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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C19orf25-TCF3 (FusionGDB2 ID:HG148223TG6929)

Fusion Gene Summary for C19orf25-TCF3

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf25-TCF3
Fusion gene ID: hg148223tg6929
HgeneTgene
Gene symbol

C19orf25

TCF3

Gene ID

148223

6929

Gene namechromosome 19 open reading frame 25transcription factor 3
Synonyms-AGM8|E2A|E47|ITF1|TCF-3|VDIR|bHLHb21|p75
Cytomap('C19orf25')('TCF3')

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0449 protein C19orf25transcription factor E2-alphaNOL1-TCF3 fusionVDR interacting repressorclass B basic helix-loop-helix protein 21helix-loop-helix protein HE47immunoglobulin transcription factor 1kappa-E2-binding factornegative vitamin D response element-binding prot
Modification date2020031320200313
UniProtAcc

Q9UFG5

P15923

Ensembl transtripts involved in fusion geneENST00000436106, ENST00000585675, 
ENST00000586564, ENST00000588427, 
ENST00000588849, ENST00000588871, 
ENST00000592872, ENST00000591027, 
ENST00000427685, 		ENST00000427685, 
ENST00000436106, ENST00000585675, 
ENST00000586564, ENST00000588849, 
ENST00000588871, ENST00000591027, 
ENST00000592872, ENST00000588427, 
Fusion gene scores* DoF score10 X 4 X 9=36012 X 15 X 8=1440
# samples 1217
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1440*10)=-3.08246216019197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C19orf25 [Title/Abstract] AND TCF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf25(1478773)-TCF3(1632404), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TCF3-C19orf25 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
C19orf25-TCF3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTCF3

GO:0000122

negative regulation of transcription by RNA polymerase II

14576336

TgeneTCF3

GO:0006351

transcription, DNA-templated

10775504

TgeneTCF3

GO:0033152

immunoglobulin V(D)J recombination

16428437

TgeneTCF3

GO:0045893

positive regulation of transcription, DNA-templated

2105528

TgeneTCF3

GO:0045944

positive regulation of transcription by RNA polymerase II

16428437|19362560

TgeneTCF3

GO:0051091

positive regulation of DNA-binding transcription factor activity

14752053


check buttonFusion gene breakpoints across C19orf25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TCF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-0970-01BC19orf25chr19

1478773

-TCF3chr19

1632404

-


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Fusion Gene ORF analysis for C19orf25-TCF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000436106ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000436106ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000436106ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000585675ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000585675ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000585675ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000586564ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000586564ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000586564ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588427ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588427ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588427ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588849ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588849ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588849ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588871ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588871ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000588871ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000592872ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000592872ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5CDS-intronENST00000592872ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
5UTR-3CDSENST00000591027ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
5UTR-3CDSENST00000591027ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
5UTR-intronENST00000591027ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
5UTR-intronENST00000591027ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
5UTR-intronENST00000591027ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000436106ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000436106ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000586564ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000586564ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588427ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588427ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588849ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588849ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588871ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000588871ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000592872ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
Frame-shiftENST00000592872ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
In-frameENST00000585675ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
In-frameENST00000585675ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
intron-3CDSENST00000427685ENST00000262965C19orf25chr19

1478773

-TCF3chr19

1632404

-
intron-3CDSENST00000427685ENST00000344749C19orf25chr19

1478773

-TCF3chr19

1632404

-
intron-intronENST00000427685ENST00000395423C19orf25chr19

1478773

-TCF3chr19

1632404

-
intron-intronENST00000427685ENST00000453954C19orf25chr19

1478773

-TCF3chr19

1632404

-
intron-intronENST00000427685ENST00000588136C19orf25chr19

1478773

-TCF3chr19

1632404

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585675C19orf25chr191478773-ENST00000344749TCF3chr191632404-4398174441984646
ENST00000585675C19orf25chr191478773-ENST00000262965TCF3chr191632404-4407174441993649

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585675ENST00000344749C19orf25chr191478773-TCF3chr191632404-0.0193674420.9806325
ENST00000585675ENST00000262965C19orf25chr191478773-TCF3chr191632404-0.0173278580.9826721

