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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYP2E1-AMACR (FusionGDB2 ID:HG1571TG23600)

Fusion Gene Summary for CYP2E1-AMACR

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP2E1-AMACR
Fusion gene ID: hg1571tg23600
HgeneTgene
Gene symbol

CYP2E1

AMACR

Gene ID

1571

23600

Gene namecytochrome P450 family 2 subfamily E member 1alpha-methylacyl-CoA racemase
SynonymsCPE1|CYP2E|P450-J|P450C2EAMACRD|CBAS4|P504S|RACE|RM
Cytomap('CYP2E1')('AMACR')

10q26.3

5p13.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 2E14-nitrophenol 2-hydroxylaseCYPIIE1cytochrome P450, family 2, subfamily E, polypeptide 1cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1cytochrome P450-Jflavoprotein-linked monooxygenasemicrosomal monooxygenasexealpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
Modification date2020031520200313
UniProtAcc.

Q9UHK6

Ensembl transtripts involved in fusion geneENST00000480558, ENST00000252945, 
ENST00000463117, 
Fusion gene scores* DoF score8 X 5 X 3=12028 X 3 X 4=336
# samples 823
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/336*10)=-0.546827371834385
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP2E1 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYP2E1(135342144)-AMACR(34006004), # samples:1
Anticipated loss of major functional domain due to fusion event.CYP2E1-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYP2E1-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP2E1

GO:0002933

lipid hydroxylation

10553002

HgeneCYP2E1

GO:0016098

monoterpenoid metabolic process

16401082

HgeneCYP2E1

GO:0017144

drug metabolic process

19219744

HgeneCYP2E1

GO:0018960

4-nitrophenol metabolic process

9348445

HgeneCYP2E1

GO:0046483

heterocycle metabolic process

19651758

HgeneCYP2E1

GO:0055114

oxidation-reduction process

16401082|19219744

TgeneAMACR

GO:0008206

bile acid metabolic process

10655068


check buttonFusion gene breakpoints across CYP2E1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AMACR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A39W-01ACYP2E1chr10

135342144

+AMACRchr5

34006004

-


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Fusion Gene ORF analysis for CYP2E1-AMACR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480558ENST00000335606CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-3CDSENST00000480558ENST00000382072CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000382068CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000382085CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000426255CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000441713CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000502637CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000512079CYP2E1chr10

135342144

+AMACRchr5

34006004

-
3UTR-5UTRENST00000480558ENST00000514195CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000382068CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000382085CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000426255CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000441713CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000502637CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000512079CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000252945ENST00000514195CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000382068CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000382085CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000426255CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000441713CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000502637CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000512079CYP2E1chr10

135342144

+AMACRchr5

34006004

-
5CDS-5UTRENST00000463117ENST00000514195CYP2E1chr10

135342144

+AMACRchr5

34006004

-
In-frameENST00000252945ENST00000335606CYP2E1chr10

135342144

+AMACRchr5

34006004

-
In-frameENST00000252945ENST00000382072CYP2E1chr10

135342144

+AMACRchr5

34006004

-
In-frameENST00000463117ENST00000335606CYP2E1chr10

135342144

+AMACRchr5

34006004

-
In-frameENST00000463117ENST00000382072CYP2E1chr10

135342144

+AMACRchr5

34006004

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000463117CYP2E1chr10135342144+ENST00000335606AMACRchr534006004-44266092001510436
ENST00000463117CYP2E1chr10135342144+ENST00000382072AMACRchr534006004-3269609200958252
ENST00000252945CYP2E1chr10135342144+ENST00000335606AMACRchr534006004-4187370331271412
ENST00000252945CYP2E1chr10135342144+ENST00000382072AMACRchr534006004-303037033719228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000463117ENST00000335606CYP2E1chr10135342144+AMACRchr534006004-0.0002880960.99971193
ENST00000463117ENST00000382072CYP2E1chr10135342144+AMACRchr534006004-0.0398366380.9601633
ENST00000252945ENST00000335606CYP2E1chr10135342144+AMACRchr534006004-8.25E-050.9999175
ENST00000252945ENST00000382072CYP2E1chr10135342144+AMACRchr534006004-0.0047440160.995256

