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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNNA1-AP3B1 (FusionGDB2 ID:HG1495TG8546)

Fusion Gene Summary for CTNNA1-AP3B1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNA1-AP3B1
Fusion gene ID: hg1495tg8546
HgeneTgene
Gene symbol

CTNNA1

AP3B1

Gene ID

1495

8546

Gene namecatenin alpha 1adaptor related protein complex 3 subunit beta 1
SynonymsCAP102|MDPT2ADTB3|ADTB3A|HPS|HPS2|PE
Cytomap('CTNNA1')('AP3B1')

5q31.2

5q14.1

Type of geneprotein-codingprotein-coding
Descriptioncatenin alpha-1alpha-E-catenincatenin (cadherin-associated protein), alpha 1, 102kDaepididymis secretory sperm binding proteinrenal carcinoma antigen NY-REN-13AP-3 complex subunit beta-1AP-3 complex beta-3A subunitadaptor protein complex AP-3 subunit beta-1adaptor related protein complex 3 beta 1 subunitbeta-3A-adaptinclathrin assembly protein complex 3 beta-1 large chain
Modification date2020031320200313
UniProtAcc

P35221

.
Ensembl transtripts involved in fusion geneENST00000520400, ENST00000302763, 
ENST00000355078, ENST00000518825, 
ENST00000540387, 
Fusion gene scores* DoF score25 X 19 X 12=570011 X 11 X 6=726
# samples 3412
** MAII scorelog2(34/5700*10)=-4.06735526780176
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/726*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNNA1 [Title/Abstract] AND AP3B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNNA1(138223331)-AP3B1(77477486), # samples:1
Anticipated loss of major functional domain due to fusion event.CTNNA1-AP3B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNNA1-AP3B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNNA1-AP3B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNNA1-AP3B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNA1

GO:0071681

cellular response to indole-3-methanol

10868478


check buttonFusion gene breakpoints across CTNNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AP3B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-BI-A0VR-01ACTNNA1chr5

138223331

+AP3B1chr5

77477486

-


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Fusion Gene ORF analysis for CTNNA1-AP3B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000520400ENST00000255194CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
3UTR-3CDSENST00000520400ENST00000519295CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
3UTR-intronENST00000520400ENST00000523204CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
5CDS-intronENST00000302763ENST00000523204CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
5CDS-intronENST00000355078ENST00000523204CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
5CDS-intronENST00000518825ENST00000523204CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
5CDS-intronENST00000540387ENST00000523204CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000302763ENST00000255194CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000302763ENST00000519295CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000355078ENST00000255194CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000355078ENST00000519295CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000518825ENST00000255194CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000518825ENST00000519295CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000540387ENST00000255194CTNNA1chr5

138223331

+AP3B1chr5

77477486

-
In-frameENST00000540387ENST00000519295CTNNA1chr5

138223331

+AP3B1chr5

77477486

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355078CTNNA1chr5138223331+ENST00000255194AP3B1chr577477486-6068119220236901162
ENST00000355078CTNNA1chr5138223331+ENST00000519295AP3B1chr577477486-4267119220236901162
ENST00000302763CTNNA1chr5138223331+ENST00000255194AP3B1chr577477486-626213869038841264
ENST00000302763CTNNA1chr5138223331+ENST00000519295AP3B1chr577477486-446113869038841264
ENST00000518825CTNNA1chr5138223331+ENST00000255194AP3B1chr577477486-61741298237961264
ENST00000518825CTNNA1chr5138223331+ENST00000519295AP3B1chr577477486-43731298237961264
ENST00000540387CTNNA1chr5138223331+ENST00000255194AP3B1chr577477486-51963201342818894
ENST00000540387CTNNA1chr5138223331+ENST00000519295AP3B1chr577477486-33953201342818894

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355078ENST00000255194CTNNA1chr5138223331+AP3B1chr577477486-0.0001954390.99980456
ENST00000355078ENST00000519295CTNNA1chr5138223331+AP3B1chr577477486-0.0008192090.99918073
ENST00000302763ENST00000255194CTNNA1chr5138223331+AP3B1chr577477486-0.0001704210.99982953
ENST00000302763ENST00000519295CTNNA1chr5138223331+AP3B1chr577477486-0.0007022830.99929774
ENST00000518825ENST00000255194CTNNA1chr5138223331+AP3B1chr577477486-0.0001482570.9998517
ENST00000518825ENST00000519295CTNNA1chr5138223331+AP3B1chr577477486-0.0005990660.999401
ENST00000540387ENST00000255194CTNNA1chr5138223331+AP3B1chr577477486-0.0002356080.9997644
ENST00000540387ENST00000519295CTNNA1chr5138223331+AP3B1chr577477486-0.0008762430.99912375

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Fusion Genomic Features for CTNNA1-AP3B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CTNNA1-AP3B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:138223331/chr5:77477486)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNNA1

P35221

.
FUNCTION: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000302763+9182_228432907.0RegionNote=Involved in homodimerization
TgeneAP3B1chr5:138223331chr5:77477486ENST00000255194627677_8022621095.0Compositional biasNote=Glu/Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000540387+3122_22862537.0RegionNote=Involved in homodimerization


