Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCK-GRSF1 (FusionGDB2 ID:HG1633TG2926)

Fusion Gene Summary for DCK-GRSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCK-GRSF1
Fusion gene ID: hg1633tg2926
HgeneTgene
Gene symbol

DCK

GRSF1

Gene ID

1633

2926

Gene namedeoxycytidine kinaseG-rich RNA sequence binding factor 1
Synonyms--
Cytomap('DCK')('GRSF1')

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptiondeoxycytidine kinasedeoxynucleoside kinaseG-rich sequence factor 1
Modification date2020031320200313
UniProtAcc

P27707

Q12849

Ensembl transtripts involved in fusion geneENST00000286648, ENST00000504730, 
ENST00000504952, 
Fusion gene scores* DoF score1 X 1 X 1=111 X 10 X 4=440
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCK [Title/Abstract] AND GRSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCK(71863899)-GRSF1(71702031), # samples:3
Anticipated loss of major functional domain due to fusion event.DCK-GRSF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCK-GRSF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCK-GRSF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DCK-GRSF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCK

GO:0006220

pyrimidine nucleotide metabolic process

12808445

TgeneGRSF1

GO:0000962

positive regulation of mitochondrial RNA catabolic process

29967381


check buttonFusion gene breakpoints across DCK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GRSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F2-01ADCKchr4

71863899

-GRSF1chr4

71702031

-
ChimerDB4BRCATCGA-BH-A1F2-01ADCKchr4

71863899

+GRSF1chr4

71702031

-
ChimerDB4BRCATCGA-BH-A1F2DCKchr4

71863899

+GRSF1chr4

71702031

-


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Fusion Gene ORF analysis for DCK-GRSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000286648ENST00000439371DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000286648ENST00000502323DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000286648ENST00000508091DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000286648ENST00000545193DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504730ENST00000439371DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504730ENST00000502323DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504730ENST00000508091DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504730ENST00000545193DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504952ENST00000439371DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504952ENST00000502323DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504952ENST00000508091DCKchr4

71863899

+GRSF1chr4

71702031

-
5CDS-5UTRENST00000504952ENST00000545193DCKchr4

71863899

+GRSF1chr4

71702031

-
In-frameENST00000286648ENST00000254799DCKchr4

71863899

+GRSF1chr4

71702031

-
In-frameENST00000504730ENST00000254799DCKchr4

71863899

+GRSF1chr4

71702031

-
In-frameENST00000504952ENST00000254799DCKchr4

71863899

+GRSF1chr4

71702031

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000286648DCKchr471863899+ENST00000254799GRSF1chr471702031-67956043971689430
ENST00000504952DCKchr471863899+ENST00000254799GRSF1chr471702031-65964051981490430
ENST00000504730DCKchr471863899+ENST00000254799GRSF1chr471702031-65964051981490430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000286648ENST00000254799DCKchr471863899+GRSF1chr471702031-0.0002005010.99979955
ENST00000504952ENST00000254799DCKchr471863899+GRSF1chr471702031-0.0001960020.99980396
ENST00000504730ENST00000254799DCKchr471863899+GRSF1chr471702031-0.0001960020.99980396

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Fusion Genomic Features for DCK-GRSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DCK-GRSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:71863899/chr4:71702031)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCK

P27707

GRSF1

Q12849

FUNCTION: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893}.FUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCKchr4:71863899chr4:71702031ENST00000286648+2728_3669261.0Nucleotide bindingNote=ATP
TgeneGRSF1chr4:71863899chr4:71702031ENST0000043937101055_11101891.3333333333333Compositional biasNote=Ala-rich
TgeneGRSF1chr4:71863899chr4:71702031ENST0000050232301055_1110430.6666666666667Compositional biasNote=Ala-rich
TgeneGRSF1chr4:71863899chr4:71702031ENST00000254799010122_2461191988.6666666666667DomainRRM 1
TgeneGRSF1chr4:71863899chr4:71702031ENST00000254799010250_3261191988.6666666666667DomainRRM 2
TgeneGRSF1chr4:71863899chr4:71702031ENST00000254799010401_4801191988.6666666666667DomainRRM 3
TgeneGRSF1chr4:71863899chr4:71702031ENST00000439371010122_24601891.3333333333333DomainRRM 1
TgeneGRSF1chr4:71863899chr4:71702031ENST00000439371010250_32601891.3333333333333DomainRRM 2
TgeneGRSF1chr4:71863899chr4:71702031ENST00000439371010401_48001891.3333333333333DomainRRM 3
TgeneGRSF1chr4:71863899chr4:71702031ENST00000502323010122_2460430.6666666666667DomainRRM 1
TgeneGRSF1chr4:71863899chr4:71702031ENST00000502323010250_3260430.6666666666667DomainRRM 2
TgeneGRSF1chr4:71863899chr4:71702031ENST00000502323010401_4800430.6666666666667DomainRRM 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCKchr4:71863899chr4:71702031ENST00000286648+27188_19269261.0Nucleotide bindingNote=ATP
HgeneDCKchr4:71863899chr4:71702031ENST00000286648+27240_24269261.0Nucleotide bindingNote=ATP
TgeneGRSF1chr4:71863899chr4:71702031ENST0000025479901055_1111191988.6666666666667Compositional biasNote=Ala-rich


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Fusion Gene Sequence for DCK-GRSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21609_21609_1_DCK-GRSF1_DCK_chr4_71863899_ENST00000286648_GRSF1_chr4_71702031_ENST00000254799_length(transcript)=6795nt_BP=604nt
ACCCGACTCCGGAACCTCTTCCCGCGCCCTGCCCGGGCGCCTGGCTGCTTGGGGTAGAGGCCTTCCGCCACACGCGCGGCCCCGCCCCGG
CCTTCACGTGACCTGGCGTGCGGAGCGCGCACGCGGGAACCCGCGCTGGAGGCGGGCGAGGGCCGAGGGGCAGCTAGGGAGCGCGGCTTG
AGGAGGGCGGGGCCGCCCCGCAGGCCCGCCAGTGTCCTCAGCTGCCTCCGCGCGCCAAAGTCAAACCCCGACACCCGCCGGCGGGCCGGT
GAGCTCACTAGCTGACCCGGCAGGTCAGGATCTGGCTTAGCGGCGCCGCGAGCTCCAGTGCGCGCACCCGTGGCCGCCTCCCAGCCCTCT
TTGCCGGACGAGCTCTGGGCCGCCACAAGACTAAGGAATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGG
GACCCGCATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATCCTTAAACAATTGTGTGAAGATTG
GGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAATGTTCAAAGTACTCAAGATGAATTTGAGGAGTCCAAAACTACTTACCTGGAAGA
CCTTCCACCACCCCCTGAGTATGAATTGGCCCCGTCCAAGTTAGAAGAGGAAGTGGATGATGTCTTTCTCATTCGAGCTCAAGGACTGCC
CTGGTCATGCACTATGGAAGATGTGCTTAACTTTTTTTCAGACTGCAGAATCCGCAACGGTGAGAATGGAATACATTTTCTCCTAAACAG
AGATGGGAAACGAAGGGGTGATGCCTTAATTGAAATGGAGTCAGAGCAGGATGTGCAGAAAGCCTTAGAGAAGCACCGCATGTACATGGG
CCAGCGGTATGTGGAAGTATATGAGATAAACAATGAAGATGTGGATGCCTTAATGAAGAGCTTGCAGGTCAAATCTTCGCCTGTGGTAAA
TGATGGTGTGGTTCGTTTGAGAGGACTTCCTTATAGTTGCAATGAGAAAGACATTGTAGACTTCTTTGCAGGACTGAATATAGTTGACAT
TACTTTTGTGATGGACTATAGAGGGAGGCGAAAAACAGGGGAAGCCTATGTGCAATTTGAAGAACCAGAAATGGCCAACCAAGCCCTGTT
GAAACACAGGGAAGAAATTGGTAATCGATACATCGAGATATTTCCAAGCAGAAGGAATGAAGTTCGAACACATGTCGGTTCTTATAAGGG
AAAGAAAATCGCATCTTTTCCTACTGCTAAGTATATAACTGAGCCAGAAATGGTCTTTGAAGAACATGAAGTAAATGAGGATATTCAACC
CATGACAGCTTTTGAAAGTGAGAAGGAAATAGAATTGCCTAAGGAGGTGCCAGAAAAGCTTCCAGAGGCTGCTGATTTTGGAACTACGTC
TTCTCTGCATTTTGTCCACATGAGAGGATTACCTTTCCAAGCCAATGCCCAAGACATTATAAACTTTTTTGCTCCACTCAAGCCTGTTAG
AATCACCATGGAATACAGCTCCAGTGGGAAGGCCACTGGAGAAGCTGATGTGCACTTTGAGACCCATGAGGATGCTGTTGCAGCGATGCT
CAAGGATCGGTCCCACGTTCATCATAGGTATATTGAACTGTTCCTGAATTCATGTCCAAAAGGAAAATAAGACTCTAGGGGCTCCAGATA
ATAAGGGTGAAGCAAGAAGCATTTCATTTGCACATCTTTCTTGGACTTGGGATATACAGTTCCAGTTTATTAGCAGCAACTGCTAGGGAA
ATGATTTTGGTGTTTTGGGTTAATTGCTTCTAAGAAAAGTTTCATAGTGGACTGTTTAGAAGAAGAAATGAAAGATCCAGTTTGGGATTA
TGAAATAAACCACAAATTAAAATTTTTGTTTAAACTGTCCAGGATCTGATTTAAAAATATGGTCTTTGTTTTATATGATTAAATGGTTTG
TTTTCATAGATGATATGTTACTCATTGTAAAGACCACATATTTTTATTCAGCAGTGTTCTTTAAACGGTTTCATTTAAAAAGTAACTTTT
