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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:COMMD1-FARS2 (FusionGDB2 ID:HG150684TG10667)

Fusion Gene Summary for COMMD1-FARS2

Fusion gene summary

Fusion gene information	Fusion gene name: COMMD1-FARS2
	Fusion gene ID: hg150684tg10667
		Hgene	Tgene
	Gene symbol	COMMD1	FARS2
	Gene ID	150684	10667
	Gene name	copper metabolism domain containing 1	phenylalanyl-tRNA synthetase 2, mitochondrial
	Synonyms	C2orf5\|MURR1	COXPD14\|FARS1\|HSPC320\|PheRS\|SPG77\|mtPheRS
	Cytomap	('COMMD1')('FARS2') 2p15	6p25.1
	Type of gene	protein-coding	protein-coding
	Description	COMM domain-containing protein 1copper metabolism (Murr1) domain containing 1copper metabolism gene MURR1protein Murr1	phenylalanine--tRNA ligase, mitochondrialdJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))mitochondrial PHERSphenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine-tRNA synthetase 1 (
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000472729, ENST00000311832, ENST00000538736,
Fusion gene scores	* DoF score	5 X 4 X 5=100	15 X 13 X 10=1950
	# samples	7	21
	** MAII score	log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/1950*10)=-3.21501289097085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: COMMD1 [Title/Abstract] AND FARS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	COMMD1(62228117)-FARS2(5771524), # samples:2
Anticipated loss of major functional domain due to fusion event.	COMMD1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COMMD1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COMMD1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COMMD1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COMMD1-FARS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. COMMD1-FARS2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COMMD1	GO:0031398	positive regulation of protein ubiquitination	17183367\|21741370
Hgene	COMMD1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	15799966\|16573520
Hgene	COMMD1	GO:0048227	plasma membrane to endosome transport	21741370
Hgene	COMMD1	GO:0055070	copper ion homeostasis	14685266
Hgene	COMMD1	GO:1902306	negative regulation of sodium ion transmembrane transport	14645214
Hgene	COMMD1	GO:2000009	negative regulation of protein localization to cell surface	21741370
Tgene	FARS2	GO:0006432	phenylalanyl-tRNA aminoacylation	10329163
Tgene	FARS2	GO:0008033	tRNA processing	10329163

Fusion gene breakpoints across COMMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GV-A3QI-01A	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
ChimerDB4	BLCA	TCGA-GV-A3QI	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+

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Fusion Gene ORF analysis for COMMD1-FARS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000472729	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
3UTR-3CDS	ENST00000472729	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+
3UTR-3CDS	ENST00000472729	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
3UTR-3CDS	ENST00000472729	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+
Frame-shift	ENST00000311832	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
Frame-shift	ENST00000311832	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+
Frame-shift	ENST00000538736	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
Frame-shift	ENST00000538736	ENST00000274680	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+
In-frame	ENST00000311832	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
In-frame	ENST00000311832	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+
In-frame	ENST00000538736	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+
In-frame	ENST00000538736	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000311832

COMMD1

chr2

62228117

ENST00000324331

FARS2

chr6

5771524

633

494

631

200

ENST00000538736

COMMD1

chr2

62228117

ENST00000324331

FARS2

chr6

5771524

606

467

604

200

ENST00000311832

COMMD1

chr2

62228117

ENST00000324331

FARS2

chr6

5771523

633

494

631

200

ENST00000538736

COMMD1

chr2

62228117

ENST00000324331

FARS2

chr6

5771523

606

467

604

200

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000311832	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+	0.30821767	0.69178236
ENST00000538736	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771524	+	0.26961696	0.73038304
ENST00000311832	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	0.30821767	0.69178236
ENST00000538736	ENST00000324331	COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	0.26961696	0.73038304

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Fusion Genomic Features for COMMD1-FARS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	8.42E-06	0.99999154
COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	8.42E-06	0.99999154
COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	8.42E-06	0.99999154
COMMD1	chr2	62228117	+	FARS2	chr6	5771523	+	8.42E-06	0.99999154

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for COMMD1-FARS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:62228117/chr6:5771524)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COMMD1

chr2:62228117

chr6:5771523

ENST00000311832

118_186

154

191.0

Domain

COMM

Hgene

COMMD1

chr2:62228117

chr6:5771524

ENST00000311832

118_186

154

191.0

Domain

COMM

Hgene

COMMD1

chr2:62228117

chr6:5771523

ENST00000311832

125_190

154

191.0

Region

Required for binding to PtdIns(4%2C5)P2

Hgene

COMMD1

chr2:62228117

chr6:5771524

ENST00000311832

125_190

154

191.0

Region

Required for binding to PtdIns(4%2C5)P2

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000274680

358_450

405

452.0

Domain

FDX-ACB

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000324331

358_450

405

452.0

Domain

FDX-ACB

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000274680

358_450

405

452.0

Domain

FDX-ACB

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000324331

358_450

405

452.0

Domain

FDX-ACB

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000274680

157_160

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000274680

186_188

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000274680

193_195

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000324331

157_160

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000324331

186_188

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771523

ENST00000324331

193_195

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000274680

157_160

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000274680

186_188

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000274680

193_195

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000324331

157_160

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000324331

186_188

405

452.0

Region

Note=Substrate binding

Tgene

FARS2

chr2:62228117

chr6:5771524

ENST00000324331

193_195

405

452.0

Region

Note=Substrate binding

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Fusion Gene Sequence for COMMD1-FARS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>18516_18516_1_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000311832_FARS2_chr6_5771523_ENST00000324331_length(transcript)=633nt_BP=494nt
TCAGCTGTTGCGGGGCGGGGCCTTCGCAGAGCATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGG
CCCAGGACACTTTCCACGGGTACCCCGGCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCC
CCTTTCTGGCAAAGATGAGGGGGATTCTTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAA
CCAAAAAGCAAGGTGGGATCACATCTGACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCA
TGAACCAGAGCCGCTGGAATAGCGGGCTTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACA
CACCTGTTGCCATTATAGAGCTGGAATTAGGCAAATATGGACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATG
GAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTC

>18516_18516_1_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000311832_FARS2_chr6_5771523_ENST00000324331_length(amino acids)=200AA_BP=154
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQ
AAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQDAQDQPLLPHHVPPHGTDSVPERGQA

--------------------------------------------------------------
>18516_18516_2_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000311832_FARS2_chr6_5771524_ENST00000324331_length(transcript)=633nt_BP=494nt
TCAGCTGTTGCGGGGCGGGGCCTTCGCAGAGCATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGG
CCCAGGACACTTTCCACGGGTACCCCGGCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCC
CCTTTCTGGCAAAGATGAGGGGGATTCTTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAA
CCAAAAAGCAAGGTGGGATCACATCTGACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCA
TGAACCAGAGCCGCTGGAATAGCGGGCTTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACA
CACCTGTTGCCATTATAGAGCTGGAATTAGGCAAATATGGACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATG
GAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTC

>18516_18516_2_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000311832_FARS2_chr6_5771524_ENST00000324331_length(amino acids)=200AA_BP=154
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQ
AAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQDAQDQPLLPHHVPPHGTDSVPERGQA

--------------------------------------------------------------
>18516_18516_3_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000538736_FARS2_chr6_5771523_ENST00000324331_length(transcript)=606nt_BP=467nt
AGAGCATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGGCCCAGGACACTTTCCACGGGTACCCCG
GCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCCCCTTTCTGGCAAAGATGAGGGGGATTC
TTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAACCAAAAAGCAAGGTGGGATCACATCTG
ACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCATGAACCAGAGCCGCTGGAATAGCGGGC
TTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACACACCTGTTGCCATTATAGAGCTGGAAT
TAGGCAAATATGGACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTC

>18516_18516_3_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000538736_FARS2_chr6_5771523_ENST00000324331_length(amino acids)=200AA_BP=154
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQ
AAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQDAQDQPLLPHHVPPHGTDSVPERGQA

--------------------------------------------------------------
>18516_18516_4_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000538736_FARS2_chr6_5771524_ENST00000324331_length(transcript)=606nt_BP=467nt
AGAGCATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGGCCCAGGACACTTTCCACGGGTACCCCG
GCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCCCCTTTCTGGCAAAGATGAGGGGGATTC
TTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAACCAAAAAGCAAGGTGGGATCACATCTG
ACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCATGAACCAGAGCCGCTGGAATAGCGGGC
TTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACACACCTGTTGCCATTATAGAGCTGGAAT
TAGGCAAATATGGACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTC

>18516_18516_4_COMMD1-FARS2_COMMD1_chr2_62228117_ENST00000538736_FARS2_chr6_5771524_ENST00000324331_length(amino acids)=200AA_BP=154
MAAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQ
AAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQDAQDQPLLPHHVPPHGTDSVPERGQA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COMMD1-FARS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for COMMD1-FARS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for COMMD1-FARS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	COMMD1	C0019189	Hepatitis, Chronic	2	CTD_human
Hgene	COMMD1	C0149519	Chronic Persistent Hepatitis	2	CTD_human
Hgene	COMMD1	C0520463	Chronic active hepatitis	2	CTD_human
Hgene	COMMD1	C0524611	Cryptogenic Chronic Hepatitis	2	CTD_human
Hgene	COMMD1	C0013221	Drug toxicity	1	CTD_human
Hgene	COMMD1	C0020517	Hypersensitivity	1	CTD_human
Hgene	COMMD1	C0023890	Liver Cirrhosis	1	CTD_human
Hgene	COMMD1	C0041755	Adverse reaction to drug	1	CTD_human
Hgene	COMMD1	C0239946	Fibrosis, Liver	1	CTD_human
Hgene	COMMD1	C1527304	Allergic Reaction	1	CTD_human
Hgene	COMMD1	C1876165	Copper-Overload Cirrhosis	1	CTD_human
Tgene		C0023264	Leigh Disease	7	CLINGEN
Tgene		C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	7	CLINGEN
Tgene		C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	7	CLINGEN
Tgene		C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	7	CLINGEN
Tgene		C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	7	CLINGEN
Tgene		C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	7	CLINGEN
Tgene		C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	7	CLINGEN
Tgene		C3554168	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 14	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C4310750	SPASTIC PARAPLEGIA 77, AUTOSOMAL RECESSIVE	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:COMMD1-FARS2 (FusionGDB2 ID:HG150684TG10667)

Fusion Gene Summary for COMMD1-FARS2

Fusion Gene ORF analysis for COMMD1-FARS2

Fusion Genomic Features for COMMD1-FARS2

Fusion Protein Features for COMMD1-FARS2

Fusion Gene Sequence for COMMD1-FARS2

Fusion Gene PPI Analysis for COMMD1-FARS2

Related Drugs for COMMD1-FARS2

Related Diseases for COMMD1-FARS2

Fusion Gene Studies
in Kim Lab