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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:B3GALNT2-PCNXL2 (FusionGDB2 ID:HG148789TG80003)

Fusion Gene Summary for B3GALNT2-PCNXL2

Fusion gene summary

Fusion gene information	Fusion gene name: B3GALNT2-PCNXL2
	Fusion gene ID: hg148789tg80003
		Hgene	Tgene
	Gene symbol	B3GALNT2	PCNXL2
	Gene ID	148789	80003
	Gene name	beta-1,3-N-acetylgalactosaminyltransferase 2	pecanex 2
	Synonyms	B3GalNAc-T2\|MDDGA11	PCNXL2
	Cytomap	('B3GALNT2')('PCNXL2') 1q42.3	1q42.2
	Type of gene	protein-coding	protein-coding
	Description	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2beta-1,3-GalNAc-T2	pecanex-like protein 2pecanex homolog 2
	Modification date	20200313	20200313
	UniProtAcc	Q8NCR0	.
	Ensembl transtripts involved in fusion gene	ENST00000313984, ENST00000366600, ENST00000494378,
Fusion gene scores	* DoF score	7 X 8 X 7=392	7 X 6 X 5=210
	# samples	8	9
	** MAII score	log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: B3GALNT2 [Title/Abstract] AND PCNXL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	B3GALNT2(235667441)-PCNXL2(233398909), # samples:1
Anticipated loss of major functional domain due to fusion event.	B3GALNT2-PCNXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. B3GALNT2-PCNXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	B3GALNT2	GO:0006493	protein O-linked glycosylation	23929950

Fusion gene breakpoints across B3GALNT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCNXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8210-01A	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-

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Fusion Gene ORF analysis for B3GALNT2-PCNXL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000313984	ENST00000430153	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-5UTR	ENST00000366600	ENST00000430153	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000313984	ENST00000344698	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000313984	ENST00000488780	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000313984	ENST00000520463	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000366600	ENST00000344698	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000366600	ENST00000488780	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5CDS-intron	ENST00000366600	ENST00000520463	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5UTR-3CDS	ENST00000494378	ENST00000258229	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5UTR-5UTR	ENST00000494378	ENST00000430153	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5UTR-intron	ENST00000494378	ENST00000344698	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5UTR-intron	ENST00000494378	ENST00000488780	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
5UTR-intron	ENST00000494378	ENST00000520463	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
In-frame	ENST00000313984	ENST00000258229	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-
In-frame	ENST00000366600	ENST00000258229	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366600	B3GALNT2	chr1	235667441	-	ENST00000258229	PCNXL2	chr1	233398909	-	7471	341	167	6601	2144
ENST00000313984	B3GALNT2	chr1	235667441	-	ENST00000258229	PCNXL2	chr1	233398909	-	7412	282	108	6542	2144

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366600	ENST00000258229	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-	0.002793145	0.99720687
ENST00000313984	ENST00000258229	B3GALNT2	chr1	235667441	-	PCNXL2	chr1	233398909	-	0.00267545	0.99732447

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Fusion Genomic Features for B3GALNT2-PCNXL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for B3GALNT2-PCNXL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:235667441/chr1:233398909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
B3GALNT2 Q8NCR0	.
FUNCTION: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269\|PubMed:14724282, ECO:0000269\|PubMed:23453667, ECO:0000269\|PubMed:23929950}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000313984

1_6

327.0

Topological domain

Cytoplasmic

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000366600

1_6

501.0

Topological domain

Cytoplasmic

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000313984

7_23

327.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000366600

7_23

501.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1937_2063

2138.0

Compositional bias

Note=Ser-rich

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1937_2063

778.0

Compositional bias

Note=Ser-rich

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1937_2063

287.0

Compositional bias

Note=Ser-rich

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1029_1049

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1099_1119

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1124_1144

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1193_1213

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1237_1257

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1265_1285

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1302_1322

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

1324_1344

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

57_77

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

844_864

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

868_888

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

901_921

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

952_972

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

983_1003

2138.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1029_1049

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1099_1119

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1124_1144

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1193_1213

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1237_1257

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1265_1285

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1302_1322

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

1324_1344

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

34_54

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

57_77

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

844_864

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

868_888

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

901_921

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

952_972

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000344698

983_1003

778.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1029_1049

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1099_1119

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1124_1144

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1193_1213

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1237_1257

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1265_1285

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1302_1322

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

1324_1344

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

34_54

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

57_77

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

844_864

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

868_888

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

901_921

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

952_972

287.0

Transmembrane

Helical

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000430153

983_1003

287.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000313984

24_500

327.0

Topological domain

Lumenal

Hgene

B3GALNT2

chr1:235667441

chr1:233398909

ENST00000366600

24_500

501.0

Topological domain

Lumenal

Tgene

PCNXL2

chr1:235667441

chr1:233398909

ENST00000258229

34_54

2138.0

Transmembrane

Helical

