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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CYB561-GNAS (FusionGDB2 ID:HG1534TG2778) |
Fusion Gene Summary for CYB561-GNAS |
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Fusion gene information | Fusion gene name: CYB561-GNAS | Fusion gene ID: hg1534tg2778 | Hgene | Tgene | Gene symbol | CYB561 | GNAS | Gene ID | 1534 | 2778 |
Gene name | cytochrome b561 | GNAS complex locus | |
Synonyms | CYB561A1|FRRS2|ORTHYP2 | AHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVI | |
Cytomap | ('CYB561')('GNAS') 17q23.3 | 20q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome b561cytochrome b-561cytochrome b561 family, member A1ferric-chelate reductase 2 | protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | P49447 | . | |
Ensembl transtripts involved in fusion gene | ENST00000392975, ENST00000360793, ENST00000392976, ENST00000448884, ENST00000542042, ENST00000581163, ENST00000581573, ENST00000582034, ENST00000582297, ENST00000582997, ENST00000584031, | ||
Fusion gene scores | * DoF score | 13 X 11 X 6=858 | 111 X 41 X 18=81918 |
# samples | 15 | 111 | |
** MAII score | log2(15/858*10)=-2.51601514700366 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(111/81918*10)=-6.20554891117303 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CYB561 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CYB561(61518088)-GNAS(57470667), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PCPG | TCGA-WB-A81I-01A | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
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Fusion Gene ORF analysis for CYB561-GNAS |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000392975 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-3UTR | ENST00000392975 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-3UTR | ENST00000392975 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-3UTR | ENST00000392975 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-3UTR | ENST00000392975 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
5UTR-intron | ENST00000392975 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000360793 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000360793 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000360793 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000360793 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000360793 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000392976 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000392976 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000392976 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000392976 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000392976 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000448884 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000448884 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000448884 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000448884 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000448884 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000542042 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000542042 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000542042 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000542042 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000542042 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581163 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581163 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581163 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581163 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581163 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581573 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581573 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581573 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581573 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000581573 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582034 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582034 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582034 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582034 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582034 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582297 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582297 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582297 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582297 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582297 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582997 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582997 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582997 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582997 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000582997 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000584031 | ENST00000313949 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000584031 | ENST00000371075 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000584031 | ENST00000371098 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000584031 | ENST00000371100 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-3UTR | ENST00000584031 | ENST00000464624 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000360793 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000392976 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000448884 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000542042 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581163 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000581573 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582034 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582297 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000582997 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000265620 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000306090 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000306120 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000354359 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000371081 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000371085 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000371095 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000371099 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
