Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FAM98C-SPINT2 (FusionGDB2 ID:HG147965TG10653)

Fusion Gene Summary for FAM98C-SPINT2

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM98C-SPINT2
Fusion gene ID: hg147965tg10653
HgeneTgene
Gene symbol

FAM98C

SPINT2

Gene ID

147965

10653

Gene namefamily with sequence similarity 98 member Cserine peptidase inhibitor, Kunitz type 2
Synonyms-DIAR3|HAI-2|HAI2|Kop|PB
Cytomap('FAM98C')('SPINT2')

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM98Ckunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183
Modification date2020031320200315
UniProtAcc

Q17RN3

.
Ensembl transtripts involved in fusion geneENST00000585954, ENST00000252530, 
ENST00000343358, ENST00000588262, 
Fusion gene scores* DoF score5 X 3 X 4=6011 X 6 X 8=528
# samples 513
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM98C [Title/Abstract] AND SPINT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM98C(38894334)-SPINT2(38774267), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPINT2

GO:0022408

negative regulation of cell-cell adhesion

19592578

TgeneSPINT2

GO:2000146

negative regulation of cell motility

19592578


check buttonFusion gene breakpoints across FAM98C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPINT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2094-01AFAM98Cchr19

38894334

+SPINT2chr19

38774267

+


Top

Fusion Gene ORF analysis for FAM98C-SPINT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000585954ENST00000301244FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
3UTR-5UTRENST00000585954ENST00000587090FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
3UTR-intronENST00000585954ENST00000454580FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-5UTRENST00000252530ENST00000587090FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-5UTRENST00000343358ENST00000587090FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-5UTRENST00000588262ENST00000587090FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-intronENST00000252530ENST00000454580FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-intronENST00000343358ENST00000454580FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
5CDS-intronENST00000588262ENST00000454580FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
In-frameENST00000252530ENST00000301244FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
In-frameENST00000343358ENST00000301244FAM98Cchr19

38894334

+SPINT2chr19

38774267

+
In-frameENST00000588262ENST00000301244FAM98Cchr19

38894334

+SPINT2chr19

38774267

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000588262FAM98Cchr1938894334+ENST00000301244SPINT2chr1938774267+1629368191020333
ENST00000252530FAM98Cchr1938894334+ENST00000301244SPINT2chr1938774267+1629368191020333
ENST00000343358FAM98Cchr1938894334+ENST00000301244SPINT2chr1938774267+161034901001333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000588262ENST00000301244FAM98Cchr1938894334+SPINT2chr1938774267+0.002108860.9978911
ENST00000252530ENST00000301244FAM98Cchr1938894334+SPINT2chr1938774267+0.002108860.9978911
ENST00000343358ENST00000301244FAM98Cchr1938894334+SPINT2chr1938774267+0.0021137050.99788624

Top

Fusion Genomic Features for FAM98C-SPINT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM98Cchr1938894334+SPINT2chr1938774266+3.61E-091
FAM98Cchr1938894334+SPINT2chr1938774266+3.61E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for FAM98C-SPINT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:38894334/chr19:38774267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM98C

Q17RN3

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPINT2chr19:38894334chr19:38774267ENST0000030124407219_25235253.0Topological domainCytoplasmic
TgeneSPINT2chr19:38894334chr19:38774267ENST0000045458006219_2520196.0Topological domainCytoplasmic
TgeneSPINT2chr19:38894334chr19:38774267ENST000004545800628_1970196.0Topological domainExtracellular
TgeneSPINT2chr19:38894334chr19:38774267ENST0000030124407198_21835253.0TransmembraneHelical
TgeneSPINT2chr19:38894334chr19:38774267ENST0000045458006198_2180196.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPINT2chr19:38894334chr19:38774267ENST000003012440728_19735253.0Topological domainExtracellular


Top

Fusion Gene Sequence for FAM98C-SPINT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29295_29295_1_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000252530_SPINT2_chr19_38774267_ENST00000301244_length(transcript)=1629nt_BP=368nt
GCGCCGAGACCACACTTTCATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGG
AGGTGTCCCGGGGGCGGCGTCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGG
CGCCCTCGAGCAGCAGCGAGAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGG
CAGCCTGCTGCGGGAGCTGCACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCG
CCTGCTGCACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTG
CCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGA
GAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTC
CAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGT
GGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTG
CTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCT
GGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGA
GCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTA
AATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGG
ATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGAT
TTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTT
GTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAA
AAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACAC
TATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGTCC
TATTACTGA

>29295_29295_1_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000252530_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=333AA_BP=112
MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL
HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL
ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN
PPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