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Fusion Gene Sequence for B3GALNT2-PCNXL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8662_8662_1_B3GALNT2-PCNXL2_B3GALNT2_chr1_235667441_ENST00000313984_PCNXL2_chr1_233398909_ENST00000258229_length(transcript)=7412nt_BP=282nt
GGAGGAGCGGGGCCGGGAGCTGCGAGGAGCCCTCCAGACGTCGCCGAGCGCGAGGGCGGGCGTGCTCGGAGTGGTCGCTCGTCAGCCGCC
GCCCCTCAGTCTCCGCACTTGCAGGTCCCCTCCCTCTCCGCCGGGACGCGGGAGAGCCCGGCTCGCGGCGGGGGCGGCCAATGCGAAACT
GGCTGGTGCTGCTGTGCCCGTGTGTGCTCGGGGCCGCGCTGCACCTCTGGCTGCGGCTGCGCTCCCCGCCGCCCGCCTGCGCCTCCGGGG
CCGGCCCTGCAGGCTTTTCCTCCAAATGCGATCATTGTATTTTTCTACTGCAGTGCAGTGACTATATTCTTCACAATAATCAAACTGGTC
AGTTATCGCCTACACCTCATGTTTGACAAAGGAGAAGTAATTCAGCAAAAGCCCTCCAGAAAGGAAGAAAAGCCAAATAAAGACAAGGAG
GCCAAAGGTGAACACATAACTAATCACAGAAATCCAAGCAATAATAGGCAGATTCACAATGGCAAAAAGGAAGAGGCCAGTCGAAACCTC
TCCACGCCTCCCCTCCGCTGCAGCTCCAGAGGGCAAAGCATAACCTCTCATCACTCTTCTGGGCCATTGGAGTTGTCAGCACAGGAAACT
GTAGAAGATCTCAAAGGTGTCATTCTATTAGAAGACCATCCCATAGCACCAGTGTCATCTACCTCACCTGGTATCAAAGTGGAAAGCTTA
CCTGCGTCTCAAGCACACATGCTGGAAACCACGACCAAGTCAGTAATACCTGTAAAACCAGTTGCCACAGAAACTCTCATCAATGGTAAA
GGAAAGGAAAGAGGAGGCAAGGGGCAGCCTCCTTTGCGCCACAGATCCGAGGGTGGCTTAGTGGATAAGGGACCCTTGAAGAAGTTGCCC
CACCTGTCTTTGTCTCAGTATGACTTACTAGAAACAGACGTTTCTTTCCAGCCGTGGGGGAGTGAGAATTCAGTCCTGATTCCAGAACCT
GTCAGTTGTCCCCGGGGCTCCATAAGGGAACGGGTACAAAGCAAGTCACCTCAGGACAGCCTGAGCAGCAGCTGCCCTCAATGTGACACC
ATCGTGGCCAAGCCTGTGGAGGAGCCAGCAGACACATCCTGTCAGGTAGATACCTCCTGCCAGGGGGACCTGCCCTTGCACCAGGAAGTG
GACTCCTCAGATAGTGAGGTAGCTGTTACTCTCATCGATACTTCTCAACCCGGAGACCCACTGAGTCTACATGAGCCCATAAAAATTGTT
ATCACGATGAGCAGTACCCCAAACTCCATGACAGATTTGGAAAGCTCCCTCCACCTGAGGGTGGTTGGCACAGAGAAGACCAGTGTAAAG
TCTGACGCTGAGCCCACTAACCCAGGGGCGGCCGGTTCTCCAAATGCCGAGCAGATCTCAATTCCTGTAATCACCCTGGACCTGCCTGAG
GGTGGGGGAGGAGGTGTTCCCTGTCCCGAAGGCAATGGAAGTGAAAGGACTCCAGAGAGACTGAAGACGAGGGTATCCACCAATCAGTGT
TCTGGCTACGGATCTGGGGAGGGGGGAAATGCCATCAAGGATCACAGTTCTTCATCACGGGAACCCTGGGAATCGGTGTCCCGGCTTACA
CCTGATACAGGCTCCGAGTCTAAGGTGGGGAAGGAAGGCCAGACTAACCTTGACCCATCGTCTTGTAAGTCCAGCCATGAAAAGAGGCAT
GCCCGGGTGCTCAGTGTGGACAGTGGGACAGATGTCTTCTTGAGTAAAAGTTCTGCAGAAATTGTTAACGATACAGAGAAAACAATGCCA
ACTTCCAAATCTGACCTAGAGGCTAAGGAAGGACAAATGCCAAATGAGTCCAACTTCCTGGAATTTGTCTCCCTGTTAGAATCCATTAAT
ACTTCCAAGATGACGGCATCCAGTCAACTGAATGGCTCAGCTGAGCAGAATGAAGAAAGTGGGCTTCTCCGAGATAACTGTTCCCAGGAA
AAAAAGGAGGAAATCCTGGAAAATGAAAAGCCCAGTGGACACAGTTCTAAGCAAGGAAAACCAGATTTGCAAAGTCAAGACCATACTAGC
ACCGGCCCCGCATGCACTCAGCCTGCCAAGACCACAGCCTTTTTTCAGGGCAATAGACAAAGACAGATAATCTACAGGGTAACTTCCCAA
CAAGATAGTTCTGTCTTGCAAGTCATCAGTGGGCCTGAAACATCTGTACAAGAAGAGATATCTGTGGATGCTATGCATGTCTTCATTGAT
GAACATGGGGAAATTAGATCCTGTTATTTAAAATCTGGAAATCAGAAAGAAGGCCCTTTACAGCCTCTACCATCAAATAATGACTGTCTC
TCTCAGGCTCGAGAGATGCAGGTCAGCTCCTCCAGTACCACAACTTCTGAGAGTCAAGATCCGTCTTCTGGGGACCCTGCCGTCAGTGCC
CTTCAGCAACAGCTGTTACTGATGGTGGCTCGCAGGACCCAGTCGGAAACCCCACGGCATGTGAGTCAGGATCTGGAAGCCTCGTCATGT
TCTTCAACACAAGGAAAATTTAACCGAGAGCAGTTTTACAAATTTATCATTTTCCCTGGCAAGTGGATTAAAGTCTGGTATGATCGACTG
ACCTTGCTGGCATTACTTGATCGAACTGAAGACATCAAGGAGAATGTACTGGCGATTTTACTCATTGTCCTGGTTTCCCTCCTTGGATTT
CTGACCTTGAGCCAAGGCTTTTGCAAAGATATGTGGGTGCTCCTCTTCTGCCTCGTCATGGCCAGCTGCCAGTACTCCCTGCTAAAGAGT
GTTCAGCCTGACCCCGCCTCACCAATACACGGACACAACCAAATCATAACATATAGCAGACCAATCTATTTTTGTGTGCTGTGTGGCCTT
ATTTTGCTTCTTGATACAGGGGCCAAAGCCAGGCACCCTCCCAGTTACGTTGTGTATGGCCTGAAGCTCTTCTCTCCAGTGTTTCTACAA
TCAGCTAGGGACTACTTAATAGTATTTTTATATTGCTTCCCTGCTATTTCCCTCCTTGGGCTCTTCCCGCAAATCAACACTTTCTGCACT
TATCTTTTGGAGCAAATTGACATGCTGTTTTTTGGTGGTTCTGCTGTGTCTGGGATAACCTCGGCTGTTTACAGTGTGGCCCGGAGCGTC
TTGGCTGCCGCCCTGCTCCACGCAGTCTGCTTCAGTGCAGTGAAGGAACCGTGGAGCATGCAACACATCCCGGCACTGTTTTCGGCCTTC
TGTGGCCTCTTGGTCGCCCTTTCTTACCATCTGAGCCGTCAGAGCAGTGACCCATCTGTACTCATGTCCTTCATCCAATGCAGGCTGTTT
CCTAAATTTTTACATCAAAATCTGGCAGAGTCAGCTGCTGACCCTCTCCCCAAGAAGATGAAAGATTCAGTGACGGATGTCTTAAAATGG
GATCTCATCGTCTGCGCAGTGGTTGCTGTCCTCTCATTTGCAGTCAGCGCCAGCACTGTATTCCTGTCATTGCGACCATTTCTCAGCATC
GTGCTGTTTGCCTTGGCTGGAGCCGTGGGGTTTGTAACACATTACGTGCTCCCTCAGCTCCGCAAGCATCATCCCTGGATGTGGATTTCA