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Fusion Gene Sequence for CTNNA1-AP3B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20249_20249_1_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000302763_AP3B1_chr5_77477486_ENST00000255194_length(transcript)=6262nt_BP=1386nt
TCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAGAA
ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG
CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT
TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT
GTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAG
CGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTA
CTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTA
AAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCT
AGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAAC
AGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCAC
CAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGC
TTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGT
GAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAAGA
AGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACGTT
TCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATGCC
CAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAG
AAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGC
AGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTG
CGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCT
TATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCC
AACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGA
TGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAA
AGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATC
ACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAG
ATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAG
ACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTT
ATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCT
TTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCA
GAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGAAT
TCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGT
GGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGACGG
GAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAA
AAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAAGT
GAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGAT
CTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTACAC
TTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAA
GGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTACT
GATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTGAG
CCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATTGC
TTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGCTA
ACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAGCC
AATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTG
GAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTGTC
CTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATTTA
TAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATCAT
GTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCGTT
TTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATTGG
AAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACATA
CTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTCAT
CATGAAATTATCTCTCAATAATAAGATAAATAAACTAGCATATGAATCATATTTGTCTTTGCATTTTTAATGAGAAACTATTAATAATCC
TGAAGTTCATATGCTAAAGTTTTCTTATTTTAAAGCAAGTATTTTGAGTGTTACATTATGCAGAGAAGCAATGTGGTTTAGTTAGCGAAA
GAAAAACCACTTCCAAACCAAGTAAATTTTCTACTTATAGTTTACTCCAAGGAAAAAAAATTGGTGTATTTAATAACAAAAACAAAAATC
TTCATATTGCAAAATAAACATCTTCTAGGTAGTTTTGATCTATTAGTAGATATCTGATTATGTGGCCTGCTGAATAAATTCTTTGAATCT
CATTTTTCCTTATGCCCAACTTTGGAAACTAACTAGCATAAACTTATAGAAATGTTTAAAACTAGTTATATGATCAACCTATTAGCATCT
TTTCCTAGAGTATTTGTTTTATTTGCTACCTTAAGTTACTGTTTTCAAGGTTGTTCTATAATCAGAGAACTTTTCTAATACTTTCGTACC
TTTTTAAAACCAGCTGAAATTTTACTTCCTTTTTGAAGCAAGGTAATGGACTTTCAGGTAGTATAAGCTACTCAGTTCTTTTTGTATAGA
GCCACATACATAATGATTTTTAAAAAGTAAAAAGGAAGTGACTGTACATTGCTTGAAGCATTATAGGAAGGCTGAAAAGAAAAGAATGGA
ATTTTCTTGGAACATACATATTGAAAAGAACAAAACAGAGTCGAAAAATTATTTAAATTTTCAAGCTGGTGGGATGACAAGAGTAAACAA
AATTGTTAAATTTTCCTGCTCCAGAAAGAAATATAGCCCTGAATCTCCGGGAAGAGAATGTACAGAAGTGCAATGTACAGAAGCCACGTG
TACATTTTGTGCCAATTCCGTACCATGTGTACATTCTGTACCATTCTGTACCAATGTATGGAAGCCACGAGTTCCACTTCCCTCTGGAGC
CTGGGCGCTGTGGTAACACACCCAAAAGCCCCTTTGTAATCGCAGGTCGTTGGCATTTCCATATTAGCCTTATTGCTCAGAGCTTCATAA
CTTTGAATTTTAAGTCAATAACTTTTTGAAATGTCAGACAGAATTTGACAGGTTTAATACCTGTTTTCTGAGGAAGAAAAAAAAATTATA
TCCATGCTGTCTTCAGGCAGAGGGAAAGTGCATGTTGTGATTGAGAAAGGTCTTATTTTTCCTTAAATTAGGACACTCATCTTTAAAAGA
TAGTTCACACATTTGTATTTTTTTAAACTAAGGAAATTTAATTAGGGCTTTACTTTTGACTAAGTTATTTTTGGCTGCTAACTTTTAAAA
TTATGGTAAATCAATAATATAATGTAGTATGAATCAGTGAACAGTATGTATCGATTGTAATGTGCGCTACCAGTTGAAACCATTTTAACA
CTAGTAGCTTAATATCATTAAAATGTTTTTCACGTAAAACAGAAAAACGACCAAAGCCCCAAGTTAAAGGTTTGGTTTTTTTTCTTTTGT
GGTGTGGTGATTCAGAGTTCCTTGCCTCATATTTCCTTTAACTTTGTCATAATCCATGATTATCTTTAAATTGTTCCATTGAGTCGAGTT
AGTCAATGTTGAATTCTTAATTCTAGCTATATTTTTTCATTTTAATGTTCACTTAATGGGACATTTTATGTACACCAATCTTGAAGAATG
GCTCTCATAGTATATTTCAGACTAAGCCTCATTTTTGATATCACAATACATTTGCTTTATTTATTATGAGAGTTTTTTTATTCTAAAGAG

>20249_20249_1_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000302763_AP3B1_chr5_77477486_ENST00000255194_length(amino acids)=1264AA_BP=432
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER
SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQ
KEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEP
YLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAE
SVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQ
TKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWP
EVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGR
ESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLD
LDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTT
DRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVL
TGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPV

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>20249_20249_2_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000302763_AP3B1_chr5_77477486_ENST00000519295_length(transcript)=4461nt_BP=1386nt
TCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAGAA
ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG
CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT
TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT
GTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAG
CGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTA
CTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTA
AAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCT
AGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAAC
AGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCAC
CAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGC
TTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGT
GAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAAGA
AGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACGTT
TCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATGCC
CAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAG
AAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGC
AGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTG
CGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCT
TATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCC
AACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGA
TGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAA
AGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATC
ACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAG
ATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAG
ACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTT
ATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCT
TTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCA
GAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGAAT
TCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGT
GGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGACGG
GAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAA
AAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAAGT
GAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGAT
CTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTACAC
TTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAA
GGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTACT
GATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTGAG
CCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATTGC
TTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGCTA
ACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAGCC
AATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTG
GAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTGTC
CTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATTTA
TAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATCAT
GTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCGTT
TTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATTGG
AAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACATA
CTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTCAT

>20249_20249_2_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000302763_AP3B1_chr5_77477486_ENST00000519295_length(amino acids)=1264AA_BP=432
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER
SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQ
KEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEP
YLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAE
SVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQ
TKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWP
EVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGR
ESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLD
LDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTT
DRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVL
TGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPV

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>20249_20249_3_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000355078_AP3B1_chr5_77477486_ENST00000255194_length(transcript)=6068nt_BP=1192nt
TTTCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAG
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAGCGAGGCAACATGGT
TCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTACTTGTTCAGCTGAA
AGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTAAAACCTGAAGTGGA
TAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCTAGAGGAATCCTGCA
GAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAACAGGGACCTGATATA
CAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCACCAGGGTGGAGGAGG
AGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGCTTTAGGCCTTCCCT
GGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGTGAGCGAATTGTGGC
AGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAAGAAGTGATGCACTCAA
TTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACGTTTCAGATTCTTTCCT
GGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATGCCCAAGTTTTCCGTGA
ACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGA
CAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGT
GGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAG
CAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTT
CTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCT
TCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACAT
CTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTAT
AAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGC
TAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTT
CACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTAC
CCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGT
AAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGA
TCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGA
CCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTT
TTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGTGGAGAACAAGGCGA
AAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGA
AAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAAAAATCTAAAACTTC
AGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAG
AAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGATCTGGATGATTTTAA
CCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTC
TTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAAGGACTAGCTGCCCA
TTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTACTGATCGAAAGATAGA
AAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTGAGCCTGAGGGATCCAT
TACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATTGCTTCAATGTTAATAT
TCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGCTAACAGGAATGAATGA
AACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAGCCAATGTAGGTGCAGT
CCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTGGAACTGAAGGAAGG
CTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTGTCCTGTCTCAGGGGTA
ACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATTTATAATAATAGCCCTT
CCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATCATGTATGCAATACTTT
CCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCGTTTTCTCTGTCCTGCT
GCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATTGGAAATCTTCTTCCCT
ACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACATACTTTTTAAATCCAA
ATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTCATCATGAAATTATCTC
TCAATAATAAGATAAATAAACTAGCATATGAATCATATTTGTCTTTGCATTTTTAATGAGAAACTATTAATAATCCTGAAGTTCATATGC
TAAAGTTTTCTTATTTTAAAGCAAGTATTTTGAGTGTTACATTATGCAGAGAAGCAATGTGGTTTAGTTAGCGAAAGAAAAACCACTTCC
AAACCAAGTAAATTTTCTACTTATAGTTTACTCCAAGGAAAAAAAATTGGTGTATTTAATAACAAAAACAAAAATCTTCATATTGCAAAA
TAAACATCTTCTAGGTAGTTTTGATCTATTAGTAGATATCTGATTATGTGGCCTGCTGAATAAATTCTTTGAATCTCATTTTTCCTTATG
CCCAACTTTGGAAACTAACTAGCATAAACTTATAGAAATGTTTAAAACTAGTTATATGATCAACCTATTAGCATCTTTTCCTAGAGTATT
TGTTTTATTTGCTACCTTAAGTTACTGTTTTCAAGGTTGTTCTATAATCAGAGAACTTTTCTAATACTTTCGTACCTTTTTAAAACCAGC
TGAAATTTTACTTCCTTTTTGAAGCAAGGTAATGGACTTTCAGGTAGTATAAGCTACTCAGTTCTTTTTGTATAGAGCCACATACATAAT
GATTTTTAAAAAGTAAAAAGGAAGTGACTGTACATTGCTTGAAGCATTATAGGAAGGCTGAAAAGAAAAGAATGGAATTTTCTTGGAACA
TACATATTGAAAAGAACAAAACAGAGTCGAAAAATTATTTAAATTTTCAAGCTGGTGGGATGACAAGAGTAAACAAAATTGTTAAATTTT
CCTGCTCCAGAAAGAAATATAGCCCTGAATCTCCGGGAAGAGAATGTACAGAAGTGCAATGTACAGAAGCCACGTGTACATTTTGTGCCA
ATTCCGTACCATGTGTACATTCTGTACCATTCTGTACCAATGTATGGAAGCCACGAGTTCCACTTCCCTCTGGAGCCTGGGCGCTGTGGT
AACACACCCAAAAGCCCCTTTGTAATCGCAGGTCGTTGGCATTTCCATATTAGCCTTATTGCTCAGAGCTTCATAACTTTGAATTTTAAG
TCAATAACTTTTTGAAATGTCAGACAGAATTTGACAGGTTTAATACCTGTTTTCTGAGGAAGAAAAAAAAATTATATCCATGCTGTCTTC
AGGCAGAGGGAAAGTGCATGTTGTGATTGAGAAAGGTCTTATTTTTCCTTAAATTAGGACACTCATCTTTAAAAGATAGTTCACACATTT
GTATTTTTTTAAACTAAGGAAATTTAATTAGGGCTTTACTTTTGACTAAGTTATTTTTGGCTGCTAACTTTTAAAATTATGGTAAATCAA
TAATATAATGTAGTATGAATCAGTGAACAGTATGTATCGATTGTAATGTGCGCTACCAGTTGAAACCATTTTAACACTAGTAGCTTAATA
TCATTAAAATGTTTTTCACGTAAAACAGAAAAACGACCAAAGCCCCAAGTTAAAGGTTTGGTTTTTTTTCTTTTGTGGTGTGGTGATTCA
GAGTTCCTTGCCTCATATTTCCTTTAACTTTGTCATAATCCATGATTATCTTTAAATTGTTCCATTGAGTCGAGTTAGTCAATGTTGAAT
TCTTAATTCTAGCTATATTTTTTCATTTTAATGTTCACTTAATGGGACATTTTATGTACACCAATCTTGAAGAATGGCTCTCATAGTATA
TTTCAGACTAAGCCTCATTTTTGATATCACAATACATTTGCTTTATTTATTATGAGAGTTTTTTTATTCTAAAGAGACTGTAACAATGCA

