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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYP2E1-NEBL (FusionGDB2 ID:HG1571TG10529)

Fusion Gene Summary for CYP2E1-NEBL

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP2E1-NEBL
Fusion gene ID: hg1571tg10529
HgeneTgene
Gene symbol

CYP2E1

NEBL

Gene ID

1571

10529

Gene namecytochrome P450 family 2 subfamily E member 1nebulette
SynonymsCPE1|CYP2E|P450-J|P450C2EC10orf113|LASP2|LNEBL|bA165O3.1
Cytomap('CYP2E1')('NEBL')

10q26.3

10p12.31

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 2E14-nitrophenol 2-hydroxylaseCYPIIE1cytochrome P450, family 2, subfamily E, polypeptide 1cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1cytochrome P450-Jflavoprotein-linked monooxygenasemicrosomal monooxygenasexenebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk protein
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000252945, ENST00000463117, 
ENST00000480558, 
Fusion gene scores* DoF score8 X 5 X 3=12012 X 11 X 6=792
# samples 813
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP2E1 [Title/Abstract] AND NEBL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYP2E1(135341076)-NEBL(21101869), # samples:1
Anticipated loss of major functional domain due to fusion event.CYP2E1-NEBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-NEBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-NEBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-NEBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP2E1

GO:0002933

lipid hydroxylation

10553002

HgeneCYP2E1

GO:0016098

monoterpenoid metabolic process

16401082

HgeneCYP2E1

GO:0017144

drug metabolic process

19219744

HgeneCYP2E1

GO:0018960

4-nitrophenol metabolic process

9348445

HgeneCYP2E1

GO:0046483

heterocycle metabolic process

19651758

HgeneCYP2E1

GO:0055114

oxidation-reduction process

16401082|19219744


check buttonFusion gene breakpoints across CYP2E1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NEBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-DD-A1EB-11ACYP2E1chr10

135341076

+NEBLchr10

21101869

-


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Fusion Gene ORF analysis for CYP2E1-NEBL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252945ENST00000377119CYP2E1chr10

135341076

+NEBLchr10

21101869

-
5CDS-intronENST00000252945ENST00000464278CYP2E1chr10

135341076

+NEBLchr10

21101869

-
5CDS-intronENST00000463117ENST00000377119CYP2E1chr10

135341076

+NEBLchr10

21101869

-
5CDS-intronENST00000463117ENST00000464278CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000252945ENST00000377122CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000252945ENST00000377159CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000252945ENST00000417816CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000463117ENST00000377122CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000463117ENST00000377159CYP2E1chr10

135341076

+NEBLchr10

21101869

-
In-frameENST00000463117ENST00000417816CYP2E1chr10

135341076

+NEBLchr10

21101869

-
intron-3CDSENST00000480558ENST00000377122CYP2E1chr10

135341076

+NEBLchr10

21101869

-
intron-3CDSENST00000480558ENST00000377159CYP2E1chr10

135341076

+NEBLchr10

21101869

-
intron-3CDSENST00000480558ENST00000417816CYP2E1chr10

135341076

+NEBLchr10

21101869

-
intron-intronENST00000480558ENST00000377119CYP2E1chr10

135341076

+NEBLchr10

21101869

-
intron-intronENST00000480558ENST00000464278CYP2E1chr10

135341076

+NEBLchr10

21101869

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000463117CYP2E1chr10135341076+ENST00000377122NEBLchr1021101869-69224492001147315
ENST00000463117CYP2E1chr10135341076+ENST00000417816NEBLchr1021101869-2746449200904234
ENST00000463117CYP2E1chr10135341076+ENST00000377159NEBLchr1021101869-1181449200904234
ENST00000252945CYP2E1chr10135341076+ENST00000377122NEBLchr1021101869-668321033908291
ENST00000252945CYP2E1chr10135341076+ENST00000417816NEBLchr1021101869-250721033665210
ENST00000252945CYP2E1chr10135341076+ENST00000377159NEBLchr1021101869-94221033665210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000463117ENST00000377122CYP2E1chr10135341076+NEBLchr1021101869-0.0001561790.99984384
ENST00000463117ENST00000417816CYP2E1chr10135341076+NEBLchr1021101869-0.0006270270.999373
ENST00000463117ENST00000377159CYP2E1chr10135341076+NEBLchr1021101869-0.0025345550.9974655
ENST00000252945ENST00000377122CYP2E1chr10135341076+NEBLchr1021101869-8.55E-050.9999144
ENST00000252945ENST00000417816CYP2E1chr10135341076+NEBLchr1021101869-0.0003001670.99969983
ENST00000252945ENST00000377159CYP2E1chr10135341076+NEBLchr1021101869-0.0009534170.9990466

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Fusion Genomic Features for CYP2E1-NEBL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CYP2E1-NEBL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:135341076/chr10:21101869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228954_10147821015.0DomainSH3
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637954_1014119271.0DomainSH3
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228836_9537821015.0RegionNote=Linker
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637836_953119271.0RegionNote=Linker
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228795_8307821015.0RepeatNote=Nebulin 23
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637137_172119271.0RepeatNote=Nebulin 4
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637173_205119271.0RepeatNote=Nebulin 5
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637206_241119271.0RepeatNote=Nebulin 6
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637242_278119271.0RepeatNote=Nebulin 7
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637279_313119271.0RepeatNote=Nebulin 8
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637314_348119271.0RepeatNote=Nebulin 9
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637349_385119271.0RepeatNote=Nebulin 10
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637386_422119271.0RepeatNote=Nebulin 11
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637423_459119271.0RepeatNote=Nebulin 12
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637460_496119271.0RepeatNote=Nebulin 13
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637497_533119271.0RepeatNote=Nebulin 14
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637534_569119271.0RepeatNote=Nebulin 15
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637570_599119271.0RepeatNote=Nebulin 16
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637600_635119271.0RepeatNote=Nebulin 17
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637636_666119271.0RepeatNote=Nebulin 18
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637667_693119271.0RepeatNote=Nebulin 19
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637694_728119271.0RepeatNote=Nebulin 20
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637729_759119271.0RepeatNote=Nebulin 21
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637760_794119271.0RepeatNote=Nebulin 22
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637795_830119271.0RepeatNote=Nebulin 23

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYP2E1chr10:135341076chr10:21101869ENST00000252945+19298_30359494.0RegionSubstrate binding
HgeneCYP2E1chr10:135341076chr10:21101869ENST00000463117+311298_30359494.0RegionSubstrate binding
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228100_1367821015.0RepeatNote=Nebulin 3
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228137_1727821015.0RepeatNote=Nebulin 4
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228173_2057821015.0RepeatNote=Nebulin 5
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228206_2417821015.0RepeatNote=Nebulin 6
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228242_2787821015.0RepeatNote=Nebulin 7
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228279_3137821015.0RepeatNote=Nebulin 8
TgeneNEBLchr10:135341076chr10:21101869ENST00000377122222829_637821015.0RepeatNote=Nebulin 1
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228314_3487821015.0RepeatNote=Nebulin 9
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228349_3857821015.0RepeatNote=Nebulin 10
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228386_4227821015.0RepeatNote=Nebulin 11
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228423_4597821015.0RepeatNote=Nebulin 12
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228460_4967821015.0RepeatNote=Nebulin 13
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228497_5337821015.0RepeatNote=Nebulin 14
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228534_5697821015.0RepeatNote=Nebulin 15
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228570_5997821015.0RepeatNote=Nebulin 16
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228600_6357821015.0RepeatNote=Nebulin 17
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228636_6667821015.0RepeatNote=Nebulin 18
TgeneNEBLchr10:135341076chr10:21101869ENST00000377122222864_997821015.0RepeatNote=Nebulin 2
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228667_6937821015.0RepeatNote=Nebulin 19
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228694_7287821015.0RepeatNote=Nebulin 20
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228729_7597821015.0RepeatNote=Nebulin 21
TgeneNEBLchr10:135341076chr10:21101869ENST000003771222228760_7947821015.0RepeatNote=Nebulin 22
TgeneNEBLchr10:135341076chr10:21101869ENST0000041781637100_136119271.0RepeatNote=Nebulin 3
TgeneNEBLchr10:135341076chr10:21101869ENST000004178163729_63119271.0RepeatNote=Nebulin 1
TgeneNEBLchr10:135341076chr10:21101869ENST000004178163764_99119271.0RepeatNote=Nebulin 2


