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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTNND2-DAP (FusionGDB2 ID:HG1501TG1611)

Fusion Gene Summary for CTNND2-DAP

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND2-DAP
Fusion gene ID: hg1501tg1611
HgeneTgene
Gene symbol

CTNND2

DAP

Gene ID

1501

1611

Gene namecatenin delta 2death associated protein
SynonymsGT24|NPRAP-
Cytomap('CTNND2')('DAP')

5p15.2

5p15.2

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungindeath-associated protein 1DAP-1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304623, ENST00000359640, 
ENST00000503622, ENST00000511377, 
ENST00000458100, ENST00000495388, 
ENST00000458100, ENST00000495388, 
ENST00000503622, ENST00000511377, 
ENST00000304623, ENST00000359640, 
Fusion gene scores* DoF score14 X 13 X 7=127412 X 7 X 7=588
# samples 1512
** MAII scorelog2(15/1274*10)=-3.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/588*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND2 [Title/Abstract] AND DAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTNND2(11565056)-DAP(10683683), # samples:2
Anticipated loss of major functional domain due to fusion event.CTNND2-DAP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-DAP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTNND2-DAP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CTNND2-DAP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DAP-CTNND2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DAP-CTNND2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDAP

GO:0034198

cellular response to amino acid starvation

20537536


check buttonFusion gene breakpoints across CTNND2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N6-A4VD-01ACTNND2chr5

11565056

-DAPchr5

10683683

-
ChimerDB4UCSTCGA-N6-A4VDCTNND2chr5

11565056

-DAPchr5

10683683

-


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Fusion Gene ORF analysis for CTNND2-DAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304623ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000304623ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000359640ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000359640ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000503622ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000503622ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000511377ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
5CDS-intronENST00000511377ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-
5UTR-3CDSENST00000458100ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
5UTR-intronENST00000458100ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
5UTR-intronENST00000458100ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-
Frame-shiftENST00000503622ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
Frame-shiftENST00000511377ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
In-frameENST00000304623ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
In-frameENST00000359640ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
intron-3CDSENST00000495388ENST00000230895CTNND2chr5

11565056

-DAPchr5

10683683

-
intron-intronENST00000495388ENST00000432074CTNND2chr5

11565056

-DAPchr5

10683683

-
intron-intronENST00000495388ENST00000510546CTNND2chr5

11565056

-DAPchr5

10683683

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304623CTNND2chr511565056-ENST00000230895DAPchr510683683-24604775270176
ENST00000359640CTNND2chr511565056-ENST00000230895DAPchr510683683-2415432446937163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304623ENST00000230895CTNND2chr511565056-DAPchr510683683-0.0273138860.97268605
ENST00000359640ENST00000230895CTNND2chr511565056-DAPchr510683683-0.0306847230.96931535

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Fusion Genomic Features for CTNND2-DAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CTNND2-DAP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:11565056/chr5:10683683)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-32249_84951226.0Coiled coilOntology_term=ECO:0000255
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-32149_84951168.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322216_226951226.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322811_817951226.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321216_226951168.0Compositional biasNote=Poly-Pro
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321811_817951168.0Compositional biasNote=Poly-Lys
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322394_438951226.0RepeatNote=ARM 1
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322540_579951226.0RepeatNote=ARM 2
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322582_621951226.0RepeatNote=ARM 3
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322626_666951226.0RepeatNote=ARM 4
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322682_724951226.0RepeatNote=ARM 5
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322728_773951226.0RepeatNote=ARM 6
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322835_875951226.0RepeatNote=ARM 7
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322882_921951226.0RepeatNote=ARM 8
HgeneCTNND2chr5:11565056chr5:10683683ENST00000304623-322975_1018951226.0RepeatNote=ARM 9
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321394_438951168.0RepeatNote=ARM 1
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321540_579951168.0RepeatNote=ARM 2
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321582_621951168.0RepeatNote=ARM 3
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321626_666951168.0RepeatNote=ARM 4
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321682_724951168.0RepeatNote=ARM 5
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321728_773951168.0RepeatNote=ARM 6
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321835_875951168.0RepeatNote=ARM 7
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321882_921951168.0RepeatNote=ARM 8
HgeneCTNND2chr5:11565056chr5:10683683ENST00000359640-321975_1018951168.0RepeatNote=ARM 9


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Fusion Gene Sequence for CTNND2-DAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20389_20389_1_CTNND2-DAP_CTNND2_chr5_11565056_ENST00000304623_DAP_chr5_10683683_ENST00000230895_length(transcript)=2460nt_BP=477nt
GCGTCGGGAGCCGCCTCTCGCCCGCGGCGCTCGCCCCTGCCGCCCGCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGG
AAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGGGCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGG
CGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTTGGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAA
GACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGGCTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGA
ACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGAACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATC
CGAGACTGGCAGCATGAGCAGCATGAGTCCACCTAAACCCACTGTGTTCATCTCTGGGGTCATCGCCCGGGGTGACAAAGATTTCCCCCC
GGCGGCTGCGCAGGTGGCTCACCAGAAGCCGCATGCCTCCATGGACAAGCATCCTTCCCCAAGAACCCAGCACATCCAGCAGCCACGCAA
GTGAGCCTGGAGTCCACCAGCCTGCCCCATGGCCCCGGCTCTGCTGCACTTGGTATTTCCCTGACAGAGAGAACCAGCAGTTTCGCCCAA
ATCCTACTCTGCTGGGAAATCTAAGGCAAAACCAAGTGCTCTGTCCTTTGCCTTACATTTCCATATTTAAAACTAGAAACAGCTCCAGCC
CAAACCTTGTTTATGGGGAGTCTGGTTGGATGTCATTTGAGGATCATTGTGCCCCTAGAGGTGCCATTAGCAGAATTTGCCAAGATCCGA
GAAAAATTTTAGCTTTAGTTCTATTTCAGCAGTCACCTGACGTCCTTGTCTATGGTCTTAAAAACAAGAAGGCACACATTTGAGAAGATG
AGATTAAGGTTAGGAGAAAACCTCAGTCATTGCATGCTTTTTAGTATGGGCCAATAAAATCTCAACACCTGTGGGAGAGTAAGAACTAAG
GGAATGAGTTTGGGCGGCCCCTCATAAAGGACCTTAGAGGCAGGGAACAGCAATGCCAAATTTCCCTCTCTCGTGAGATGGGGGATCCTG
TGCAGGCTGATGAGGCACCCATGAGAAAAGCCGAAAAAGCATGCATCTTAGAAATAGCCCCTCAATTCCAGGAGTCAACATGCCAAAGAA
TGAGGCTGGAGACAGGTAGCTCCGAGGGAGGACTTCTGGCATGAGATCTCGGCACGGCAAGCCCAGCATCGCCTCAGCCCAGACAGGCTC
CACCAGGAGATCAAGCAAGGGCTGCCTTTCAGGAGTCACCTCCTGAGCCACTTCAGAGTTCTGGAAGTGACCACGGACCAGGGTGGAGGA
ATAGACTTCTAGTTCATTCTGGGACACTTGAGCCAGAGAGTTGAAAGCTTGGAAAGACCAGATAAGAAACCTGCCCTTTGTCTCCCTAGG
GACATGAGACACCACATTCCATTTGTGCTAGAAAAACCTATCCACTGATGAGTCTAACTGTTCCAAACGCCTCCCACCTGGTGTGCACAG
CTGCCTGGGTCCATTGTCACTTGGGTGCATCAGGTTGTCCTCCGATTTTTAGATGAGTTTCCTGTCTAGAGATGTCCTAGTCTGCTCACT
GGCTGGTGGCAGTAGGGTACCCTGCGTCCTCGAAAAGCCAGAGGGTTCACCTAGTCAGACGAAACTCCAGAACAGTGCTTGTGGAGGGCC
TGACTGTCCTGCTCACCCACAGCCGATCTGCTGCAGGTCAGCAACTGTGTCGTGAGCAGCTGCCAACCACCAGCCTTTCTGGTGCTGTTC
TCCAGTTCACGTCTGCCAGCTGGTGAGGGCAGAGGCAGACCTGGTCAGACCCAGCGCCCCTCCTCCCTGAGGGAGCATGGCACAGCCTCA
CACTTGAAAGACGGTGTTTGGTTTCCCATCTAATCAACTTAAGGGAAGCCGGCATGTACCCTTCAAGGCCCTGTCACCACCTATTTCCTG
ATCAGTTGGTATAAACTGAGGGTGGCTTTTAGAGACCCAGACTTGGTTGGCAGCGCTGCCATGGAACACCCCAGCAAGCACCTCCCAGCC
TGCCTTTCGGAGCAGCACCCAGGAGGGGATGCCGCGCTCCAGCAACACCAGGTCAGGCCTGTGCAGACCCCTGCCCTGCCGCTGCAGAAA
TCCAGAAGCATCCTTAATGCTTCTCAGTCTTCAGCCAGAGGGAGGGCTGTTATTTCCAGAGGTGCGCTTTTTATGTACTTTTAGCTAGAT
GTGGCATGCATCTGTGAGCTTTAGATCATTAAATCCAAAATGTTTGCCTAAATGAGTTTATCAGTTGTTAACTTCAAGAATATTAAATGA

>20389_20389_1_CTNND2-DAP_CTNND2_chr5_11565056_ENST00000304623_DAP_chr5_10683683_ENST00000230895_length(amino acids)=176AA_BP=3
MSPRAMTPEMNTVGLGGLMLLMLPVSDPSLHRSSWLATICRSASSSRVSLSNCNSCSLTEARMAEVVSVSEPSPLEVFKPGLRELVFSEA

--------------------------------------------------------------
>20389_20389_2_CTNND2-DAP_CTNND2_chr5_11565056_ENST00000359640_DAP_chr5_10683683_ENST00000230895_length(transcript)=2415nt_BP=432nt
GCCAGCATCCCTTGTCCCGCGGCCGCGCTCAGACAACAAAAGCGGAAGATGCTGCAGTTGGGCAAGGTCAGGACCTTGCCCTGAAGCCGG
GCGGCGCCGCGCACGCCTCTTCCCGGACTGAGGAGCTGTCGCCGGCGGAGGGTGCATGTTTGCGAGGAAGCCGCCGGGCGCCGCGCCTTT
GGGAGCTATGCCTGTTCCAGACCAGCCTTCATCAGCCTCAGAGAAGACGAGTTCCCTGAGCCCCGGCTTAAACACCTCCAACGGGGATGG
CTCTGAAACAGAAACCACCTCTGCCATCCTCGCCTCAGTCAAAGAACAGGAATTACAGTTTGAAAGGCTGACCCGAGAGCTGGAGGCTGA
ACGGCAGATCGTAGCCAGCCAGCTGGAGCGATGCAAGCTCGGATCCGAGACTGGCAGCATGAGCAGCATGAGTCCACCTAAACCCACTGT
GTTCATCTCTGGGGTCATCGCCCGGGGTGACAAAGATTTCCCCCCGGCGGCTGCGCAGGTGGCTCACCAGAAGCCGCATGCCTCCATGGA
CAAGCATCCTTCCCCAAGAACCCAGCACATCCAGCAGCCACGCAAGTGAGCCTGGAGTCCACCAGCCTGCCCCATGGCCCCGGCTCTGCT
GCACTTGGTATTTCCCTGACAGAGAGAACCAGCAGTTTCGCCCAAATCCTACTCTGCTGGGAAATCTAAGGCAAAACCAAGTGCTCTGTC
CTTTGCCTTACATTTCCATATTTAAAACTAGAAACAGCTCCAGCCCAAACCTTGTTTATGGGGAGTCTGGTTGGATGTCATTTGAGGATC
ATTGTGCCCCTAGAGGTGCCATTAGCAGAATTTGCCAAGATCCGAGAAAAATTTTAGCTTTAGTTCTATTTCAGCAGTCACCTGACGTCC
TTGTCTATGGTCTTAAAAACAAGAAGGCACACATTTGAGAAGATGAGATTAAGGTTAGGAGAAAACCTCAGTCATTGCATGCTTTTTAGT
ATGGGCCAATAAAATCTCAACACCTGTGGGAGAGTAAGAACTAAGGGAATGAGTTTGGGCGGCCCCTCATAAAGGACCTTAGAGGCAGGG
AACAGCAATGCCAAATTTCCCTCTCTCGTGAGATGGGGGATCCTGTGCAGGCTGATGAGGCACCCATGAGAAAAGCCGAAAAAGCATGCA
TCTTAGAAATAGCCCCTCAATTCCAGGAGTCAACATGCCAAAGAATGAGGCTGGAGACAGGTAGCTCCGAGGGAGGACTTCTGGCATGAG
ATCTCGGCACGGCAAGCCCAGCATCGCCTCAGCCCAGACAGGCTCCACCAGGAGATCAAGCAAGGGCTGCCTTTCAGGAGTCACCTCCTG
AGCCACTTCAGAGTTCTGGAAGTGACCACGGACCAGGGTGGAGGAATAGACTTCTAGTTCATTCTGGGACACTTGAGCCAGAGAGTTGAA
