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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTSB-TXNL1 (FusionGDB2 ID:HG1508TG9352)

Fusion Gene Summary for CTSB-TXNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTSB-TXNL1
Fusion gene ID: hg1508tg9352
HgeneTgene
Gene symbol

CTSB

TXNL1

Gene ID

1508

9352

Gene namecathepsin Bthioredoxin like 1
SynonymsAPPS|CPSB|RECEUPHEL-S-114|TRP32|TXL-1|TXNL|Txl
Cytomap('CTSB')('TXNL1')

8p23.1

18q21.31

Type of geneprotein-codingprotein-coding
Descriptioncathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseepididymis secretory sperm binding proteinthioredoxin-like protein 132 kDa thioredoxin-related proteinepididymis secretory protein Li 114thioredoxin-related 32 kDa proteinthioredoxin-related protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000345125, ENST00000353047, 
ENST00000415599, ENST00000434271, 
ENST00000453527, ENST00000530640, 
ENST00000531089, ENST00000533455, 
ENST00000534510, ENST00000525076, 
Fusion gene scores* DoF score24 X 19 X 10=45609 X 8 X 4=288
# samples 2510
** MAII scorelog2(25/4560*10)=-4.18903382439002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTSB [Title/Abstract] AND TXNL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTSB(11710119)-TXNL1(54293688), # samples:1
Anticipated loss of major functional domain due to fusion event.CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSB-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CTSB-TXNL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSB

GO:0006508

proteolysis

7890620|8811434

HgeneCTSB

GO:0030574

collagen catabolic process

22952693

HgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693


check buttonFusion gene breakpoints across CTSB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TXNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5730-11ACTSBchr8

11710119

-TXNL1chr18

54293688

-


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Fusion Gene ORF analysis for CTSB-TXNL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000345125ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000353047ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000415599ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000434271ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000453527ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000530640ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000531089ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000533455ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000534510ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000345125ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000345125ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000353047ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000353047ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000415599ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000415599ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000434271ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000434271ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000453527ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000453527ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000530640ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000530640ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000531089ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000531089ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000533455ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000533455ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000534510ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5CDS-intronENST00000534510ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
5UTR-3CDSENST00000525076ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
5UTR-5UTRENST00000525076ENST00000540155CTSBchr8

11710119

-TXNL1chr18

54293688

-
5UTR-intronENST00000525076ENST00000585497CTSBchr8

11710119

-TXNL1chr18

54293688

-
5UTR-intronENST00000525076ENST00000590954CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000345125ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000353047ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000415599ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000453527ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000531089ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
Frame-shiftENST00000534510ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
In-frameENST00000434271ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
In-frameENST00000530640ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-
In-frameENST00000533455ENST00000217515CTSBchr8

11710119

-TXNL1chr18

54293688

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000434271CTSBchr811710119-ENST00000217515TXNL1chr1854293688-70414502381221327
ENST00000530640CTSBchr811710119-ENST00000217515TXNL1chr1854293688-69403491371120327
ENST00000533455CTSBchr811710119-ENST00000217515TXNL1chr1854293688-70224312191202327

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434271ENST00000217515CTSBchr811710119-TXNL1chr1854293688-4.63E-050.99995375
ENST00000530640ENST00000217515CTSBchr811710119-TXNL1chr1854293688-4.66E-050.9999534
ENST00000533455ENST00000217515CTSBchr811710119-TXNL1chr1854293688-4.72E-050.9999528

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Fusion Genomic Features for CTSB-TXNL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CTSB-TXNL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11710119/chr18:54293688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTXNL1chr8:11710119chr18:54293688ENST0000021751508115_28532290.0DomainPITH
TgeneTXNL1chr8:11710119chr18:54293688ENST00000590954210115_28532290.0DomainPITH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTXNL1chr8:11710119chr18:54293688ENST00000217515082_10932290.0DomainNote=Thioredoxin
TgeneTXNL1chr8:11710119chr18:54293688ENST000005909542102_10932290.0DomainNote=Thioredoxin


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Fusion Gene Sequence for CTSB-TXNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>20479_20479_1_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000434271_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=7041nt_BP=450nt
GGGGCGGGGCCGGGAGGGTACTTAGGGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCG
CTCCGCTGCGCGCAGGCTGGGCTGCAGGCTCTCGGCTGCAGCGCTGGGTGAGTGCTGGGGACCCGGGGCCACCGCAGCGTAAGTGACCCA
GAGAGGTGTCCTGATGCCCTCTGTCCTCTCCAGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCT
GCTGGTGTTGGCCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTG
GCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAG
GTGTGGGCCATGTTTGAGGATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCA
GTGTCAGGGAACAGCTGCCACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGG
AGCAGATGCTGTGGGATTAGAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTA
TATGGATTTAATGCCTTTTATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGA
CACAACCTTCTTGGAATCTGACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCA
AGGGCCAGATAATGGTCAGGGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGA
ACCAACTCAAGCTCTGGAACTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAG
TGTAACTATATTTGTTCAGTCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAAC
AAATATGAATGACTTCAAACGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGAT
CTACAGCTCCTGGATAATTGCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAG
ATGGTATCACTAGTGTTTCCATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCT
AAATCAGTATTTTCTCTTTCCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAA
AGCCAGTTTCTTTAGAAAAGGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAAC
CTGGAACAGCTAACCATGTTAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAAT
TAGAAGAAATAAACAGGTTTAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAA
GATTTTAATCTCTTCTGGTAAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCA
GACAGTTGGGGAAAAAATACAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGG
GAGGCCAAGGCGGGCGAATCACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAA
ATTAGCCAGGCATGGTGGCGGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTG
CAGTGAGCTGAGATTGCGCCATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAA
TCAAGTATTTATTACCTGAACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAA
ATGTTTAAAAGGTCTTTCACAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGT
TTTAATTTTAAAATTTCTGAGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGC
ATTCTTGTCTAGGAATATGGTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTT
TAGTGTTGAAAGAGTCCCTTTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGAT
CTTAACACTCCTTAAATAGACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGT
ACACTTAACCTTTCTGAGTAATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAG
TGAAACAAATTTCGTATTTGTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGT
ATTACATAATTCAAATTGTAAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAAT
GTGCATAATTGGCATTTAAAATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATT
TATATATAACACTGAATTTTCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATC
TAGAAAACTGGTATTCAGTTTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAG
GTGCTTTTGATGAGAAACAACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAAT
GCTGAAGCCAAGAGTAGCACAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCC
ACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATA
TACTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATA
ACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCC
CCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAA
TATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACT
TAACAATTAGAGTTGAAACCTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAG
TTGTTTATTTGGCCTCAGCAGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCT
TGTTCCTCTTAATGTCTAAAAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAA
AAACATGAAATTTAAGGCTTACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTC
TTCTGGAACTGATAATTTGTAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCAT
GCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCC
TGTCTCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTG
AACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAA
AAAAAAATCCATTCACAGAACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTT
TACAGTTTTGTAAATATAGATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGA
CTATTCCCCAGTTAAGCCTATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAAT
AAGGTTTTTTTTTTTTTTTAACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTT
GTGGTCCATGTAAAATTATTAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAAT
TGTACACAGCTTGGAATATTAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTAT
GGGAAGAGGAATTTTATTTTGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACA
CGCATTTGGAGATACTGGCTCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATC
TTGAGCAAGTAACATCCTTCAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTT
ACTTTGTATCTGGAACAAGGATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACT
GCAGTGCCTCCTAATTGTCTCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTC
TTTGTAATGTAATCTCTCCTCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCC
TAATATCGCATGCCTTCCTCTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGG
GAATAATCATAACAATTGTGCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGA
TCTGTAGTCTTATTTGGACTACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATT
AAATACAATGTTGAAAAAATTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTA
AGGAAGATAATTTAGCTGAAGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAG
GAGAAGCTGAAAGAGCAAGTAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGA
GCGAGCATAGAGAAGTCTGTGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAG
AGGGGAAGATGAATATGGTTTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAA
TGTGATTTTAGAGCTTAGAGCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAG
AATATAAAGGGAGAGAATGAAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTA
GAGTAGTAAACAGGAAAGGGAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATG
TGATATTGAAATTAGCTGGGATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGAT
CATATTAATAAACTTTCAGTTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCAT
TGAACACAGTTTTACATGACACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCA

>20479_20479_1_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000434271_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------
>20479_20479_2_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000530640_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=6940nt_BP=349nt
GGCCGGGGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGC
AGGCTCTCGGCTGCAGCGCTGGGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGG
CCAATGCCCGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGC
ACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGGTGTGGGCCAT
GTTTGAGGATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCAGTGTCAGGGAA
CAGCTGCCACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGGAGCAGATGCTG
TGGGATTAGAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTATATGGATTTAA
TGCCTTTTATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGACACAACCTTCT
TGGAATCTGACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCAAGGGCCAGATA
ATGGTCAGGGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGAACCAACTCAAG
CTCTGGAACTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAGTGTAACTATAT
TTGTTCAGTCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAACAAATATGAATG
ACTTCAAACGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGATCTACAGCTCCT
GGATAATTGCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAGATGGTATCACT
AGTGTTTCCATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCTAAATCAGTATT
TTCTCTTTCCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAAAGCCAGTTTCT
TTAGAAAAGGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAACCTGGAACAGCT
AACCATGTTAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAATTAGAAGAAATA
AACAGGTTTAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAAGATTTTAATCT
CTTCTGGTAAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCAGACAGTTGGGG
AAAAAATACAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGGGAGGCCAAGGC
GGGCGAATCACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGC
ATGGTGGCGGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGA
GATTGCGCCATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAATCAAGTATTTA
TTACCTGAACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAAATGTTTAAAAG
GTCTTTCACAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGTTTTAATTTTAA
AATTTCTGAGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGCATTCTTGTCTA
GGAATATGGTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTTTAGTGTTGAAA
GAGTCCCTTTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGATCTTAACACTCC
TTAAATAGACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGTACACTTAACCT
TTCTGAGTAATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAGTGAAACAAATT
TCGTATTTGTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGTATTACATAATT
CAAATTGTAAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAATGTGCATAATTG
GCATTTAAAATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATTTATATATAACA
CTGAATTTTCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATCTAGAAAACTGG
TATTCAGTTTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAGGTGCTTTTGAT
GAGAAACAACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAATGCTGAAGCCAA
GAGTAGCACAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCCACGTTGTTCCC
CAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAG
GCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATAACAATTAGAGT
TGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTC
CCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAATATTCTGTTGG
AGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACTTAACAATTAGA
GTTGAAACCTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAGTTGTTTATTTG
GCCTCAGCAGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCTTGTTCCTCTTA
ATGTCTAAAAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAAAAACATGAAAT
TTAAGGCTTACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTCTTCTGGAACTG
ATAATTTGTAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCATGCCTGTAATCC
CAGCATTTTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCCTGTCTCTACTA
AAAATACAAAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCGGGAGG
CGGAGGTTGCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAAAAAAAAATCCA
TTCACAGAACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTTTACAGTTTTGT
AAATATAGATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGACTATTCCCCAG
TTAAGCCTATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAATAAGGTTTTTTT
TTTTTTTTAACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTTGTGGTCCATGT
AAAATTATTAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAATTGTACACAGCT
TGGAATATTAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTATGGGAAGAGGAA
TTTTATTTTGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACACGCATTTGGAG
ATACTGGCTCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATCTTGAGCAAGTA
ACATCCTTCAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTTACTTTGTATCT
GGAACAAGGATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACTGCAGTGCCTCC
TAATTGTCTCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTCTTTGTAATGTA
ATCTCTCCTCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCCTAATATCGCAT
GCCTTCCTCTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGGGAATAATCATA
ACAATTGTGCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGATCTGTAGTCTT
ATTTGGACTACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATTAAATACAATGT
TGAAAAAATTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTAAGGAAGATAAT
TTAGCTGAAGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAGGAGAAGCTGAA
AGAGCAAGTAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGAGCGAGCATAGA
GAAGTCTGTGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAGAGGGGAAGATG
AATATGGTTTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAATGTGATTTTAG
AGCTTAGAGCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAGAATATAAAGGG
AGAGAATGAAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTAGAGTAGTAAAC
AGGAAAGGGAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATGTGATATTGAAA
TTAGCTGGGATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGATCATATTAATAA
ACTTTCAGTTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCATTGAACACAGTT
TTACATGACACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCATTAAAGGATCT

>20479_20479_2_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000530640_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------
>20479_20479_3_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000533455_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=7022nt_BP=431nt
GGCTGGCCCAGGCTACGGCGGCTGCAGGGCTCCGGCAACCGCTCCGGCAACGCCAACCGCTCCGCTGCGCGCAGGCTGGGCTGCAGGCTC
TCGGCTGCAGCGCTGGGCTGGTGTGCAGTGGTGCGACCACGGCTCACGGCAGCCTCAGCCACCCAGATGTAAGCGATCTGGTTCCCACCT
CAGCCTCCCGAGTAGTGGATCTAGGATCCGGCTTCCAACATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCC
CGGAGCAGGCCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACGTGGCAGGCCGGGCACAACTTC
TACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGTACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGGTGTGGGCCATGTTTGAGG
ATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCAGTGTCAGGGAACAGCTGCC
ACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGGAGCAGATGCTGTGGGATTA
GAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTATATGGATTTAATGCCTTTT
ATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGACACAACCTTCTTGGAATCT
GACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCAAGGGCCAGATAATGGTCAG
GGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGAACCAACTCAAGCTCTGGAA
CTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAGTGTAACTATATTTGTTCAG
TCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAACAAATATGAATGACTTCAAA
CGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGATCTACAGCTCCTGGATAATT
GCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAGATGGTATCACTAGTGTTTC
CATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCTAAATCAGTATTTTCTCTTT
CCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAAAGCCAGTTTCTTTAGAAAA
GGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAACCTGGAACAGCTAACCATGT
TAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAATTAGAAGAAATAAACAGGTT
TAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAAGATTTTAATCTCTTCTGGT
AAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCAGACAGTTGGGGAAAAAATA
CAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGGGAGGCCAAGGCGGGCGAAT
CACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGC
GGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGC
CATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAATCAAGTATTTATTACCTGA
ACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAAATGTTTAAAAGGTCTTTCA
CAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGTTTTAATTTTAAAATTTCTG
AGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGCATTCTTGTCTAGGAATATG
GTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTTTAGTGTTGAAAGAGTCCCT
TTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGATCTTAACACTCCTTAAATAG
ACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGTACACTTAACCTTTCTGAGT
AATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAGTGAAACAAATTTCGTATTT
GTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGTATTACATAATTCAAATTGT
AAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAATGTGCATAATTGGCATTTAA
AATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATTTATATATAACACTGAATTT
TCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATCTAGAAAACTGGTATTCAGT
TTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAGGTGCTTTTGATGAGAAACA
ACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAATGCTGAAGCCAAGAGTAGCA
CAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCCACGTTGTTCCCCAGTCTCA
ATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCAC
GTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATAACAATTAGAGTTGAAACCT
GCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCT
CAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCC
ACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACTTAACAATTAGAGTTGAAAC
CTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAGTTGTTTATTTGGCCTCAGC
AGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCTTGTTCCTCTTAATGTCTAA
AAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAAAAACATGAAATTTAAGGCT
TACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTCTTCTGGAACTGATAATTTG
TAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCATGCCTGTAATCCCAGCATTT
TGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCCTGTCTCTACTAAAAATACA
AAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCGGGAGGCGGAGGTT
GCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAAAAAAAAATCCATTCACAGA
ACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTTTACAGTTTTGTAAATATAG
ATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGACTATTCCCCAGTTAAGCCT
ATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAATAAGGTTTTTTTTTTTTTTT
AACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTTGTGGTCCATGTAAAATTAT
TAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAATTGTACACAGCTTGGAATAT
TAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTATGGGAAGAGGAATTTTATTT
TGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACACGCATTTGGAGATACTGGC
TCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATCTTGAGCAAGTAACATCCTT
CAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTTACTTTGTATCTGGAACAAG
GATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACTGCAGTGCCTCCTAATTGTC
TCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTCTTTGTAATGTAATCTCTCC
TCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCCTAATATCGCATGCCTTCCT
CTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGGGAATAATCATAACAATTGT
GCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGATCTGTAGTCTTATTTGGAC
TACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATTAAATACAATGTTGAAAAAA
TTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTAAGGAAGATAATTTAGCTGA
AGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAGGAGAAGCTGAAAGAGCAAG
TAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGAGCGAGCATAGAGAAGTCTG
TGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAGAGGGGAAGATGAATATGGT
TTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAATGTGATTTTAGAGCTTAGA
GCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAGAATATAAAGGGAGAGAATG
AAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTAGAGTAGTAAACAGGAAAGG
GAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATGTGATATTGAAATTAGCTGG
GATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGATCATATTAATAAACTTTCAG
TTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCATTGAACACAGTTTTACATGA
CACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCATTAAAGGATCTTATCAGGT

>20479_20479_3_CTSB-TXNL1_CTSB_chr8_11710119_ENST00000533455_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=327AA_BP=70
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRCGPCLRIAPAFSSMSNKYP
QAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESD
EHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CTSB-TXNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTSB-TXNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTSB-TXNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTSBC0027626Neoplasm Invasiveness2CTD_human
HgeneCTSBC0007134Renal Cell Carcinoma1CTD_human
HgeneCTSBC0017636Glioblastoma1CTD_human
HgeneCTSBC0026848Myopathy1CTD_human
HgeneCTSBC0027540Necrosis1CTD_human
HgeneCTSBC0033578Prostatic Neoplasms1CTD_human
HgeneCTSBC0033687Proteinuria1CTD_human
HgeneCTSBC0235874Disease Exacerbation1CTD_human
HgeneCTSBC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneCTSBC0334588Giant Cell Glioblastoma1CTD_human
HgeneCTSBC0376358Malignant neoplasm of prostate1CTD_human
HgeneCTSBC0406756Keratolytic winter erythema1CTD_human;ORPHANET
HgeneCTSBC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneCTSBC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneCTSBC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneCTSBC1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneCTSBC1621958Glioblastoma Multiforme1CTD_human