CACCCCATTCTCAAAAACAAAGAGTATCATCAACGGGAAGTGAGAGATGTTGCCCATTTAATGTGGTTCGAAAGACTCTATGTTTGGCTT
CAGTGTTTTGAAAAATACATCTTGTACCCAGCGCTAATTTTGAATGCCCTCACTATTGATGCATTTTTAATAAGCAATCACCGGAGACTT
GGTACCCACTGGGACATTTTTCTGATGATCATTGCTGGCATGAAGCTGTTGCGGACATCATTCTGCAACCCGGTTTACCAGTTTATTAAC
TTGAGCTTCACTGTCATCTTTTTCCACTTTGACTACAAAGATATTTCAGAGAGCTTCTTACTGGATTTCTTCATGGTGTCCATTTTATTT
AGCAAGCTCGGGGACCTGCTTCACAAGTTACAGTTCGTCCTGACATATGTGGCTCCTTGGCAGATGGCTTGGGGTTCTTCGTTTCACGTG
TTTGCTCAGCTCTTTGCCATTCCTCATTCTGCCATGCTTTTCTTTCAGACGATTGCCACATCAATCTTTTCTACCCCATTGAGCCCATTT
CTTGGGAGTGTCATTTTCATCACATCATATGTCAGGCCAGTGAAATTCTGGGAGAAAAACTACAATACAAGGCGAGTGGATAATTCCAAC
ACAAGACTGGCAGTCCAAATTGAAAGAGATCCAGGGAATGATGACAACAATCTCAATTCCATTTTTTATGAACACTTGACAAGGACCCTC
CAGGAGTCCCTCTGTGGAGACTTAGTTCTTGGACGTTGGGGCAACTACAGCTCTGGCGATTGCTTTATTTTGGCTTCAGATGACCTCAAT
GCCTTTGTTCACCTGATTGAAATTGGAAATGGTCTTGTCACCTTTCAACTTCGAGGACTGGAATTCCGAGGAACCTACTGCCAGCAGAGG
GAGGTAGAAGCCATCATGGAGGGCGACGAGGAGGACAGAGGCTGCTGCTGCTGCAAACCAGGCCACTTGCCTCACCTGCTGTCCTGCAAC
GCTGCCTTTCACCTCCGCTGGCTCACCTGGGAAATCACGCAGACCCAGTACATCCTGGAGGGCTACAGCATCCTGGACAACAACGCGGCC
ACCATGCTGCAGGTGTTTGACCTCCGAAGGATCCTCATCCGCTACTACATCAAGAGTATAATATACTATATGGTAACGTCTCCCAAACTC
CTCTCCTGGATCAAAAATGAATCACTTCTGAAGTCCCTGCAGCCCTTTGCCAAGTGGCATTACATTGAGCGTGACCTTGCAATGTTCAAC
ATTAACATTGATGATGACTACGTCCCGTGTCTCCAGGGGATCACACGAGCTAGCTTCTGCAATGTTTATCTAGAATGGATTCAACACTGT
GCACGGAAAAGACAAGAGCCTTCAACGACCCTGGACAGTGACGAGGACTCTCCCTTGGTGACTCTGTCCTTCGCCCTGTGCACCCTGGGG
AGGAGAGCTCTGGGAACAGCCGCTCACAATATGGCCATCAGCCTGGATTCTTTCCTGTATGGCCTCCATGTCCTCTTCAAAGGTGACTTC
AGAATAACAGCACGTGACGAGTGGGTATTTGCTGACATGGACCTACTGCATAAAGTTGTAGCTCCAGCTATCAGGATGTCCCTGAAACTT
CACCAGGACCAGTTCACTTGCCCTGACGAGTATGAAGACCCAGCAGTCCTCTACGAGGCCATCCAGTCCTTCGAGAAGAAGGTGGTCATC
TGCCACGAGGGCGACCCGGCCTGGCGGGGCGCAGTGCTGTCCAACAAGGAAGAGCTGCTCACCCTGCGGCACGTGGTGGACGAGGGTGCC
GACGAGTACAAGGTCATCATGCTCCACAGAAGCTTCCTGAGCTTCAAGGTGATCAAGGTTAACAAAGAATGCGTCCGAGGACTTTGGGCC
GGGCAGCAGCAGGAGCTTATATTTCTTCGCAACCGCAATCCGGAGCGCGGCAGTATCCAGAACAATAAGCAGGTCCTGCGGAACTTGATT
AACTCCTCCTGCGATCAGCCCCTGGGGTACCCCATGTATGTCTCCCCACTAACCACATCCTACCTAGGGACACACAGGCAGCTGAAGAAC
ATCTGGGGTGGACCCATCACTTTGGACAGAATTAGGACCTGGTTCTGGACCAAGTGGGTAAGGATGCGGAAGGATTGCAATGCCCGCCAG
CACAGTGGCGGCAACATTGAAGACGTGGACGGAGGAGGGGCCCCGACGACAGGTGGCAACAATGCCCCGAGTGGTGGCAGCCAGGAGAGC
AGCGCAGAACAGCCCAGAAAAGGCGGTGCTCAGCACGGGGTGTCATCCTGTGAAGGGACACAGAGAACAGGCAGGAGGAAAGGCAGGAGC
CAGTCCGTGCAGGCACACTCAGCGCTAAGCCAAAGGCCGCCCATGCTGAGCTCATCTGGCCCCATCTTAGAGAGCCGCCAAACATTCCTC
CAGACGTCCACCTCAGTGCACGAGCTGGCCCAGAGGCTCTCGGGCAGCCGGCTCTCCTTGCACGCCTCGGCCACGTCCCTGCACTCTCAG
CCCCCGCCCGTCACCACCACCGGCCACCTGAGTGTCCGTGAGCGGGCCGAGGCGCTCATCAGGTCCAGCCTGGGCTCCTCCACCAGCTCC
ACCCTGAGCTTCCTCTTCGGCAAGAGGAGCTTTTCCAGCGCGCTCGTCATTTCCGGACTCTCTGCTGCGGAGGGGGGCAATACCAGTGAC
ACCCAGTCATCCAGCAGCGTCAACATCGTGATGGGCCCCTCAGCCAGGGCTGCCAGCCAGGCCACTCGGCACCTCTCCGAGCCATGTGAG
CCCCCTGATGCCACCGAGCAGGGGCAGCTTCATGACCGATGTCTGGCTGAGGCTGTGGCGGACACTCTCGGGGTTGTCTGCAGGAGAGCA
AGCCAGGAGGACATGGGCCTGGACGACACGGCCTCGCAGCAAAGTGTGTCAGACGAGCAGTGACGGGCGTGCGGCCGGGCGGGGAGGCTG
GCTCCCCCACACCTCCCACCTGCATTGCTCTCCCTCGTGCTCCCCAAATCACCACAACCAACCAATACCGCGATCCATGAGGGACTCCTC
CTGTGGAAAAGGAGAGCTGTTCCAGAACACAGAACTGATCTCAGGTTTTTGAAAAAAAAAAAAAAAAAAAAAAAAAAATCAAACAACAAC
AACAAAAAAACCTCACATGATGGGGAAACAAAAAAAAGCAACAAAGAAGCCACACCACACCTCCCTGGCCAGGCACAGCGCTGCCCAGAG
CGGCACACCGCGGACAGCACCACACATGTTCCAGAATCTGAAATCTCAAAAGCCATTCACTAACTTAAAACAACTCAACAGAGCCATGAA
ACAAATGCCCTGATGAAAATAAGACAACTGCATGTTACATCATCGGCACTTTATACATTACTGTTACCATGAAAAAGAAATGAACAGCAG
CACGTCTGATACCATCAGCTGGGCAGATGCATTAAGGTTAAATCTAAGTGTCAAGAAAACCCTATTTCTTTATAATATTTATGCAGCTGT
TAAGCGTAACATGGTGGCAGCTTCACAACAAGAACCGTGATCATGCATGCAGTCATGTCTCCAGTATTCTGTGAAAAGCCAGGATACGTT
AGGATGTGAGTTTAGAAACTGAGTCCATTCGGTGCATGGAAATCCACCGCGGAGTCACACAATGCTCCTCACTGTAGTCCAGGCGATTGG
TGGGCCGCCAGCACCCTGCGGGCTTCACAGGGACGCGTGCTTGTTCTCCAAGCCCCGCAACCCTTACTGTGCACACAACATCGCACACAC