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Fusion Genomic Features for C19orf25-TCF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C19orf25-TCF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1478773/chr19:1632404)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C19orf25

Q9UFG5

TCF3

P15923

FUNCTION: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTCF3chr19:1478773chr19:1632404ENST00000262965219549_60248655.0DomainbHLH
TgeneTCF3chr19:1478773chr19:1632404ENST00000344749219549_60248652.0DomainbHLH
TgeneTCF3chr19:1478773chr19:1632404ENST00000588136119549_60248527.0DomainbHLH
TgeneTCF3chr19:1478773chr19:1632404ENST00000262965219170_17648655.0MotifNuclear localization signal
TgeneTCF3chr19:1478773chr19:1632404ENST00000344749219170_17648652.0MotifNuclear localization signal
TgeneTCF3chr19:1478773chr19:1632404ENST00000588136119170_17648527.0MotifNuclear localization signal
TgeneTCF3chr19:1478773chr19:1632404ENST00000262965219389_42548655.0RegionNote=Leucine-zipper
TgeneTCF3chr19:1478773chr19:1632404ENST00000344749219389_42548652.0RegionNote=Leucine-zipper
TgeneTCF3chr19:1478773chr19:1632404ENST00000588136119389_42548527.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC19orf25chr19:1478773chr19:1632404ENST00000436106-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr19:1632404ENST00000585675-2381_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr19:1632404ENST00000586564-1281_10943119.0Coiled coilOntology_term=ECO:0000255
HgeneC19orf25chr19:1478773chr19:1632404ENST00000592872-2381_10943119.0Coiled coilOntology_term=ECO:0000255
TgeneTCF3chr19:1478773chr19:1632404ENST0000026296521919_2748655.0MotifNote=9aaTAD
TgeneTCF3chr19:1478773chr19:1632404ENST0000034474921919_2748652.0MotifNote=9aaTAD
TgeneTCF3chr19:1478773chr19:1632404ENST0000058813611919_2748527.0MotifNote=9aaTAD