AGCTTGGAAAGACCAGATAAGAAACCTGCCCTTTGTCTCCCTAGGGACATGAGACACCACATTCCATTTGTGCTAGAAAAACCTATCCAC
TGATGAGTCTAACTGTTCCAAACGCCTCCCACCTGGTGTGCACAGCTGCCTGGGTCCATTGTCACTTGGGTGCATCAGGTTGTCCTCCGA
TTTTTAGATGAGTTTCCTGTCTAGAGATGTCCTAGTCTGCTCACTGGCTGGTGGCAGTAGGGTACCCTGCGTCCTCGAAAAGCCAGAGGG
TTCACCTAGTCAGACGAAACTCCAGAACAGTGCTTGTGGAGGGCCTGACTGTCCTGCTCACCCACAGCCGATCTGCTGCAGGTCAGCAAC
TGTGTCGTGAGCAGCTGCCAACCACCAGCCTTTCTGGTGCTGTTCTCCAGTTCACGTCTGCCAGCTGGTGAGGGCAGAGGCAGACCTGGT
CAGACCCAGCGCCCCTCCTCCCTGAGGGAGCATGGCACAGCCTCACACTTGAAAGACGGTGTTTGGTTTCCCATCTAATCAACTTAAGGG
AAGCCGGCATGTACCCTTCAAGGCCCTGTCACCACCTATTTCCTGATCAGTTGGTATAAACTGAGGGTGGCTTTTAGAGACCCAGACTTG
GTTGGCAGCGCTGCCATGGAACACCCCAGCAAGCACCTCCCAGCCTGCCTTTCGGAGCAGCACCCAGGAGGGGATGCCGCGCTCCAGCAA
CACCAGGTCAGGCCTGTGCAGACCCCTGCCCTGCCGCTGCAGAAATCCAGAAGCATCCTTAATGCTTCTCAGTCTTCAGCCAGAGGGAGG
GCTGTTATTTCCAGAGGTGCGCTTTTTATGTACTTTTAGCTAGATGTGGCATGCATCTGTGAGCTTTAGATCATTAAATCCAAAATGTTT

>20389_20389_2_CTNND2-DAP_CTNND2_chr5_11565056_ENST00000359640_DAP_chr5_10683683_ENST00000230895_length(amino acids)=163AA_BP=
MCSSLGSSPGVTKISPRRLRRWLTRSRMPPWTSILPQEPSTSSSHASEPGVHQPAPWPRLCCTWYFPDRENQQFRPNPTLLGNLRQNQVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTNND2-DAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTNND2-DAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTNND2-DAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCTNND2C0017636Glioblastoma1CTD_human
HgeneCTNND2C0036341Schizophrenia1PSYGENET
HgeneCTNND2C0041696Unipolar Depression1PSYGENET
HgeneCTNND2C0334588Giant Cell Glioblastoma1CTD_human
HgeneCTNND2C1269683Major Depressive Disorder1PSYGENET
HgeneCTNND2C1621958Glioblastoma Multiforme1CTD_human
HgeneCTNND2C1832841EPILEPSY, FAMILIAL ADULT MYOCLONIC, 11ORPHANET
HgeneCTNND2C3495676Anorectal Malformations1GENOMICS_ENGLAND
TgeneC0009324Ulcerative Colitis1CTD_human