>8662_8662_1_B3GALNT2-PCNXL2_B3GALNT2_chr1_235667441_ENST00000313984_PCNXL2_chr1_233398909_ENST00000258229_length(amino acids)=2144AA_BP=44
MQVPSLSAGTRESPARGGGGQCETGWCCCARVCSGPRCTSGCGCAPRRPPAPPGPALQAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHL
MFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKG
VILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQ
YDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSE
VAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGV
PCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSV
DSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEIL
ENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIR
SCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGK
FNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPA
SPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQI
DMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQ
NLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKN
KEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVI
FFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIF
ITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLI
EIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVF
DLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQE
PSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFT
CPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQEL
IFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNI
EDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSV
HELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSS

--------------------------------------------------------------
>8662_8662_2_B3GALNT2-PCNXL2_B3GALNT2_chr1_235667441_ENST00000366600_PCNXL2_chr1_233398909_ENST00000258229_length(transcript)=7471nt_BP=341nt
AGGCGGAGGGGGCGGGGCTTCGGCCGGCTAAGCCGCGGCCACCCGCGGTCTGAGGGACCGGAGGAGCGGGGCCGGGAGCTGCGAGGAGCC
CTCCAGACGTCGCCGAGCGCGAGGGCGGGCGTGCTCGGAGTGGTCGCTCGTCAGCCGCCGCCCCTCAGTCTCCGCACTTGCAGGTCCCCT
CCCTCTCCGCCGGGACGCGGGAGAGCCCGGCTCGCGGCGGGGGCGGCCAATGCGAAACTGGCTGGTGCTGCTGTGCCCGTGTGTGCTCGG
GGCCGCGCTGCACCTCTGGCTGCGGCTGCGCTCCCCGCCGCCCGCCTGCGCCTCCGGGGCCGGCCCTGCAGGCTTTTCCTCCAAATGCGA
TCATTGTATTTTTCTACTGCAGTGCAGTGACTATATTCTTCACAATAATCAAACTGGTCAGTTATCGCCTACACCTCATGTTTGACAAAG
GAGAAGTAATTCAGCAAAAGCCCTCCAGAAAGGAAGAAAAGCCAAATAAAGACAAGGAGGCCAAAGGTGAACACATAACTAATCACAGAA
ATCCAAGCAATAATAGGCAGATTCACAATGGCAAAAAGGAAGAGGCCAGTCGAAACCTCTCCACGCCTCCCCTCCGCTGCAGCTCCAGAG
GGCAAAGCATAACCTCTCATCACTCTTCTGGGCCATTGGAGTTGTCAGCACAGGAAACTGTAGAAGATCTCAAAGGTGTCATTCTATTAG
AAGACCATCCCATAGCACCAGTGTCATCTACCTCACCTGGTATCAAAGTGGAAAGCTTACCTGCGTCTCAAGCACACATGCTGGAAACCA
CGACCAAGTCAGTAATACCTGTAAAACCAGTTGCCACAGAAACTCTCATCAATGGTAAAGGAAAGGAAAGAGGAGGCAAGGGGCAGCCTC
CTTTGCGCCACAGATCCGAGGGTGGCTTAGTGGATAAGGGACCCTTGAAGAAGTTGCCCCACCTGTCTTTGTCTCAGTATGACTTACTAG
AAACAGACGTTTCTTTCCAGCCGTGGGGGAGTGAGAATTCAGTCCTGATTCCAGAACCTGTCAGTTGTCCCCGGGGCTCCATAAGGGAAC
GGGTACAAAGCAAGTCACCTCAGGACAGCCTGAGCAGCAGCTGCCCTCAATGTGACACCATCGTGGCCAAGCCTGTGGAGGAGCCAGCAG
ACACATCCTGTCAGGTAGATACCTCCTGCCAGGGGGACCTGCCCTTGCACCAGGAAGTGGACTCCTCAGATAGTGAGGTAGCTGTTACTC
TCATCGATACTTCTCAACCCGGAGACCCACTGAGTCTACATGAGCCCATAAAAATTGTTATCACGATGAGCAGTACCCCAAACTCCATGA