--------------------------------------------------------------
>29295_29295_2_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000343358_SPINT2_chr19_38774267_ENST00000301244_length(transcript)=1610nt_BP=349nt
ATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGGAGGTGTCCCGGGGGCGGCG
TCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGGCGCCCTCGAGCAGCAGCGA
GAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGGCAGCCTGCTGCGGGAGCTG
CACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCGCCTGCTGCACTTCTGCCTG
GTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTGCCAGCTGTTTGTGTATGGG
GGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTG
GCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTCCAGCGATATGTTCAACTAT
GAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAAT
AACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAGCAGGAGAAT
CCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTAC
CTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACA
TATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTAAATAGAGGGATTGACTCGG
ATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAAT
CCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCCTCCAGGTAGAG
TTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTTGTTTGTCTGATTTATGGTT
TTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAAAAAGGGGCCTTCCCCTTTA
GAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACACTATCTGAGGTGTCCCATTC
TAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGTCCTATTACTGA

>29295_29295_2_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000343358_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=333AA_BP=112
MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL
HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL
ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN
PPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

--------------------------------------------------------------
>29295_29295_3_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000588262_SPINT2_chr19_38774267_ENST00000301244_length(transcript)=1629nt_BP=368nt
GCGCCGAGACCACACTTTCATGGAGGCGGTGAAGGCGGAAGCGTGGGAGGGGGCCGCGGTGGCCCAGGACCTGCTGGCTCTGGGGTATGG
AGGTGTCCCGGGGGCGGCGTCGCGGGGCGCCTCATGCCCAGACTTCAGGGGGCTGTGCGTGCGGCTGGCGGCGGAGCTGGCGACGCTGGG
CGCCCTCGAGCAGCAGCGAGAGGCGGGCGCGGAGGTGCTGAGCGCCGGCGACGGCCCTGGCGCGGAGGAGGACTTTCTGCGGCAGCTCGG
CAGCCTGCTGCGGGAGCTGCACTGCCCGGATCGCGCGCTCTGCGGCGGGGATGGCGCGGCTGCGCTTCGGGAACCCGGTGCCGGACTGCG
CCTGCTGCACTTCTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTCACTGACGGATCCTG
CCAGCTGTTTGTGTATGGGGGCTGTGACGGAAACAGCAATAATTACCTGACCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGA
GAATGCCACGGGTGACCTGGCCACCAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCACTC
CAGCGATATGTTCAACTATGAAGAATACTGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTGGTACTTTGACGT
GGAGAGGAACTCCTGCAATAACTTCATCTATGGAGGCTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTG
CTTCCGCCAGCAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGGTGTTGATCCTCTTCCT
GGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGAGCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGA
GCAGCTGGTGAAGAACACATATGTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTTTTTA
AATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAGGTAGGACGGCTGCTTCCTGGTCTGGCAGGG
ATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCCTCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGAT
TTCTTTCCTCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGATGTTGGAATCGTTTCTTTT
GTTTGTCTGATTTATGGTTTTTTTAAGTATAAACAAAAGTTTTTTATTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAA
AAAGGGGCCTTCCCCTTTAGAATAAATTTCAGCATGTGCTTTCTTTATGGGAGTCCTAATTTCAACCCTACCAAAATGATCACAAGACAC
TATCTGAGGTGTCCCATTCTAGAAATAGACCCCTCAAAATAGCGTCTTTCAGATCTTTTTGAATGAATCCACAAGATGAAATAAATGTCC
TATTACTGA

>29295_29295_3_FAM98C-SPINT2_FAM98C_chr19_38894334_ENST00000588262_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=333AA_BP=112
MEAVKAEAWEGAAVAQDLLALGYGGVPGAASRGASCPDFRGLCVRLAAELATLGALEQQREAGAEVLSAGDGPGAEEDFLRQLGSLLREL
HCPDRALCGGDGAAALREPGAGLRLLHFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL
ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN
PPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FAM98C-SPINT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FAM98C-SPINT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FAM98C-SPINT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0267663Congenital secretory diarrhea, sodium type (disorder)3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0007097Carcinoma1CTD_human
TgeneC0011999Diastematomyelia1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0027794Neural Tube Defects1CTD_human
TgeneC0027806Neurenteric Cyst1CTD_human
TgeneC0032045Placenta Disorders1CTD_human
TgeneC0080218Tethered Cord Syndrome1CTD_human
TgeneC0152234Iniencephaly1CTD_human
TgeneC0152426Craniorachischisis1CTD_human
TgeneC0152427Polydactyly1GENOMICS_ENGLAND
TgeneC0155299Coloboma of optic disc1GENOMICS_ENGLAND
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0266453Exencephaly1CTD_human
TgeneC0302246Hexadactyly1GENOMICS_ENGLAND
TgeneC0344479Spinal Cord Myelodysplasia1CTD_human
TgeneC0702169Acrania1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC4275062Intestinal epithelial dysplasia1GENOMICS_ENGLAND