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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:GRK2-IQGAP1 (FusionGDB2 ID:HG156TG8826)

Fusion Gene Summary for GRK2-IQGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRK2-IQGAP1
Fusion gene ID: hg156tg8826
HgeneTgene
Gene symbol

GRK2

IQGAP1

Gene ID

156

8826

Gene nameG protein-coupled receptor kinase 2IQ motif containing GTPase activating protein 1
SynonymsADRBK1|BARK1|BETA-ARK1HUMORFA01|SAR1|p195
Cytomap('ADRBK1','GRK2')('IQGAP1','IQGAP1')

11q13.2

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionbeta-adrenergic receptor kinase 1adrenergic beta receptor kinase 1beta-ARK-1ras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifs
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308595, ENST00000526285, 
ENST00000527176, 
Fusion gene scores* DoF score9 X 3 X 5=13517 X 15 X 7=1785
# samples 919
** MAII scorelog2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1785*10)=-3.23185275058551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRK2 [Title/Abstract] AND IQGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADRBK1(67034283)-IQGAP1(90969342), # samples:1
GRK2(67034283)-IQGAP1(90969342), # samples:1
Anticipated loss of major functional domain due to fusion event.ADRBK1-IQGAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADRBK1-IQGAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADRBK1-IQGAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADRBK1-IQGAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRK2

GO:0007217

tachykinin receptor signaling pathway

17986524

HgeneGRK2

GO:0031623

receptor internalization

20074556

TgeneIQGAP1

GO:0071277

cellular response to calcium ion

18567582


check buttonFusion gene breakpoints across ADRBK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IQGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TS-01AADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
ChimerDB4BRCATCGA-AR-A0TS-01AGRK2chr11

67034283

+IQGAP1chr15

90969342

+


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Fusion Gene ORF analysis for GRK2-IQGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308595ENST00000560020ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
5CDS-intronENST00000308595ENST00000560738ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
5CDS-intronENST00000526285ENST00000560020ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
5CDS-intronENST00000526285ENST00000560738ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
In-frameENST00000308595ENST00000268182ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
In-frameENST00000526285ENST00000268182ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
intron-3CDSENST00000527176ENST00000268182ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
intron-intronENST00000527176ENST00000560020ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+
intron-intronENST00000527176ENST00000560738ADRBK1chr11

67034283

-IQGAP1chr15

90969342

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308595ADRBK1chr1167034283-ENST00000268182IQGAP1chr1590969342+735740329052211643
ENST00000526285ADRBK1chr1167034283-ENST00000268182IQGAP1chr1590969342+728633221951501643

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308595ENST00000268182ADRBK1chr1167034283-IQGAP1chr1590969342+0.0005015540.9994985
ENST00000526285ENST00000268182ADRBK1chr1167034283-IQGAP1chr1590969342+0.0004497530.9995503

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Fusion Genomic Features for GRK2-IQGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GRK2-IQGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67034283/:90969342)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIQGAP1chr11:67034283chr15:90969342ENST000002681821381004_1237511658.0DomainRas-GAP
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138679_712511658.0DomainWW
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138745_774511658.0DomainIQ 1
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138775_804511658.0DomainIQ 2
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138805_834511658.0DomainIQ 3
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138835_864511658.0DomainIQ 4
TgeneIQGAP1chr11:67034283chr15:90969342ENST000002681821381276_1657511658.0RegionNote=C2
TgeneIQGAP1chr11:67034283chr15:90969342ENST00000268182138956_1274511658.0RegionNote=C1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-121191_45337690.0DomainProtein kinase
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-121454_52137690.0DomainAGC-kinase C-terminal
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-12154_17537690.0DomainRGS
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-121558_65237690.0DomainPH
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-121197_20537690.0Nucleotide bindingATP
HgeneADRBK1chr11:67034283chr15:90969342ENST00000308595-1211_19037690.0RegionNote=N-terminal
TgeneIQGAP1chr11:67034283chr15:90969342ENST0000026818213844_159511658.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for GRK2-IQGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2538_2538_1_ADRBK1-IQGAP1_ADRBK1_chr11_67034283_ENST00000308595_IQGAP1_chr15_90969342_ENST00000268182_length(transcript)=7357nt_BP=403nt
GGAGGCGGCGGCGGCTCCGGGGCGCGGGCGCGCGGGCGGCGGCGGCGGCGGCGCCCCGACTGCAGTCCCGGCGGGAGCGGAGCGCGAGCC
GGGGCCGGGCCCGAGCCGGCGCCATGGGGCGGCGCCGCCTGTGAGCGGCGGCGAGCGGAGCCGCGGGCGCCGAGCAGGGCCAGGCGGGAG
GCGTCGGCGCCCGAGGCCGAGCGAGCCGCGGCCGGGCCGGGCCGAGCGCCGAGCGAGCAGGAGCGGCGGCGGCGGCGGCGGCGGCGGGAG
GAGGCAGCGCCGCCGCCAAGATGGCGGACCTGGAGGCGGTGCTGGCCGACGTGAGCTACCTGATGGCCATGGAGAAGAGCAAGGCCACGC
CGGCCGCGCGCGCCAGCAAGAAGATCCTGCTGCCCGAGCCCAGGTGGATGGAAGCATGCCTAGGGGAAGATCTGCCTCCCACCACAGAAC
TGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGCCAAACTGGGGAACTTCTTCTCTCCCAAAGTAGTGTCCCTGAAAAAAATCTATGATC
GAGAACAGACCAGATACAAGGCGACTGGCCTCCACTTTAGACACACTGATAATGTGATTCAGTGGTTGAATGCCATGGATGAGATTGGAT
TGCCTAAGATTTTTTACCCAGAAACTACAGATATCTATGATCGAAAGAACATGCCAAGATGTATCTACTGTATCCATGCACTCAGTTTGT
ACCTGTTCAAGCTAGGCCTGGCCCCTCAGATTCAAGACCTATATGGAAAGGTTGACTTCACAGAAGAAGAAATCAACAACATGAAGACTG
AGTTGGAGAAGTATGGCATCCAGATGCCTGCCTTTAGCAAGATTGGGGGCATCTTGGCTAATGAACTGTCAGTGGATGAAGCCGCATTAC
ATGCTGCTGTTATTGCTATTAATGAAGCTATTGACCGTAGAATTCCAGCCGACACATTTGCAGCTTTGAAAAATCCGAATGCCATGCTTG
TAAATCTTGAAGAGCCCTTGGCATCCACTTACCAGGATATACTTTACCAGGCTAAGCAGGACAAAATGACAAATGCTAAAAACAGGACAG
AAAACTCAGAGAGAGAAAGAGATGTTTATGAGGAGCTGCTCACGCAAGCTGAAATTCAAGGCAATATAAACAAAGTCAATACATTTTCTG
CATTAGCAAATATCGACCTGGCTTTAGAACAAGGAGATGCACTGGCCTTGTTCAGGGCTCTGCAGTCACCAGCCCTGGGGCTTCGAGGAC
TGCAGCAACAGAATAGCGACTGGTACTTGAAGCAGCTCCTGAGTGATAAACAGCAGAAGAGACAGAGTGGTCAGACTGACCCCCTGCAGA
AGGAGGAGCTGCAGTCTGGAGTGGATGCTGCAAACAGTGCTGCCCAGCAATATCAGAGAAGATTGGCAGCAGTAGCACTGATTAATGCTG
CAATCCAGAAGGGTGTTGCTGAGAAGACTGTTTTGGAACTGATGAATCCCGAAGCCCAGCTGCCCCAGGTGTATCCATTTGCCGCCGATC
TCTATCAGAAGGAGCTGGCTACCCTGCAGCGACAAAGTCCTGAACATAATCTCACCCACCCAGAGCTCTCTGTCGCAGTGGAGATGTTGT
CATCGGTGGCCCTGATCAACAGGGCATTGGAATCAGGAGATGTGAATACAGTGTGGAAGCAATTGAGCAGTTCAGTTACTGGTCTTACCA
ATATTGAGGAAGAAAACTGTCAGAGGTATCTCGATGAGTTGATGAAACTGAAGGCTCAGGCACATGCAGAGAATAATGAATTCATTACAT
GGAATGATATCCAAGCTTGCGTGGACCATGTGAACCTGGTGGTGCAAGAGGAACATGAGAGGATTTTAGCCATTGGTTTAATTAATGAAG
CCCTGGATGAAGGTGATGCCCAAAAGACTCTGCAGGCCCTACAGATTCCTGCAGCTAAACTTGAGGGAGTCCTTGCAGAAGTGGCCCAGC
ATTACCAAGACACGCTGATTAGAGCGAAGAGAGAGAAAGCCCAGGAAATCCAGGATGAGTCAGCTGTGTTATGGTTGGATGAAATTCAAG
GTGGAATCTGGCAGTCCAACAAAGACACCCAAGAAGCACAGAAGTTTGCCTTAGGAATCTTTGCCATTAATGAGGCAGTAGAAAGTGGTG
ATGTTGGCAAAACACTGAGTGCCCTTCGCTCCCCTGATGTTGGCTTGTATGGAGTCATCCCTGAGTGTGGTGAAACTTACCACAGTGATC
TTGCTGAAGCCAAGAAGAAAAAACTGGCAGTAGGAGATAATAACAGCAAGTGGGTGAAGCACTGGGTAAAAGGTGGATATTATTATTACC
ACAATCTGGAGACCCAGGAAGGAGGATGGGATGAACCTCCAAATTTTGTGCAAAATTCTATGCAGCTTTCTCGGGAGGAGATCCAGAGTT
CTATCTCTGGGGTGACTGCCGCATATAACCGAGAACAGCTGTGGCTGGCCAATGAAGGCCTGATCACCAGGCTGCAGGCTCGCTGCCGTG
GATACTTAGTTCGACAGGAATTCCGATCCAGGATGAATTTCCTGAAGAAACAAATCCCTGCCATCACCTGCATTCAGTCACAGTGGAGAG
GATACAAGCAGAAGAAGGCATATCAAGATCGGTTAGCTTACCTGCGCTCCCACAAAGATGAAGTTGTAAAGATTCAGTCCCTGGCAAGGA
TGCACCAAGCTCGAAAGCGCTATCGAGATCGCCTGCAGTACTTCCGGGACCATATAAATGACATTATCAAAATCCAGGCTTTTATTCGGG
CAAACAAAGCTCGGGATGACTACAAGACTCTCATCAATGCTGAGGATCCTCCTATGGTTGTGGTCCGAAAATTTGTCCACCTGCTGGACC
AAAGTGACCAGGATTTTCAGGAGGAGCTTGACCTTATGAAGATGCGGGAAGAGGTTATCACCCTCATTCGTTCTAACCAGCAGCTGGAGA
ATGACCTCAATCTCATGGATATCAAAATTGGACTGCTAGTGAAAAATAAGATTACGTTGCAGGATGTGGTTTCCCACAGTAAAAAACTTA
CCAAAAAAAATAAGGAACAGTTGTCTGATATGATGATGATAAATAAACAGAAGGGAGGTCTCAAGGCTTTGAGCAAGGAGAAGAGAGAGA
AGTTGGAAGCTTACCAGCACCTGTTTTATTTATTGCAAACCAATCCCACCTATCTGGCCAAGCTCATTTTTCAGATGCCCCAGAACAAGT
CCACCAAGTTCATGGACTCTGTAATCTTCACACTCTACAACTACGCGTCCAACCAGCGAGAGGAGTACCTGCTCCTGCGGCTCTTTAAGA
CAGCACTCCAAGAGGAAATCAAGTCGAAGGTAGATCAGATTCAAGAGATTGTGACAGGAAATCCTACGGTTATTAAAATGGTTGTAAGTT
TCAACCGTGGTGCCCGTGGCCAGAATGCCCTGAGACAGATCTTGGCCCCAGTCGTGAAGGAAATTATGGATGACAAATCTCTCAACATCA
AAACTGACCCTGTGGATATTTACAAATCTTGGGTTAATCAGATGGAGTCTCAGACAGGAGAGGCAAGCAAACTGCCCTATGATGTGACCC
CTGAGCAGGCGCTAGCTCATGAAGAAGTGAAGACACGGCTAGACAGCTCCATCAGGAACATGCGGGCTGTGACAGACAAGTTTCTCTCAG
CCATTGTCAGCTCTGTGGACAAAATCCCTTATGGGATGCGCTTCATTGCCAAAGTGCTGAAGGACTCGTTGCATGAGAAGTTCCCTGATG
CTGGTGAGGATGAGCTGCTGAAGATTATTGGTAACTTGCTTTATTATCGATACATGAATCCAGCCATTGTTGCTCCTGATGCCTTTGACA
TCATTGACCTGTCAGCAGGAGGCCAGCTTACCACAGACCAACGCCGAAATCTGGGCTCCATTGCAAAAATGCTTCAGCATGCTGCTTCCA
ATAAGATGTTTCTGGGAGATAATGCCCACTTAAGCATCATTAATGAATATCTTTCCCAGTCCTACCAGAAATTCAGACGGTTTTTCCAAA
CTGCTTGTGATGTCCCAGAGCTTCAGGATAAATTTAATGTGGATGAGTACTCTGATTTAGTAACCCTCACCAAACCAGTAATCTACATTT
