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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK1A1-ARHGEF37 (FusionGDB2 ID:HG1452TG389337)

Fusion Gene Summary for CSNK1A1-ARHGEF37

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1A1-ARHGEF37
Fusion gene ID: hg1452tg389337
HgeneTgene
Gene symbol

CSNK1A1

ARHGEF37

Gene ID

1452

389337

Gene namecasein kinase 1 alpha 1Rho guanine nucleotide exchange factor 37
SynonymsCK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975-
Cytomap('CSNK1A1')('ARHGEF37')

5q32

5q32

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77prho guanine nucleotide exchange factor 37Rho guanine nucleotide exchange factor (GEF) 37
Modification date2020031320200313
UniProtAcc

P48729

A1IGU5

Ensembl transtripts involved in fusion geneENST00000261798, ENST00000377843, 
ENST00000515748, ENST00000515768, 
ENST00000504676, ENST00000515435, 
ENST00000606299, ENST00000606719, 
Fusion gene scores* DoF score17 X 20 X 8=27206 X 7 X 4=168
# samples 268
** MAII scorelog2(26/2720*10)=-3.38702312310925
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK1A1 [Title/Abstract] AND ARHGEF37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1A1(148929638)-ARHGEF37(148980671), # samples:1
CSNK1A1(148929638)-ARHGEF37(148977322), # samples:1
Anticipated loss of major functional domain due to fusion event.CSNK1A1-ARHGEF37 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CSNK1A1-ARHGEF37 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CSNK1A1-ARHGEF37 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

HgeneCSNK1A1

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1A1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19364825



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-A5HZ-01ACSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
ChimerDB4HNSCTCGA-BB-A5HZCSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+


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Fusion Gene ORF analysis for CSNK1A1-ARHGEF37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261798ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
5CDS-5UTRENST00000377843ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
5CDS-5UTRENST00000515748ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
5CDS-5UTRENST00000515768ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
5UTR-3CDSENST00000504676ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
5UTR-3CDSENST00000515435ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
5UTR-5UTRENST00000504676ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
5UTR-5UTRENST00000515435ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
Frame-shiftENST00000261798ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
Frame-shiftENST00000377843ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
Frame-shiftENST00000515748ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
Frame-shiftENST00000515768ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
intron-3CDSENST00000606299ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
intron-3CDSENST00000606719ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148980671

+
intron-5UTRENST00000606299ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+
intron-5UTRENST00000606719ENST00000333677CSNK1A1chr5

148929638

-ARHGEF37chr5

148977322

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CSNK1A1-ARHGEF37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK1A1chr5148929637-ARHGEF37chr5148980670+1.93E-121
CSNK1A1chr5148929637-ARHGEF37chr5148977321+9.27E-091
CSNK1A1chr5148929637-ARHGEF37chr5148980670+1.93E-121
CSNK1A1chr5148929637-ARHGEF37chr5148977321+9.27E-091


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CSNK1A1-ARHGEF37


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148929638/:148980671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1A1

P48729

ARHGEF37

A1IGU5

FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:23902688}.FUNCTION: May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CSNK1A1-ARHGEF37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CSNK1A1-ARHGEF37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK1A1-ARHGEF37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCSNK1A1P48729DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for CSNK1A1-ARHGEF37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCSNK1A1C0376634Craniofacial Abnormalities1CTD_human