CAGATTTGGAAAGCTCCCTCCACCTGAGGGTGGTTGGCACAGAGAAGACCAGTGTAAAGTCTGACGCTGAGCCCACTAACCCAGGGGCGG
CCGGTTCTCCAAATGCCGAGCAGATCTCAATTCCTGTAATCACCCTGGACCTGCCTGAGGGTGGGGGAGGAGGTGTTCCCTGTCCCGAAG
GCAATGGAAGTGAAAGGACTCCAGAGAGACTGAAGACGAGGGTATCCACCAATCAGTGTTCTGGCTACGGATCTGGGGAGGGGGGAAATG
CCATCAAGGATCACAGTTCTTCATCACGGGAACCCTGGGAATCGGTGTCCCGGCTTACACCTGATACAGGCTCCGAGTCTAAGGTGGGGA
AGGAAGGCCAGACTAACCTTGACCCATCGTCTTGTAAGTCCAGCCATGAAAAGAGGCATGCCCGGGTGCTCAGTGTGGACAGTGGGACAG
ATGTCTTCTTGAGTAAAAGTTCTGCAGAAATTGTTAACGATACAGAGAAAACAATGCCAACTTCCAAATCTGACCTAGAGGCTAAGGAAG
GACAAATGCCAAATGAGTCCAACTTCCTGGAATTTGTCTCCCTGTTAGAATCCATTAATACTTCCAAGATGACGGCATCCAGTCAACTGA
ATGGCTCAGCTGAGCAGAATGAAGAAAGTGGGCTTCTCCGAGATAACTGTTCCCAGGAAAAAAAGGAGGAAATCCTGGAAAATGAAAAGC
CCAGTGGACACAGTTCTAAGCAAGGAAAACCAGATTTGCAAAGTCAAGACCATACTAGCACCGGCCCCGCATGCACTCAGCCTGCCAAGA
CCACAGCCTTTTTTCAGGGCAATAGACAAAGACAGATAATCTACAGGGTAACTTCCCAACAAGATAGTTCTGTCTTGCAAGTCATCAGTG
GGCCTGAAACATCTGTACAAGAAGAGATATCTGTGGATGCTATGCATGTCTTCATTGATGAACATGGGGAAATTAGATCCTGTTATTTAA
AATCTGGAAATCAGAAAGAAGGCCCTTTACAGCCTCTACCATCAAATAATGACTGTCTCTCTCAGGCTCGAGAGATGCAGGTCAGCTCCT
CCAGTACCACAACTTCTGAGAGTCAAGATCCGTCTTCTGGGGACCCTGCCGTCAGTGCCCTTCAGCAACAGCTGTTACTGATGGTGGCTC
GCAGGACCCAGTCGGAAACCCCACGGCATGTGAGTCAGGATCTGGAAGCCTCGTCATGTTCTTCAACACAAGGAAAATTTAACCGAGAGC
AGTTTTACAAATTTATCATTTTCCCTGGCAAGTGGATTAAAGTCTGGTATGATCGACTGACCTTGCTGGCATTACTTGATCGAACTGAAG
ACATCAAGGAGAATGTACTGGCGATTTTACTCATTGTCCTGGTTTCCCTCCTTGGATTTCTGACCTTGAGCCAAGGCTTTTGCAAAGATA
TGTGGGTGCTCCTCTTCTGCCTCGTCATGGCCAGCTGCCAGTACTCCCTGCTAAAGAGTGTTCAGCCTGACCCCGCCTCACCAATACACG
GACACAACCAAATCATAACATATAGCAGACCAATCTATTTTTGTGTGCTGTGTGGCCTTATTTTGCTTCTTGATACAGGGGCCAAAGCCA
GGCACCCTCCCAGTTACGTTGTGTATGGCCTGAAGCTCTTCTCTCCAGTGTTTCTACAATCAGCTAGGGACTACTTAATAGTATTTTTAT
ATTGCTTCCCTGCTATTTCCCTCCTTGGGCTCTTCCCGCAAATCAACACTTTCTGCACTTATCTTTTGGAGCAAATTGACATGCTGTTTT
TTGGTGGTTCTGCTGTGTCTGGGATAACCTCGGCTGTTTACAGTGTGGCCCGGAGCGTCTTGGCTGCCGCCCTGCTCCACGCAGTCTGCT
TCAGTGCAGTGAAGGAACCGTGGAGCATGCAACACATCCCGGCACTGTTTTCGGCCTTCTGTGGCCTCTTGGTCGCCCTTTCTTACCATC
TGAGCCGTCAGAGCAGTGACCCATCTGTACTCATGTCCTTCATCCAATGCAGGCTGTTTCCTAAATTTTTACATCAAAATCTGGCAGAGT
CAGCTGCTGACCCTCTCCCCAAGAAGATGAAAGATTCAGTGACGGATGTCTTAAAATGGGATCTCATCGTCTGCGCAGTGGTTGCTGTCC
TCTCATTTGCAGTCAGCGCCAGCACTGTATTCCTGTCATTGCGACCATTTCTCAGCATCGTGCTGTTTGCCTTGGCTGGAGCCGTGGGGT
TTGTAACACATTACGTGCTCCCTCAGCTCCGCAAGCATCATCCCTGGATGTGGATTTCACACCCCATTCTCAAAAACAAAGAGTATCATC
AACGGGAAGTGAGAGATGTTGCCCATTTAATGTGGTTCGAAAGACTCTATGTTTGGCTTCAGTGTTTTGAAAAATACATCTTGTACCCAG
CGCTAATTTTGAATGCCCTCACTATTGATGCATTTTTAATAAGCAATCACCGGAGACTTGGTACCCACTGGGACATTTTTCTGATGATCA
TTGCTGGCATGAAGCTGTTGCGGACATCATTCTGCAACCCGGTTTACCAGTTTATTAACTTGAGCTTCACTGTCATCTTTTTCCACTTTG
ACTACAAAGATATTTCAGAGAGCTTCTTACTGGATTTCTTCATGGTGTCCATTTTATTTAGCAAGCTCGGGGACCTGCTTCACAAGTTAC
AGTTCGTCCTGACATATGTGGCTCCTTGGCAGATGGCTTGGGGTTCTTCGTTTCACGTGTTTGCTCAGCTCTTTGCCATTCCTCATTCTG
CCATGCTTTTCTTTCAGACGATTGCCACATCAATCTTTTCTACCCCATTGAGCCCATTTCTTGGGAGTGTCATTTTCATCACATCATATG
TCAGGCCAGTGAAATTCTGGGAGAAAAACTACAATACAAGGCGAGTGGATAATTCCAACACAAGACTGGCAGTCCAAATTGAAAGAGATC
CAGGGAATGATGACAACAATCTCAATTCCATTTTTTATGAACACTTGACAAGGACCCTCCAGGAGTCCCTCTGTGGAGACTTAGTTCTTG