>20249_20249_3_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000355078_AP3B1_chr5_77477486_ENST00000255194_length(amino acids)=1162AA_BP=330
MMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAA
KRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYAL
NNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMT
KKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQKEKTDKKKKPYT
MDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDP
TMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQ
PAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLG
KYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVE
VIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKR
NSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVA
LPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEK
KLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIA

--------------------------------------------------------------
>20249_20249_4_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000355078_AP3B1_chr5_77477486_ENST00000519295_length(transcript)=4267nt_BP=1192nt
TTTCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAG
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGAAGCGAGGCAACATGGT
TCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAATTACTTGTTCAGCTGAA
AGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCCTAAAACCTGAAGTGGA
TAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAGCTAGAGGAATCCTGCA
GAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCAACAGGGACCTGATATA
CAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGCACCAGGGTGGAGGAGG
AGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGCGCTTTAGGCCTTCCCT
GGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTCGTGAGCGAATTGTGGC
AGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAAGAAGTGATGCACTCAA
TTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACGTTTCAGATTCTTTCCT
GGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATGCCCAAGTTTTCCGTGA
ACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATCAGAAGGAAAAGACTGA
CAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGAGCAGGAATGCTGCGGT
GGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAGTGCGTTTACTTCGTAG
CAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAACCTTATCTGAAGAGTTT
CTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAGCCAACATATCAACTCT
TCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCAGATGTGCAACCAACAT
CTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTGAAAGTGTGGTTGTTAT
AAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTATCACTGTTCCTGTTGC
TAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGAAGATGGCTAAAAGCTT
CACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAACAGACAAAATTGCTTAC
CCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGCTTATTGTTCCGAATGT
AAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTCCTTTTAAAGATAGAGA
TCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGCCAGAGGTGGCGCCCGA
CCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGAATTCTGCTAAGAAGTT
TTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAAGTGGAGAACAAGGCGA
AAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGACGGGAGTCAGGCCTAGA
AAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATGAAAAATCTAAAACTTC
AGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAAGTGAATCTGAATCCAG
AAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAGATCTGGATGATTTTAA
CCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTACACTTGTCAACTTCCTC
TTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAAAAGGACTAGCTGCCCA
TTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTACTGATCGAAAGATAGA
AAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTGAGCCTGAGGGATCCAT
TACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATTGCTTCAATGTTAATAT
TCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGCTAACAGGAATGAATGA
AACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAGCCAATGTAGGTGCAGT
CCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAGTGGAACTGAAGGAAGG
CTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTGTCCTGTCTCAGGGGTA
ACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATTTATAATAATAGCCCTT
CCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATCATGTATGCAATACTTT
CCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCGTTTTCTCTGTCCTGCT
GCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATTGGAAATCTTCTTCCCT
ACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACATACTTTTTAAATCCAA
ATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTCATCATGAAATTATCTC

>20249_20249_4_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000355078_AP3B1_chr5_77477486_ENST00000519295_length(amino acids)=1162AA_BP=330
MMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAA
KRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYAL
NNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMT
KKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQKEKTDKKKKPYT
MDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDP
TMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQ
PAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLG
KYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVE
VIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKR
NSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVA
LPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEK
KLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIA

--------------------------------------------------------------
>20249_20249_5_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000518825_AP3B1_chr5_77477486_ENST00000255194_length(transcript)=6174nt_BP=1298nt
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATG
TTTTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGC
TTGTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGA
AGCGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAAT
TACTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCC
TAAAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAG
CTAGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCA
ACAGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGC
ACCAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGC
GCTTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTC
GTGAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAA
GAAGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACG
TTTCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATG
CCCAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATC
AGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGA
GCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAG
TGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAAC
CTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAG
CCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCA
GATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTG
AAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTA
TCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGA
AGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAAC
AGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGC
TTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTC
CTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGC
CAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGA
ATTCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAA
GTGGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGAC
GGGAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATG
AAAAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAA
GTGAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAG
ATCTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTAC
ACTTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAA
AAGGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTA
CTGATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTG
AGCCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATT
GCTTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGC
TAACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAG
CCAATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAG
TGGAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTG
TCCTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATT
TATAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATC
ATGTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCG
TTTTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATT
GGAAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACA
TACTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTC
ATCATGAAATTATCTCTCAATAATAAGATAAATAAACTAGCATATGAATCATATTTGTCTTTGCATTTTTAATGAGAAACTATTAATAAT
CCTGAAGTTCATATGCTAAAGTTTTCTTATTTTAAAGCAAGTATTTTGAGTGTTACATTATGCAGAGAAGCAATGTGGTTTAGTTAGCGA
AAGAAAAACCACTTCCAAACCAAGTAAATTTTCTACTTATAGTTTACTCCAAGGAAAAAAAATTGGTGTATTTAATAACAAAAACAAAAA
TCTTCATATTGCAAAATAAACATCTTCTAGGTAGTTTTGATCTATTAGTAGATATCTGATTATGTGGCCTGCTGAATAAATTCTTTGAAT
CTCATTTTTCCTTATGCCCAACTTTGGAAACTAACTAGCATAAACTTATAGAAATGTTTAAAACTAGTTATATGATCAACCTATTAGCAT
CTTTTCCTAGAGTATTTGTTTTATTTGCTACCTTAAGTTACTGTTTTCAAGGTTGTTCTATAATCAGAGAACTTTTCTAATACTTTCGTA
CCTTTTTAAAACCAGCTGAAATTTTACTTCCTTTTTGAAGCAAGGTAATGGACTTTCAGGTAGTATAAGCTACTCAGTTCTTTTTGTATA
GAGCCACATACATAATGATTTTTAAAAAGTAAAAAGGAAGTGACTGTACATTGCTTGAAGCATTATAGGAAGGCTGAAAAGAAAAGAATG
GAATTTTCTTGGAACATACATATTGAAAAGAACAAAACAGAGTCGAAAAATTATTTAAATTTTCAAGCTGGTGGGATGACAAGAGTAAAC
AAAATTGTTAAATTTTCCTGCTCCAGAAAGAAATATAGCCCTGAATCTCCGGGAAGAGAATGTACAGAAGTGCAATGTACAGAAGCCACG
TGTACATTTTGTGCCAATTCCGTACCATGTGTACATTCTGTACCATTCTGTACCAATGTATGGAAGCCACGAGTTCCACTTCCCTCTGGA
GCCTGGGCGCTGTGGTAACACACCCAAAAGCCCCTTTGTAATCGCAGGTCGTTGGCATTTCCATATTAGCCTTATTGCTCAGAGCTTCAT
AACTTTGAATTTTAAGTCAATAACTTTTTGAAATGTCAGACAGAATTTGACAGGTTTAATACCTGTTTTCTGAGGAAGAAAAAAAAATTA
TATCCATGCTGTCTTCAGGCAGAGGGAAAGTGCATGTTGTGATTGAGAAAGGTCTTATTTTTCCTTAAATTAGGACACTCATCTTTAAAA
GATAGTTCACACATTTGTATTTTTTTAAACTAAGGAAATTTAATTAGGGCTTTACTTTTGACTAAGTTATTTTTGGCTGCTAACTTTTAA
AATTATGGTAAATCAATAATATAATGTAGTATGAATCAGTGAACAGTATGTATCGATTGTAATGTGCGCTACCAGTTGAAACCATTTTAA
CACTAGTAGCTTAATATCATTAAAATGTTTTTCACGTAAAACAGAAAAACGACCAAAGCCCCAAGTTAAAGGTTTGGTTTTTTTTCTTTT
GTGGTGTGGTGATTCAGAGTTCCTTGCCTCATATTTCCTTTAACTTTGTCATAATCCATGATTATCTTTAAATTGTTCCATTGAGTCGAG
TTAGTCAATGTTGAATTCTTAATTCTAGCTATATTTTTTCATTTTAATGTTCACTTAATGGGACATTTTATGTACACCAATCTTGAAGAA
TGGCTCTCATAGTATATTTCAGACTAAGCCTCATTTTTGATATCACAATACATTTGCTTTATTTATTATGAGAGTTTTTTTATTCTAAAG

>20249_20249_5_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000518825_AP3B1_chr5_77477486_ENST00000255194_length(amino acids)=1264AA_BP=432
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER
SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQ
KEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEP
YLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAE
SVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQ
TKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWP
EVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGR
ESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLD
LDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTT
DRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVL
TGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPV

--------------------------------------------------------------
>20249_20249_6_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000518825_AP3B1_chr5_77477486_ENST00000519295_length(transcript)=4373nt_BP=1298nt
AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG
AGCCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATG
TTTTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGC
TTGTGGCTGCTGTAGAAGATGTTCGAAAACAAGGTGATTTGATGAAGGCTGCTGCAGGAGAGTTCGCAGATGATCCCTGCTCTTCTGTGA
AGCGAGGCAACATGGTTCGGGCAGCTCGAGCTTTGCTCTCTGCTGTTACCCGGTTGCTGATTTTGGCTGACATGGCAGATGTCTACAAAT
TACTTGTTCAGCTGAAAGTTGTGGAAGATGGTATCTTGAAGTTGAGGAATGCTGGCAATGAACAAGACTTAGGAATCCAGTATAAAGCCC
TAAAACCTGAAGTGGATAAGCTGAACATTATGGCAGCCAAAAGACAACAGGAATTGAAAGATGTTGGCCATCGTGATCAGATGGCTGCAG
CTAGAGGAATCCTGCAGAAGAACGTTCCGATCCTCTATACTGCATCCCAGGCATGCCTACAGCACCCTGATGTCGCAGCCTATAAGGCCA
ACAGGGACCTGATATACAAGCAGCTGCAGCAGGCGGTCACAGGCATTTCCAATGCAGCCCAGGCCACTGCCTCAGACGATGCCTCACAGC
ACCAGGGTGGAGGAGGAGGAGAACTGGCATATGCACTCAATAACTTTGACAAACAAATCATTGTGGACCCCTTGAGCTTCAGCGAGGAGC
GCTTTAGGCCTTCCCTGGAGGAGCGTCTGGAAAGCATCATTAGTGGGGCTGCCTTGATGGCCGACTCGTCCTGCACGCGTGATGACCGTC
GTGAGCGAATTGTGGCAGAGTGTAATGCTGTCCGCCAGGCCCTGCAGGACCTGCTTTCGGAGTACATGGGCAATGCTGGACGTAAAGAAA
GAAGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTGTCATGGACCACG
TTTCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAGTTAAGGAGTATG
CCCAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAATCTGATGATGATC
AGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGCCTTTGCTTCAGA
GCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTTCTAAATCACTAG
TGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGGGGATGTTTGAAC
CTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACTTGGCAAATGAAG
CCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTCAGACTATAGGCA
GATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAATAGTTGTTGCTG
AAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAACTCCTGGACAGTA
TCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTGATGTTTTGAGGA
AGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAACCAACTCCAAAC
AGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGATTTATTAGGCAGC
TTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCACTGCTTGAGTCTC
CTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAATTATCTAATTGGC
CAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAGCAAAGCAAGAGA
ATTCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAATCTGGAAGTGAAA
GTGGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACAGTGAGAGTGGAC
GGGAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGGAGAAGGAAAATG
AAAAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGTCAGAACCTGAAA
GTGAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATGTTTCACTTCTAG
ATCTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATCTTGAAGGTTTAC
ACTTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATCGAATGAGTGGAA
AAGGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACACTGAATAACACTA
CTGATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAATAGACTCTCTTG
AGCCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTACCAAGGATGATT
GCTTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAGAGCAAGGAGTGC
TAACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGGTTGTAAATGTAG
CCAATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGATGCTAGTCACAG
TGGAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGGAACTGAAGCCTG
TCCTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTGCTGCCTTTCATT
TATAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAGTGTGTATCTATC
ATGTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGAATCCATGTGGCG
TTTTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATATTTAAAGTTCATT
GGAAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAAAATGAGATCACA
TACTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTATTGATAACTGTC

>20249_20249_6_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000518825_AP3B1_chr5_77477486_ENST00000519295_length(amino acids)=1264AA_BP=432
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL
VAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL
KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQH
QGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER
SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQ
KEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEP
YLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAE
SVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQ
TKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWP
EVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGR
ESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLD
LDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTT
DRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVL
TGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPV

--------------------------------------------------------------
>20249_20249_7_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000540387_AP3B1_chr5_77477486_ENST00000255194_length(transcript)=5196nt_BP=320nt
CTGCCGATTCTGCATAGAGAGATCATCTAAATGGGCAGAAGCCTGCACAATTTATGAAGTGCTGATTTAACACCAGCCTATGCAAGGCTG
GACGTAAAGAAAGAAGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTG
TCATGGACCACGTTTCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAG
TTAAGGAGTATGCCCAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAAT
CTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGC
CTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTT
CTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGG
GGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACT
TGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTC
AGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAA
TAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAAC
TCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTG
ATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAA
CCAACTCCAAACAGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGAT
TTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCAC
TGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAAT
TATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAG
CAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAAT
CTGGAAGTGAAAGTGGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACA
GTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGG
AGAAGGAAAATGAAAAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGT
CAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATG
TTTCACTTCTAGATCTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATC
TTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATC
GAATGAGTGGAAAAGGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACAC
TGAATAACACTACTGATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAA
TAGACTCTCTTGAGCCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTA
CCAAGGATGATTGCTTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAG
AGCAAGGAGTGCTAACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGG
TTGTAAATGTAGCCAATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGA
TGCTAGTCACAGTGGAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGG
AACTGAAGCCTGTCCTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTG
CTGCCTTTCATTTATAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAG
TGTGTATCTATCATGTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGA
ATCCATGTGGCGTTTTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATAT
TTAAAGTTCATTGGAAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAA
AATGAGATCACATACTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTA
TTGATAACTGTCATCATGAAATTATCTCTCAATAATAAGATAAATAAACTAGCATATGAATCATATTTGTCTTTGCATTTTTAATGAGAA
ACTATTAATAATCCTGAAGTTCATATGCTAAAGTTTTCTTATTTTAAAGCAAGTATTTTGAGTGTTACATTATGCAGAGAAGCAATGTGG
TTTAGTTAGCGAAAGAAAAACCACTTCCAAACCAAGTAAATTTTCTACTTATAGTTTACTCCAAGGAAAAAAAATTGGTGTATTTAATAA
CAAAAACAAAAATCTTCATATTGCAAAATAAACATCTTCTAGGTAGTTTTGATCTATTAGTAGATATCTGATTATGTGGCCTGCTGAATA
AATTCTTTGAATCTCATTTTTCCTTATGCCCAACTTTGGAAACTAACTAGCATAAACTTATAGAAATGTTTAAAACTAGTTATATGATCA
ACCTATTAGCATCTTTTCCTAGAGTATTTGTTTTATTTGCTACCTTAAGTTACTGTTTTCAAGGTTGTTCTATAATCAGAGAACTTTTCT
AATACTTTCGTACCTTTTTAAAACCAGCTGAAATTTTACTTCCTTTTTGAAGCAAGGTAATGGACTTTCAGGTAGTATAAGCTACTCAGT
TCTTTTTGTATAGAGCCACATACATAATGATTTTTAAAAAGTAAAAAGGAAGTGACTGTACATTGCTTGAAGCATTATAGGAAGGCTGAA
AAGAAAAGAATGGAATTTTCTTGGAACATACATATTGAAAAGAACAAAACAGAGTCGAAAAATTATTTAAATTTTCAAGCTGGTGGGATG
ACAAGAGTAAACAAAATTGTTAAATTTTCCTGCTCCAGAAAGAAATATAGCCCTGAATCTCCGGGAAGAGAATGTACAGAAGTGCAATGT
ACAGAAGCCACGTGTACATTTTGTGCCAATTCCGTACCATGTGTACATTCTGTACCATTCTGTACCAATGTATGGAAGCCACGAGTTCCA
CTTCCCTCTGGAGCCTGGGCGCTGTGGTAACACACCCAAAAGCCCCTTTGTAATCGCAGGTCGTTGGCATTTCCATATTAGCCTTATTGC
TCAGAGCTTCATAACTTTGAATTTTAAGTCAATAACTTTTTGAAATGTCAGACAGAATTTGACAGGTTTAATACCTGTTTTCTGAGGAAG
AAAAAAAAATTATATCCATGCTGTCTTCAGGCAGAGGGAAAGTGCATGTTGTGATTGAGAAAGGTCTTATTTTTCCTTAAATTAGGACAC
TCATCTTTAAAAGATAGTTCACACATTTGTATTTTTTTAAACTAAGGAAATTTAATTAGGGCTTTACTTTTGACTAAGTTATTTTTGGCT
GCTAACTTTTAAAATTATGGTAAATCAATAATATAATGTAGTATGAATCAGTGAACAGTATGTATCGATTGTAATGTGCGCTACCAGTTG
AAACCATTTTAACACTAGTAGCTTAATATCATTAAAATGTTTTTCACGTAAAACAGAAAAACGACCAAAGCCCCAAGTTAAAGGTTTGGT
TTTTTTTCTTTTGTGGTGTGGTGATTCAGAGTTCCTTGCCTCATATTTCCTTTAACTTTGTCATAATCCATGATTATCTTTAAATTGTTC
CATTGAGTCGAGTTAGTCAATGTTGAATTCTTAATTCTAGCTATATTTTTTCATTTTAATGTTCACTTAATGGGACATTTTATGTACACC
AATCTTGAAGAATGGCTCTCATAGTATATTTCAGACTAAGCCTCATTTTTGATATCACAATACATTTGCTTTATTTATTATGAGAGTTTT

>20249_20249_7_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000540387_AP3B1_chr5_77477486_ENST00000255194_length(amino acids)=894AA_BP=62
MTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQKEKTDKKKKP
YTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRST
DPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQ
MQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILN
LGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRN
VEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTA
KRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTP
VALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIG
EKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVI

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>20249_20249_8_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000540387_AP3B1_chr5_77477486_ENST00000519295_length(transcript)=3395nt_BP=320nt
CTGCCGATTCTGCATAGAGAGATCATCTAAATGGGCAGAAGCCTGCACAATTTATGAAGTGCTGATTTAACACCAGCCTATGCAAGGCTG
GACGTAAAGAAAGAAGTGATGCACTCAATTCTGCAATAGATAAAATGACCAAGAAGACCAGGGACTTGCGTAGACAGCTCCGCAAAGCTG
TCATGGACCACGTTTCAGATTCTTTCCTGGAAACCAATGTTCCACTTTTGGTATTGATTGAAGCTGCAAAGAATGGAAATGAGAAAGAAG
TTAAGGAGTATGCCCAAGTTTTCCGTGAACATGCCAACAAATTGATTGAGGGTGATGAATTAGAAGACAATGGAAAGAATTTCTACGAAT
CTGATGATGATCAGAAGGAAAAGACTGACAAAAAGAAGAAGCCGTATACTATGGATCCAGATCATAGACTCTTAATTAGAAATACAAAGC
CTTTGCTTCAGAGCAGGAATGCTGCGGTGGTTATGGCAGTTGCTCAGCTGTATTGGCACATATCACCAAAATCTGAAGCTGGCATAATTT
CTAAATCACTAGTGCGTTTACTTCGTAGCAATAGGGAGGTGCAGTATATTGTCCTACAAAATATAGCAACTATGTCAATTCAAAGAAAGG
GGATGTTTGAACCTTATCTGAAGAGTTTCTATGTTAGGTCAACTGATCCAACTATGATCAAGACACTGAAGCTTGAAATTTTGACAAACT
TGGCAAATGAAGCCAACATATCAACTCTTCTTCGAGAATTTCAGACCTATGTGAAAAGCCAGGATAAACAATTTGCAGCAGCCACTATTC
AGACTATAGGCAGATGTGCAACCAACATCTTGGAAGTCACTGACACGTGCCTCAATGGCTTGGTCTGTCTGCTGTCCAACAGGGATGAAA
TAGTTGTTGCTGAAAGTGTGGTTGTTATAAAGAAATTACTGCAAATGCAACCTGCACAACATGGTGAAATTATTAAACATATGGCCAAAC
TCCTGGACAGTATCACTGTTCCTGTTGCTAGAGCAAGTATTCTTTGGCTAATTGGAGAAAACTGTGAACGAGTTCCTAAAATTGCCCCTG
ATGTTTTGAGGAAGATGGCTAAAAGCTTCACTAGTGAAGATGATCTGGTAAAACTGCAGATATTAAATCTGGGAGCAAAATTGTATTTAA
CCAACTCCAAACAGACAAAATTGCTTACCCAGTACATATTAAATCTCGGCAAGTATGATCAAAACTACGACATCAGAGACCGTACAAGAT
TTATTAGGCAGCTTATTGTTCCGAATGTAAAGAGTGGAGCTTTAAGTAAATATGCCAAAAAAATATTCCTAGCACAAAAGCCTGCACCAC
TGCTTGAGTCTCCTTTTAAAGATAGAGATCATTTCCAGCTTGGCACCTTATCTCATACTCTCAACATTAAAGCTACTGGGTACCTGGAAT
TATCTAATTGGCCAGAGGTGGCGCCCGACCCATCAGTTCGAAATGTAGAAGTAATAGAGTTGGCAAAAGAATGGACCCCAGCAGGAAAAG
CAAAGCAAGAGAATTCTGCTAAGAAGTTTTATTCTGAATCTGAGGAAGAGGAGGACTCTTCTGATAGTAGCAGTGACAGTGAGAGTGAAT
CTGGAAGTGAAAGTGGAGAACAAGGCGAAAGTGGGGAGGAAGGAGACAGCAATGAGGACAGCAGTGAGGACTCCTCCAGTGAGCAGGACA
GTGAGAGTGGACGGGAGTCAGGCCTAGAAAACAAAAGAACAGCCAAGAGGAACTCAAAAGCCAAAGGAAAAAGTGATTCTGAAGATGGGG
AGAAGGAAAATGAAAAATCTAAAACTTCAGATTCTTCAAATGACGAATCTAGTTCAATAGAAGACAGTTCTTCCGATTCTGAATCAGAGT
CAGAACCTGAAAGTGAATCTGAATCCAGAAGAGTCACTAAGGAGAAAGAAAAGAAAACAAAGCAAGATAGAACTCCTCTTACCAAAGATG
TTTCACTTCTAGATCTGGATGATTTTAACCCAGTATCCACTCCAGTTGCACTTCCCACACCAGCTCTTTCTCCAAGTTTGATGGCTGATC
TTGAAGGTTTACACTTGTCAACTTCCTCTTCAGTCATCAGTGTCAGTACTCCTGCATTTGTACCAACGAAAACTCACGTGCTGCTTCATC
GAATGAGTGGAAAAGGACTAGCTGCCCATTATTTCTTTCCAAGACAGCCTTGCATTTTTGGTGATAAGATGGTCTCTATACAAATAACAC
TGAATAACACTACTGATCGAAAGATAGAAAATATCCACATAGGGGAAAAAAAACTTCCTATAGGCATGAAAATGCATGTTTTTAATCCAA
TAGACTCTCTTGAGCCTGAGGGATCCATTACAGTTTCAATGGGTATTGACTTTTGTGATTCTACTCAGACTGCCAGTTTCCAGTTGTGTA
CCAAGGATGATTGCTTCAATGTTAATATTCAGCCACCTGTTGGAGAACTGCTTTTACCTGTGGCCATGTCAGAGAAAGATTTTAAGAAAG
AGCAAGGAGTGCTAACAGGAATGAATGAAACTTCTGCTGTAATCATTGCTGCACCACAGAATTTCACTCCCTCTGTGATCTTTCAGAAGG
TTGTAAATGTAGCCAATGTAGGTGCAGTCCCTTCTGGCCAGGATAATATACACAGGTTTGCAGCTAAAACTGTGCACAGTGGGTCATTGA
TGCTAGTCACAGTGGAACTGAAGGAAGGCTCTACAGCCCAGCTTATCATAAACACTGAGAAAACTGTGATTGGCTCTGTTCTGCTGCGGG
AACTGAAGCCTGTCCTGTCTCAGGGGTAACCTGCTTACATCTGGACTTTAGAATCTGGCACACAACAAAAGTGCCTGGCATCCACTACTG
CTGCCTTTCATTTATAATAATAGCCCTTCCATCTGGCAGTGGGGGTAGAATACACTCTTGACATTCTTGTCTCCTGCTTTAGAATGCTAG
TGTGTATCTATCATGTATGCAATACTTTCCCCCTTTTTGCTTTGCTAACCAAAGAGCATATATTTTACTGTCAGTTGTCTCAACTCTTGA
ATCCATGTGGCGTTTTCTCTGTCCTGCTGCTTCTTTTGGCCTCCTCGTTTTCCTTCTCTTTTTCGACAATGGTAGACATGAATGAGATAT
TTAAAGTTCATTGGAAATCTTCTTCCCTACAGCAGTAAGCAAAAATTAGCAAAGAGATAGTCTAAATGGCCTCTCAGCTTGGTATGTGAA
AATGAGATCACATACTTTTTAAATCCAAATACAAAAGCATAGTCTCTGCAAGATTTTGTTCTTTGAATTTCTTGATATTGTAATTGATTA