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Fusion Gene Sequence for CYP2E1-NEBL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21062_21062_1_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000377122_length(transcript)=6683nt_BP=210nt
CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG
GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA
TTGAAGAATATTCCCAAGTCCTTCACCCGGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGAC
GATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGAC
AGGAGACCTGGAATCATTGTTGACCTCAAAGTTTGGCGCACAGATCCTGGCTCCATCTTCGACCTTGATCCCCTGGAAGACAATATTCAG
TCTAGAAGTCTCCATATGCTCTCTGAAAAGGCGAGTCACTATAGGCGACACTGGTCTCGATCCCATTCCAGCAGTACTTTCGGTACAGGT
CTCGGAGACGACAGGTCAGAAATCTCCGAGATTTACCCTAGCTTTTCATGCTGCAGTGAGGTAACAAGACCGTCTGATGAAGGAGCACCT
GTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCAT
TCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTC
AACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTT
GTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGAC
AACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAA
CAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGG
CTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAGAGAAGTTGATTGTCCCTTAAATGTAGTGTGTGTTTGAAACTTCTTA
GCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGTAATGCAGCCAATAATTTCAAACCCGTTTTGCTTTTGAGTCATGAGG
CAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAAACAGTGGCAGAAGGACAGTCTGGTTAAAATTATATTGACTGGTGGC
CTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGTTCCCTAGGCTGACTGGTATCTATTTATTTCTCATTTGTACCAAGGC
ATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCTCAGTTCCACAGAATGTCAGGACCAAATAACTTCACAGCTACTCTGC
AAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCATTTACCCTGTTGCATGTCATGTAGATTCAAGCTTCTGTAACATAGG
CAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACTGATACCTAAAAGCCCTTTCTTCCTCTAGTCGCCAGCTCATCAGAAA
AACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCACTCTAGTTTTGAAGGATTTACATCTTAGGAAATAACATGTATACTC
TAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTAACTTAATGCCACCATTGATTTCAAAGTGAAGAAAATGTAACAGAAG
CCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCAGCAAACAAAGTTACCAATTCCATACAGAGATGATCTGGTATCTTCT
TTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACCAAAACGGGTTAATCAAAAGACGTCCTTTTCCATTTTTTTTTGCTTT
TATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATCAGAGATTTTTTAGTACAGGCCCAAGAGCCTGTTCTCTAAGAAAGAA
ATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCTTTATGCTAGCCCTTGCTGGTGGGTCTTGAAATTTCATCCAGAGTCT
GCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGTGTTTTTCTGATTGTGCCGTTTACTGTGACCTGCAACGGGGTGGCAT
TCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGCAAAACTGCAAAAAAGTACTAAGATGTACGGGTCTTGGGGATATCTG
CCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAAACATCGTTTAAGGAAACGTTTACTAGTCCAAAGGCCAAAGCTAATT
TATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGTGATTTCATTTTATTAGGCTAAAAGGGTAAATAGGCTTTATTACACT
GAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAATGCAGGCAAATAACTAGAGACTTCTTTTAAGGGGGTTTGGCTGGTT
TTCTCTCACTGAAATGGCCAGTCGTGATTAAAGTGATAAAACCCCATATCTGTTTTGGTATATTGTACACAAACCTACAAAAATAAACTG
AACTTGCAATATTTTTGCAAAAAAATCTGTCGTTAAAACTGAGGATAAAATACCTGCTCAATTTTATTTTACTAAGTATATATTTACATT
TCACCCAGGCAGGCCATTTTCTTTTGTGATTATAAGAAAGAGTAGTTGTTGATTAAATTTTCAGACTAAATATAGGACAGGTACAATTTT
GGATAAATAGCACATTTATAAGAACCGCAATGAAAACTGACTTGAAATAATGCTTGTAATCAGGAAAGTAATTTCATCCACCGATTTCAA
AACCAGATTCACTGAGCATAAAAGTCAATACATATTTGAGGAATAAGTCTCCTAAAATTTTAAGCTTCACGTAATAATGTTTGCATAGCA
AAATATTTCTGCTTCAAGCCTTTAGGAATTAAGATCTGATCAGAATTTAACTAAAGGGTAGTTGTTTTACAATGAAGACTAAAACTGAAC
AAGATGTTGCATGCTCTTGAGGCCATAATTTGGTAGTGTTGGCAGTTGTTAATAAAGCTTGTCAGGATGTTAAGCATCTCAGGAGAAATA
TTGGAAAATTATATGTATAAAACCAAAGTGCTATTTTTAAAAGCATCATTTAAAAAAAAATGACATGCCTGAACAACTTTTCCACTTTCC
ACGTGCTTCCCTCCCACCTTTGGTTTGGCAACAGGTATCTCGTGCATGAAGCTGACAGCTAAAGAAGATTTTAAAAATTGAGTTAAAGAT
GACTGTGTAAATGTCCAAGCACAGAGAGCATGCACCTGACTTTCTAAAGTTTGATGTGTTCTCAAGCCTGACAGAAGCACAAGGAACAGT
TTGATACACTTTTAAAAGGTTCTGAAAACAAAGCTGTATAGGGATCCTCTCTCTCTTGAGCAAAGTATAGCAACAGAATATATTGCTTTT
GTTGTAAGCTTTTGTAGTACATGTTTTTACTAATAATTCTTGTTCTCTAGAAAGCTTTCTATTTCTAACCTATGGCAAAATGAATCCTTC
ATGTCTTCTTGTTATTGTTTACACACTTGCAGTGTAGCCCAGTTTGAAATATTTATTTGGTTATCAACTGCCCATGGAGGAGGCTCTTGA
TGATCCCAGGTCTCCTCGACCTCCATACACCACACAGGCATTTGTAAGCACAGTTTCCACAAGCACCTTGTAGGAATATGGATAAGATTA
GACCAGCCCCTCTCTGTCCACTGGGTTTATTTCTTGAAGAAGATGCAGATCTGGTTTTTCCAATGTGCCACAGTCTTTCCTTATCCTCTC
CATGCTGAGCTTGACAACACTCTGGGAATGAGGAACAAGACTTTTTCTAAAAAGATAGTGGAAGTTCAAGGGATGTACCTCGTTTTCAGG
TTCATCCATCTCCAGTGGAATGTTTTCAATAAAAGATGAAGAAAATGTGTGTGATCTTTAATAACACATCCCTATAGAAAGTGGATAAAA
GATATACCAAAACTGTAATACAGATATATACAAATATAGGTGCCTTTTTGATTACTCTTGTTTGTCTAGTATGCTCTTGGAAAGAAAACC
AAGCAAGCAAGTTGCTGCCTATTCTATAGTAATATTTTATTACACATGATTGATATTTTTGTGGTAGGGAAGTGGGATGCTCCTCAGATA
TTAAAGGTGTTAGCTGATTGTATTTTATCTCTAAAGATTTAGAACTTTAGAAAATGCCGACTTCTTCCATCTATTTCTGAAAGGTTCTTT
GTGGATTTATATAGAGTTGAGCTATATAAACATTAACTTTAGATTTGGGATTTAAAATGCCTATTGTAAGATAGAATAATTGTGAGGCTG
GATTCACTACACAAGATGAACTTCACTTCATAAATTAATTATACCTTAGCGATTTGCTTCTGATAATCTAAAAGTGGCTAGATTGTGGTT
GTTTTGGTTAAGGTGATATGGAGGTGGGAGAGCTTTTAGTTAAGTAAGAAGCTATGTAAACTGACAAGGATGCTAAAATAAAAGTCTCTG
AAGTATTCCATGCCTTTTGGACCCTTTCCTCGCAACTAACTGTCAACTGTTGATCAAAAAAGTCAAGGCATTGTATGTTGCTTCTGTGGT
TATTATTCTGTGATGCTTAGACTACTTGAACCCATAAACTTGGAAGAATCTTTGAGCAAATTTTCTCAGTTGTCTGTATGACTTCAGTAT
ATTCCTGGGAATGCCATAGGATTTTTTGTGCTTGATACATGGTATCCAGTTTGCATAGTATCACTTCTTTGTAATCCAGTTGCTGTTAAG
AATGATGTACTTTAAAGGAAAAGAGAAAACTGCATCACAGTCCCATTCTCCAGTGTCCATGCAATGAATTGCTGAGCATTTAGGAAGCAG
CACCAAGTCTATTACAGGCATGGTGTGAAACTTGATGTTTGACCTGTGATCAAAATTGAACCATTGTACAGTTTGGCTTCTGTTTGCTTC
AAAATATGTAGAATTGTGGTTGATGATTAATTTGCGAGACTAACTTTGAGAGTGTAACAGTTTTGAAGAAAACATTGAATGTTTTGCAAA
TGAAGGGGCTTCACGGAATGTTACAATGTTACTAATATAATTTGGCTTTTGTTATGCAAATTGTTAACACCAGCTATTAAAATATATTTT
AGTAGAAATGCTTTAATTCATATTTTTTTCCTCTACACTGTGAATCTTTAAGCCTTGGTGGACTAGAGCAACATCGTGCTGCCCAAAGGA
CTAACCTATGCAAACTAGTTCACATTTTAGTGGATGTCGCAGTTAATGTGTAATAAGACATTATTTCCCCTGCATAATGTACAACAGCAT
TGAAATGACACATTAAGCCTAGCATCACATTGTATAGTACAGTCACTCACAAACCCTTCAAGGCTACCCTAATCATTAACATTAATATTT
GTTTAAAAGCAAATCACCGATTTATCTATTGAAACTACTTAAATGACGGCAAACCAGGAATGACAGATGGCTGTGTCAGCAATGGCTTTA
ATGTGTTCCCTGCAAGTGGTCTCCTATGATAGAACTGCGTTCTCAAATGCACTCTCTTCAGGGTCTTAATATTCTGTGTTTTCTCTCTGT
ATTTGTAAAACATTATAACACATTAATTTCCTATCTCTACACATTTGGTTTGCTTAAATAAATGCAGGATATAAAAAAAATGGTTCACTT
CTTGGCTCTCACCGTGGTTTCTTGGAGCATGGGTTGTTAGATGCAAGCAATGCACCCTAATAATACCCCGGGTCTGAGATTTAACATGAC
AACTCACATCAAATCGCATCAGAGGTGTGTGCTGCCTTCAGTGCATTTACATTGGTGAATCAGTCAAGATATTTTCCTCCCCCAAATAAA
CTTAGTTGTAAGTGATAACAATATTATGCTTCTCCAAGCTCAGTATCTTTCTGATTTTATATCAAAGTACCGCAACAATGCATCATTGTA
GTTAATTTATTTCAAGAATAAATTCCTCATATGTCCTCAATAGTACAATTCTAATTTTCTTCTATTCATAAGATGAAAGAAATGGTTTGG
AGCATAGAATAGAAAGTGCACAAATTGAGTACATAAAATGGGAAGCAACTGATTTCTCAGCTAAGAAAGGCTCATTTATCACAGAACACA
ATTGCTTTTCTCCCCCCACTACGCTTCCCATAATTGAAAAAGTGAGTCCCTATTTTTCACACTCATATAAATCTATGCGATTTGGATGCT
AGTCTTATTGTATTATTTTGTAAAACTTTCTCTTTGGCTCATAATCCTTCCTAATTGTAAATTGATAAACTTTGCGGATGACATCTGCTC
GTAGAATAAACACTTCTTCCAAA

>21062_21062_1_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000377122_length(amino acids)=291AA_BP=59
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDFEKTKGRGFTPVVDDPVTERVRKNT
QVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEI
YPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMY
GTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------
>21062_21062_2_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000377159_length(transcript)=942nt_BP=210nt
CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG
GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA
TTGAAGAATATTCCCAAGTCCTTCACCCGGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGAC
GATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGAC
AGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGT
GTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTC
TCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGA
ATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTT
TTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGG
AAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTA
ATTGTGTTCATGGTTTCCTTTGATTGGCTATTGAACCCTTCT

>21062_21062_2_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000377159_length(amino acids)=210AA_BP=59
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDFEKTKGRGFTPVVDDPVTERVRKNT
QVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNV
QPIDDGWMYGTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------
>21062_21062_3_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000417816_length(transcript)=2507nt_BP=210nt
CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG
GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA
TTGAAGAATATTCCCAAGTCCTTCACCCGGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGAC
GATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGAC
AGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGT
GTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTC
TCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGA
ATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTT
TTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGG
AAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTA
ATTGTGTTCATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAGAGAAGTTGATTGTCCCTTA
AATGTAGTGTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGTAATGCAGCCAATAATTTCA
AACCCGTTTTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAAACAGTGGCAGAAGGACAGT
CTGGTTAAAATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGTTCCCTAGGCTGACTGGTAT
CTATTTATTTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCTCAGTTCCACAGAATGTCAG
GACCAAATAACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCATTTACCCTGTTGCATGTCA
TGTAGATTCAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACTGATACCTAAAAGCCCTTTC
TTCCTCTAGTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCACTCTAGTTTTGAAGGATTT
ACATCTTAGGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTAACTTAATGCCACCATTGAT
TTCAAAGTGAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCAGCAAACAAAGTTACCAATT
CCATACAGAGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACCAAAACGGGTTAATCAAAAG
ACGTCCTTTTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATCAGAGATTTTTTAGTACAGG
CCCAAGAGCCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCTTTATGCTAGCCCTTGCTGG
TGGGTCTTGAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGTGTTTTTCTGATTGTGCCGT
TTACTGTGACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGCAAAACTGCAAAAAAGTACT
AAGATGTACGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAAACATCGTTTAAGGAAACGT
TTACTAGTCCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGTGATTTCATTTTATTAGGCT
AAAAGGGTAAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAATGCAGG

>21062_21062_3_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000252945_NEBL_chr10_21101869_ENST00000417816_length(amino acids)=210AA_BP=59
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDFEKTKGRGFTPVVDDPVTERVRKNT
QVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNV
QPIDDGWMYGTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------
>21062_21062_4_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000377122_length(transcript)=6922nt_BP=449nt
ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC
CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT
TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA
CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT
GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGG
TAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACA
CCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGACCTCAAAG
TTTGGCGCACAGATCCTGGCTCCATCTTCGACCTTGATCCCCTGGAAGACAATATTCAGTCTAGAAGTCTCCATATGCTCTCTGAAAAGG
CGAGTCACTATAGGCGACACTGGTCTCGATCCCATTCCAGCAGTACTTTCGGTACAGGTCTCGGAGACGACAGGTCAGAAATCTCCGAGA
TTTACCCTAGCTTTTCATGCTGCAGTGAGGTAACAAGACCGTCTGATGAAGGAGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATT
CCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGT
ACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGT
ACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAG
CTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCC
TTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAA
AAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTG
TAGACTTTAATAGAGAAGTTGATTGTCCCTTAAATGTAGTGTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATT
CTCTTAACTCTGTAATGCAGCCAATAATTTCAAACCCGTTTTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAAT
ATAATAAGTGTAAACAGTGGCAGAAGGACAGTCTGGTTAAAATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGA
GAAATTTCCTTGTTCCCTAGGCTGACTGGTATCTATTTATTTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGAC
CCAAGTCTATGCTCAGTTCCACAGAATGTCAGGACCAAATAACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAAT
TTCCCTAGTAGCATTTACCCTGTTGCATGTCATGTAGATTCAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGC
AAAAAGGGTGACTGATACCTAAAAGCCCTTTCTTCCTCTAGTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTC
CTGCTGCATCGCACTCTAGTTTTGAAGGATTTACATCTTAGGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGA
ACAGCTTTGATTAACTTAATGCCACCATTGATTTCAAAGTGAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACT
GGAAAAATACTCAGCAAACAAAGTTACCAATTCCATACAGAGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGG
AAATCTAGCCACCAAAACGGGTTAATCAAAAGACGTCCTTTTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAA
CAGGAATGTCATCAGAGATTTTTTAGTACAGGCCCAAGAGCCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGT
GACTTTGCAGGCTTTATGCTAGCCCTTGCTGGTGGGTCTTGAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCG
TCGGCAACCCTGTGTTTTTCTGATTGTGCCGTTTACTGTGACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACA
AAACCGAAAAAGCAAAACTGCAAAAAAGTACTAAGATGTACGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAA
AACATCCTGTAAAACATCGTTTAAGGAAACGTTTACTAGTCCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCT
TTTGAAAATCTGTGATTTCATTTTATTAGGCTAAAAGGGTAAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAG
TTGAAAAAATAAATGCAGGCAAATAACTAGAGACTTCTTTTAAGGGGGTTTGGCTGGTTTTCTCTCACTGAAATGGCCAGTCGTGATTAA
AGTGATAAAACCCCATATCTGTTTTGGTATATTGTACACAAACCTACAAAAATAAACTGAACTTGCAATATTTTTGCAAAAAAATCTGTC
GTTAAAACTGAGGATAAAATACCTGCTCAATTTTATTTTACTAAGTATATATTTACATTTCACCCAGGCAGGCCATTTTCTTTTGTGATT
ATAAGAAAGAGTAGTTGTTGATTAAATTTTCAGACTAAATATAGGACAGGTACAATTTTGGATAAATAGCACATTTATAAGAACCGCAAT
GAAAACTGACTTGAAATAATGCTTGTAATCAGGAAAGTAATTTCATCCACCGATTTCAAAACCAGATTCACTGAGCATAAAAGTCAATAC
ATATTTGAGGAATAAGTCTCCTAAAATTTTAAGCTTCACGTAATAATGTTTGCATAGCAAAATATTTCTGCTTCAAGCCTTTAGGAATTA
AGATCTGATCAGAATTTAACTAAAGGGTAGTTGTTTTACAATGAAGACTAAAACTGAACAAGATGTTGCATGCTCTTGAGGCCATAATTT
GGTAGTGTTGGCAGTTGTTAATAAAGCTTGTCAGGATGTTAAGCATCTCAGGAGAAATATTGGAAAATTATATGTATAAAACCAAAGTGC
TATTTTTAAAAGCATCATTTAAAAAAAAATGACATGCCTGAACAACTTTTCCACTTTCCACGTGCTTCCCTCCCACCTTTGGTTTGGCAA
CAGGTATCTCGTGCATGAAGCTGACAGCTAAAGAAGATTTTAAAAATTGAGTTAAAGATGACTGTGTAAATGTCCAAGCACAGAGAGCAT
GCACCTGACTTTCTAAAGTTTGATGTGTTCTCAAGCCTGACAGAAGCACAAGGAACAGTTTGATACACTTTTAAAAGGTTCTGAAAACAA
AGCTGTATAGGGATCCTCTCTCTCTTGAGCAAAGTATAGCAACAGAATATATTGCTTTTGTTGTAAGCTTTTGTAGTACATGTTTTTACT
AATAATTCTTGTTCTCTAGAAAGCTTTCTATTTCTAACCTATGGCAAAATGAATCCTTCATGTCTTCTTGTTATTGTTTACACACTTGCA
GTGTAGCCCAGTTTGAAATATTTATTTGGTTATCAACTGCCCATGGAGGAGGCTCTTGATGATCCCAGGTCTCCTCGACCTCCATACACC
ACACAGGCATTTGTAAGCACAGTTTCCACAAGCACCTTGTAGGAATATGGATAAGATTAGACCAGCCCCTCTCTGTCCACTGGGTTTATT
TCTTGAAGAAGATGCAGATCTGGTTTTTCCAATGTGCCACAGTCTTTCCTTATCCTCTCCATGCTGAGCTTGACAACACTCTGGGAATGA
GGAACAAGACTTTTTCTAAAAAGATAGTGGAAGTTCAAGGGATGTACCTCGTTTTCAGGTTCATCCATCTCCAGTGGAATGTTTTCAATA
AAAGATGAAGAAAATGTGTGTGATCTTTAATAACACATCCCTATAGAAAGTGGATAAAAGATATACCAAAACTGTAATACAGATATATAC
AAATATAGGTGCCTTTTTGATTACTCTTGTTTGTCTAGTATGCTCTTGGAAAGAAAACCAAGCAAGCAAGTTGCTGCCTATTCTATAGTA
ATATTTTATTACACATGATTGATATTTTTGTGGTAGGGAAGTGGGATGCTCCTCAGATATTAAAGGTGTTAGCTGATTGTATTTTATCTC
TAAAGATTTAGAACTTTAGAAAATGCCGACTTCTTCCATCTATTTCTGAAAGGTTCTTTGTGGATTTATATAGAGTTGAGCTATATAAAC
ATTAACTTTAGATTTGGGATTTAAAATGCCTATTGTAAGATAGAATAATTGTGAGGCTGGATTCACTACACAAGATGAACTTCACTTCAT
AAATTAATTATACCTTAGCGATTTGCTTCTGATAATCTAAAAGTGGCTAGATTGTGGTTGTTTTGGTTAAGGTGATATGGAGGTGGGAGA
GCTTTTAGTTAAGTAAGAAGCTATGTAAACTGACAAGGATGCTAAAATAAAAGTCTCTGAAGTATTCCATGCCTTTTGGACCCTTTCCTC
GCAACTAACTGTCAACTGTTGATCAAAAAAGTCAAGGCATTGTATGTTGCTTCTGTGGTTATTATTCTGTGATGCTTAGACTACTTGAAC
CCATAAACTTGGAAGAATCTTTGAGCAAATTTTCTCAGTTGTCTGTATGACTTCAGTATATTCCTGGGAATGCCATAGGATTTTTTGTGC
TTGATACATGGTATCCAGTTTGCATAGTATCACTTCTTTGTAATCCAGTTGCTGTTAAGAATGATGTACTTTAAAGGAAAAGAGAAAACT
GCATCACAGTCCCATTCTCCAGTGTCCATGCAATGAATTGCTGAGCATTTAGGAAGCAGCACCAAGTCTATTACAGGCATGGTGTGAAAC
TTGATGTTTGACCTGTGATCAAAATTGAACCATTGTACAGTTTGGCTTCTGTTTGCTTCAAAATATGTAGAATTGTGGTTGATGATTAAT
TTGCGAGACTAACTTTGAGAGTGTAACAGTTTTGAAGAAAACATTGAATGTTTTGCAAATGAAGGGGCTTCACGGAATGTTACAATGTTA
CTAATATAATTTGGCTTTTGTTATGCAAATTGTTAACACCAGCTATTAAAATATATTTTAGTAGAAATGCTTTAATTCATATTTTTTTCC
TCTACACTGTGAATCTTTAAGCCTTGGTGGACTAGAGCAACATCGTGCTGCCCAAAGGACTAACCTATGCAAACTAGTTCACATTTTAGT
GGATGTCGCAGTTAATGTGTAATAAGACATTATTTCCCCTGCATAATGTACAACAGCATTGAAATGACACATTAAGCCTAGCATCACATT
GTATAGTACAGTCACTCACAAACCCTTCAAGGCTACCCTAATCATTAACATTAATATTTGTTTAAAAGCAAATCACCGATTTATCTATTG
AAACTACTTAAATGACGGCAAACCAGGAATGACAGATGGCTGTGTCAGCAATGGCTTTAATGTGTTCCCTGCAAGTGGTCTCCTATGATA
GAACTGCGTTCTCAAATGCACTCTCTTCAGGGTCTTAATATTCTGTGTTTTCTCTCTGTATTTGTAAAACATTATAACACATTAATTTCC
TATCTCTACACATTTGGTTTGCTTAAATAAATGCAGGATATAAAAAAAATGGTTCACTTCTTGGCTCTCACCGTGGTTTCTTGGAGCATG
GGTTGTTAGATGCAAGCAATGCACCCTAATAATACCCCGGGTCTGAGATTTAACATGACAACTCACATCAAATCGCATCAGAGGTGTGTG
CTGCCTTCAGTGCATTTACATTGGTGAATCAGTCAAGATATTTTCCTCCCCCAAATAAACTTAGTTGTAAGTGATAACAATATTATGCTT
CTCCAAGCTCAGTATCTTTCTGATTTTATATCAAAGTACCGCAACAATGCATCATTGTAGTTAATTTATTTCAAGAATAAATTCCTCATA
TGTCCTCAATAGTACAATTCTAATTTTCTTCTATTCATAAGATGAAAGAAATGGTTTGGAGCATAGAATAGAAAGTGCACAAATTGAGTA
CATAAAATGGGAAGCAACTGATTTCTCAGCTAAGAAAGGCTCATTTATCACAGAACACAATTGCTTTTCTCCCCCCACTACGCTTCCCAT
AATTGAAAAAGTGAGTCCCTATTTTTCACACTCATATAAATCTATGCGATTTGGATGCTAGTCTTATTGTATTATTTTGTAAAACTTTCT
CTTTGGCTCATAATCCTTCCTAATTGTAAATTGATAAACTTTGCGGATGACATCTGCTCGTAGAATAAACACTTCTTCCAAA

>21062_21062_4_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000377122_length(amino acids)=315AA_BP=83
MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDF
EKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRH
WSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQD
EDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------
>21062_21062_5_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000377159_length(transcript)=1181nt_BP=449nt
ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC
CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT
TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA
CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT
GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGG
TAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACA
CCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTC
TTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCAC
CAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACG
TGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTA
ATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACT
TGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGC
AGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGGCTAT
TGAACCCTTCT

>21062_21062_5_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000377159_length(amino acids)=234AA_BP=83
MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDF
EKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYR
AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------
>21062_21062_6_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000417816_length(transcript)=2746nt_BP=449nt
ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC
CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT
TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA
CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT
GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGG
TAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACA
CCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTC
TTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCAC
CAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACG
TGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTA
ATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACT
TGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGC
AGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGGCTAT
TGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAGAGAAGTTGATTGTCCCTTAAATGTAGTGTGTGTTTGAAACTTCTTAGCTG
TCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGTAATGCAGCCAATAATTTCAAACCCGTTTTGCTTTTGAGTCATGAGGCAAT
TTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAAACAGTGGCAGAAGGACAGTCTGGTTAAAATTATATTGACTGGTGGCCTTA
GGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGTTCCCTAGGCTGACTGGTATCTATTTATTTCTCATTTGTACCAAGGCATCT
CCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCTCAGTTCCACAGAATGTCAGGACCAAATAACTTCACAGCTACTCTGCAAAG
GGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCATTTACCCTGTTGCATGTCATGTAGATTCAAGCTTCTGTAACATAGGCAGC
TGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACTGATACCTAAAAGCCCTTTCTTCCTCTAGTCGCCAGCTCATCAGAAAAACA
TACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCACTCTAGTTTTGAAGGATTTACATCTTAGGAAATAACATGTATACTCTAGT
AAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTAACTTAATGCCACCATTGATTTCAAAGTGAAGAAAATGTAACAGAAGCCAG
TGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCAGCAAACAAAGTTACCAATTCCATACAGAGATGATCTGGTATCTTCTTTTG
GAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACCAAAACGGGTTAATCAAAAGACGTCCTTTTCCATTTTTTTTTGCTTTTATT
TTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATCAGAGATTTTTTAGTACAGGCCCAAGAGCCTGTTCTCTAAGAAAGAAATTG
TTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCTTTATGCTAGCCCTTGCTGGTGGGTCTTGAAATTTCATCCAGAGTCTGCAG
TCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGTGTTTTTCTGATTGTGCCGTTTACTGTGACCTGCAACGGGGTGGCATTCAC
TTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGCAAAACTGCAAAAAAGTACTAAGATGTACGGGTCTTGGGGATATCTGCCTT
ATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAAACATCGTTTAAGGAAACGTTTACTAGTCCAAAGGCCAAAGCTAATTTATT
TCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGTGATTTCATTTTATTAGGCTAAAAGGGTAAATAGGCTTTATTACACTGAAG
CTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAATGCAGG

>21062_21062_6_CYP2E1-NEBL_CYP2E1_chr10_135341076_ENST00000463117_NEBL_chr10_21101869_ENST00000417816_length(amino acids)=234AA_BP=83
MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRVKYHEDF
EKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYR
AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYP2E1-NEBL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYP2E1-NEBL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYP2E1-NEBL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYP2E1C0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
HgeneCYP2E1C0085762Alcohol abuse6CTD_human;PSYGENET
HgeneCYP2E1C0019193Hepatitis, Toxic4CTD_human
HgeneCYP2E1C0860207Drug-Induced Liver Disease4CTD_human
HgeneCYP2E1C1262760Hepatitis, Drug-Induced4CTD_human
HgeneCYP2E1C3658290Drug-Induced Acute Liver Injury4CTD_human
HgeneCYP2E1C4277682Chemical and Drug Induced Liver Injury4CTD_human
HgeneCYP2E1C4279912Chemically-Induced Liver Toxicity4CTD_human
HgeneCYP2E1C0024121Lung Neoplasms2CTD_human
HgeneCYP2E1C0027540Necrosis2CTD_human
HgeneCYP2E1C0242379Malignant neoplasm of lung2CTD_human
HgeneCYP2E1C0001418Adenocarcinoma1CTD_human
HgeneCYP2E1C0001956Alcohol Use Disorder1CTD_human
HgeneCYP2E1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCYP2E1C0011609Drug Eruptions1CTD_human
HgeneCYP2E1C0013221Drug toxicity1CTD_human
HgeneCYP2E1C0015695Fatty Liver1CTD_human
HgeneCYP2E1C0015696Fatty Liver, Alcoholic1CTD_human
HgeneCYP2E1C0018800Cardiomegaly1CTD_human
HgeneCYP2E1C0019207Hepatoma, Morris1CTD_human
HgeneCYP2E1C0019208Hepatoma, Novikoff1CTD_human
HgeneCYP2E1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneCYP2E1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneCYP2E1C0023891Liver Cirrhosis, Alcoholic1CTD_human
HgeneCYP2E1C0023903Liver neoplasms1CTD_human
HgeneCYP2E1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneCYP2E1C0024302Reticulosarcoma1CTD_human
HgeneCYP2E1C0024304Lymphoma, Mixed-Cell1CTD_human
HgeneCYP2E1C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneCYP2E1C0024306Lymphoma, Undifferentiated1CTD_human
HgeneCYP2E1C0027626Neoplasm Invasiveness1CTD_human
HgeneCYP2E1C0028754Obesity1CTD_human
HgeneCYP2E1C0030567Parkinson Disease1CTD_human
HgeneCYP2E1C0033578Prostatic Neoplasms1CTD_human
HgeneCYP2E1C0036341Schizophrenia1PSYGENET
HgeneCYP2E1C0041755Adverse reaction to drug1CTD_human
HgeneCYP2E1C0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneCYP2E1C0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneCYP2E1C0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneCYP2E1C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneCYP2E1C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneCYP2E1C0086404Experimental Hepatoma1CTD_human
HgeneCYP2E1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneCYP2E1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneCYP2E1C0205643Carcinoma, Cribriform1CTD_human
HgeneCYP2E1C0205644Carcinoma, Granular Cell1CTD_human
HgeneCYP2E1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneCYP2E1C0345904Malignant neoplasm of liver1CTD_human
HgeneCYP2E1C0376358Malignant neoplasm of prostate1CTD_human
HgeneCYP2E1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneCYP2E1C0406537Morbilliform Drug Reaction1CTD_human
HgeneCYP2E1C1383860Cardiac Hypertrophy1CTD_human
HgeneCYP2E1C1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneCYP2E1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
HgeneCYP2E1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneCYP2E1C2239176Liver carcinoma1CTD_human
HgeneCYP2E1C2711227Steatohepatitis1CTD_human
HgeneCYP2E1C2718067Alcoholic Steatohepatitis1CTD_human
HgeneCYP2E1C3241937Nonalcoholic Steatohepatitis1CTD_human
HgeneCYP2E1C3714542Lymphoma, Diffuse1CTD_human
HgeneCYP2E1C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human
TgeneC0004238Atrial Fibrillation1CTD_human
TgeneC0235480Paroxysmal atrial fibrillation1CTD_human
TgeneC0340427Familial dilated cardiomyopathy1ORPHANET
TgeneC2585653Persistent atrial fibrillation1CTD_human
TgeneC3468561familial atrial fibrillation1CTD_human