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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CSNK1E-KDELR3 (FusionGDB2 ID:HG1454TG11015) |
Fusion Gene Summary for CSNK1E-KDELR3 |
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Fusion gene information | Fusion gene name: CSNK1E-KDELR3 | Fusion gene ID: hg1454tg11015 | Hgene | Tgene | Gene symbol | CSNK1E | KDELR3 | Gene ID | 1454 | 11015 |
Gene name | casein kinase 1 epsilon | KDEL endoplasmic reticulum protein retention receptor 3 | |
Synonyms | CKIe|CKIepsilon|HCKIE | ERD2L3 | |
Cytomap | ('CSNK1E')('KDELR3') 22q13.1 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | casein kinase I isoform epsilon | ER lumen protein-retaining receptor 3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3KDEL receptor 3 | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P49674 | O43731 | |
Ensembl transtripts involved in fusion gene | ENST00000400206, ENST00000359867, ENST00000396832, ENST00000403904, ENST00000405675, ENST00000413574, ENST00000498529, | ||
Fusion gene scores | * DoF score | 13 X 9 X 10=1170 | 4 X 4 X 3=48 |
# samples | 17 | 4 | |
** MAII score | log2(17/1170*10)=-2.78290187833307 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CSNK1E [Title/Abstract] AND KDELR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CSNK1E(38776375)-KDELR3(38870528), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
Hgene | CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
Hgene | CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
Hgene | CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
Hgene | CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
Tgene | KDELR3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 18086916 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-36-1574-01A | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
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Fusion Gene ORF analysis for CSNK1E-KDELR3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000400206 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
5UTR-3CDS | ENST00000400206 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
5UTR-3UTR | ENST00000400206 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000359867 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000359867 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000396832 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000396832 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000403904 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000403904 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000405675 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000405675 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000413574 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000413574 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000498529 | ENST00000216014 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3CDS | ENST00000498529 | ENST00000409006 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000359867 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000396832 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000403904 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000405675 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000413574 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
intron-3UTR | ENST00000498529 | ENST00000471268 | CSNK1E | chr22 | 38776375 | - | KDELR3 | chr22 | 38870528 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CSNK1E-KDELR3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CSNK1E | chr22 | 38776374 | - | KDELR3 | chr22 | 38870527 | + | 0.08559896 | 0.914401 |
CSNK1E | chr22 | 38776374 | - | KDELR3 | chr22 | 38870527 | + | 0.08559896 | 0.914401 |
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Fusion Protein Features for CSNK1E-KDELR3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38776375/:38870528) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CSNK1E | KDELR3 |
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191}. | FUNCTION: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269|PubMed:18086916}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CSNK1E-KDELR3 |
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Fusion Gene PPI Analysis for CSNK1E-KDELR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CSNK1E-KDELR3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CSNK1E-KDELR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CSNK1E | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | CSNK1E | C0036341 | Schizophrenia | 2 | PSYGENET |