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Fusion Gene Sequence for C19orf25-TCF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11176_11176_1_C19orf25-TCF3_C19orf25_chr19_1478773_ENST00000585675_TCF3_chr19_1632404_ENST00000262965_length(transcript)=4407nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTCTTG
AGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACT
TCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCT
TCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTT
CGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCA
AGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACC
CGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCC
CGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAA
GCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCAT
CCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCC
GAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGT
CCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCA
GCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCA
CAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAG
GCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCA
CCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGG
AGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACTCGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCCCAG
ACGAGGACGAGGACGACCTTCTCCCCCCAGAGCAGAAGGCCGAGCGGGAGAAGGAGCGCCGGGTGGCCAATAACGCCCGGGAGCGGCTGC
GGGTCCGTGACATCAACGAGGCCTTTAAGGAGCTGGGGCGCATGTGCCAACTGCACCTCAACAGCGAGAAGCCCCAGACCAAACTGCTCA
TCCTGCACCAGGCTGTCTCGGTCATCCTGAACTTGGAGCAGCAAGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGC
GAGAAGAGGAAAAGGTGTCAGGTGTGGTTGGAGACCCCCAGATGGTGCTTTCAGCTCCCCACCCAGGCCTGAGCGAAGCCCACAACCCCG
CCGGGCACATGTGAAAGGTATGCCTCCGTGGGACGAGCCACCCGCTTTCAGCCCTGTGCTCTGGCCCCAGAACGGCCACTCGAGACCCCG
GGCTTCATCCACATCCACACCTCACACACCTGTTGTCAGCATCGAGCCAACACCAACCTGACAAGGTTCGGAGTGATGGGGGCGGCCAAG
GTGACACTGGGTCCAGGAGCTCCCTGGGGCCCTGGCCTACCACTCACTGGCCTCGCTCCCCCTGTCCCCGAATCTCAGCCACCGTGTCAC
TCTGTGACCTGTCCCATGGATCCTGAAACTGCATCTTGGCCCTGTTGCCTGGGCTGACAGGAGCATTTTTTTTTTTTCCAGTAAACAAAA
CCTGAAAGCAAGCAACAAAACATACACTTTGTCAGAGAAGAAAAAAATGCCTTAACTATAAAAAGCGGAGAAATGGAAACATATCACTCA
AGGGGGATGCTGTGGAAACCTGGCTTATTCTTCTAAAGCCACCAGCAAATTGTGCCTAAGCGAAATATTTTTTTTAAGGAAAATAAAAAC
ATTAGTTACAAGATTTTTTTTTTCTTAATGTAGATGAAAATTAGCAAGGATGCTGCCTTTGGTCTCTGGTTTTTTTAAGCTTTTTTTGCA
TATGTTTTGTAAGCAACAAATTTTTTTGTATAAAAGTCCCGTGTCTCTCGCTATTTCTGCTGCTGTTCCTAGACTGAGCATTGCATTTCT
TGATCAACCAGATGATTAAACGTTGTATTAAAAAGACCCCGTGTAAACCTGAGCCCCCCCGTCCCCCCCCCCCCCCGGAAGCCACTGCAC
ACAGACAGAACGGGGACAGGCGGCGGGTCTTTTGTTTTTTTGATGTTGGGGGTTCTCTTGGTTTTGTCATGTGGAAAGTGATGCGTGGGC
GTTCCCTGATGAAGGCACCTTGGGGCTTCCCTGCCGCATCCTCTCCCCTCAGGAAGGGGACTGACCTGGGCTTGGGGGAAGGGACGTCAG
CAAGGTGGCTCTGACCCTCCCAGGTGACTCTGCCAAGCAGCTGTGGCCCCCAGGGCTACCCTACACAACGCCCTCCCCAGGCCCCCCTAA
GCTGCTCTCCCTTGGAACCTGCACAGCTCTCTGAAATGGGGCATTTTGTTGGGACCAGTGACCCCTGGCATGGGGACCACACCCTGGAGC
CCGGTGCTGGGGACCTCCTGGACACCCTGTCCTTCACTCCTTTGCCCCAGGGACCCAGGCTCATGCTCTGAACTCTGGCTGAGAGGATGC
TGCTCAGGAGCCAGCACAGGACACCCCCCACCCCACCCCACCATGTCCCCATTACACCAGAGGGCCATCGTGACGTAGACAGGATGCCAG
GGGCCTGGCCAGCCTCCCCCAATGCTGGGGAGCATCCCTGGGCCTGGGGCCACACCTGCTGCCCTCCCTCTGTGTGGTCCAAGGGCAAGA
GTGGCTGGAGCCGGGGGACTGTGCTGGTCTGAGCCCCACGAAGGCCTTGGGCTGTGCGTCCGACCCTGCTGCAGAACCAGCAGGGTGTCC
CCTCGGGCCCATCTGTGTCCCATGTCCCAGCACCCAGGCCTCTCTCCAGGTCTCCTTTTCTGGTCTTTTGCCATGAGGGTAACCAGCTCT
TCCCAGCTGGCTGGGGACTGTCTTGGGTTTAAAACTGCAAGTCTCCTACCCTGGGATCCCATCCAGTTCCACACGAACTAGGGCAGTGGT
CACTGTGGCACCCAGGTGTGGGCCTGGCTAGCTGGGGGCCTTCATGTGCCCTTCATGCCCCTCCCTGCATTGAGGCCTTGTGGACCCCTG
GGCTGGCTGTGTTCATCCCCGCTGCAGGTCGGGCGTCTCCCCCCGTGCCACTCCTGAGACTCCCACCGTTACCCCCAGGAGATCCTGGAC
TGCCTGACTCCCCTCCCCAGACTGGCTTGGGAGCCTGGGCCCCATGGTAGATGCAAGGGAAACCTCAAGGCCAGCTCAATGCCTGGTATC
TGCCCCCAGTCCAGGCCAGGCGGAGGGGAGGGGCTGTCCGGCTGCCTCTCCCTTCTCGGTGGCTTCCCCTACGCCCTGGGAGTTTGATCT
CTTAAGGGAACTTGCCTCTCCCTCTTGTTTTGCTCCTGGCCCTGCCCCTAGGTCTGGGTGGGCAGTGGCCCCATAGCCTCTGGAACTGTG
CGTTCTGCATAGAATTCAAACGAGATTCACCCAGCGCGAGGAGGAAGAAACAGCAGTTCCTGGGAACCACAATTATGGGGGGTGGGGGGT
GTGATCTGAGTGCCTCAAGATGGTTTTCAAAAAAATTTTTTTAAAGAAAATAATTGTATACGTGTCAACACAGCTGGCTGGATGATTGGG