>20249_20249_8_CTNNA1-AP3B1_CTNNA1_chr5_138223331_ENST00000540387_AP3B1_chr5_77477486_ENST00000519295_length(amino acids)=894AA_BP=62
MTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEGDELEDNGKNFYESDDDQKEKTDKKKKP
YTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRST
DPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQ
MQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILN
LGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRN
VEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTA
KRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTP
VALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIG
EKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVI

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Fusion Gene PPI Analysis for CTNNA1-AP3B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000302763+918325_394432.0907.0alpha-actinin
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000302763+91897_148432.0907.0JUP and CTNNB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000540387+312325_39462.0537.0alpha-actinin
HgeneCTNNA1chr5:138223331chr5:77477486ENST00000540387+31297_14862.0537.0JUP and CTNNB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNNA1-AP3B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNNA1-AP3B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNNA1C1708349Hereditary Diffuse Gastric Cancer3ORPHANET
HgeneCTNNA1C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCTNNA1C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneCTNNA1C0238198Gastrointestinal Stromal Tumors1CTD_human
HgeneCTNNA1C1837029Macular Dystrophy, Butterfly-Shaped Pigmentary, 21CTD_human;UNIPROT
HgeneCTNNA1C1868569Patterned dystrophy of retinal pigment epithelium1CTD_human
HgeneCTNNA1C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneCTNNA1C2713368Hematopoetic Myelodysplasia1CTD_human
HgeneCTNNA1C3179349Gastrointestinal Stromal Sarcoma1CTD_human
HgeneCTNNA1C3463824MYELODYSPLASTIC SYNDROME1CTD_human
HgeneCTNNA1C4511237Butterfly-shaped pigmentary macular dystrophy1ORPHANET
TgeneC1842362HERMANSKY-PUDLAK SYNDROME 26CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0024115Lung diseases1GENOMICS_ENGLAND
TgeneC0034069Pulmonary Fibrosis1GENOMICS_ENGLAND
TgeneC0079504Hermanski-Pudlak Syndrome1GENOMICS_ENGLAND