TTTTTTTGCCTGTGAATTGAGTGCTCTGATGTAAAACTTCTCATGGAGTGAAACAGTGATTTATTTTAACCAAACATTCACCAAAGCAAA
GAACGGTTTCAGACCTTTGAACTGGTATGGTTTGGCAGAATAGTTTTAAATTTTGCTGTATTTGATTACTTAGAGATAGGAATTTTTAAA
AATCAAAACAAAAAATACCACAGCTTAGTGTAAATGACAATTTGGCGGTTTTATGTCTTTAGAAATGTTTTGCCTTTCTAAGCCTTGTGC
TAAAGGCGTATAACGGTGGTGCCTATCTACTTAAGGGGGCATTCTAGTCTTAACTTAAAAGTTGTCTAAACTGTCCCTCCCTGGCTTTTT
TTGGTTTGGGGTAGACCTAAGGGTGTTTGTTAGTCTCAAAACTGTGAAGTGACATGTCAGAACAGTCCAGACTGGTAAGAAAATTAATGG
CTTCACTTGAATTTAAACCAGCTCTAGATAGGAAAAAAATCAGTCTCCTCATTTGCTTTTTAAATGGAGTAGTACATCCCATATTTTAGA
ACAAGTAGGGGTGCCTTGCTTAAATAAAAATAGCATTTAATGTATAATTGTGTGAAGGGTTTATGGATAAAGCTGTACTTCTGTCACAAT
GTGGCAGTACTTTCTGCTTTAATATTAAACAGCTTGTTATTTAAATATTGGACAAAATGGCTGGCTTCAAAATATAGTCATTAATAAACT
AACTTTATGTGCACCTGTGTAGGAGAATCAAAATCCTGTATGCTTTCTTTGCCTTGTTCCTGTTCTCAGGGTGACGACTGCCACCAGGAG
ATGCAGTTCTAGTTCTTAAAATTAAATTTGCCCAGGTTTCTGACAGGTGATACCTGGAAGAGAGACTATGTCTTCTCTTACTTAATACAT
AACCATCTTTGATTACCAGCTAAGATGCGAAATCACTGTACTGTAGTCAATAAATGAAGACTTGTTTCAGGCTGAAGATTACCTAAGAGT
ATTTATTATTGGAGTCTGTGAGTCAACTGAATATATTATTACCTCAAGTCCTGCTATATTAATATAAGTAGTAAGGGTTAATTTTCGTGT
GTGTGTTCTCTAAAATCCTGTGAACATGACTTAACCAGCTTAACATCATCAGTAGTACTGCCTAGATGGAAATGCGTTTTCATATATGGT
TGAATATGCCAAGCTATGAGAACTGGTATCTGTAGTTGTACGAACTATTAGAATGTGATCTTTGTTGCTCTTTCACATTTGGTATCTGAT
TTGCTGTGGAAAAGATCTGTGGGGCCTACTGTGAGGAATTCATCTGCAATTGATTTAAGCTAATGAGTTTTATTTGCACATCTCTGGAAA
AAGAATGCAAGCAAAGCATTAAAATGCTATATGATGGATGGGTAAGGTTGAAAGGATATATCTTCTTGGCACGCTACAGGCTGAGTTTTC
TGTACAAAATGTGGCCATTATTGGGAAATCATTTTATGTATTTGAATGCTCCCTTTTGTTTTTGTTCATGATCTAGGCTAGTACGTAAGT
GATTGCTAAGGTGGATGTAGTTATGGGAAAGGAAGAGAAGCACATAATACAGTAAAAGTAATCTTATTTCCATGCAAGTGGAAGACGGTA
CCGTCTCCCCACATTTGAGAAGACTGTTTTGCATCACTCTTTGCTATTGAAGGAAGCAGTGATGGTGAATTTCCTTCTGTTTGGGTTCCT
TGTGTCTATAACTTCCTTTGTGGTAAAGCCATCAGGAAGAATAGTGGGAGTGGGGCATATGGTCAGGGTGCTCATATCCTGCTTTAGCCT
AGCTGCTGCTTACGGAGTGCAAGGGAGAACTCTGAGAAGCAGTATGTAAATACCAGGGAGCTGATTGCTGAATATTGTGGTCTCATCTGA
ATATTGTGGTCTCATCTAAATATTGACACCAGGCAATGAAGCAGAAATAGAGTATGTGTCCCTTTATGCGTGGGTAACTTAAGCTTCTGT
CATGTGGGAAGGGGGACCGAATCTTCCCTGGGAGGAAGGCTCCAAATTCTCACTACTTCTGTGTTACTTGAAGGGGGAAGCATAAGGAAC
CCAGTTTGAAGGCAACATTGTGTGCCATGAATCTGCTTATTAATCAACATGCCTTGTTAATGTCCTCTGCCCTGAACAGCCCTTACTCAG
TTCTCATTTGGAAAGTTATTTTTTGGGGTTACATCCTGTTTGTTTCAGAATTTAAAACCCTCCATGGTGGGTCACTTGAGGTCAGGAGTT
CAAGATTAGCCTGGCCAACTTAGTGAAACTCCGGCTCTACTGAAAATGCAAAAATTAGCCAGGTGTGGCACACGCCTGTAATCCCAGTTA
CTTGGGAGGCCAAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTAGCGAGCCAAGATCACACCATTGCACTCCAGCCTGGGCA
ACAGAGTGAGACTCTGTCAAAATCAAAAAAACCAAAATACAAAAAACTCCATTGTTCTGAGAGTTTCCCCTAAATTATCGGAAGACACTC
ACATTGAATTGGTAGGACCTATAGTATAGAGGAGAATGGTATGTATGTCAGCAGTAGAGTTCCAATCCAAATTGCGCTATCGCATTAGAA
ATACATTACCCTCCCACTCCCCAAGTTCAGCAAATTAGAAGAGAATCTGAAGTTTGTAGGAAGGGAATAAAGCTGCTATAAACATTTATG
TGCAGGTTTTTGTGTAGACTCGTTTTCAGCTCCTTTGGGTAAATACCAAGGAACCAGGTTGCTGGATTGTAAGTTAAGAGTATGTTTAGT
TTTGGAAGAAACTGCCAAACTGTTCCAACATGACTATTTTGAATTCCCATTGACAATGAATAAGAGTTCCTGTAGCTCCTCACCCTCATT
AGTATTTGGTGATGTCACTCTTGCATTTTAGCTAATGGGTGAATAGTGGTCTCATCGTTTTAATTCCCAATCCCATAGTGATGTGGAGCA
CCTTTTCATATACTTAATCTGCCATCCTTATATCATCATTGGTGAGGTGTCTGGATTTTCTGTCCAGAATTTTAGTTCTAGTGGTTTTCT
TATTTTTAGAAAGGAAGTATAGGAAGGAAGGTTTAATCTGTCTTAAGCCTGATTATATGAAAATCAAGAATAGGCTAGGTGTGGTGGCTG
ACATCTGTAATCCCCGCACTTTGTGAGGCTGAAGTGGGAGGACTGCTTGAGCCTGGGAAGTCAAGCCTGCAGTGAGCCATGACTGTTGCT
GCACTCCAGCCTGAGTGACAGAGTGAGACCCTGTCTCAGAAAAAAAAAAAGCAGGCTCATTTTAAAGTTGTTTATATTTTATTTTTTGAA
GGAAATAAACTTGAAGAGATACAAACGGTAGTGAAGATTCTCCTTCCCCTCCTGTAATTCAGCTGTTTAGTTTCTATTCTCGCACAGCCC
TGTTATCAGTTTCTAGTGTAAGCTTGCAGTGACTTTTACTTTATTTATAAGCAAGTGTTAGTGGGTGTTGTCATTTCTTTTAAAAATATA
AATTATACTGTACATGCTATTTTGTATTTTGGCTTTTCTCCCACCTAAACACCCTAAAGATCATTTTCTGTCAGTATATAAAATCTTGGT
GATGCCAATACCCATCCCTTAGATTGTACAAGCAGCATTTTGCCATGCTTTATCCCATAGCCTGCCTCCTGCAGTCTCATCTTTTTTTCT
ATATGCATGTCCAAGTAAGTTGTAGACATTTTTCACTTTTAATCCTTTCAGCATACATGTCATGGGAATTTGTTTTTGTTTTTGTTTTTT
GTGTTTGAGACAGTCGCTCTGTCACCCAGGCTGGAGTTATAGTGACGTGATCCCAGCTCATTACAGCCTCCACCTCCCAGTTTCAAGCAA
TTCTCATGCCTCAGATTCCCGAGTAGCTGGGATTACAGATGTGCACCACCACGCCTGACTAATTTTTGTATTTTTAGTAGAGATGGGGTT
TCATCATGTTGGCCAGGCTGGTCTGGAACTCCTGGCCTCCAGTCATTTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATCAG
CCACCACACCCAGCCGTCATTGGAGTTTTTTTGAGGGAGATTTGCAGTAAGGTGAATAAATGTTAAGTGTATCATTTGATGAGGTTTTTT
CTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGTATCGCCCAGGCTAGAGTGCAGTGGCCTGGTCTTGGCTCACTGCAACCTCCACCTC
CTGGGTTCAAGGGAGTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGAGCCACCATACCCAGACTCATTTGATGAGTTTT
GATGTAAAAGCATGTAACTCAAACCCCTATGTCTGGAACATCTGTATTACATCTGAATTTTTTCACCTAGTCAATTCCTGCACCTCTCTC
TCCTGTCCCTTCTTCCCTCCCCTGGCAGTCAGCTACTGTTAGGATTTTGTTCACTGTAGATTAATTTTGCCTATTCTAGAACTTCATATA
ACGGACTCACTTATGCAGTATGTATTCTGTAAGTTCCTTTTACTCAGCATGTTTGTATGTTCATCAGTGTGTTTAAGCTTTGTTCCTTTT
TATGGCTGAGCAGTGTTCTATGTATGAATGCCACATTTTAACGTTTCACCTGTTAGGTGAACAACTAACTGGTGAACAATGGGCTGTTTC

>21609_21609_1_DCK-GRSF1_DCK_chr4_71863899_ENST00000286648_GRSF1_chr4_71702031_ENST00000254799_length(amino acids)=430AA_BP=69
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEESKTTYLEDLPPPPEYELAPS
KLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNE
DVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIE
IFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPF

--------------------------------------------------------------
>21609_21609_2_DCK-GRSF1_DCK_chr4_71863899_ENST00000504730_GRSF1_chr4_71702031_ENST00000254799_length(transcript)=6596nt_BP=405nt
GCAGGCCCGCCAGTGTCCTCAGCTGCCTCCGCGCGCCAAAGTCAAACCCCGACACCCGCCGGCGGGCCGGTGAGCTCACTAGCTGACCCG
GCAGGTCAGGATCTGGCTTAGCGGCGCCGCGAGCTCCAGTGCGCGCACCCGTGGCCGCCTCCCAGCCCTCTTTGCCGGACGAGCTCTGGG
CCGCCACAAGACTAAGGAATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGCATCAAGAAAATC
TCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATCCTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCT
GTTGCCAGATGGTGCAATGTTCAAAGTACTCAAGATGAATTTGAGGAGTCCAAAACTACTTACCTGGAAGACCTTCCACCACCCCCTGAG
TATGAATTGGCCCCGTCCAAGTTAGAAGAGGAAGTGGATGATGTCTTTCTCATTCGAGCTCAAGGACTGCCCTGGTCATGCACTATGGAA
GATGTGCTTAACTTTTTTTCAGACTGCAGAATCCGCAACGGTGAGAATGGAATACATTTTCTCCTAAACAGAGATGGGAAACGAAGGGGT
GATGCCTTAATTGAAATGGAGTCAGAGCAGGATGTGCAGAAAGCCTTAGAGAAGCACCGCATGTACATGGGCCAGCGGTATGTGGAAGTA
TATGAGATAAACAATGAAGATGTGGATGCCTTAATGAAGAGCTTGCAGGTCAAATCTTCGCCTGTGGTAAATGATGGTGTGGTTCGTTTG
AGAGGACTTCCTTATAGTTGCAATGAGAAAGACATTGTAGACTTCTTTGCAGGACTGAATATAGTTGACATTACTTTTGTGATGGACTAT
AGAGGGAGGCGAAAAACAGGGGAAGCCTATGTGCAATTTGAAGAACCAGAAATGGCCAACCAAGCCCTGTTGAAACACAGGGAAGAAATT
GGTAATCGATACATCGAGATATTTCCAAGCAGAAGGAATGAAGTTCGAACACATGTCGGTTCTTATAAGGGAAAGAAAATCGCATCTTTT
CCTACTGCTAAGTATATAACTGAGCCAGAAATGGTCTTTGAAGAACATGAAGTAAATGAGGATATTCAACCCATGACAGCTTTTGAAAGT
GAGAAGGAAATAGAATTGCCTAAGGAGGTGCCAGAAAAGCTTCCAGAGGCTGCTGATTTTGGAACTACGTCTTCTCTGCATTTTGTCCAC
ATGAGAGGATTACCTTTCCAAGCCAATGCCCAAGACATTATAAACTTTTTTGCTCCACTCAAGCCTGTTAGAATCACCATGGAATACAGC
TCCAGTGGGAAGGCCACTGGAGAAGCTGATGTGCACTTTGAGACCCATGAGGATGCTGTTGCAGCGATGCTCAAGGATCGGTCCCACGTT
CATCATAGGTATATTGAACTGTTCCTGAATTCATGTCCAAAAGGAAAATAAGACTCTAGGGGCTCCAGATAATAAGGGTGAAGCAAGAAG
CATTTCATTTGCACATCTTTCTTGGACTTGGGATATACAGTTCCAGTTTATTAGCAGCAACTGCTAGGGAAATGATTTTGGTGTTTTGGG
TTAATTGCTTCTAAGAAAAGTTTCATAGTGGACTGTTTAGAAGAAGAAATGAAAGATCCAGTTTGGGATTATGAAATAAACCACAAATTA
AAATTTTTGTTTAAACTGTCCAGGATCTGATTTAAAAATATGGTCTTTGTTTTATATGATTAAATGGTTTGTTTTCATAGATGATATGTT
ACTCATTGTAAAGACCACATATTTTTATTCAGCAGTGTTCTTTAAACGGTTTCATTTAAAAAGTAACTTTTTTTTTTTGCCTGTGAATTG
AGTGCTCTGATGTAAAACTTCTCATGGAGTGAAACAGTGATTTATTTTAACCAAACATTCACCAAAGCAAAGAACGGTTTCAGACCTTTG
AACTGGTATGGTTTGGCAGAATAGTTTTAAATTTTGCTGTATTTGATTACTTAGAGATAGGAATTTTTAAAAATCAAAACAAAAAATACC
ACAGCTTAGTGTAAATGACAATTTGGCGGTTTTATGTCTTTAGAAATGTTTTGCCTTTCTAAGCCTTGTGCTAAAGGCGTATAACGGTGG
TGCCTATCTACTTAAGGGGGCATTCTAGTCTTAACTTAAAAGTTGTCTAAACTGTCCCTCCCTGGCTTTTTTTGGTTTGGGGTAGACCTA
AGGGTGTTTGTTAGTCTCAAAACTGTGAAGTGACATGTCAGAACAGTCCAGACTGGTAAGAAAATTAATGGCTTCACTTGAATTTAAACC
AGCTCTAGATAGGAAAAAAATCAGTCTCCTCATTTGCTTTTTAAATGGAGTAGTACATCCCATATTTTAGAACAAGTAGGGGTGCCTTGC
TTAAATAAAAATAGCATTTAATGTATAATTGTGTGAAGGGTTTATGGATAAAGCTGTACTTCTGTCACAATGTGGCAGTACTTTCTGCTT
TAATATTAAACAGCTTGTTATTTAAATATTGGACAAAATGGCTGGCTTCAAAATATAGTCATTAATAAACTAACTTTATGTGCACCTGTG
TAGGAGAATCAAAATCCTGTATGCTTTCTTTGCCTTGTTCCTGTTCTCAGGGTGACGACTGCCACCAGGAGATGCAGTTCTAGTTCTTAA
AATTAAATTTGCCCAGGTTTCTGACAGGTGATACCTGGAAGAGAGACTATGTCTTCTCTTACTTAATACATAACCATCTTTGATTACCAG
CTAAGATGCGAAATCACTGTACTGTAGTCAATAAATGAAGACTTGTTTCAGGCTGAAGATTACCTAAGAGTATTTATTATTGGAGTCTGT
GAGTCAACTGAATATATTATTACCTCAAGTCCTGCTATATTAATATAAGTAGTAAGGGTTAATTTTCGTGTGTGTGTTCTCTAAAATCCT
GTGAACATGACTTAACCAGCTTAACATCATCAGTAGTACTGCCTAGATGGAAATGCGTTTTCATATATGGTTGAATATGCCAAGCTATGA
GAACTGGTATCTGTAGTTGTACGAACTATTAGAATGTGATCTTTGTTGCTCTTTCACATTTGGTATCTGATTTGCTGTGGAAAAGATCTG
TGGGGCCTACTGTGAGGAATTCATCTGCAATTGATTTAAGCTAATGAGTTTTATTTGCACATCTCTGGAAAAAGAATGCAAGCAAAGCAT
TAAAATGCTATATGATGGATGGGTAAGGTTGAAAGGATATATCTTCTTGGCACGCTACAGGCTGAGTTTTCTGTACAAAATGTGGCCATT
ATTGGGAAATCATTTTATGTATTTGAATGCTCCCTTTTGTTTTTGTTCATGATCTAGGCTAGTACGTAAGTGATTGCTAAGGTGGATGTA
GTTATGGGAAAGGAAGAGAAGCACATAATACAGTAAAAGTAATCTTATTTCCATGCAAGTGGAAGACGGTACCGTCTCCCCACATTTGAG
AAGACTGTTTTGCATCACTCTTTGCTATTGAAGGAAGCAGTGATGGTGAATTTCCTTCTGTTTGGGTTCCTTGTGTCTATAACTTCCTTT
GTGGTAAAGCCATCAGGAAGAATAGTGGGAGTGGGGCATATGGTCAGGGTGCTCATATCCTGCTTTAGCCTAGCTGCTGCTTACGGAGTG
CAAGGGAGAACTCTGAGAAGCAGTATGTAAATACCAGGGAGCTGATTGCTGAATATTGTGGTCTCATCTGAATATTGTGGTCTCATCTAA
ATATTGACACCAGGCAATGAAGCAGAAATAGAGTATGTGTCCCTTTATGCGTGGGTAACTTAAGCTTCTGTCATGTGGGAAGGGGGACCG
AATCTTCCCTGGGAGGAAGGCTCCAAATTCTCACTACTTCTGTGTTACTTGAAGGGGGAAGCATAAGGAACCCAGTTTGAAGGCAACATT
GTGTGCCATGAATCTGCTTATTAATCAACATGCCTTGTTAATGTCCTCTGCCCTGAACAGCCCTTACTCAGTTCTCATTTGGAAAGTTAT
TTTTTGGGGTTACATCCTGTTTGTTTCAGAATTTAAAACCCTCCATGGTGGGTCACTTGAGGTCAGGAGTTCAAGATTAGCCTGGCCAAC
TTAGTGAAACTCCGGCTCTACTGAAAATGCAAAAATTAGCCAGGTGTGGCACACGCCTGTAATCCCAGTTACTTGGGAGGCCAAGGCAGG