CCATTGGTGAAATCATCAACACCCACACTCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAACTGC
TGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTA
AGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATA
CAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAG
CAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACA
GCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAAT
ACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAAC
AGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACT
TAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGAC
TACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAG
TTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATG
AAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGT
AATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAA
GACCTAGCCAACAACAGCACCTCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTT
TTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAAACTCCACT
AAAATTTCTCTGTGTTGTTACAGTCTTAGAGGTTGCAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATTAGCAATAGGGATGGTAGGA
TTCAAATGTGTGTCATTTAGAAGTGGAAGCTATTAGCACCAATGACATAAATACATACAAGACACACAACTAAAATGTCATGTTATTAAC
AGTTATTAGGTTGTCATTTAAAAATAAAGTTCCTTTATATTTCTGTCCCATCAGGAAAACTGAAGGATATGGGGAATCATTGGTTATCTT
CCATTGTGTTTTTCTTTATGGACAGGAGCTAATGGAAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAAAAAAGGAGATAATGTTTTT
AAATTTCATTATCAAACTTGGGCAATTCTGTTTGTGTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTGCTAAAATTCAGCTACTCAG
ATAAATTCAGAATGGGTCAAGGCACCTGCCTGTTTTTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGACAATTCACTCCATCCCTAT
GGCAGAGGAATGGGTTAGCCCTAATGTAGAATGTCATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCCTTATTAAAGTATAGATGTA
TGTCTTAAAATGTGGGTGATAGGAATTTTAAAGATTTATATAATGCATCAAAAGCCTTAGAATAAGAAAAGCTTTTTTTAAATTGCTTTA
TCTGTATATCTGAACTCTTGAAACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTCAGGGAGATAATTCTGCCTTTAATTGTCTAA
AACAAAAACAAAACCAGCCAACCTATGTTACACGTGAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCTTTTTTCTCTTGCTGCCCAC
ATTGTGCCTTTATTTTATGAGCCCCAGTTTTCTGGGCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGCATTTAGAAAGCTTTTGTTC
TTGGATAAAAAGTCATACACTTTAAAAAAAAAAAAAACTTTTTCCAGGAAAATATATTGAAATCATGCTGCTGAGCCTCTATTTTCTTTC
TTTGATGTTTTGATTCAGTATTCTTTTATCATAAATTTTTAGCATTTAAAAATTCACTGATGTACATTAAGCCAATAAACTGCTTTAATG
AATAACAAACTATGTAGTGTGTCCCTATTATAAATGCATTGGAGAAGTATTTTTATGAGACTCTTTACTCAGGTGCATGGTTACAGCCCA
CAGGGAGGCATGGAGTGCCATGGAAGGATTCGCCACTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGACAGGTTTTTTAAAGAAACA
TTTTCCTCAGATTAAAAGATGATGCTATTACAACTAGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTGTCAACCCTGTTTCCTTAAA
AGAGGCTATGAATCCCAAAGGCCACATCCAAGACAGGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAAAATGTGTCAGTAATTTTAA
GGTTTATAGTTCCCTCAACACAATTGCTAATGCAGAATAGTGTAAAATGCGCTTCAAGAATGTTGATGATGATGATATAGAATTGTGGCT
TTAGTAGCACAGAGGATGCCCCAACAAACTCATGGCGTTGAAACCACACAGTTCTCATTACTGTTATTTATTAGCTGTAGCATTCTCTGT
CTCCTCTCTCTCCTCCTTTGACCTTCTCCTCGACCAGCCATCATGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGGACTGCCCG

>2538_2538_1_ADRBK1-IQGAP1_ADRBK1_chr11_67034283_ENST00000308595_IQGAP1_chr15_90969342_ENST00000268182_length(amino acids)=1643AA_BP=37
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYK
ATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGI
QMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERER
DVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSG
VDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALIN
RALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDA
QKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLS
ALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTA
AYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKR
YRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDS
VIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDI
YKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELL
KIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPE
LQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLT
LTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQE
KKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKV
SKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMK

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>2538_2538_2_ADRBK1-IQGAP1_ADRBK1_chr11_67034283_ENST00000526285_IQGAP1_chr15_90969342_ENST00000268182_length(transcript)=7286nt_BP=332nt
CGGGAGCGGAGCGCGAGCCGGGGCCGGGCCCGAGCCGGCGCCATGGGGCGGCGCCGCCTGTGAGCGGCGGCGAGCGGAGCCGCGGGCGCC
GAGCAGGGCCAGGCGGGAGGCGTCGGCGCCCGAGGCCGAGCGAGCCGCGGCCGGGCCGGGCCGAGCGCCGAGCGAGCAGGAGCGGCGGCG
GCGGCGGCGGCGGCGGGAGGAGGCAGCGCCGCCGCCAAGATGGCGGACCTGGAGGCGGTGCTGGCCGACGTGAGCTACCTGATGGCCATG
GAGAAGAGCAAGGCCACGCCGGCCGCGCGCGCCAGCAAGAAGATCCTGCTGCCCGAGCCCAGGTGGATGGAAGCATGCCTAGGGGAAGAT
CTGCCTCCCACCACAGAACTGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGCCAAACTGGGGAACTTCTTCTCTCCCAAAGTAGTGTCC
CTGAAAAAAATCTATGATCGAGAACAGACCAGATACAAGGCGACTGGCCTCCACTTTAGACACACTGATAATGTGATTCAGTGGTTGAAT
GCCATGGATGAGATTGGATTGCCTAAGATTTTTTACCCAGAAACTACAGATATCTATGATCGAAAGAACATGCCAAGATGTATCTACTGT
ATCCATGCACTCAGTTTGTACCTGTTCAAGCTAGGCCTGGCCCCTCAGATTCAAGACCTATATGGAAAGGTTGACTTCACAGAAGAAGAA
ATCAACAACATGAAGACTGAGTTGGAGAAGTATGGCATCCAGATGCCTGCCTTTAGCAAGATTGGGGGCATCTTGGCTAATGAACTGTCA
GTGGATGAAGCCGCATTACATGCTGCTGTTATTGCTATTAATGAAGCTATTGACCGTAGAATTCCAGCCGACACATTTGCAGCTTTGAAA
AATCCGAATGCCATGCTTGTAAATCTTGAAGAGCCCTTGGCATCCACTTACCAGGATATACTTTACCAGGCTAAGCAGGACAAAATGACA
AATGCTAAAAACAGGACAGAAAACTCAGAGAGAGAAAGAGATGTTTATGAGGAGCTGCTCACGCAAGCTGAAATTCAAGGCAATATAAAC
AAAGTCAATACATTTTCTGCATTAGCAAATATCGACCTGGCTTTAGAACAAGGAGATGCACTGGCCTTGTTCAGGGCTCTGCAGTCACCA
GCCCTGGGGCTTCGAGGACTGCAGCAACAGAATAGCGACTGGTACTTGAAGCAGCTCCTGAGTGATAAACAGCAGAAGAGACAGAGTGGT
CAGACTGACCCCCTGCAGAAGGAGGAGCTGCAGTCTGGAGTGGATGCTGCAAACAGTGCTGCCCAGCAATATCAGAGAAGATTGGCAGCA
GTAGCACTGATTAATGCTGCAATCCAGAAGGGTGTTGCTGAGAAGACTGTTTTGGAACTGATGAATCCCGAAGCCCAGCTGCCCCAGGTG
TATCCATTTGCCGCCGATCTCTATCAGAAGGAGCTGGCTACCCTGCAGCGACAAAGTCCTGAACATAATCTCACCCACCCAGAGCTCTCT
GTCGCAGTGGAGATGTTGTCATCGGTGGCCCTGATCAACAGGGCATTGGAATCAGGAGATGTGAATACAGTGTGGAAGCAATTGAGCAGT
TCAGTTACTGGTCTTACCAATATTGAGGAAGAAAACTGTCAGAGGTATCTCGATGAGTTGATGAAACTGAAGGCTCAGGCACATGCAGAG
AATAATGAATTCATTACATGGAATGATATCCAAGCTTGCGTGGACCATGTGAACCTGGTGGTGCAAGAGGAACATGAGAGGATTTTAGCC
ATTGGTTTAATTAATGAAGCCCTGGATGAAGGTGATGCCCAAAAGACTCTGCAGGCCCTACAGATTCCTGCAGCTAAACTTGAGGGAGTC
CTTGCAGAAGTGGCCCAGCATTACCAAGACACGCTGATTAGAGCGAAGAGAGAGAAAGCCCAGGAAATCCAGGATGAGTCAGCTGTGTTA
TGGTTGGATGAAATTCAAGGTGGAATCTGGCAGTCCAACAAAGACACCCAAGAAGCACAGAAGTTTGCCTTAGGAATCTTTGCCATTAAT
GAGGCAGTAGAAAGTGGTGATGTTGGCAAAACACTGAGTGCCCTTCGCTCCCCTGATGTTGGCTTGTATGGAGTCATCCCTGAGTGTGGT
GAAACTTACCACAGTGATCTTGCTGAAGCCAAGAAGAAAAAACTGGCAGTAGGAGATAATAACAGCAAGTGGGTGAAGCACTGGGTAAAA
GGTGGATATTATTATTACCACAATCTGGAGACCCAGGAAGGAGGATGGGATGAACCTCCAAATTTTGTGCAAAATTCTATGCAGCTTTCT
CGGGAGGAGATCCAGAGTTCTATCTCTGGGGTGACTGCCGCATATAACCGAGAACAGCTGTGGCTGGCCAATGAAGGCCTGATCACCAGG
CTGCAGGCTCGCTGCCGTGGATACTTAGTTCGACAGGAATTCCGATCCAGGATGAATTTCCTGAAGAAACAAATCCCTGCCATCACCTGC
ATTCAGTCACAGTGGAGAGGATACAAGCAGAAGAAGGCATATCAAGATCGGTTAGCTTACCTGCGCTCCCACAAAGATGAAGTTGTAAAG
ATTCAGTCCCTGGCAAGGATGCACCAAGCTCGAAAGCGCTATCGAGATCGCCTGCAGTACTTCCGGGACCATATAAATGACATTATCAAA
ATCCAGGCTTTTATTCGGGCAAACAAAGCTCGGGATGACTACAAGACTCTCATCAATGCTGAGGATCCTCCTATGGTTGTGGTCCGAAAA
TTTGTCCACCTGCTGGACCAAAGTGACCAGGATTTTCAGGAGGAGCTTGACCTTATGAAGATGCGGGAAGAGGTTATCACCCTCATTCGT
TCTAACCAGCAGCTGGAGAATGACCTCAATCTCATGGATATCAAAATTGGACTGCTAGTGAAAAATAAGATTACGTTGCAGGATGTGGTT
TCCCACAGTAAAAAACTTACCAAAAAAAATAAGGAACAGTTGTCTGATATGATGATGATAAATAAACAGAAGGGAGGTCTCAAGGCTTTG
AGCAAGGAGAAGAGAGAGAAGTTGGAAGCTTACCAGCACCTGTTTTATTTATTGCAAACCAATCCCACCTATCTGGCCAAGCTCATTTTT
CAGATGCCCCAGAACAAGTCCACCAAGTTCATGGACTCTGTAATCTTCACACTCTACAACTACGCGTCCAACCAGCGAGAGGAGTACCTG
CTCCTGCGGCTCTTTAAGACAGCACTCCAAGAGGAAATCAAGTCGAAGGTAGATCAGATTCAAGAGATTGTGACAGGAAATCCTACGGTT
ATTAAAATGGTTGTAAGTTTCAACCGTGGTGCCCGTGGCCAGAATGCCCTGAGACAGATCTTGGCCCCAGTCGTGAAGGAAATTATGGAT
GACAAATCTCTCAACATCAAAACTGACCCTGTGGATATTTACAAATCTTGGGTTAATCAGATGGAGTCTCAGACAGGAGAGGCAAGCAAA
CTGCCCTATGATGTGACCCCTGAGCAGGCGCTAGCTCATGAAGAAGTGAAGACACGGCTAGACAGCTCCATCAGGAACATGCGGGCTGTG
ACAGACAAGTTTCTCTCAGCCATTGTCAGCTCTGTGGACAAAATCCCTTATGGGATGCGCTTCATTGCCAAAGTGCTGAAGGACTCGTTG
CATGAGAAGTTCCCTGATGCTGGTGAGGATGAGCTGCTGAAGATTATTGGTAACTTGCTTTATTATCGATACATGAATCCAGCCATTGTT
GCTCCTGATGCCTTTGACATCATTGACCTGTCAGCAGGAGGCCAGCTTACCACAGACCAACGCCGAAATCTGGGCTCCATTGCAAAAATG
CTTCAGCATGCTGCTTCCAATAAGATGTTTCTGGGAGATAATGCCCACTTAAGCATCATTAATGAATATCTTTCCCAGTCCTACCAGAAA
TTCAGACGGTTTTTCCAAACTGCTTGTGATGTCCCAGAGCTTCAGGATAAATTTAATGTGGATGAGTACTCTGATTTAGTAACCCTCACC
AAACCAGTAATCTACATTTCCATTGGTGAAATCATCAACACCCACACTCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAAT
GATCCAATCCACGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCA
AATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCT
CGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCA
GCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCA
AAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACC
GTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCC
GAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATC
AAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTG
AAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAA
ATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGAC
CTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAAC
AAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTC
TTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACCTCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGAT
GGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGG
AAAGAGTGGAAACTCCACTAAAATTTCTCTGTGTTGTTACAGTCTTAGAGGTTGCAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATT
AGCAATAGGGATGGTAGGATTCAAATGTGTGTCATTTAGAAGTGGAAGCTATTAGCACCAATGACATAAATACATACAAGACACACAACT
AAAATGTCATGTTATTAACAGTTATTAGGTTGTCATTTAAAAATAAAGTTCCTTTATATTTCTGTCCCATCAGGAAAACTGAAGGATATG
GGGAATCATTGGTTATCTTCCATTGTGTTTTTCTTTATGGACAGGAGCTAATGGAAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAA
AAAAGGAGATAATGTTTTTAAATTTCATTATCAAACTTGGGCAATTCTGTTTGTGTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTG
CTAAAATTCAGCTACTCAGATAAATTCAGAATGGGTCAAGGCACCTGCCTGTTTTTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGA
CAATTCACTCCATCCCTATGGCAGAGGAATGGGTTAGCCCTAATGTAGAATGTCATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCC
TTATTAAAGTATAGATGTATGTCTTAAAATGTGGGTGATAGGAATTTTAAAGATTTATATAATGCATCAAAAGCCTTAGAATAAGAAAAG
CTTTTTTTAAATTGCTTTATCTGTATATCTGAACTCTTGAAACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTCAGGGAGATAAT
TCTGCCTTTAATTGTCTAAAACAAAAACAAAACCAGCCAACCTATGTTACACGTGAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCT
TTTTTCTCTTGCTGCCCACATTGTGCCTTTATTTTATGAGCCCCAGTTTTCTGGGCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGC
ATTTAGAAAGCTTTTGTTCTTGGATAAAAAGTCATACACTTTAAAAAAAAAAAAAACTTTTTCCAGGAAAATATATTGAAATCATGCTGC
TGAGCCTCTATTTTCTTTCTTTGATGTTTTGATTCAGTATTCTTTTATCATAAATTTTTAGCATTTAAAAATTCACTGATGTACATTAAG
CCAATAAACTGCTTTAATGAATAACAAACTATGTAGTGTGTCCCTATTATAAATGCATTGGAGAAGTATTTTTATGAGACTCTTTACTCA
GGTGCATGGTTACAGCCCACAGGGAGGCATGGAGTGCCATGGAAGGATTCGCCACTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGA
CAGGTTTTTTAAAGAAACATTTTCCTCAGATTAAAAGATGATGCTATTACAACTAGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTG
TCAACCCTGTTTCCTTAAAAGAGGCTATGAATCCCAAAGGCCACATCCAAGACAGGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAA
AATGTGTCAGTAATTTTAAGGTTTATAGTTCCCTCAACACAATTGCTAATGCAGAATAGTGTAAAATGCGCTTCAAGAATGTTGATGATG
ATGATATAGAATTGTGGCTTTAGTAGCACAGAGGATGCCCCAACAAACTCATGGCGTTGAAACCACACAGTTCTCATTACTGTTATTTAT
TAGCTGTAGCATTCTCTGTCTCCTCTCTCTCCTCCTTTGACCTTCTCCTCGACCAGCCATCATGACATTTACCATGAATTTACTTCCTCC

>2538_2538_2_ADRBK1-IQGAP1_ADRBK1_chr11_67034283_ENST00000526285_IQGAP1_chr15_90969342_ENST00000268182_length(amino acids)=1643AA_BP=37
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYK
ATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGI
QMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERER
DVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSG
VDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALIN
RALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDA
QKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLS
ALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTA
AYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKR
YRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDS
VIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDI
YKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELL
KIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPE
LQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLT
LTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQE
KKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKV
SKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMK

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Fusion Gene PPI Analysis for GRK2-IQGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRK2-IQGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRK2-IQGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRK2C0000768Congenital Abnormality1CTD_human
HgeneGRK2C0003873Rheumatoid Arthritis1CTD_human
HgeneGRK2C0007222Cardiovascular Diseases1CTD_human
HgeneGRK2C0012684Blastocyst Disintegration1CTD_human
HgeneGRK2C0013937Embryo Resorption1CTD_human
HgeneGRK2C0018800Cardiomegaly1CTD_human
HgeneGRK2C0018801Heart failure1CTD_human
HgeneGRK2C0018802Congestive heart failure1CTD_human
HgeneGRK2C0020538Hypertensive disease1CTD_human
HgeneGRK2C0023212Left-Sided Heart Failure1CTD_human
HgeneGRK2C0033141Cardiomyopathies, Primary1CTD_human
HgeneGRK2C0036529Myocardial Diseases, Secondary1CTD_human
HgeneGRK2C0162820Dermatitis, Allergic Contact1CTD_human
HgeneGRK2C0235527Heart Failure, Right-Sided1CTD_human
HgeneGRK2C0752350Embryo Death1CTD_human
HgeneGRK2C0752351Embryo Loss1CTD_human
HgeneGRK2C0878544Cardiomyopathies1CTD_human
HgeneGRK2C1136082Embryo Disintegration1CTD_human
HgeneGRK2C1383860Cardiac Hypertrophy1CTD_human
HgeneGRK2C1959583Myocardial Failure1CTD_human
HgeneGRK2C1961112Heart Decompensation1CTD_human
TgeneC0006118Brain Neoplasms1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0043094Weight Gain1CTD_human
TgeneC0153633Malignant neoplasm of brain1CTD_human
TgeneC0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneC0750974Brain Tumor, Primary1CTD_human
TgeneC0750977Recurrent Brain Neoplasm1CTD_human
TgeneC0750979Primary malignant neoplasm of brain1CTD_human
TgeneC1527390Neoplasms, Intracranial1CTD_human
TgeneC2239176Liver carcinoma1CTD_human