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Fusion Genomic Features for CYP2E1-AMACR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CYP2E1-AMACR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:135342144/chr5:34006004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AMACR

Q9UHK6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAMACRchr10:135342144chr5:34006004ENST0000033560605380_38282383.0MotifMicrobody targeting signal
TgeneAMACRchr10:135342144chr5:34006004ENST0000038207204380_38282199.0MotifMicrobody targeting signal
TgeneAMACRchr10:135342144chr5:34006004ENST0000038208506380_38282395.0MotifMicrobody targeting signal
TgeneAMACRchr10:135342144chr5:34006004ENST0000044171304380_38282230.0MotifMicrobody targeting signal
TgeneAMACRchr10:135342144chr5:34006004ENST0000033560605121_12682383.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST0000038207204121_12682199.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST0000038208506121_12682395.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST0000044171304121_12682230.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYP2E1chr10:135342144chr5:34006004ENST00000252945+29298_303112494.0RegionSubstrate binding
HgeneCYP2E1chr10:135342144chr5:34006004ENST00000463117+411298_303112494.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST000003356060555_5882383.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST000003820720455_5882199.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST000003820850655_5882395.0RegionSubstrate binding
TgeneAMACRchr10:135342144chr5:34006004ENST000004417130455_5882230.0RegionSubstrate binding


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Fusion Gene Sequence for CYP2E1-AMACR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21055_21055_1_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000335606_length(transcript)=4187nt_BP=370nt
CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG
GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA
TTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTG
ATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCAC
AGGGACAGGGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGA
TTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGT
GGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTT
GACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAG
AAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAA
TTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATG
AGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGC
ACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAG
GAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACAC
ACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAA
GCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAA
ACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAA
ATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATA
TTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTA
TTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGC
ATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGA
AAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGT
CCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCT
CCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACC
CCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTT
TACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGG
TGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAA
TCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCG
CCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATT
ATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAA
CTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCT
CCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTAT
AGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTC
AAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATAT
TTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAG
GAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGG
ACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAG
GATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCT
AAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATAT
AACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGG
CAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCC
AAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTT
CCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTA
GCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATT
CCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCT
CCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAA
ATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGT

>21055_21055_1_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=412AA_BP=112
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL
LDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLL
ADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF
YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPL

--------------------------------------------------------------
>21055_21055_2_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3030nt_BP=370nt
CTCCCGGGCTGGCAGCAGGGCCCCAGCGGCACCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTG
GTGTCCATGTGGAGGCAGGTGCACAGCAGCTGGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAA
TTGAAGAATATTCCCAAGTCCTTCACCCGGTTGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTG
ATGCACGGCTACAAGGCGGTGAAGGAAGCGCTGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCAC
AGGGACAGGGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGA
TTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTC
TTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTA
CAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGA
TGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTG
GTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGG
CTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGA
TCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCAT
TGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACA
TAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAG
TGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCC
TTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGA
AGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTG
AAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCAC
ACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTG
TTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGG
GCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAG
AAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACA
AAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGA
TTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTAT
CTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTA
GTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGT
CCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCT
ATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACT
GCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATG
AAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTT
TCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAG
AAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTT
GTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCA

>21055_21055_2_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000252945_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=228AA_BP=112
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL
LDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGGRNSIFKFFSVENSEIESV

--------------------------------------------------------------
>21055_21055_3_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000335606_length(transcript)=4426nt_BP=609nt
ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC
CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT
TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA
CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT
GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGT
TGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGC
TGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGTGTCATGGAGAAACTCCAGC
TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG
CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCC
TGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCA
TTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGAC
AGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGT
TCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGA
AGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTT
TTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTC
TGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCA
GCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCA
AGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACC
ACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAA
ACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATT
TTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAAT
GAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATC
TCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCT
TCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTG
TATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAG
CAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGAC
TGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCC
CTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGA
TGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCA
TCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCC
AAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAA
ATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTG
GACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTT
TTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTAC
CTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTG
AGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCA
GAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCC
CAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAA
ATTATCCAGGTATGGTGGTGTGTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACA
GTGAATTAGGATTGCACCACTGCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAA
AAGATGTTTTCCCTACAACTCAGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAA
TTTAATATAAAGAATTCCACTGGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCA
AGACCACTCCTATGGTTGCAGGGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGA
CACTGGCAGTAATACCTCAGGGAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAG
TGTCTCCCATTAGCCAAATCTACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAAT
AGATCTGAGCAGACAGGCAGCACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTA
GGTGCCAGGTATCATGATACTTGCTGGGGATACCATAATGAACAAAACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAG
GATATGGAATAAACCCAGAATTATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATT
TGAAGAAGGGTGTGACCTGCCACCATTTTAAATCTAGTTATTTCACTCCTGAGCTGTGTGTGTGGAAAACTTGTAGTAAAAAATAGAATG

>21055_21055_3_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=436AA_BP=136
MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGP
VFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINY
LALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGG
APFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHH

--------------------------------------------------------------
>21055_21055_4_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3269nt_BP=609nt
ACTTCCGGGTTGTTTGCTCCCGGAGCCATAACCGCAGCTCAGCGTGCGGGCAGAGCCGGCTGACAGGAGACAGGACACAGCACAGAGCCC
CGCGCCCTCTGAGGCGGGAGGCTTCGTTCCTGCACCAGCGTGGCTTGCCCTTTGGACGCGGCGAGTTAACTTGAGAAAGTGGAATCGAAT
TCCGATGTTGAATTTTCCTTCTGGCCCCATTCATGTGGCAGGTGGTGATTCAGGATTGTCTCCCGGGCTGGCAGCAGGGCCCCAGCGGCA
CCATGTCTGCCCTCGGAGTCACCGTGGCCCTGCTGGTGTGGGCGGCCTTCCTCCTGCTGGTGTCCATGTGGAGGCAGGTGCACAGCAGCT
GGAATCTGCCCCCAGGCCCTTTCCCGCTTCCCATCATCGGGAACCTCTTCCAGTTGGAATTGAAGAATATTCCCAAGTCCTTCACCCGGT
TGGCCCAGCGCTTCGGGCCGGTGTTCACGCTGTACGTGGGCTCGCAGCGCATGGTGGTGATGCACGGCTACAAGGCGGTGAAGGAAGCGC
TGCTGGACTACAAGGACGAGTTCTCGGGCAGAGGCGACCTCCCCGCGTTCCATGCGCACAGGGACAGGGGTGTCATGGAGAAACTCCAGC
TGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAG
CTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTG
TGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTT
GGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGAT
TGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGT
GTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTG
AGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATA
CTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAA
CTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAAC
AGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATT
AGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATT
AAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTG
ATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTT
TGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCT
GTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAG
TCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGA
TTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTC
GTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCA
GCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGT
AGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAA
GGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTT
TTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAA
CTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAG
GAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGT
CCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTA
TGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAAT
ATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAAT
ATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCAT
AAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCT

>21055_21055_4_CYP2E1-AMACR_CYP2E1_chr10_135342144_ENST00000463117_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=252AA_BP=136
MAPFMWQVVIQDCLPGWQQGPSGTMSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGP
VFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYP2E1-AMACR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYP2E1-AMACR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYP2E1-AMACR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYP2E1C0001973Alcoholic Intoxication, Chronic6CTD_human;PSYGENET
HgeneCYP2E1C0085762Alcohol abuse6CTD_human;PSYGENET
HgeneCYP2E1C0019193Hepatitis, Toxic4CTD_human
HgeneCYP2E1C0860207Drug-Induced Liver Disease4CTD_human
HgeneCYP2E1C1262760Hepatitis, Drug-Induced4CTD_human
HgeneCYP2E1C3658290Drug-Induced Acute Liver Injury4CTD_human
HgeneCYP2E1C4277682Chemical and Drug Induced Liver Injury4CTD_human
HgeneCYP2E1C4279912Chemically-Induced Liver Toxicity4CTD_human
HgeneCYP2E1C0024121Lung Neoplasms2CTD_human
HgeneCYP2E1C0027540Necrosis2CTD_human
HgeneCYP2E1C0242379Malignant neoplasm of lung2CTD_human
HgeneCYP2E1C0001418Adenocarcinoma1CTD_human
HgeneCYP2E1C0001956Alcohol Use Disorder1CTD_human
HgeneCYP2E1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCYP2E1C0011609Drug Eruptions1CTD_human
HgeneCYP2E1C0013221Drug toxicity1CTD_human
HgeneCYP2E1C0015695Fatty Liver1CTD_human
HgeneCYP2E1C0015696Fatty Liver, Alcoholic1CTD_human
HgeneCYP2E1C0018800Cardiomegaly1CTD_human
HgeneCYP2E1C0019207Hepatoma, Morris1CTD_human
HgeneCYP2E1C0019208Hepatoma, Novikoff1CTD_human
HgeneCYP2E1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneCYP2E1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneCYP2E1C0023891Liver Cirrhosis, Alcoholic1CTD_human
HgeneCYP2E1C0023903Liver neoplasms1CTD_human
HgeneCYP2E1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneCYP2E1C0024302Reticulosarcoma1CTD_human
HgeneCYP2E1C0024304Lymphoma, Mixed-Cell1CTD_human
HgeneCYP2E1C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneCYP2E1C0024306Lymphoma, Undifferentiated1CTD_human
HgeneCYP2E1C0027626Neoplasm Invasiveness1CTD_human
HgeneCYP2E1C0028754Obesity1CTD_human
HgeneCYP2E1C0030567Parkinson Disease1CTD_human
HgeneCYP2E1C0033578Prostatic Neoplasms1CTD_human
HgeneCYP2E1C0036341Schizophrenia1PSYGENET
HgeneCYP2E1C0041755Adverse reaction to drug1CTD_human
HgeneCYP2E1C0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneCYP2E1C0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneCYP2E1C0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneCYP2E1C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneCYP2E1C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneCYP2E1C0086404Experimental Hepatoma1CTD_human
HgeneCYP2E1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneCYP2E1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneCYP2E1C0205643Carcinoma, Cribriform1CTD_human
HgeneCYP2E1C0205644Carcinoma, Granular Cell1CTD_human
HgeneCYP2E1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneCYP2E1C0345904Malignant neoplasm of liver1CTD_human
HgeneCYP2E1C0376358Malignant neoplasm of prostate1CTD_human
HgeneCYP2E1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneCYP2E1C0406537Morbilliform Drug Reaction1CTD_human
HgeneCYP2E1C1383860Cardiac Hypertrophy1CTD_human
HgeneCYP2E1C1449861Micronuclei, Chromosome-Defective1CTD_human
HgeneCYP2E1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
HgeneCYP2E1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneCYP2E1C2239176Liver carcinoma1CTD_human
HgeneCYP2E1C2711227Steatohepatitis1CTD_human
HgeneCYP2E1C2718067Alcoholic Steatohepatitis1CTD_human
HgeneCYP2E1C3241937Nonalcoholic Steatohepatitis1CTD_human
HgeneCYP2E1C3714542Lymphoma, Diffuse1CTD_human
HgeneCYP2E1C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human
TgeneC0033578Prostatic Neoplasms3CTD_human
TgeneC0376358Malignant neoplasm of prostate3CTD_human
TgeneC1858328Bile acid synthesis defect, congenital, 43CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3280428Alpha-Methylacyl-CoA Racemase Deficiency3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneC0001430Adenoma1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0011195Dejerine-Sottas Disease (disorder)1CTD_human
TgeneC0019816Hereditary, Type VII, Motor and Sensory Neuropathy1CTD_human
TgeneC0023895Liver diseases1CTD_human
TgeneC0027888Hereditary Motor and Sensory Neuropathies1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0086565Liver Dysfunction1CTD_human
TgeneC0205646Adenoma, Basal Cell1CTD_human
TgeneC0205647Follicular adenoma1CTD_human
TgeneC0205648Adenoma, Microcystic1CTD_human
TgeneC0205649Adenoma, Monomorphic1CTD_human
TgeneC0205650Papillary adenoma1CTD_human
TgeneC0205651Adenoma, Trabecular1CTD_human