>11176_11176_1_C19orf25-TCF3_C19orf25_chr19_1478773_ENST00000585675_TCF3_chr19_1632404_ENST00000262965_length(amino acids)=649AA_BP=31
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLG
PGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVY
PPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMG
YQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAG
TSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGS
TSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAE
REKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQM

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>11176_11176_2_C19orf25-TCF3_C19orf25_chr19_1478773_ENST00000585675_TCF3_chr19_1632404_ENST00000344749_length(transcript)=4398nt_BP=174nt
TTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAG
CGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTCTTG
AGGACCGGCCCAGCTCAGGCTCCTGGGGCAGCGGCGACCAGAGCAGCTCCTCCTTTGACCCCAGCCGGACCTTCAGCGAGGGCACCCACT
TCACTGAGTCGCACAGCAGCCTCTCTTCATCCACATTCCTGGGACCGGGACTCGGAGGCAAGAGCGGTGAGCGGGGCGCCTATGCCTCCT
TCGGGAGAGACGCAGGCGTGGGCGGCCTGACTCAGGCTGGCTTCCTGTCAGGCGAGCTGGCCCTCAACAGCCCCGGGCCCCTGTCCCCTT
CGGGCATGAAGGGGACCTCCCAGTACTACCCCTCCTACTCCGGCAGCTCCCGGCGGAGAGCGGCAGACGGCAGCCTAGACACGCAGCCCA
AGAAGGTCCGGAAGGTCCCGCCGGGTCTTCCATCCTCGGTGTACCCACCCAGCTCAGGTGAGGACTACGGCAGGGATGCCACCGCCTACC
CGTCCGCCAAGACCCCCAGCAGCACCTATCCCGCCCCCTTCTACGTGGCAGATGGCAGCCTGCACCCCTCAGCCGAGCTCTGGAGTCCCC
CGGGCCAGGCGGGCTTCGGGCCCATGCTGGGTGGGGGCTCATCCCCGCTGCCCCTCCCGCCCGGTAGCGGCCCGGTGGGCAGCAGTGGAA
GCAGCAGCACGTTTGGTGGCCTGCACCAGCACGAGCGTATGGGCTACCAGCTGCATGGAGCAGAGGTGAACGGTGGGCTCCCATCTGCAT
CCTCCTTCTCCTCAGCCCCCGGAGCCACGTACGGCGGCGTCTCCAGCCACACGCCGCCTGTCAGCGGGGCCGACAGCCTCCTGGGCTCCC
GAGGGACCACAGCTGGCAGCTCCGGGGATGCCCTCGGCAAAGCACTGGCCTCGATCTACTCCCCGGATCACTCAAGCAATAACTTCTCGT
CCAGCCCTTCTACCCCCGTGGGCTCCCCCCAGGGCCTGGCAGGAACGTCACAGTGGCCTCGAGCAGGAGCCCCCGGTGCCTTATCGCCCA
GCTACGACGGGGGTCTCCACGGCCTGCAGAGTAAGATAGAAGACCACCTGGACGAGGCCATCCACGTGCTCCGCAGCCACGCCGTGGGCA
CAGCCGGCGACATGCACACGCTGCTGCCTGGCCACGGGGCGCTGGCCTCAGGTTTCACCGGCCCCATGTCACTGGGCGGGCGGCACGCAG
GCCTGGTTGGAGGCAGCCACCCCGAGGACGGCCTCGCAGGCAGCACCAGCCTCATGCACAACCACGCGGCCCTCCCCAGCCAGCCAGGCA
CCCTCCCTGACCTGTCTCGGCCTCCCGACTCCTACAGTGGGCTAGGGCGAGCAGGTGCCACGGCGGCCGCCAGCGAGATCAAGCGGGAGG
AGAAGGAGGACGAGGAGAACACGTCAGCGGCTGACCACTCGGAGGAGGAGAAGAAGGAGCTGAAGGCCCCCCGGGCCCGGACCAGCAGTA
CGGACGAGGTGCTGTCCCTGGAGGAGAAAGACCTGAGGGACCGGGAGAGGCGCATGGCCAATAACGCGCGGGAGCGGGTGCGCGTGCGGG
ATATTAACGAGGCCTTCCGGGAGCTGGGGCGCATGTGCCAGATGCACCTCAAGTCGGACAAAGCGCAGACCAAGCTGCTCATCCTGCAGC
AGGCCGTGCAGGTCATCCTGGGGCTGGAGCAGCAGGTGCGAGAGCGGAACCTGAATCCCAAAGCAGCCTGTTTGAAACGGCGAGAAGAGG
AAAAGGTGTCAGGTGTGGTTGGAGACCCCCAGATGGTGCTTTCAGCTCCCCACCCAGGCCTGAGCGAAGCCCACAACCCCGCCGGGCACA
TGTGAAAGGTATGCCTCCGTGGGACGAGCCACCCGCTTTCAGCCCTGTGCTCTGGCCCCAGAACGGCCACTCGAGACCCCGGGCTTCATC
CACATCCACACCTCACACACCTGTTGTCAGCATCGAGCCAACACCAACCTGACAAGGTTCGGAGTGATGGGGGCGGCCAAGGTGACACTG
GGTCCAGGAGCTCCCTGGGGCCCTGGCCTACCACTCACTGGCCTCGCTCCCCCTGTCCCCGAATCTCAGCCACCGTGTCACTCTGTGACC
TGTCCCATGGATCCTGAAACTGCATCTTGGCCCTGTTGCCTGGGCTGACAGGAGCATTTTTTTTTTTTCCAGTAAACAAAACCTGAAAGC
AAGCAACAAAACATACACTTTGTCAGAGAAGAAAAAAATGCCTTAACTATAAAAAGCGGAGAAATGGAAACATATCACTCAAGGGGGATG
CTGTGGAAACCTGGCTTATTCTTCTAAAGCCACCAGCAAATTGTGCCTAAGCGAAATATTTTTTTTAAGGAAAATAAAAACATTAGTTAC
AAGATTTTTTTTTTCTTAATGTAGATGAAAATTAGCAAGGATGCTGCCTTTGGTCTCTGGTTTTTTTAAGCTTTTTTTGCATATGTTTTG
TAAGCAACAAATTTTTTTGTATAAAAGTCCCGTGTCTCTCGCTATTTCTGCTGCTGTTCCTAGACTGAGCATTGCATTTCTTGATCAACC
AGATGATTAAACGTTGTATTAAAAAGACCCCGTGTAAACCTGAGCCCCCCCGTCCCCCCCCCCCCCCGGAAGCCACTGCACACAGACAGA
ACGGGGACAGGCGGCGGGTCTTTTGTTTTTTTGATGTTGGGGGTTCTCTTGGTTTTGTCATGTGGAAAGTGATGCGTGGGCGTTCCCTGA
TGAAGGCACCTTGGGGCTTCCCTGCCGCATCCTCTCCCCTCAGGAAGGGGACTGACCTGGGCTTGGGGGAAGGGACGTCAGCAAGGTGGC
TCTGACCCTCCCAGGTGACTCTGCCAAGCAGCTGTGGCCCCCAGGGCTACCCTACACAACGCCCTCCCCAGGCCCCCCTAAGCTGCTCTC
CCTTGGAACCTGCACAGCTCTCTGAAATGGGGCATTTTGTTGGGACCAGTGACCCCTGGCATGGGGACCACACCCTGGAGCCCGGTGCTG
GGGACCTCCTGGACACCCTGTCCTTCACTCCTTTGCCCCAGGGACCCAGGCTCATGCTCTGAACTCTGGCTGAGAGGATGCTGCTCAGGA
GCCAGCACAGGACACCCCCCACCCCACCCCACCATGTCCCCATTACACCAGAGGGCCATCGTGACGTAGACAGGATGCCAGGGGCCTGGC
CAGCCTCCCCCAATGCTGGGGAGCATCCCTGGGCCTGGGGCCACACCTGCTGCCCTCCCTCTGTGTGGTCCAAGGGCAAGAGTGGCTGGA
GCCGGGGGACTGTGCTGGTCTGAGCCCCACGAAGGCCTTGGGCTGTGCGTCCGACCCTGCTGCAGAACCAGCAGGGTGTCCCCTCGGGCC
CATCTGTGTCCCATGTCCCAGCACCCAGGCCTCTCTCCAGGTCTCCTTTTCTGGTCTTTTGCCATGAGGGTAACCAGCTCTTCCCAGCTG
GCTGGGGACTGTCTTGGGTTTAAAACTGCAAGTCTCCTACCCTGGGATCCCATCCAGTTCCACACGAACTAGGGCAGTGGTCACTGTGGC
