frameENST00000343307ENST00000538315B3GALTLchr13

31789237

+MRPS35chr12

27872740

+
intron-3CDSENST00000461652ENST00000081029B3GALTLchr13

31789237

+MRPS35chr12

27872741

+
intron-3CDSENST00000461652ENST00000081029B3GALTLchr13

31789237

+MRPS35chr12

27872740

+
intron-3CDSENST00000461652ENST00000538315B3GALTLchr13

31789237

+MRPS35chr12

27872741

+
intron-3CDSENST00000461652ENST00000538315B3GALTLchr13

31789237

+MRPS35chr12

27872740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000343307B3GALTLchr1331789237+ENST00000081029MRPS35chr1227872740+17652692919305
ENST00000343307B3GALTLchr1331789237+ENST00000538315MRPS35chr1227872740+16542692532176
ENST00000343307B3GALTLchr1331789237+ENST00000081029MRPS35chr1227872741+17652692919305
ENST00000343307B3GALTLchr1331789237+ENST00000538315MRPS35chr1227872741+16542692532176

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343307ENST00000081029B3GALTLchr1331789237+MRPS35chr1227872740+0.0014262960.99857366
ENST00000343307ENST00000538315B3GALTLchr1331789237+MRPS35chr1227872740+0.216643170.78335685
ENST00000343307ENST00000081029B3GALTLchr1331789237+MRPS35chr1227872741+0.0014262960.99857366
ENST00000343307ENST00000538315B3GALTLchr1331789237+MRPS35chr1227872741+0.216643170.78335685

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Fusion Genomic Features for B3GLCT-MRPS35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
B3GALTLchr1331789237+MRPS35chr1227872740+3.66E-091
B3GALTLchr1331789237+MRPS35chr1227872740+3.66E-091
B3GALTLchr1331789237+MRPS35chr1227872740+3.66E-091
B3GALTLchr1331789237+MRPS35chr1227872740+3.66E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for B3GLCT-MRPS35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31789237/:27872740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB3GALTLchr13:31789237chr12:27872740ENST00000343307+2151_640499.0Topological domainCytoplasmic
HgeneB3GALTLchr13:31789237chr12:27872741ENST00000343307+2151_640499.0Topological domainCytoplasmic
HgeneB3GALTLchr13:31789237chr12:27872740ENST00000343307+2157_2740499.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneB3GALTLchr13:31789237chr12:27872741ENST00000343307+2157_2740499.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneMRPS35chr13:31789237chr12:27872740ENST0000008102928257_321107324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr13:31789237chr12:27872740ENST0000053831527257_321107526.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr13:31789237chr12:27872741ENST0000008102928257_321107324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr13:31789237chr12:27872741ENST0000053831527257_321107526.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB3GALTLchr13:31789237chr12:27872740ENST00000343307+21528_49840499.0Topological domainLumenal
HgeneB3GALTLchr13:31789237chr12:27872741ENST00000343307+21528_49840499.0Topological domainLumenal


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Fusion Gene Sequence for B3GLCT-MRPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8676_8676_1_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872740_ENST00000081029_length(transcript)=1765nt_BP=269nt
CGATGGCGCGGCGGAGACGGAGGGAGGAGGGGAGCCGGCAGAGAAGGGTCAGCCGCGGCGGCAGGGCGGCGGCGGCAGCGGCGCAGCTCC
GCTCCCCGCGCGTCTCCCTTCCCCGCGCCCAGGTAGGGCGCTCAGCCTCCGCCGCCAGGATGCGGCCGCCCGCCTGCTGGTGGCTGCTCG
CGCCGCCGGCGCTGCTCGCGCTCCTCACCTGCTCCCTGGCTTTTGGTTTGGCTTCTGAAGATACAAAGAAAGAGGTCAAGCAGTCTCAGA
TTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCCAGCCGCACTGG
ACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCGGAACCCCAGAG
CACGAGTAGTAGTCTTAAGAGTAAAGCTTTCCAGTTTGAATTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGAT
ACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAG
TGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCAT
CAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAG
AAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGA
GACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATAT
AAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGA
GTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAG
CTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCT
TTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGT
CTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATG
TTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTA
CCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTA
AGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTA

>8676_8676_1_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872740_ENST00000081029_length(amino acids)=305AA_BP=89
MARRRRREEGSRQRRVSRGGRAAAAAAQLRSPRVSLPRAQVGRSASAARMRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQI
PNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERY
CKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKE

--------------------------------------------------------------
>8676_8676_2_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872740_ENST00000538315_length(transcript)=1654nt_BP=269nt
CGATGGCGCGGCGGAGACGGAGGGAGGAGGGGAGCCGGCAGAGAAGGGTCAGCCGCGGCGGCAGGGCGGCGGCGGCAGCGGCGCAGCTCC
GCTCCCCGCGCGTCTCCCTTCCCCGCGCCCAGGTAGGGCGCTCAGCCTCCGCCGCCAGGATGCGGCCGCCCGCCTGCTGGTGGCTGCTCG
CGCCGCCGGCGCTGCTCGCGCTCCTCACCTGCTCCCTGGCTTTTGGTTTGGCTTCTGAAGATACAAAGAAAGAGGTCAAGCAGTCTCAGA
TTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCCAGCCGCACTGG
ACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCGGAACCCCAGAG
CACGAGTAGTAGTCTTAAGAGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGG
AATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAA
ACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAG
TCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGA
ATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAA
ATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTG
GGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATA
CATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTT
ACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCAC
ATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGC
ATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGG
GTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTAC
CCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATT

>8676_8676_2_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872740_ENST00000538315_length(amino acids)=176AA_BP=89
MARRRRREEGSRQRRVSRGGRAAAAAAQLRSPRVSLPRAQVGRSASAARMRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQI

--------------------------------------------------------------
>8676_8676_3_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872741_ENST00000081029_length(transcript)=1765nt_BP=269nt
CGATGGCGCGGCGGAGACGGAGGGAGGAGGGGAGCCGGCAGAGAAGGGTCAGCCGCGGCGGCAGGGCGGCGGCGGCAGCGGCGCAGCTCC
GCTCCCCGCGCGTCTCCCTTCCCCGCGCCCAGGTAGGGCGCTCAGCCTCCGCCGCCAGGATGCGGCCGCCCGCCTGCTGGTGGCTGCTCG
CGCCGCCGGCGCTGCTCGCGCTCCTCACCTGCTCCCTGGCTTTTGGTTTGGCTTCTGAAGATACAAAGAAAGAGGTCAAGCAGTCTCAGA
TTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCCAGCCGCACTGG
ACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCGGAACCCCAGAG
CACGAGTAGTAGTCTTAAGAGTAAAGCTTTCCAGTTTGAATTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGAT
ACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAG
TGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCAT
CAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAG
AAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGA
GACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATAT
AAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGA
GTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAG
CTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCT
TTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGT
CTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATG
TTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTA
CCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTA
AGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTA

>8676_8676_3_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872741_ENST00000081029_length(amino acids)=305AA_BP=89
MARRRRREEGSRQRRVSRGGRAAAAAAQLRSPRVSLPRAQVGRSASAARMRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQI
PNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSGPSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERY
CKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKE

--------------------------------------------------------------
>8676_8676_4_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872741_ENST00000538315_length(transcript)=1654nt_BP=269nt
CGATGGCGCGGCGGAGACGGAGGGAGGAGGGGAGCCGGCAGAGAAGGGTCAGCCGCGGCGGCAGGGCGGCGGCGGCAGCGGCGCAGCTCC
GCTCCCCGCGCGTCTCCCTTCCCCGCGCCCAGGTAGGGCGCTCAGCCTCCGCCGCCAGGATGCGGCCGCCCGCCTGCTGGTGGCTGCTCG
CGCCGCCGGCGCTGCTCGCGCTCCTCACCTGCTCCCTGGCTTTTGGTTTGGCTTCTGAAGATACAAAGAAAGAGGTCAAGCAGTCTCAGA
TTCCCAATTTTCTGCATTTGACTCCTGTAGCAATTAAAAAGCACTGTGAAGCCCTTAAAGATTTTTGCACTGAGTGGCCAGCCGCACTGG
ACAGTGACGAGAAATGTGAGAAGCATTTTCCAATTGAAATTGACAGCACTGATTATGTTTCATCAGGACCATCTGTTCGGAACCCCAGAG
CACGAGTAGTAGTCTTAAGAGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGG
AATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAA
ACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAG
TCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGA
ATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAA
ATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTG
GGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATA
CATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTT
ACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCAC
ATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGC
ATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGG
GTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTAC
CCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATT

>8676_8676_4_B3GALTL-MRPS35_B3GALTL_chr13_31789237_ENST00000343307_MRPS35_chr12_27872741_ENST00000538315_length(amino acids)=176AA_BP=89
MARRRRREEGSRQRRVSRGGRAAAAAAQLRSPRVSLPRAQVGRSASAARMRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for B3GLCT-MRPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for B3GLCT-MRPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for B3GLCT-MRPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneB3GLCTC0796012Krause-Kivlin syndrome6CTD_human;GENOMICS_ENGLAND
HgeneB3GLCTC0015397Disorder of eye1GENOMICS_ENGLAND