AGAATCGCTTGAACCTGGGAGGCAGAGGTTGTAGCGAGCCAAGATCACACCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCA
AAATCAAAAAAACCAAAATACAAAAAACTCCATTGTTCTGAGAGTTTCCCCTAAATTATCGGAAGACACTCACATTGAATTGGTAGGACC
TATAGTATAGAGGAGAATGGTATGTATGTCAGCAGTAGAGTTCCAATCCAAATTGCGCTATCGCATTAGAAATACATTACCCTCCCACTC
CCCAAGTTCAGCAAATTAGAAGAGAATCTGAAGTTTGTAGGAAGGGAATAAAGCTGCTATAAACATTTATGTGCAGGTTTTTGTGTAGAC
TCGTTTTCAGCTCCTTTGGGTAAATACCAAGGAACCAGGTTGCTGGATTGTAAGTTAAGAGTATGTTTAGTTTTGGAAGAAACTGCCAAA
CTGTTCCAACATGACTATTTTGAATTCCCATTGACAATGAATAAGAGTTCCTGTAGCTCCTCACCCTCATTAGTATTTGGTGATGTCACT
CTTGCATTTTAGCTAATGGGTGAATAGTGGTCTCATCGTTTTAATTCCCAATCCCATAGTGATGTGGAGCACCTTTTCATATACTTAATC
TGCCATCCTTATATCATCATTGGTGAGGTGTCTGGATTTTCTGTCCAGAATTTTAGTTCTAGTGGTTTTCTTATTTTTAGAAAGGAAGTA
TAGGAAGGAAGGTTTAATCTGTCTTAAGCCTGATTATATGAAAATCAAGAATAGGCTAGGTGTGGTGGCTGACATCTGTAATCCCCGCAC
TTTGTGAGGCTGAAGTGGGAGGACTGCTTGAGCCTGGGAAGTCAAGCCTGCAGTGAGCCATGACTGTTGCTGCACTCCAGCCTGAGTGAC
AGAGTGAGACCCTGTCTCAGAAAAAAAAAAAGCAGGCTCATTTTAAAGTTGTTTATATTTTATTTTTTGAAGGAAATAAACTTGAAGAGA
TACAAACGGTAGTGAAGATTCTCCTTCCCCTCCTGTAATTCAGCTGTTTAGTTTCTATTCTCGCACAGCCCTGTTATCAGTTTCTAGTGT
AAGCTTGCAGTGACTTTTACTTTATTTATAAGCAAGTGTTAGTGGGTGTTGTCATTTCTTTTAAAAATATAAATTATACTGTACATGCTA
TTTTGTATTTTGGCTTTTCTCCCACCTAAACACCCTAAAGATCATTTTCTGTCAGTATATAAAATCTTGGTGATGCCAATACCCATCCCT
TAGATTGTACAAGCAGCATTTTGCCATGCTTTATCCCATAGCCTGCCTCCTGCAGTCTCATCTTTTTTTCTATATGCATGTCCAAGTAAG
TTGTAGACATTTTTCACTTTTAATCCTTTCAGCATACATGTCATGGGAATTTGTTTTTGTTTTTGTTTTTTGTGTTTGAGACAGTCGCTC
TGTCACCCAGGCTGGAGTTATAGTGACGTGATCCCAGCTCATTACAGCCTCCACCTCCCAGTTTCAAGCAATTCTCATGCCTCAGATTCC
CGAGTAGCTGGGATTACAGATGTGCACCACCACGCCTGACTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCATCATGTTGGCCAGGCT
GGTCTGGAACTCCTGGCCTCCAGTCATTTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCACACCCAGCCGTCA
TTGGAGTTTTTTTGAGGGAGATTTGCAGTAAGGTGAATAAATGTTAAGTGTATCATTTGATGAGGTTTTTTCTTTTTTTTTTTTTTTTTT
TGAGATGGAGTCTTGTATCGCCCAGGCTAGAGTGCAGTGGCCTGGTCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGGGAGTCTC
CTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGAGCCACCATACCCAGACTCATTTGATGAGTTTTGATGTAAAAGCATGTAACT
CAAACCCCTATGTCTGGAACATCTGTATTACATCTGAATTTTTTCACCTAGTCAATTCCTGCACCTCTCTCTCCTGTCCCTTCTTCCCTC
CCCTGGCAGTCAGCTACTGTTAGGATTTTGTTCACTGTAGATTAATTTTGCCTATTCTAGAACTTCATATAACGGACTCACTTATGCAGT
ATGTATTCTGTAAGTTCCTTTTACTCAGCATGTTTGTATGTTCATCAGTGTGTTTAAGCTTTGTTCCTTTTTATGGCTGAGCAGTGTTCT
ATGTATGAATGCCACATTTTAACGTTTCACCTGTTAGGTGAACAACTAACTGGTGAACAATGGGCTGTTTCTAGTTTGGGGCTATCATGA