ACCCAGGTGTGGGCCTGGCTAGCTGGGGGCCTTCATGTGCCCTTCATGCCCCTCCCTGCATTGAGGCCTTGTGGACCCCTGGGCTGGCTG
TGTTCATCCCCGCTGCAGGTCGGGCGTCTCCCCCCGTGCCACTCCTGAGACTCCCACCGTTACCCCCAGGAGATCCTGGACTGCCTGACT
CCCCTCCCCAGACTGGCTTGGGAGCCTGGGCCCCATGGTAGATGCAAGGGAAACCTCAAGGCCAGCTCAATGCCTGGTATCTGCCCCCAG
TCCAGGCCAGGCGGAGGGGAGGGGCTGTCCGGCTGCCTCTCCCTTCTCGGTGGCTTCCCCTACGCCCTGGGAGTTTGATCTCTTAAGGGA
ACTTGCCTCTCCCTCTTGTTTTGCTCCTGGCCCTGCCCCTAGGTCTGGGTGGGCAGTGGCCCCATAGCCTCTGGAACTGTGCGTTCTGCA
TAGAATTCAAACGAGATTCACCCAGCGCGAGGAGGAAGAAACAGCAGTTCCTGGGAACCACAATTATGGGGGGTGGGGGGTGTGATCTGA
GTGCCTCAAGATGGTTTTCAAAAAAATTTTTTTAAAGAAAATAATTGTATACGTGTCAACACAGCTGGCTGGATGATTGGGACTTTAAAA

>11176_11176_2_C19orf25-TCF3_C19orf25_chr19_1478773_ENST00000585675_TCF3_chr19_1632404_ENST00000344749_length(amino acids)=646AA_BP=31
MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPEGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLG
PGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVY
PPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMG
YQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAG
TSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGS
TSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSSTDEVLSLEEKDLRDR
ERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQAVQVILGLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLS

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Fusion Gene PPI Analysis for C19orf25-TCF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C19orf25-TCF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C19orf25-TCF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006413Burkitt Lymphoma2CTD_human;ORPHANET
TgeneC0343640African Burkitt's lymphoma2CTD_human
TgeneC4721444Burkitt Leukemia2CTD_human
TgeneC0001768Agammaglobulinemia1CTD_human;GENOMICS_ENGLAND
TgeneC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneC0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneC0398686Primary immune deficiency disorder1GENOMICS_ENGLAND
TgeneC1832241Agammaglobulinemia, non-Bruton type1ORPHANET
TgeneC1844383Recurrent bacterial infection1GENOMICS_ENGLAND
TgeneC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneC4310786AGAMMAGLOBULINEMIA 8, AUTOSOMAL DOMINANT1GENOMICS_ENGLAND