intron-intron | ENST00000584031 | ENST00000371102 | CYB561 | chr17 | 61518088 | - | GNAS | chr20 | 57470667 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CYB561-GNAS |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CYB561 | chr17 | 61518087 | - | GNAS | chr20 | 57470666 | + | 2.45E-05 | 0.99997556 |
CYB561 | chr17 | 61518087 | - | GNAS | chr20 | 57470666 | + | 2.45E-05 | 0.99997556 |
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Fusion Protein Features for CYB561-GNAS |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61518088/:57470667) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CYB561 | . |
FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes. {ECO:0000250|UniProtKB:P10897}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CYB561-GNAS |
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Fusion Gene PPI Analysis for CYB561-GNAS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CYB561-GNAS |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CYB561-GNAS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CYB561 | C4748569 | ORTHOSTATIC HYPOTENSION 2 | 1 | UNIPROT |
Tgene | C3494506 | Pseudohypoparathyroidism, Type Ia | 17 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0242292 | McCune-Albright Syndrome | 7 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0016065 | Polyostotic fibrous dysplasia | 5 | CTD_human;ORPHANET | |
Tgene | C1864100 | PSEUDOHYPOPARATHYROIDISM, TYPE IB | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C2931404 | Albright's hereditary osteodystrophy | 4 | CTD_human;GENOMICS_ENGLAND | |
Tgene | C0033806 | Pseudohypoparathyroidism | 3 | CTD_human | |
Tgene | C0334041 | Osteoma cutis | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0014130 | Endocrine System Diseases | 2 | CTD_human | |
Tgene | C0016064 | Fibrous Dysplasia, Monostotic | 2 | ORPHANET | |
Tgene | C0034013 | Precocious Puberty | 2 | CTD_human | |
Tgene | C0221263 | Cafe-au-Lait Spots | 2 | CTD_human | |
Tgene | C0271527 | Cryptogenic sexual precocity | 2 | CTD_human | |
Tgene | C0342543 | Central Precocious Puberty | 2 | CTD_human | |
Tgene | C1504412 | Testotoxicosis | 2 | CTD_human | |
Tgene | C1857451 | Acth-Independent Macronodular Adrenal Hyperplasia | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C2932716 | Pseudohypoparathyroidism Type 1C | 2 | GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0001206 | Acromegaly | 1 | CTD_human | |
Tgene | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human | |
Tgene | C0003129 | Anoxemia | 1 | CTD_human | |
Tgene | C0003130 | Anoxia | 1 | CTD_human | |
Tgene | C0008370 | Cholestasis | 1 | GENOMICS_ENGLAND | |
Tgene | C0009438 | Common Bile Duct Calculi | 1 | CTD_human | |
Tgene | C0011573 | Endogenous depression | 1 | PSYGENET | |
Tgene | C0019087 | Hemorrhagic Disorders | 1 | CTD_human | |
Tgene | C0020538 | Hypertensive disease | 1 | CTD_human | |
Tgene | C0020796 | Profound Mental Retardation | 1 | CTD_human | |
Tgene | C0021655 | Insulin Resistance | 1 | CTD_human | |
Tgene | C0023897 | Liver Diseases, Parasitic | 1 | CTD_human | |
Tgene | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human | |
Tgene | C0027819 | Neuroblastoma | 1 | CTD_human | |
Tgene | C0028754 | Obesity | 1 | CTD_human | |
Tgene | C0029396 | Heterotopic Ossification | 1 | CTD_human | |
Tgene | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human | |
Tgene | C0033835 | Pseudopseudohypoparathyroidism | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C0035204 | Respiration Disorders | 1 | CTD_human | |
Tgene | C0036341 | Schizophrenia | 1 | PSYGENET | |
Tgene | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human | |
Tgene | C0039231 | Tachycardia | 1 | CTD_human | |
Tgene | C0080203 | Tachyarrhythmia | 1 | CTD_human | |
Tgene | C0086189 | Drug Withdrawal Symptoms | 1 | CTD_human | |
Tgene | C0087169 | Withdrawal Symptoms | 1 | CTD_human | |
Tgene | C0206698 | Cholangiocarcinoma | 1 | CTD_human | |
Tgene | C0221357 | Brachydactyly | 1 | CTD_human | |
Tgene | C0242184 | Hypoxia | 1 | CTD_human | |
Tgene | C0242216 | Biliary calculi | 1 | CTD_human | |
Tgene | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human | |
Tgene | C0346302 | Growth Hormone-Secreting Pituitary Adenoma | 1 | CTD_human | |
Tgene | C0700292 | Hypoxemia | 1 | CTD_human | |
Tgene | C0750887 | Adrenal Cancer | 1 | CTD_human | |
Tgene | C0917816 | Mental deficiency | 1 | CTD_human | |
Tgene | C0920563 | Insulin Sensitivity | 1 | CTD_human | |
Tgene | C1136382 | Sclerocystic Ovaries | 1 | CTD_human | |
Tgene | C2932715 | Pseudohypoparathyroidism Type 1B | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C3489630 | Somatotrophinoma, Familial | 1 | CTD_human | |
Tgene | C3697137 | Fibrous dysplasia of bone with intramuscular myxoma | 1 | ORPHANET | |
Tgene | C3714756 | Intellectual Disability | 1 | CTD_human | |
Tgene | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |