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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADRBK1-RPLP0 (FusionGDB2 ID:HG156TG6175)

Fusion Gene Summary for ADRBK1-RPLP0

check button Fusion gene summary
Fusion gene informationFusion gene name: ADRBK1-RPLP0
Fusion gene ID: hg156tg6175
HgeneTgene
Gene symbol

ADRBK1

RPLP0

Gene ID

156

6175

Gene nameG protein-coupled receptor kinase 2ribosomal protein lateral stalk subunit P0
SynonymsADRBK1|BARK1|BETA-ARK1L10E|LP0|P0|PRLP0|RPP0
Cytomap('ADRBK1')('RPLP0')

11q13.2

12q24.23

Type of geneprotein-codingprotein-coding
Descriptionbeta-adrenergic receptor kinase 1adrenergic beta receptor kinase 1beta-ARK-160S acidic ribosomal protein P060S ribosomal protein L10Eacidic ribosomal phosphoprotein P0large ribosomal subunit protein uL10neutral ribosomal phosphoprotein P0ribosomal protein, large, P0
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000527176, ENST00000308595, 
ENST00000526285, 
Fusion gene scores* DoF score9 X 3 X 5=13524 X 10 X 14=3360
# samples 928
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(28/3360*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADRBK1 [Title/Abstract] AND RPLP0 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADRBK1(67051844)-RPLP0(120635265), # samples:1
Anticipated loss of major functional domain due to fusion event.ADRBK1-RPLP0 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ADRBK1-RPLP0 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADRBK1-RPLP0 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADRBK1

GO:0007217

tachykinin receptor signaling pathway

17986524

HgeneADRBK1

GO:0031623

receptor internalization

20074556



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3IUADRBK1chr11

67051844

+RPLP0chr12

120635265

-


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Fusion Gene ORF analysis for ADRBK1-RPLP0

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000527176ENST00000228306ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-3CDSENST00000527176ENST00000313104ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-3CDSENST00000527176ENST00000392514ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-3CDSENST00000527176ENST00000546989ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-3CDSENST00000527176ENST00000551150ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-3CDSENST00000527176ENST00000552292ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
3UTR-intronENST00000527176ENST00000550296ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
5CDS-intronENST00000308595ENST00000550296ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000228306ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000313104ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000392514ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000546989ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000551150ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
Frame-shiftENST00000308595ENST00000552292ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000228306ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000313104ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000392514ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000546989ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000551150ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-3CDSENST00000526285ENST00000552292ADRBK1chr11

67051844

+RPLP0chr12

120635265

-
intron-intronENST00000526285ENST00000550296ADRBK1chr11

67051844

+RPLP0chr12

120635265

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADRBK1-RPLP0


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ADRBK1-RPLP0


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67051844/:120635265)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ADRBK1-RPLP0


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADRBK1-RPLP0


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADRBK1-RPLP0


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADRBK1-RPLP0


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource