Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CSNK2A1-UBB (FusionGDB2 ID:HG1457TG7314)

Fusion Gene Summary for CSNK2A1-UBB

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK2A1-UBB
Fusion gene ID: hg1457tg7314
HgeneTgene
Gene symbol

CSNK2A1

UBB

Gene ID

1457

7314

Gene namecasein kinase 2 alpha 1ubiquitin B
SynonymsCK2A1|CKII|Cka1|Cka2|OCNDSHEL-S-50
Cytomap('CSNK2A1')('UBB')

20p13

17p11.2

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase II subunit alphaCK2 catalytic subunit alphacasein kinase 2, alpha 1 polypeptidecasein kinase II alpha 1 polypeptide pseudogenecasein kinase II alpha 1 subunitprotein kinase CK2polyubiquitin-Bepididymis secretory protein Li 50polyubiquitin B
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000217244, ENST00000349736, 
ENST00000400217, ENST00000400227, 
Fusion gene scores* DoF score12 X 7 X 7=58834 X 9 X 11=3366
# samples 1534
** MAII scorelog2(15/588*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(34/3366*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK2A1 [Title/Abstract] AND UBB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK2A1(524315)-UBB(16285215), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK2A1

GO:0006468

protein phosphorylation

18548200|20625391|22406621

HgeneCSNK2A1

GO:0008284

positive regulation of cell proliferation

20625391

HgeneCSNK2A1

GO:0018105

peptidyl-serine phosphorylation

28031292

HgeneCSNK2A1

GO:0018107

peptidyl-threonine phosphorylation

15723517

HgeneCSNK2A1

GO:0030307

positive regulation of cell growth

20625391

HgeneCSNK2A1

GO:0045732

positive regulation of protein catabolic process

20625391

TgeneUBB

GO:0031398

positive regulation of protein ubiquitination

24660806

TgeneUBB

GO:0047497

mitochondrion transport along microtubule

17571083

TgeneUBB

GO:0051881

regulation of mitochondrial membrane potential

17571083

TgeneUBB

GO:0061136

regulation of proteasomal protein catabolic process

17571083

TgeneUBB

GO:1901214

regulation of neuron death

17571083

TgeneUBB

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

17571083



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H5CSNK2A1chr20

524315

-UBBchr17

16285215

+


Top

Fusion Gene ORF analysis for CSNK2A1-UBB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000217244ENST00000302182CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000217244ENST00000395837CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000217244ENST00000395839CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000217244ENST00000535788CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000349736ENST00000302182CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000349736ENST00000395837CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000349736ENST00000395839CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000349736ENST00000535788CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400217ENST00000302182CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400217ENST00000395837CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400217ENST00000395839CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400217ENST00000535788CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400227ENST00000302182CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400227ENST00000395837CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400227ENST00000395839CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-5UTRENST00000400227ENST00000535788CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-intronENST00000217244ENST00000578649CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-intronENST00000349736ENST00000578649CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-intronENST00000400217ENST00000578649CSNK2A1chr20

524315

-UBBchr17

16285215

+
5UTR-intronENST00000400227ENST00000578649CSNK2A1chr20

524315

-UBBchr17

16285215

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CSNK2A1-UBB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK2A1chr20524315-UBBchr1716285215+3.45E-111
CSNK2A1chr20524315-UBBchr1716285215+3.45E-111


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CSNK2A1-UBB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:524315/:16285215)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CSNK2A1-UBB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CSNK2A1-UBB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CSNK2A1-UBB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CSNK2A1-UBB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK2A1C0007114Malignant neoplasm of skin1CTD_human
HgeneCSNK2A1C0007137Squamous cell carcinoma1CTD_human
HgeneCSNK2A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCSNK2A1C0036572Seizures1GENOMICS_ENGLAND
HgeneCSNK2A1C0037286Skin Neoplasms1CTD_human
HgeneCSNK2A1C4310739OKUR-CHUNG NEURODEVELOPMENTAL SYNDROME1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0266122Cleft uvula1ORPHANET
TgeneC0432090Cleft of hard palate1ORPHANET
TgeneC0432098Cleft Soft Palate1ORPHANET
TgeneC0432103Submucous cleft of hard palate1ORPHANET
TgeneC4551487Submucous cleft palate1ORPHANET