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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DGKH-DGKH (FusionGDB2 ID:HG160851TG160851) |
Fusion Gene Summary for DGKH-DGKH |
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Fusion gene information | Fusion gene name: DGKH-DGKH | Fusion gene ID: hg160851tg160851 | Hgene | Tgene | Gene symbol | DGKH | DGKH | Gene ID | 160851 | 160851 |
Gene name | diacylglycerol kinase eta | diacylglycerol kinase eta | |
Synonyms | DGKeta | DGKeta | |
Cytomap | ('DGKH')('DGKH') 13q14.11 | 13q14.11 | |
Type of gene | protein-coding | protein-coding | |
Description | diacylglycerol kinase etaDAG kinase etadiglyceride kinase eta | diacylglycerol kinase etaDAG kinase etadiglyceride kinase eta | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q86XP1 | Q86XP1 | |
Ensembl transtripts involved in fusion gene | ENST00000261491, ENST00000337343, ENST00000379274, ENST00000498255, ENST00000536612, ENST00000538674, ENST00000540693, | ENST00000261491, ENST00000337343, ENST00000379274, ENST00000498255, ENST00000536612, ENST00000538674, ENST00000540693, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 13 X 13 X 4=676 |
# samples | 6 | 13 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/676*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DGKH [Title/Abstract] AND DGKH [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DGKH(42742071)-DGKH(42741978), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DGKH | GO:0046473 | phosphatidic acid metabolic process | 23949095 |
Tgene | DGKH | GO:0046473 | phosphatidic acid metabolic process | 23949095 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for DGKH-DGKH |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DGKH-DGKH |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for DGKH-DGKH |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:42742071/:42741978) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DGKH | DGKH |
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. | FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DGKH-DGKH |
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Fusion Gene PPI Analysis for DGKH-DGKH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DGKH-DGKH |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DGKH-DGKH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DGKH | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | DGKH | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | DGKH | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human |
Hgene | DGKH | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | DGKH | C2678248 | Mood instability | 1 | PSYGENET |
Tgene | C0005586 | Bipolar Disorder | 5 | PSYGENET | |
Tgene | C0011881 | Diabetic Nephropathy | 1 | CTD_human | |
Tgene | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human | |
Tgene | C0041696 | Unipolar Depression | 1 | PSYGENET | |
Tgene | C2678248 | Mood instability | 1 | PSYGENET |