Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CTNND1-TMBIM6 (FusionGDB2 ID:HG1500TG7009)

Fusion Gene Summary for CTNND1-TMBIM6

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1-TMBIM6
Fusion gene ID: hg1500tg7009
HgeneTgene
Gene symbol

CTNND1

TMBIM6

Gene ID

1500

7009

Gene namecatenin delta 1transmembrane BAX inhibitor motif containing 6
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)BAXI1|BI-1|TEGT
Cytomap('CTNND1')('TMBIM6')

11q12.1

12q13.12

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninbax inhibitor 1testis enhanced gene transcripttestis-enhanced gene transcript proteintransmembrane BAX inhibitor motif-containing protein 6
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358694, ENST00000360682, 
ENST00000361332, ENST00000361391, 
ENST00000361796, ENST00000399050, 
ENST00000415361, ENST00000426142, 
ENST00000428599, ENST00000525902, 
ENST00000526357, ENST00000526772, 
ENST00000526938, ENST00000527467, 
ENST00000528232, ENST00000528621, 
ENST00000529526, ENST00000529873, 
ENST00000529986, ENST00000530094, 
ENST00000530748, ENST00000531014, 
ENST00000532245, ENST00000532463, 
ENST00000532649, ENST00000532787, 
ENST00000532844, ENST00000533667, 
ENST00000534579, ENST00000399039, 
ENST00000524630, ENST00000529919, 
Fusion gene scores* DoF score29 X 18 X 15=783018 X 17 X 6=1836
# samples 3522
** MAII scorelog2(35/7830*10)=-4.48358548034607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(22/1836*10)=-3.06099062988915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND TMBIM6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND1(57529518)-TMBIM6(50146246), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNND1

GO:0099072

regulation of postsynaptic membrane neurotransmitter receptor levels

18602475

TgeneTMBIM6

GO:0010523

negative regulation of calcium ion transport into cytosol

26582200

TgeneTMBIM6

GO:0032091

negative regulation of protein binding

19328063

TgeneTMBIM6

GO:0033119

negative regulation of RNA splicing

19328063

TgeneTMBIM6

GO:0034620

cellular response to unfolded protein

19328063

TgeneTMBIM6

GO:0060702

negative regulation of endoribonuclease activity

19328063

TgeneTMBIM6

GO:1902065

response to L-glutamate

21075086

TgeneTMBIM6

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

21075086

TgeneTMBIM6

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

21075086

TgeneTMBIM6

GO:2001234

negative regulation of apoptotic signaling pathway

21075086



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YCCTNND1chr11

57529518

+TMBIM6chr12

50146246

+


Top

Fusion Gene ORF analysis for CTNND1-TMBIM6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000358694ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000358694ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000358694ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000358694ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000360682ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000360682ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000360682ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000360682ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361332ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361332ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361332ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361332ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361391ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361391ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361391ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361391ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361796ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361796ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361796ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000361796ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000399050ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000399050ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000399050ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000399050ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000415361ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000415361ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000415361ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000415361ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000426142ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000426142ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000426142ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000426142ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000428599ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000428599ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000428599ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000428599ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000525902ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000525902ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000525902ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000525902ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526357ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526357ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526357ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526357ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526772ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526772ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526772ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526772ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526938ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526938ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526938ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000526938ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000527467ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000527467ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000527467ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000527467ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528232ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528232ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528232ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528232ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528621ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528621ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528621ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000528621ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529526ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529526ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529526ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529526ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529873ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529873ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529873ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529873ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529986ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529986ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529986ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000529986ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530094ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530094ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530094ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530094ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530748ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530748ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530748ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000530748ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000531014ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000531014ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000531014ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000531014ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532245ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532245ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532245ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532245ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532463ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532463ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532463ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532463ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532649ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532649ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532649ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532649ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532787ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532787ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532787ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532787ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532844ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532844ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532844ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000532844ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000533667ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000533667ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000533667ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000533667ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000534579ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000534579ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000534579ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-5UTRENST00000534579ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000358694ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000358694ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000358694ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000360682ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000360682ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000360682ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361332ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361332ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361332ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361391ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361391ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361391ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361796ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361796ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000361796ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000399050ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000399050ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000399050ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000415361ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000415361ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000415361ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000426142ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000426142ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000426142ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000428599ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000428599ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000428599ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000525902ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000525902ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000525902ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526357ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526357ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526357ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526772ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526772ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526772ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526938ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526938ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000526938ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000527467ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000527467ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000527467ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528232ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528232ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528232ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528621ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528621ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000528621ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529526ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529526ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529526ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529873ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529873ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529873ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529986ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529986ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000529986ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530094ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530094ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530094ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530748ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530748ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000530748ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000531014ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000531014ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000531014ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532245ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532245ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532245ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532463ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532463ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532463ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532649ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532649ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532649ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532787ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532787ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532787ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532844ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532844ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000532844ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000533667ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000533667ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000533667ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000534579ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000534579ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
5UTR-intronENST00000534579ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000399039ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000399039ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000399039ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000399039ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000524630ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000524630ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000524630ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000524630ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000529919ENST00000267115CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000529919ENST00000395006CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000529919ENST00000423828CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-5UTRENST00000529919ENST00000549385CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000399039ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000399039ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000399039ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000524630ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000524630ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000524630ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000529919ENST00000547798CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000529919ENST00000548589CTNND1chr11

57529518

+TMBIM6chr12

50146246

+
intron-intronENST00000529919ENST00000552699CTNND1chr11

57529518

+TMBIM6chr12

50146246

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CTNND1-TMBIM6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CTNND1chr1157529518+TMBIM6chr1250146246+7.74E-080.9999999
CTNND1chr1157529518+TMBIM6chr1250146246+7.74E-080.9999999


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CTNND1-TMBIM6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57529518/:50146246)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CTNND1-TMBIM6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CTNND1-TMBIM6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CTNND1-TMBIM6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CTNND1-TMBIM6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND1C0008925Cleft Palate1GENOMICS_ENGLAND
HgeneCTNND1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET