|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AP1B1-GRK3 (FusionGDB2 ID:HG162TG157) |
Fusion Gene Summary for AP1B1-GRK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP1B1-GRK3 | Fusion gene ID: hg162tg157 | Hgene | Tgene | Gene symbol | AP1B1 | GRK3 | Gene ID | 162 | 157 |
| Gene name | adaptor related protein complex 1 subunit beta 1 | G protein-coupled receptor kinase 3 | |
| Synonyms | ADTB1|AP105A|BAM22|CLAPB2|KIDAR | ADRBK2|BARK2 | |
| Cytomap | ('AP1B1','AP1B1')('ADRBK2','GRK3') 22q12.2 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-1 complex subunit beta-1ADTB1, CLAPB2Golgi adaptor HA1/AP1 adaptin beta subunitadapter-related protein complex 1 subunit beta-1adaptor protein complex AP-1 subunit beta-1adaptor related protein complex 1 beta 1 subunitbeta-1-adaptinbeta-adaptin | beta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000317368, ENST00000356015, ENST00000357586, ENST00000402502, ENST00000405198, ENST00000415447, ENST00000432560, ENST00000472057, | ENST00000472057, ENST00000317368, ENST00000356015, ENST00000357586, ENST00000402502, ENST00000405198, ENST00000415447, ENST00000432560, | |
| Fusion gene scores | * DoF score | 11 X 11 X 7=847 | 3 X 2 X 3=18 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/847*10)=-2.70385034630374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AP1B1 [Title/Abstract] AND GRK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AP1B1(29750639)-ADRBK2(26091074), # samples:2 AP1B1(29750639)-GRK3(26091074), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ADRBK2-AP1B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADRBK2-AP1B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP1B1-ADRBK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP1B1-ADRBK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP1B1-ADRBK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP1B1-ADRBK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRK3 | GO:0031623 | receptor internalization | 20074556 |
| Fusion gene breakpoints across AP1B1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across GRK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-C4-A0F7-01A | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| ChimerDB4 | BLCA | TCGA-C4-A0F7-01A | AP1B1 | chr22 | 29750639 | - | GRK3 | chr22 | 26091074 | + |
Top |
Fusion Gene ORF analysis for AP1B1-GRK3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000317368 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000356015 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000357586 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000402502 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000405198 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000415447 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| In-frame | ENST00000432560 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| intron-3CDS | ENST00000472057 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000356015 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8984 | 1125 | 187 | 2139 | 650 |
| ENST00000432560 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8984 | 1125 | 187 | 2139 | 650 |
| ENST00000357586 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8984 | 1125 | 187 | 2139 | 650 |
| ENST00000405198 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8829 | 970 | 32 | 1984 | 650 |
| ENST00000317368 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8984 | 1125 | 187 | 2139 | 650 |
| ENST00000402502 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8829 | 970 | 32 | 1984 | 650 |
| ENST00000415447 | AP1B1 | chr22 | 29750639 | - | ENST00000324198 | ADRBK2 | chr22 | 26091074 | + | 8815 | 956 | 18 | 1970 | 650 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000356015 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000129476 | 0.99987054 |
| ENST00000432560 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000129476 | 0.99987054 |
| ENST00000357586 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000129476 | 0.99987054 |
| ENST00000405198 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000124203 | 0.9998758 |
| ENST00000317368 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000129476 | 0.99987054 |
| ENST00000402502 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000124203 | 0.9998758 |
| ENST00000415447 | ENST00000324198 | AP1B1 | chr22 | 29750639 | - | ADRBK2 | chr22 | 26091074 | + | 0.000122286 | 0.9998777 |
Top |
Fusion Genomic Features for AP1B1-GRK3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| AP1B1 | chr22 | 29750638 | - | ADRBK2 | chr22 | 26091073 | + | 4.75E-08 | 1 |
| AP1B1 | chr22 | 29750638 | - | ADRBK2 | chr22 | 26091073 | + | 4.75E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for AP1B1-GRK3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29750639/:26091074) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 454_521 | 350 | 689.0 | Domain | AGC-kinase C-terminal | |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 558_652 | 350 | 689.0 | Domain | PH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000317368 | - | 7 | 21 | 576_725 | 312 | 920.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000356015 | - | 7 | 22 | 576_725 | 312 | 943.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000357586 | - | 7 | 23 | 576_725 | 312 | 950.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000402502 | - | 6 | 20 | 576_725 | 312 | 940.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000405198 | - | 6 | 22 | 576_725 | 312 | 950.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000415447 | - | 6 | 20 | 576_725 | 312 | 940.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Hgene | AP1B1 | chr22:29750639 | chr22:26091074 | ENST00000432560 | - | 7 | 21 | 576_725 | 312 | 940.0 | Compositional bias | Note=Pro-rich (stalk region) |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 191_453 | 350 | 689.0 | Domain | Protein kinase | |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 54_175 | 350 | 689.0 | Domain | RGS | |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 197_205 | 350 | 689.0 | Nucleotide binding | ATP | |
| Tgene | ADRBK2 | chr22:29750639 | chr22:26091074 | ENST00000324198 | 11 | 21 | 1_190 | 350 | 689.0 | Region | Note=N-terminal |
Top |
Fusion Gene Sequence for AP1B1-GRK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5161_5161_1_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000317368_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8984nt_BP=1125nt CCCGCGCGCGGGCAGCTCACTTCCGCCCGGCAGGTGACAGCCGCGGGGCTCCGAGCCGCCGGCAGCCCGGACGCACCGGGAGAGCGAGAG GTGGAGGCCGCGGACATTTTGGTGCCAAGCCGAACCGAGCCGGGGCGCCGGGAGCTATTGGGACCTGCGGAAGCCTGGCTACAGATAAGG GACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGGCAGAGCTCAACAGTGACAAGAAGGA GAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTGGTCAACTGCAT GCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAGCCTGACATGGCCATTATGGCCGT CAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGAT CACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACAGCAGCTGTGTGCGTGGCCAAGCT CCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATGGTGGTGGC CAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCT GACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCA GAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGA GATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCT GCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGGCTCCCGAGGTGCTGCAGAAGGGGAC GGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCACAGCCCTTTCAGACAACATAAAAC CAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCTCCTGAACTGAAGTCCCTTTTGGA GGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAAGAGCACAGCTTTTTCAAAGGTGT TGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAATGCTGCTGATGCCTTTGATATTGG CTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAACTTCCCTTTGGTCATCTCTGAACG CTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCCAGGAAGAGAGCTAAAAATAAGCA ACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTGGGAAACCCATTTCTGACTCAGTG GCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAAAATTTACTGACAATGGAACAGAT TCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAACAATTTGTCTTGCAATGTGAGAG TGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTGCGTCGTGCCCCGAAGTTCCTCAA CAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTCTAGCACCCAGAAACAGGGAGGGT CCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTCGCTACCGGGACTCCTCCAGGCTC CCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCATTAGAAACTACTGAAGAAATAAA AGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATCACGTAAATTTTTATGTCTGATAT CAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTAAGCATTGCCACATATTCTGTCTA GTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCTTTTGTGCACTTCGCAACTGACTT CTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACTTGGGCCCTCCTCTGGGAGCCGCA CCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGACACGTACTATCCAAGTGTATGGG ATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACAGGCCGTGGAGTTTTAGGTTTCAG GGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATGCAGGAGCACTCATGGGTGAGTCC GTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAGACATATCAGTAATGGATGTACAA AAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGAATGTGTCAAAATGGGTTAACTGT GTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGACAGTGAGGACCTTAGGGCATGAA GCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCCACTGATACCCCCAAATAGATGCT GGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGTATTTGTCCCATTCTTGGAGTAGT TTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCCTGTCCTTGATATTTTTAGCAGTT CCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTATTTTGAGAGTTTGGAAGATAATT ACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGTCTATCTCAACTACTAGTTGGGGT TTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACATGCATTCTCCTTATTTAAAAAGGA AGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGAAGCAGAAAAGCCATTGTTCTTAA AGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCAAGCTCATAGGTTCTCAGCATGTG CAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTCCACCAGGGTCTGGGCTTAGCGTC TAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATACTTGTTCTAAAATTGAGCTGATCC GCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAAAAGATATATGAATTGGAAAATGC TCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTGTAATGATATGGTTGAGAAGTACA TCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAGTTGTGTTGGGGTCTGGTTTGAGT GCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCACCCGGTTGCCTGCATGGCCAGAG GAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTTTGGGATAGGGCCTCGCTCTGTCA CCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATCCTCCCACGTCAGCCTCCTGAGTA GCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGAACTCTTAGGCTCAAGTGATCCTC CTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGATGTTTTAGAAGGTTTTCCAAGTA TTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTATTTTTTTTCATTATTTTAGATTCC TGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCGGTAATAAGTCTTGATTTCATGAT TCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAATAAATTAAAAACCTTTGTGAATT CAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTCATTGGTTTTCCTTCTTTGTCATA TTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGCTCATGCCTCTGATTGGTCCATTC ACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCCTATAATCCCAGCACTTTGGGAGG CCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCTCTACTAAAAATACAAATAAAAAT TAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCA GTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAGGAGGGGGGCTAAATATCCAG TGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTGTTGCAAACAAGATGTAGCTTGAT TTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTACAAAGTAATGTTTACCAATTGAC GACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCGGAATTTGTAGCTGGGCCAATTCA ACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAAACAACGTTCTCAAAGTCTGGCCT CTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGTATGATTTAATCATATGCAGTGTT GTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCACCCTGAGTGAGGGGTTGACTTGT TGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGAATAGTGGTAGAAATCGGGCGAAG GAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATAGGTGAAGTTTCTTTTTTCCCCCC TGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAGCTGCTGAACTCATTCAGAAGCCA TTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCATGGAGGCACAGGGGACCCAGAGCT AAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACTTTGCAGCCC CCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTGTTACAAATCCACTGAAGTCCTGG TAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCCTGGGCAACACAGCAAGACCCCAT CTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTTTTCCCTCCTATGTAAAGTTTACT GGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACAAAGTTTATTATGAAACAAATGAA ATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCCTTAAGGACTAAGATAGTTGTTTT ATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTTTCTGACCTGGCTGTGTTAGCACT GATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGGTTAAGAGTATACGCATTTCATCA AACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAGCGCTCCAGTATCTAACAATCTCA GAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTTGATGTAAGGGTAGGGAATGGAGA AATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAAATGATGTATATATTATATGTGGT TTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTATAATAGATCTGGCTTTTTCTGGAT AGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTTATATTATTTATTGAATCCATAAG TTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAAGAAATGGCAGTCCTTCCTGTTCT TAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACTGTTTTCAACAACAGTTGATCTTC TGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACTGCTTTCATCTACCTCTTCAGAAG GCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTCTGTAAGACTTTGCAGTGTCATTC CCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTAGCTATCCCTCCCATGTCATTAGT AATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCACCATCAGCCTTGCCATTGCCTTAA GATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGGCAAGCTGTGCTTAGAAACACTGC TTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATGGGGTCTTAAAGGTAAGCGCCCTC ATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAGAATGAAGTCCTGTCTCTGTGAGA GAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACTATATTCTTGAATACCCTTGAAGA AAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCTAGATATTGTACCTAGACAAAATA TCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACACTCACTAGTGCACGTCTGAAATA GTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAGCACCACCGTTTTTACAGTTACTT >5161_5161_1_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000317368_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_2_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000356015_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8984nt_BP=1125nt CCCGCGCGCGGGCAGCTCACTTCCGCCCGGCAGGTGACAGCCGCGGGGCTCCGAGCCGCCGGCAGCCCGGACGCACCGGGAGAGCGAGAG GTGGAGGCCGCGGACATTTTGGTGCCAAGCCGAACCGAGCCGGGGCGCCGGGAGCTATTGGGACCTGCGGAAGCCTGGCTACAGATAAGG GACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGGCAGAGCTCAACAGTGACAAGAAGGA GAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTGGTCAACTGCAT GCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAGCCTGACATGGCCATTATGGCCGT CAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGAT CACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACAGCAGCTGTGTGCGTGGCCAAGCT CCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATGGTGGTGGC CAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCT GACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCA GAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGA GATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCT GCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGGCTCCCGAGGTGCTGCAGAAGGGGAC GGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCACAGCCCTTTCAGACAACATAAAAC CAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCTCCTGAACTGAAGTCCCTTTTGGA GGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAAGAGCACAGCTTTTTCAAAGGTGT TGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAATGCTGCTGATGCCTTTGATATTGG CTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAACTTCCCTTTGGTCATCTCTGAACG CTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCCAGGAAGAGAGCTAAAAATAAGCA ACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTGGGAAACCCATTTCTGACTCAGTG GCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAAAATTTACTGACAATGGAACAGAT TCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAACAATTTGTCTTGCAATGTGAGAG TGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTGCGTCGTGCCCCGAAGTTCCTCAA CAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTCTAGCACCCAGAAACAGGGAGGGT CCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTCGCTACCGGGACTCCTCCAGGCTC CCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCATTAGAAACTACTGAAGAAATAAA AGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATCACGTAAATTTTTATGTCTGATAT CAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTAAGCATTGCCACATATTCTGTCTA GTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCTTTTGTGCACTTCGCAACTGACTT CTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACTTGGGCCCTCCTCTGGGAGCCGCA CCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGACACGTACTATCCAAGTGTATGGG ATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACAGGCCGTGGAGTTTTAGGTTTCAG GGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATGCAGGAGCACTCATGGGTGAGTCC GTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAGACATATCAGTAATGGATGTACAA AAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGAATGTGTCAAAATGGGTTAACTGT GTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGACAGTGAGGACCTTAGGGCATGAA GCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCCACTGATACCCCCAAATAGATGCT GGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGTATTTGTCCCATTCTTGGAGTAGT TTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCCTGTCCTTGATATTTTTAGCAGTT CCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTATTTTGAGAGTTTGGAAGATAATT ACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGTCTATCTCAACTACTAGTTGGGGT TTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACATGCATTCTCCTTATTTAAAAAGGA AGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGAAGCAGAAAAGCCATTGTTCTTAA AGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCAAGCTCATAGGTTCTCAGCATGTG CAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTCCACCAGGGTCTGGGCTTAGCGTC TAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATACTTGTTCTAAAATTGAGCTGATCC GCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAAAAGATATATGAATTGGAAAATGC TCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTGTAATGATATGGTTGAGAAGTACA TCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAGTTGTGTTGGGGTCTGGTTTGAGT GCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCACCCGGTTGCCTGCATGGCCAGAG GAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTTTGGGATAGGGCCTCGCTCTGTCA CCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATCCTCCCACGTCAGCCTCCTGAGTA GCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGAACTCTTAGGCTCAAGTGATCCTC CTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGATGTTTTAGAAGGTTTTCCAAGTA TTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTATTTTTTTTCATTATTTTAGATTCC TGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCGGTAATAAGTCTTGATTTCATGAT TCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAATAAATTAAAAACCTTTGTGAATT CAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTCATTGGTTTTCCTTCTTTGTCATA TTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGCTCATGCCTCTGATTGGTCCATTC ACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCCTATAATCCCAGCACTTTGGGAGG CCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCTCTACTAAAAATACAAATAAAAAT TAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCA GTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAGGAGGGGGGCTAAATATCCAG TGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTGTTGCAAACAAGATGTAGCTTGAT TTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTACAAAGTAATGTTTACCAATTGAC GACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCGGAATTTGTAGCTGGGCCAATTCA ACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAAACAACGTTCTCAAAGTCTGGCCT CTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGTATGATTTAATCATATGCAGTGTT GTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCACCCTGAGTGAGGGGTTGACTTGT TGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGAATAGTGGTAGAAATCGGGCGAAG GAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATAGGTGAAGTTTCTTTTTTCCCCCC TGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAGCTGCTGAACTCATTCAGAAGCCA TTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCATGGAGGCACAGGGGACCCAGAGCT AAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACTTTGCAGCCC CCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTGTTACAAATCCACTGAAGTCCTGG TAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCCTGGGCAACACAGCAAGACCCCAT CTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTTTTCCCTCCTATGTAAAGTTTACT GGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACAAAGTTTATTATGAAACAAATGAA ATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCCTTAAGGACTAAGATAGTTGTTTT ATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTTTCTGACCTGGCTGTGTTAGCACT GATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGGTTAAGAGTATACGCATTTCATCA AACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAGCGCTCCAGTATCTAACAATCTCA GAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTTGATGTAAGGGTAGGGAATGGAGA AATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAAATGATGTATATATTATATGTGGT TTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTATAATAGATCTGGCTTTTTCTGGAT AGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTTATATTATTTATTGAATCCATAAG TTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAAGAAATGGCAGTCCTTCCTGTTCT TAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACTGTTTTCAACAACAGTTGATCTTC TGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACTGCTTTCATCTACCTCTTCAGAAG GCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTCTGTAAGACTTTGCAGTGTCATTC CCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTAGCTATCCCTCCCATGTCATTAGT AATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCACCATCAGCCTTGCCATTGCCTTAA GATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGGCAAGCTGTGCTTAGAAACACTGC TTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATGGGGTCTTAAAGGTAAGCGCCCTC ATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAGAATGAAGTCCTGTCTCTGTGAGA GAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACTATATTCTTGAATACCCTTGAAGA AAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCTAGATATTGTACCTAGACAAAATA TCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACACTCACTAGTGCACGTCTGAAATA GTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAGCACCACCGTTTTTACAGTTACTT >5161_5161_2_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000356015_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_3_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000357586_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8984nt_BP=1125nt CCCGCGCGCGGGCAGCTCACTTCCGCCCGGCAGGTGACAGCCGCGGGGCTCCGAGCCGCCGGCAGCCCGGACGCACCGGGAGAGCGAGAG GTGGAGGCCGCGGACATTTTGGTGCCAAGCCGAACCGAGCCGGGGCGCCGGGAGCTATTGGGACCTGCGGAAGCCTGGCTACAGATAAGG GACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGGCAGAGCTCAACAGTGACAAGAAGGA GAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTGGTCAACTGCAT GCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAGCCTGACATGGCCATTATGGCCGT CAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGAT CACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACAGCAGCTGTGTGCGTGGCCAAGCT CCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATGGTGGTGGC CAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCT GACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCA GAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGA GATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCT GCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGGCTCCCGAGGTGCTGCAGAAGGGGAC GGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCACAGCCCTTTCAGACAACATAAAAC CAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCTCCTGAACTGAAGTCCCTTTTGGA GGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAAGAGCACAGCTTTTTCAAAGGTGT TGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAATGCTGCTGATGCCTTTGATATTGG CTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAACTTCCCTTTGGTCATCTCTGAACG CTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCCAGGAAGAGAGCTAAAAATAAGCA ACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTGGGAAACCCATTTCTGACTCAGTG GCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAAAATTTACTGACAATGGAACAGAT TCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAACAATTTGTCTTGCAATGTGAGAG TGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTGCGTCGTGCCCCGAAGTTCCTCAA CAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTCTAGCACCCAGAAACAGGGAGGGT CCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTCGCTACCGGGACTCCTCCAGGCTC CCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCATTAGAAACTACTGAAGAAATAAA AGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATCACGTAAATTTTTATGTCTGATAT CAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTAAGCATTGCCACATATTCTGTCTA GTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCTTTTGTGCACTTCGCAACTGACTT CTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACTTGGGCCCTCCTCTGGGAGCCGCA CCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGACACGTACTATCCAAGTGTATGGG ATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACAGGCCGTGGAGTTTTAGGTTTCAG GGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATGCAGGAGCACTCATGGGTGAGTCC GTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAGACATATCAGTAATGGATGTACAA AAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGAATGTGTCAAAATGGGTTAACTGT GTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGACAGTGAGGACCTTAGGGCATGAA GCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCCACTGATACCCCCAAATAGATGCT GGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGTATTTGTCCCATTCTTGGAGTAGT TTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCCTGTCCTTGATATTTTTAGCAGTT CCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTATTTTGAGAGTTTGGAAGATAATT ACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGTCTATCTCAACTACTAGTTGGGGT TTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACATGCATTCTCCTTATTTAAAAAGGA AGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGAAGCAGAAAAGCCATTGTTCTTAA AGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCAAGCTCATAGGTTCTCAGCATGTG CAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTCCACCAGGGTCTGGGCTTAGCGTC TAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATACTTGTTCTAAAATTGAGCTGATCC GCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAAAAGATATATGAATTGGAAAATGC TCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTGTAATGATATGGTTGAGAAGTACA TCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAGTTGTGTTGGGGTCTGGTTTGAGT GCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCACCCGGTTGCCTGCATGGCCAGAG GAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTTTGGGATAGGGCCTCGCTCTGTCA CCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATCCTCCCACGTCAGCCTCCTGAGTA GCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGAACTCTTAGGCTCAAGTGATCCTC CTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGATGTTTTAGAAGGTTTTCCAAGTA TTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTATTTTTTTTCATTATTTTAGATTCC TGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCGGTAATAAGTCTTGATTTCATGAT TCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAATAAATTAAAAACCTTTGTGAATT CAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTCATTGGTTTTCCTTCTTTGTCATA TTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGCTCATGCCTCTGATTGGTCCATTC ACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCCTATAATCCCAGCACTTTGGGAGG CCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCTCTACTAAAAATACAAATAAAAAT TAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCA GTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAGGAGGGGGGCTAAATATCCAG TGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTGTTGCAAACAAGATGTAGCTTGAT TTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTACAAAGTAATGTTTACCAATTGAC GACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCGGAATTTGTAGCTGGGCCAATTCA ACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAAACAACGTTCTCAAAGTCTGGCCT CTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGTATGATTTAATCATATGCAGTGTT GTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCACCCTGAGTGAGGGGTTGACTTGT TGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGAATAGTGGTAGAAATCGGGCGAAG GAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATAGGTGAAGTTTCTTTTTTCCCCCC TGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAGCTGCTGAACTCATTCAGAAGCCA TTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCATGGAGGCACAGGGGACCCAGAGCT AAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACTTTGCAGCCC CCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTGTTACAAATCCACTGAAGTCCTGG TAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCCTGGGCAACACAGCAAGACCCCAT CTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTTTTCCCTCCTATGTAAAGTTTACT GGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACAAAGTTTATTATGAAACAAATGAA ATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCCTTAAGGACTAAGATAGTTGTTTT ATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTTTCTGACCTGGCTGTGTTAGCACT GATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGGTTAAGAGTATACGCATTTCATCA AACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAGCGCTCCAGTATCTAACAATCTCA GAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTTGATGTAAGGGTAGGGAATGGAGA AATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAAATGATGTATATATTATATGTGGT TTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTATAATAGATCTGGCTTTTTCTGGAT AGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTTATATTATTTATTGAATCCATAAG TTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAAGAAATGGCAGTCCTTCCTGTTCT TAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACTGTTTTCAACAACAGTTGATCTTC TGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACTGCTTTCATCTACCTCTTCAGAAG GCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTCTGTAAGACTTTGCAGTGTCATTC CCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTAGCTATCCCTCCCATGTCATTAGT AATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCACCATCAGCCTTGCCATTGCCTTAA GATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGGCAAGCTGTGCTTAGAAACACTGC TTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATGGGGTCTTAAAGGTAAGCGCCCTC ATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAGAATGAAGTCCTGTCTCTGTGAGA GAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACTATATTCTTGAATACCCTTGAAGA AAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCTAGATATTGTACCTAGACAAAATA TCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACACTCACTAGTGCACGTCTGAAATA GTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAGCACCACCGTTTTTACAGTTACTT >5161_5161_3_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000357586_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_4_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000402502_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8829nt_BP=970nt TGCAGAAGCCTGGCTACAGATAAGGGACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGG CAGAGCTCAACAGTGACAAGAAGGAGAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCC TCTTCCCCGATGTGGTCAACTGCATGCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTC AGCCTGACATGGCCATTATGGCCGTCAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCA TGGGCTGCATCCGCGTTGACAAGATCACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGA CAGCAGCTGTGTGCGTGGCCAAGCTCCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCT CCGACTCTAACCCCATGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGA ACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATA TGCCCAAGGACGACCGCGAGGCCCAGAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTG TGAAGGTGCTGATGAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCA CACTGCTGTCAGCCGAGCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGG CTCCCGAGGTGCTGCAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTC ACAGCCCTTTCAGACAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCT CTCCTGAACTGAAGTCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAA AAGAGCACAGCTTTTTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCA ATGCTGCTGATGCCTTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGA ACTTCCCTTTGGTCATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGG CCAGGAAGAGAGCTAAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAAC TGGGAAACCCATTTCTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGC AAAATTTACTGACAATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGA AACAATTTGTCTTGCAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTAT TGCGTCGTGCCCCGAAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCC TCTAGCACCCAGAAACAGGGAGGGTCCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTAT TCGCTACCGGGACTCCTCCAGGCTCCCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTG CATTAGAAACTACTGAAGAAATAAAAGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTA TCACGTAAATTTTTATGTCTGATATCAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCC TAAGCATTGCCACATATTCTGTCTAGTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTT CTTTTGTGCACTTCGCAACTGACTTCTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCA CTTGGGCCCTCCTCTGGGAGCCGCACCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACG GACACGTACTATCCAAGTGTATGGGATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGA CAGGCCGTGGAGTTTTAGGTTTCAGGGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCA TGCAGGAGCACTCATGGGTGAGTCCGTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGG AGACATATCAGTAATGGATGTACAAAAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAAT GAATGTGTCAAAATGGGTTAACTGTGTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTAC GACAGTGAGGACCTTAGGGCATGAAGCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCC CCACTGATACCCCCAAATAGATGCTGGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCAC GTATTTGTCCCATTCTTGGAGTAGTTTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCAT CCTGTCCTTGATATTTTTAGCAGTTCCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGT TATTTTGAGAGTTTGGAAGATAATTACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTT GTCTATCTCAACTACTAGTTGGGGTTTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTAC ATGCATTCTCCTTATTTAAAAAGGAAGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCA GAAGCAGAAAAGCCATTGTTCTTAAAGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCT CAAGCTCATAGGTTCTCAGCATGTGCAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGAC TCCACCAGGGTCTGGGCTTAGCGTCTAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCAT ACTTGTTCTAAAATTGAGCTGATCCGCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAG AAAAGATATATGAATTGGAAAATGCTCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATT TGTAATGATATGGTTGAGAAGTACATCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACC AGTTGTGTTGGGGTCTGGTTTGAGTGCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTG CACCCGGTTGCCTGCATGGCCAGAGGAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTT TTTGGGATAGGGCCTCGCTCTGTCACCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAA TCCTCCCACGTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTT GAACTCTTAGGCTCAAGTGATCCTCCTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTG GATGTTTTAGAAGGTTTTCCAAGTATTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCT ATTTTTTTTCATTATTTTAGATTCCTGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATG CGGTAATAAGTCTTGATTTCATGATTCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGG AATAAATTAAAAACCTTTGTGAATTCAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGC TCATTGGTTTTCCTTCTTTGTCATATTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGT GCTCATGCCTCTGATTGGTCCATTCACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACG CCTATAATCCCAGCACTTTGGGAGGCCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGT CTCTACTAAAAATACAAATAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGC ATGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAA AAAAGGAGGGGGGCTAAATATCCAGTGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTT TGTTGCAAACAAGATGTAGCTTGATTTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATC TACAAAGTAATGTTTACCAATTGACGACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACT CGGAATTTGTAGCTGGGCCAATTCAACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGA AAACAACGTTCTCAAAGTCTGGCCTCTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTT GTATGATTTAATCATATGCAGTGTTGTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCC CACCCTGAGTGAGGGGTTGACTTGTTGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGA GAATAGTGGTAGAAATCGGGCGAAGGAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAA TAGGTGAAGTTTCTTTTTTCCCCCCTGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGG AGCTGCTGAACTCATTCAGAAGCCATTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCC ATGGAGGCACAGGGGACCCAGAGCTAAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGCACTTTGCAGCCCCCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACAC TGTTACAAATCCACTGAAGTCCTGGTAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAG CCTGGGCAACACAGCAAGACCCCATCTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGAT TTTTCCCTCCTATGTAAAGTTTACTGGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAA CAAAGTTTATTATGAAACAAATGAAATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGT CCTTAAGGACTAAGATAGTTGTTTTATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTC TTTCTGACCTGGCTGTGTTAGCACTGATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATG GGTTAAGAGTATACGCATTTCATCAAACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTT AGCGCTCCAGTATCTAACAATCTCAGAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCT TTGATGTAAGGGTAGGGAATGGAGAAATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATT AAATGATGTATATATTATATGTGGTTTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATT ATAATAGATCTGGCTTTTTCTGGATAGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATT TTATATTATTTATTGAATCCATAAGTTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTA AAGAAATGGCAGTCCTTCCTGTTCTTAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGA CTGTTTTCAACAACAGTTGATCTTCTGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATA CTGCTTTCATCTACCTCTTCAGAAGGCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATT TCTGTAAGACTTTGCAGTGTCATTCCCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGG TAGCTATCCCTCCCATGTCATTAGTAATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCC ACCATCAGCCTTGCCATTGCCTTAAGATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAA GGCAAGCTGTGCTTAGAAACACTGCTTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAA TGGGGTCTTAAAGGTAAGCGCCCTCATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAAT AGAATGAAGTCCTGTCTCTGTGAGAGAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTA CTATATTCTTGAATACCCTTGAAGAAAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAAT CTAGATATTGTACCTAGACAAAATATCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATA CACTCACTAGTGCACGTCTGAAATAGTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTC AGCACCACCGTTTTTACAGTTACTTTGGAGCTGCTAGACTGGTTTTCTGTGTTGGTAAATTGCCTATATAAATCTGAATAAAAAGGATCT >5161_5161_4_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000402502_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_5_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000405198_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8829nt_BP=970nt TGCAGAAGCCTGGCTACAGATAAGGGACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGG CAGAGCTCAACAGTGACAAGAAGGAGAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCC TCTTCCCCGATGTGGTCAACTGCATGCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTC AGCCTGACATGGCCATTATGGCCGTCAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCA TGGGCTGCATCCGCGTTGACAAGATCACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGA CAGCAGCTGTGTGCGTGGCCAAGCTCCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCT CCGACTCTAACCCCATGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGA ACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATA TGCCCAAGGACGACCGCGAGGCCCAGAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTG TGAAGGTGCTGATGAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCA CACTGCTGTCAGCCGAGCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGG CTCCCGAGGTGCTGCAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTC ACAGCCCTTTCAGACAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCT CTCCTGAACTGAAGTCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAA AAGAGCACAGCTTTTTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCA ATGCTGCTGATGCCTTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGA ACTTCCCTTTGGTCATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGG CCAGGAAGAGAGCTAAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAAC TGGGAAACCCATTTCTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGC AAAATTTACTGACAATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGA AACAATTTGTCTTGCAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTAT TGCGTCGTGCCCCGAAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCC TCTAGCACCCAGAAACAGGGAGGGTCCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTAT TCGCTACCGGGACTCCTCCAGGCTCCCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTG CATTAGAAACTACTGAAGAAATAAAAGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTA TCACGTAAATTTTTATGTCTGATATCAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCC TAAGCATTGCCACATATTCTGTCTAGTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTT CTTTTGTGCACTTCGCAACTGACTTCTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCA CTTGGGCCCTCCTCTGGGAGCCGCACCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACG GACACGTACTATCCAAGTGTATGGGATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGA CAGGCCGTGGAGTTTTAGGTTTCAGGGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCA TGCAGGAGCACTCATGGGTGAGTCCGTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGG AGACATATCAGTAATGGATGTACAAAAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAAT GAATGTGTCAAAATGGGTTAACTGTGTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTAC GACAGTGAGGACCTTAGGGCATGAAGCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCC CCACTGATACCCCCAAATAGATGCTGGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCAC GTATTTGTCCCATTCTTGGAGTAGTTTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCAT CCTGTCCTTGATATTTTTAGCAGTTCCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGT TATTTTGAGAGTTTGGAAGATAATTACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTT GTCTATCTCAACTACTAGTTGGGGTTTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTAC ATGCATTCTCCTTATTTAAAAAGGAAGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCA GAAGCAGAAAAGCCATTGTTCTTAAAGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCT CAAGCTCATAGGTTCTCAGCATGTGCAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGAC TCCACCAGGGTCTGGGCTTAGCGTCTAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCAT ACTTGTTCTAAAATTGAGCTGATCCGCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAG AAAAGATATATGAATTGGAAAATGCTCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATT TGTAATGATATGGTTGAGAAGTACATCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACC AGTTGTGTTGGGGTCTGGTTTGAGTGCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTG CACCCGGTTGCCTGCATGGCCAGAGGAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTT TTTGGGATAGGGCCTCGCTCTGTCACCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAA TCCTCCCACGTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTT GAACTCTTAGGCTCAAGTGATCCTCCTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTG GATGTTTTAGAAGGTTTTCCAAGTATTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCT ATTTTTTTTCATTATTTTAGATTCCTGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATG CGGTAATAAGTCTTGATTTCATGATTCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGG AATAAATTAAAAACCTTTGTGAATTCAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGC TCATTGGTTTTCCTTCTTTGTCATATTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGT GCTCATGCCTCTGATTGGTCCATTCACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACG CCTATAATCCCAGCACTTTGGGAGGCCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGT CTCTACTAAAAATACAAATAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGC ATGAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAA AAAAGGAGGGGGGCTAAATATCCAGTGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTT TGTTGCAAACAAGATGTAGCTTGATTTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATC TACAAAGTAATGTTTACCAATTGACGACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACT CGGAATTTGTAGCTGGGCCAATTCAACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGA AAACAACGTTCTCAAAGTCTGGCCTCTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTT GTATGATTTAATCATATGCAGTGTTGTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCC CACCCTGAGTGAGGGGTTGACTTGTTGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGA GAATAGTGGTAGAAATCGGGCGAAGGAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAA TAGGTGAAGTTTCTTTTTTCCCCCCTGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGG AGCTGCTGAACTCATTCAGAAGCCATTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCC ATGGAGGCACAGGGGACCCAGAGCTAAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGCACTTTGCAGCCCCCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACAC TGTTACAAATCCACTGAAGTCCTGGTAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAG CCTGGGCAACACAGCAAGACCCCATCTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGAT TTTTCCCTCCTATGTAAAGTTTACTGGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAA CAAAGTTTATTATGAAACAAATGAAATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGT CCTTAAGGACTAAGATAGTTGTTTTATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTC TTTCTGACCTGGCTGTGTTAGCACTGATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATG GGTTAAGAGTATACGCATTTCATCAAACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTT AGCGCTCCAGTATCTAACAATCTCAGAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCT TTGATGTAAGGGTAGGGAATGGAGAAATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATT AAATGATGTATATATTATATGTGGTTTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATT ATAATAGATCTGGCTTTTTCTGGATAGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATT TTATATTATTTATTGAATCCATAAGTTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTA AAGAAATGGCAGTCCTTCCTGTTCTTAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGA CTGTTTTCAACAACAGTTGATCTTCTGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATA CTGCTTTCATCTACCTCTTCAGAAGGCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATT TCTGTAAGACTTTGCAGTGTCATTCCCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGG TAGCTATCCCTCCCATGTCATTAGTAATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCC ACCATCAGCCTTGCCATTGCCTTAAGATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAA GGCAAGCTGTGCTTAGAAACACTGCTTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAA TGGGGTCTTAAAGGTAAGCGCCCTCATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAAT AGAATGAAGTCCTGTCTCTGTGAGAGAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTA CTATATTCTTGAATACCCTTGAAGAAAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAAT CTAGATATTGTACCTAGACAAAATATCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATA CACTCACTAGTGCACGTCTGAAATAGTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTC AGCACCACCGTTTTTACAGTTACTTTGGAGCTGCTAGACTGGTTTTCTGTGTTGGTAAATTGCCTATATAAATCTGAATAAAAAGGATCT >5161_5161_5_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000405198_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_6_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000415447_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8815nt_BP=956nt TACAGATAAGGGACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGGCAGAGCTCAACAGT GACAAGAAGGAGAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTG GTCAACTGCATGCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAGCCTGACATGGCC ATTATGGCCGTCAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGC GTTGACAAGATCACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACAGCAGCTGTGTGC GTGGCCAAGCTCCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCC ATGGTGGTGGCCAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATC AACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGAC CGCGAGGCCCAGAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATG AAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCC GAGCCAGAGCTGCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGGCTCCCGAGGTGCTG CAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCACAGCCCTTTCAGA CAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCTCCTGAACTGAAG TCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAAGAGCACAGCTTT TTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAATGCTGCTGATGCC TTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAACTTCCCTTTGGTC ATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCCAGGAAGAGAGCT AAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTGGGAAACCCATTT CTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAAAATTTACTGACA ATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAACAATTTGTCTTG CAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTGCGTCGTGCCCCG AAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTCTAGCACCCAGAA ACAGGGAGGGTCCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTCGCTACCGGGACT CCTCCAGGCTCCCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCATTAGAAACTACT GAAGAAATAAAAGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATCACGTAAATTTTT ATGTCTGATATCAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTAAGCATTGCCACA TATTCTGTCTAGTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCTTTTGTGCACTTC GCAACTGACTTCTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACTTGGGCCCTCCTC TGGGAGCCGCACCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGACACGTACTATCC AAGTGTATGGGATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACAGGCCGTGGAGTT TTAGGTTTCAGGGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATGCAGGAGCACTCA TGGGTGAGTCCGTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAGACATATCAGTAA TGGATGTACAAAAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGAATGTGTCAAAAT GGGTTAACTGTGTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGACAGTGAGGACCT TAGGGCATGAAGCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCCACTGATACCCCC AAATAGATGCTGGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGTATTTGTCCCATT CTTGGAGTAGTTTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCCTGTCCTTGATAT TTTTAGCAGTTCCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTATTTTGAGAGTTT GGAAGATAATTACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGTCTATCTCAACTA CTAGTTGGGGTTTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACATGCATTCTCCTTA TTTAAAAAGGAAGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGAAGCAGAAAAGCC ATTGTTCTTAAAGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCAAGCTCATAGGTT CTCAGCATGTGCAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTCCACCAGGGTCTG GGCTTAGCGTCTAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATACTTGTTCTAAAAT TGAGCTGATCCGCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAAAAGATATATGAA TTGGAAAATGCTCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTGTAATGATATGGT TGAGAAGTACATCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAGTTGTGTTGGGGT CTGGTTTGAGTGCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCACCCGGTTGCCTG CATGGCCAGAGGAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTTTGGGATAGGGCC TCGCTCTGTCACCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATCCTCCCACGTCAG CCTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGAACTCTTAGGCTC AAGTGATCCTCCTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGATGTTTTAGAAGG TTTTCCAAGTATTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTATTTTTTTTCATTA TTTTAGATTCCTGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCGGTAATAAGTCTT GATTTCATGATTCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAATAAATTAAAAAC CTTTGTGAATTCAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTCATTGGTTTTCCT TCTTTGTCATATTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGCTCATGCCTCTGA TTGGTCCATTCACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCCTATAATCCCAGC ACTTTGGGAGGCCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCTCTACTAAAAATA CAAATAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGG CAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAGGAGGGGGGC TAAATATCCAGTGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTGTTGCAAACAAGA TGTAGCTTGATTTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTACAAAGTAATGTT TACCAATTGACGACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCGGAATTTGTAGCT GGGCCAATTCAACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAAACAACGTTCTCA AAGTCTGGCCTCTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGTATGATTTAATCA TATGCAGTGTTGTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCACCCTGAGTGAGG GGTTGACTTGTTGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGAATAGTGGTAGAA ATCGGGCGAAGGAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATAGGTGAAGTTTCT TTTTTCCCCCCTGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAGCTGCTGAACTCA TTCAGAAGCCATTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCATGGAGGCACAGGG GACCCAGAGCTAAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCA CTTTGCAGCCCCCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTGTTACAAATCCAC TGAAGTCCTGGTAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCCTGGGCAACACAG CAAGACCCCATCTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTTTTCCCTCCTATG TAAAGTTTACTGGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACAAAGTTTATTATG AAACAAATGAAATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCCTTAAGGACTAAG ATAGTTGTTTTATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTTTCTGACCTGGCT GTGTTAGCACTGATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGGTTAAGAGTATAC GCATTTCATCAAACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAGCGCTCCAGTATC TAACAATCTCAGAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTTGATGTAAGGGTA GGGAATGGAGAAATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAAATGATGTATATA TTATATGTGGTTTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTATAATAGATCTGGC TTTTTCTGGATAGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTTATATTATTTATT GAATCCATAAGTTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAAGAAATGGCAGTC CTTCCTGTTCTTAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACTGTTTTCAACAAC AGTTGATCTTCTGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACTGCTTTCATCTAC CTCTTCAGAAGGCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTCTGTAAGACTTTG CAGTGTCATTCCCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTAGCTATCCCTCCC ATGTCATTAGTAATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCACCATCAGCCTTGC CATTGCCTTAAGATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGGCAAGCTGTGCTT AGAAACACTGCTTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATGGGGTCTTAAAGG TAAGCGCCCTCATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAGAATGAAGTCCTG TCTCTGTGAGAGAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACTATATTCTTGAAT ACCCTTGAAGAAAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCTAGATATTGTACC TAGACAAAATATCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACACTCACTAGTGCA CGTCTGAAATAGTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAGCACCACCGTTTT >5161_5161_6_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000415447_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- >5161_5161_7_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000432560_ADRBK2_chr22_26091074_ENST00000324198_length(transcript)=8984nt_BP=1125nt CCCGCGCGCGGGCAGCTCACTTCCGCCCGGCAGGTGACAGCCGCGGGGCTCCGAGCCGCCGGCAGCCCGGACGCACCGGGAGAGCGAGAG GTGGAGGCCGCGGACATTTTGGTGCCAAGCCGAACCGAGCCGGGGCGCCGGGAGCTATTGGGACCTGCGGAAGCCTGGCTACAGATAAGG GACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCTGAAGGCAGAGCTCAACAGTGACAAGAAGGA GAAGAAGAAGGAGGCAGTGAAGAAAGTGATTGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTGGTCAACTGCAT GCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAAGAGTCAGCCTGACATGGCCATTATGGCCGT CAACACCTTTGTGAAGGACTGTGAGGACCCCAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGAT CACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCGCAAGACAGCAGCTGTGTGCGTGGCCAAGCT CCACGACATCAACGCCCAGCTGGTGGAGGACCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATGGTGGTGGC CAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGATCTGAACCCACAGTCCATCAACAAGCTGCT GACAGCCCTCAATGAGTGCACCGAGTGGGGCCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCA GAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTCTGCTGTGAAGGTGCTGATGAAGTTCATGGA GATGTTGTCTAAGGACTTGGACTACTACGGCACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCT GCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGTGGCACCCATGGGTACATGGCTCCCGAGGTGCTGCAGAAGGGGAC GGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCACAGCCCTTTCAGACAACATAAAAC CAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCTCCTGAACTGAAGTCCCTTTTGGA GGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAAGAGCACAGCTTTTTCAAAGGTGT TGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAATGCTGCTGATGCCTTTGATATTGG CTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAACTTCCCTTTGGTCATCTCTGAACG CTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCCAGGAAGAGAGCTAAAAATAAGCA ACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTGGGAAACCCATTTCTGACTCAGTG GCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAAAATTTACTGACAATGGAACAGAT TCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAACAATTTGTCTTGCAATGTGAGAG TGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTGCGTCGTGCCCCGAAGTTCCTCAA CAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTCTAGCACCCAGAAACAGGGAGGGT CCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTCGCTACCGGGACTCCTCCAGGCTC CCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCATTAGAAACTACTGAAGAAATAAA AGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATCACGTAAATTTTTATGTCTGATAT CAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTAAGCATTGCCACATATTCTGTCTA GTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCTTTTGTGCACTTCGCAACTGACTT CTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACTTGGGCCCTCCTCTGGGAGCCGCA CCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGACACGTACTATCCAAGTGTATGGG ATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACAGGCCGTGGAGTTTTAGGTTTCAG GGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATGCAGGAGCACTCATGGGTGAGTCC GTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAGACATATCAGTAATGGATGTACAA AAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGAATGTGTCAAAATGGGTTAACTGT GTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGACAGTGAGGACCTTAGGGCATGAA GCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCCACTGATACCCCCAAATAGATGCT GGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGTATTTGTCCCATTCTTGGAGTAGT TTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCCTGTCCTTGATATTTTTAGCAGTT CCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTATTTTGAGAGTTTGGAAGATAATT ACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGTCTATCTCAACTACTAGTTGGGGT TTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACATGCATTCTCCTTATTTAAAAAGGA AGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGAAGCAGAAAAGCCATTGTTCTTAA AGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCAAGCTCATAGGTTCTCAGCATGTG CAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTCCACCAGGGTCTGGGCTTAGCGTC TAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATACTTGTTCTAAAATTGAGCTGATCC GCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAAAAGATATATGAATTGGAAAATGC TCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTGTAATGATATGGTTGAGAAGTACA TCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAGTTGTGTTGGGGTCTGGTTTGAGT GCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCACCCGGTTGCCTGCATGGCCAGAG GAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTTTGGGATAGGGCCTCGCTCTGTCA CCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATCCTCCCACGTCAGCCTCCTGAGTA GCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGAACTCTTAGGCTCAAGTGATCCTC CTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGATGTTTTAGAAGGTTTTCCAAGTA TTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTATTTTTTTTCATTATTTTAGATTCC TGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCGGTAATAAGTCTTGATTTCATGAT TCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAATAAATTAAAAACCTTTGTGAATT CAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTCATTGGTTTTCCTTCTTTGTCATA TTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGCTCATGCCTCTGATTGGTCCATTC ACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCCTATAATCCCAGCACTTTGGGAGG CCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCTCTACTAAAAATACAAATAAAAAT TAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGCAGAGCTTGCA GTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAGGAGGGGGGCTAAATATCCAG TGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTGTTGCAAACAAGATGTAGCTTGAT TTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTACAAAGTAATGTTTACCAATTGAC GACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCGGAATTTGTAGCTGGGCCAATTCA ACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAAACAACGTTCTCAAAGTCTGGCCT CTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGTATGATTTAATCATATGCAGTGTT GTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCACCCTGAGTGAGGGGTTGACTTGT TGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGAATAGTGGTAGAAATCGGGCGAAG GAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATAGGTGAAGTTTCTTTTTTCCCCCC TGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAGCTGCTGAACTCATTCAGAAGCCA TTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCATGGAGGCACAGGGGACCCAGAGCT AAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACTTTGCAGCCC CCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTGTTACAAATCCACTGAAGTCCTGG TAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCCTGGGCAACACAGCAAGACCCCAT CTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTTTTCCCTCCTATGTAAAGTTTACT GGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACAAAGTTTATTATGAAACAAATGAA ATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCCTTAAGGACTAAGATAGTTGTTTT ATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTTTCTGACCTGGCTGTGTTAGCACT GATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGGTTAAGAGTATACGCATTTCATCA AACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAGCGCTCCAGTATCTAACAATCTCA GAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTTGATGTAAGGGTAGGGAATGGAGA AATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAAATGATGTATATATTATATGTGGT TTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTATAATAGATCTGGCTTTTTCTGGAT AGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTTATATTATTTATTGAATCCATAAG TTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAAGAAATGGCAGTCCTTCCTGTTCT TAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACTGTTTTCAACAACAGTTGATCTTC TGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACTGCTTTCATCTACCTCTTCAGAAG GCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTCTGTAAGACTTTGCAGTGTCATTC CCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTAGCTATCCCTCCCATGTCATTAGT AATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCACCATCAGCCTTGCCATTGCCTTAA GATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGGCAAGCTGTGCTTAGAAACACTGC TTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATGGGGTCTTAAAGGTAAGCGCCCTC ATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAGAATGAAGTCCTGTCTCTGTGAGA GAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACTATATTCTTGAATACCCTTGAAGA AAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCTAGATATTGTACCTAGACAAAATA TCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACACTCACTAGTGCACGTCTGAAATA GTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAGCACCACCGTTTTTACAGTTACTT >5161_5161_7_AP1B1-ADRBK2_AP1B1_chr22_29750639_ENST00000432560_ADRBK2_chr22_26091074_ENST00000324198_length(amino acids)=650AA_BP=312 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML SKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKSGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD KHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSF DEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQR RYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKP -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for AP1B1-GRK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for AP1B1-GRK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for AP1B1-GRK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AP1B1 | C0015544 | Failure to Thrive | 1 | GENOMICS_ENGLAND |
| Hgene | AP1B1 | C0037268 | Skin Abnormalities | 1 | GENOMICS_ENGLAND |
| Hgene | AP1B1 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
| Hgene | AP1B1 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Hgene | AP1B1 | C4023689 | Abnormality of copper homeostasis | 1 | GENOMICS_ENGLAND |
| Hgene | AP1B1 | C4025860 | Hearing abnormality | 1 | GENOMICS_ENGLAND |
| Tgene | C0005586 | Bipolar Disorder | 6 | CTD_human;PSYGENET | |
| Tgene | C0005587 | Depression, Bipolar | 1 | CTD_human | |
| Tgene | C0024713 | Manic Disorder | 1 | CTD_human | |
| Tgene | C0338831 | Manic | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies