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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DAG1-MAP4 (FusionGDB2 ID:HG1605TG4134)

Fusion Gene Summary for DAG1-MAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: DAG1-MAP4
Fusion gene ID: hg1605tg4134
HgeneTgene
Gene symbol

DAG1

MAP4

Gene ID

1605

4134

Gene namedystroglycan 1microtubule associated protein 4
Synonyms156DAG|A3a|AGRNR|DAG|LGMDR16|MDDGA9|MDDGC7|MDDGC9-
Cytomap('DAG1')('MAP4')

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptiondystroglycandystroglycan 1 (dystrophin-associated glycoprotein 1)microtubule-associated protein 4MAP-4
Modification date2020031320200313
UniProtAcc

Q14118

P27816

Ensembl transtripts involved in fusion geneENST00000308775, ENST00000515359, 
ENST00000538711, ENST00000539901, 
ENST00000541308, ENST00000545947, 
ENST00000479935, 
Fusion gene scores* DoF score9 X 8 X 6=43219 X 21 X 12=4788
# samples 1135
** MAII scorelog2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/4788*10)=-3.77399632511117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAG1 [Title/Abstract] AND MAP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDAG1(49571113)-MAP4(47919013), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAG1

GO:0006509

membrane protein ectodomain proteolysis

19946898

HgeneDAG1

GO:0019048

modulation by virus of host morphology or physiology

16254364



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1469-01ADAG1chr3

49571113

+MAP4chr3

47919013

-


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Fusion Gene ORF analysis for DAG1-MAP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000308775ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000308775ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000308775ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000515359ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000515359ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000538711ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000538711ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000539901ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000539901ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000541308ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000541308ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000545947ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000545947ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-5UTRENST00000479935ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-5UTRENST00000479935ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DAG1-MAP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for DAG1-MAP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:49571113/:47919013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAG1

Q14118

MAP4

P27816

FUNCTION: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}.FUNCTION: Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DAG1-MAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DAG1-MAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DAG1-MAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAP4P27816DB01248DocetaxelSmall moleculeApproved|Investigational
TgeneMAP4P27816DB01229PaclitaxelSmall moleculeApproved|Vet_approved

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Related Diseases for DAG1-MAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAG1C3151184MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 96CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDAG1C4225291MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 94GENOMICS_ENGLAND;UNIPROT
HgeneDAG1C0265221Walker-Warburg congenital muscular dystrophy3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneDAG1C0023092Lassa Fever1CTD_human
HgeneDAG1C0033578Prostatic Neoplasms1CTD_human
HgeneDAG1C0376358Malignant neoplasm of prostate1CTD_human
HgeneDAG1C0686353Muscular Dystrophies, Limb-Girdle1GENOMICS_ENGLAND
HgeneDAG1C0699743Congenital muscular dystrophy (disorder)1GENOMICS_ENGLAND
TgeneC0043094Weight Gain1CTD_human