GACGTTGGGGCAACTACAGCTCTGGCGATTGCTTTATTTTGGCTTCAGATGACCTCAATGCCTTTGTTCACCTGATTGAAATTGGAAATG
GTCTTGTCACCTTTCAACTTCGAGGACTGGAATTCCGAGGAACCTACTGCCAGCAGAGGGAGGTAGAAGCCATCATGGAGGGCGACGAGG
AGGACAGAGGCTGCTGCTGCTGCAAACCAGGCCACTTGCCTCACCTGCTGTCCTGCAACGCTGCCTTTCACCTCCGCTGGCTCACCTGGG
AAATCACGCAGACCCAGTACATCCTGGAGGGCTACAGCATCCTGGACAACAACGCGGCCACCATGCTGCAGGTGTTTGACCTCCGAAGGA
TCCTCATCCGCTACTACATCAAGAGTATAATATACTATATGGTAACGTCTCCCAAACTCCTCTCCTGGATCAAAAATGAATCACTTCTGA
AGTCCCTGCAGCCCTTTGCCAAGTGGCATTACATTGAGCGTGACCTTGCAATGTTCAACATTAACATTGATGATGACTACGTCCCGTGTC
TCCAGGGGATCACACGAGCTAGCTTCTGCAATGTTTATCTAGAATGGATTCAACACTGTGCACGGAAAAGACAAGAGCCTTCAACGACCC
TGGACAGTGACGAGGACTCTCCCTTGGTGACTCTGTCCTTCGCCCTGTGCACCCTGGGGAGGAGAGCTCTGGGAACAGCCGCTCACAATA
TGGCCATCAGCCTGGATTCTTTCCTGTATGGCCTCCATGTCCTCTTCAAAGGTGACTTCAGAATAACAGCACGTGACGAGTGGGTATTTG
CTGACATGGACCTACTGCATAAAGTTGTAGCTCCAGCTATCAGGATGTCCCTGAAACTTCACCAGGACCAGTTCACTTGCCCTGACGAGT
ATGAAGACCCAGCAGTCCTCTACGAGGCCATCCAGTCCTTCGAGAAGAAGGTGGTCATCTGCCACGAGGGCGACCCGGCCTGGCGGGGCG
CAGTGCTGTCCAACAAGGAAGAGCTGCTCACCCTGCGGCACGTGGTGGACGAGGGTGCCGACGAGTACAAGGTCATCATGCTCCACAGAA
GCTTCCTGAGCTTCAAGGTGATCAAGGTTAACAAAGAATGCGTCCGAGGACTTTGGGCCGGGCAGCAGCAGGAGCTTATATTTCTTCGCA
ACCGCAATCCGGAGCGCGGCAGTATCCAGAACAATAAGCAGGTCCTGCGGAACTTGATTAACTCCTCCTGCGATCAGCCCCTGGGGTACC
CCATGTATGTCTCCCCACTAACCACATCCTACCTAGGGACACACAGGCAGCTGAAGAACATCTGGGGTGGACCCATCACTTTGGACAGAA
TTAGGACCTGGTTCTGGACCAAGTGGGTAAGGATGCGGAAGGATTGCAATGCCCGCCAGCACAGTGGCGGCAACATTGAAGACGTGGACG
GAGGAGGGGCCCCGACGACAGGTGGCAACAATGCCCCGAGTGGTGGCAGCCAGGAGAGCAGCGCAGAACAGCCCAGAAAAGGCGGTGCTC
AGCACGGGGTGTCATCCTGTGAAGGGACACAGAGAACAGGCAGGAGGAAAGGCAGGAGCCAGTCCGTGCAGGCACACTCAGCGCTAAGCC
AAAGGCCGCCCATGCTGAGCTCATCTGGCCCCATCTTAGAGAGCCGCCAAACATTCCTCCAGACGTCCACCTCAGTGCACGAGCTGGCCC
AGAGGCTCTCGGGCAGCCGGCTCTCCTTGCACGCCTCGGCCACGTCCCTGCACTCTCAGCCCCCGCCCGTCACCACCACCGGCCACCTGA
GTGTCCGTGAGCGGGCCGAGGCGCTCATCAGGTCCAGCCTGGGCTCCTCCACCAGCTCCACCCTGAGCTTCCTCTTCGGCAAGAGGAGCT
TTTCCAGCGCGCTCGTCATTTCCGGACTCTCTGCTGCGGAGGGGGGCAATACCAGTGACACCCAGTCATCCAGCAGCGTCAACATCGTGA
TGGGCCCCTCAGCCAGGGCTGCCAGCCAGGCCACTCGGCACCTCTCCGAGCCATGTGAGCCCCCTGATGCCACCGAGCAGGGGCAGCTTC
ATGACCGATGTCTGGCTGAGGCTGTGGCGGACACTCTCGGGGTTGTCTGCAGGAGAGCAAGCCAGGAGGACATGGGCCTGGACGACACGG
CCTCGCAGCAAAGTGTGTCAGACGAGCAGTGACGGGCGTGCGGCCGGGCGGGGAGGCTGGCTCCCCCACACCTCCCACCTGCATTGCTCT
CCCTCGTGCTCCCCAAATCACCACAACCAACCAATACCGCGATCCATGAGGGACTCCTCCTGTGGAAAAGGAGAGCTGTTCCAGAACACA
GAACTGATCTCAGGTTTTTGAAAAAAAAAAAAAAAAAAAAAAAAAAATCAAACAACAACAACAAAAAAACCTCACATGATGGGGAAACAA
AAAAAAGCAACAAAGAAGCCACACCACACCTCCCTGGCCAGGCACAGCGCTGCCCAGAGCGGCACACCGCGGACAGCACCACACATGTTC
CAGAATCTGAAATCTCAAAAGCCATTCACTAACTTAAAACAACTCAACAGAGCCATGAAACAAATGCCCTGATGAAAATAAGACAACTGC
ATGTTACATCATCGGCACTTTATACATTACTGTTACCATGAAAAAGAAATGAACAGCAGCACGTCTGATACCATCAGCTGGGCAGATGCA
TTAAGGTTAAATCTAAGTGTCAAGAAAACCCTATTTCTTTATAATATTTATGCAGCTGTTAAGCGTAACATGGTGGCAGCTTCACAACAA
GAACCGTGATCATGCATGCAGTCATGTCTCCAGTATTCTGTGAAAAGCCAGGATACGTTAGGATGTGAGTTTAGAAACTGAGTCCATTCG
GTGCATGGAAATCCACCGCGGAGTCACACAATGCTCCTCACTGTAGTCCAGGCGATTGGTGGGCCGCCAGCACCCTGCGGGCTTCACAGG
GACGCGTGCTTGTTCTCCAAGCCCCGCAACCCTTACTGTGCACACAACATCGCACACACCTTTGTTTTTGAAATTAAAATGTTTATAGTT

>8662_8662_2_B3GALNT2-PCNXL2_B3GALNT2_chr1_235667441_ENST00000366600_PCNXL2_chr1_233398909_ENST00000258229_length(amino acids)=2144AA_BP=44
MQVPSLSAGTRESPARGGGGQCETGWCCCARVCSGPRCTSGCGCAPRRPPAPPGPALQAFPPNAIIVFFYCSAVTIFFTIIKLVSYRLHL
MFDKGEVIQQKPSRKEEKPNKDKEAKGEHITNHRNPSNNRQIHNGKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSAQETVEDLKG
VILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGKERGGKGQPPLRHRSEGGLVDKGPLKKLPHLSLSQ
YDLLETDVSFQPWGSENSVLIPEPVSCPRGSIRERVQSKSPQDSLSSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSE
VAVTLIDTSQPGDPLSLHEPIKIVITMSSTPNSMTDLESSLHLRVVGTEKTSVKSDAEPTNPGAAGSPNAEQISIPVITLDLPEGGGGGV
PCPEGNGSERTPERLKTRVSTNQCSGYGSGEGGNAIKDHSSSSREPWESVSRLTPDTGSESKVGKEGQTNLDPSSCKSSHEKRHARVLSV
DSGTDVFLSKSSAEIVNDTEKTMPTSKSDLEAKEGQMPNESNFLEFVSLLESINTSKMTASSQLNGSAEQNEESGLLRDNCSQEKKEEIL
ENEKPSGHSSKQGKPDLQSQDHTSTGPACTQPAKTTAFFQGNRQRQIIYRVTSQQDSSVLQVISGPETSVQEEISVDAMHVFIDEHGEIR
SCYLKSGNQKEGPLQPLPSNNDCLSQAREMQVSSSSTTTSESQDPSSGDPAVSALQQQLLLMVARRTQSETPRHVSQDLEASSCSSTQGK
FNREQFYKFIIFPGKWIKVWYDRLTLLALLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPA
SPIHGHNQIITYSRPIYFCVLCGLILLLDTGAKARHPPSYVVYGLKLFSPVFLQSARDYLIVFLYCFPAISLLGLFPQINTFCTYLLEQI
DMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCFSAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQ
NLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKN
KEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVI
FFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIF
ITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLI
EIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVF
DLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQE
PSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFT
CPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQEL
IFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNI
EDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSV
HELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSS

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Fusion Gene PPI Analysis for B3GALNT2-PCNXL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for B3GALNT2-PCNXL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for B3GALNT2-PCNXL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	B3GALNT2	C0265221	Walker-Warburg congenital muscular dystrophy	1	CTD_human;ORPHANET
Hgene	B3GALNT2	C0457133	Muscle eye brain disease	1	CTD_human;ORPHANET
Hgene	B3GALNT2	C3554638	MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 11	1	GENOMICS_ENGLAND;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:B3GALNT2-PCNXL2 (FusionGDB2 ID:HG148789TG80003)

Fusion Gene Summary for B3GALNT2-PCNXL2

Fusion Gene ORF analysis for B3GALNT2-PCNXL2

Fusion Genomic Features for B3GALNT2-PCNXL2

Fusion Protein Features for B3GALNT2-PCNXL2

Fusion Gene Sequence for B3GALNT2-PCNXL2

Fusion Gene PPI Analysis for B3GALNT2-PCNXL2

Related Drugs for B3GALNT2-PCNXL2

Related Diseases for B3GALNT2-PCNXL2

Fusion Gene Studies
in Kim Lab