>21609_21609_2_DCK-GRSF1_DCK_chr4_71863899_ENST00000504730_GRSF1_chr4_71702031_ENST00000254799_length(amino acids)=430AA_BP=69
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEESKTTYLEDLPPPPEYELAPS
KLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNE
DVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIE
IFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPF

--------------------------------------------------------------
>21609_21609_3_DCK-GRSF1_DCK_chr4_71863899_ENST00000504952_GRSF1_chr4_71702031_ENST00000254799_length(transcript)=6596nt_BP=405nt
GCAGGCCCGCCAGTGTCCTCAGCTGCCTCCGCGCGCCAAAGTCAAACCCCGACACCCGCCGGCGGGCCGGTGAGCTCACTAGCTGACCCG
GCAGGTCAGGATCTGGCTTAGCGGCGCCGCGAGCTCCAGTGCGCGCACCCGTGGCCGCCTCCCAGCCCTCTTTGCCGGACGAGCTCTGGG
CCGCCACAAGACTAAGGAATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGCATCAAGAAAATC
TCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATCCTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCT
GTTGCCAGATGGTGCAATGTTCAAAGTACTCAAGATGAATTTGAGGAGTCCAAAACTACTTACCTGGAAGACCTTCCACCACCCCCTGAG
TATGAATTGGCCCCGTCCAAGTTAGAAGAGGAAGTGGATGATGTCTTTCTCATTCGAGCTCAAGGACTGCCCTGGTCATGCACTATGGAA
GATGTGCTTAACTTTTTTTCAGACTGCAGAATCCGCAACGGTGAGAATGGAATACATTTTCTCCTAAACAGAGATGGGAAACGAAGGGGT
GATGCCTTAATTGAAATGGAGTCAGAGCAGGATGTGCAGAAAGCCTTAGAGAAGCACCGCATGTACATGGGCCAGCGGTATGTGGAAGTA
TATGAGATAAACAATGAAGATGTGGATGCCTTAATGAAGAGCTTGCAGGTCAAATCTTCGCCTGTGGTAAATGATGGTGTGGTTCGTTTG
AGAGGACTTCCTTATAGTTGCAATGAGAAAGACATTGTAGACTTCTTTGCAGGACTGAATATAGTTGACATTACTTTTGTGATGGACTAT
AGAGGGAGGCGAAAAACAGGGGAAGCCTATGTGCAATTTGAAGAACCAGAAATGGCCAACCAAGCCCTGTTGAAACACAGGGAAGAAATT
GGTAATCGATACATCGAGATATTTCCAAGCAGAAGGAATGAAGTTCGAACACATGTCGGTTCTTATAAGGGAAAGAAAATCGCATCTTTT
CCTACTGCTAAGTATATAACTGAGCCAGAAATGGTCTTTGAAGAACATGAAGTAAATGAGGATATTCAACCCATGACAGCTTTTGAAAGT
GAGAAGGAAATAGAATTGCCTAAGGAGGTGCCAGAAAAGCTTCCAGAGGCTGCTGATTTTGGAACTACGTCTTCTCTGCATTTTGTCCAC
ATGAGAGGATTACCTTTCCAAGCCAATGCCCAAGACATTATAAACTTTTTTGCTCCACTCAAGCCTGTTAGAATCACCATGGAATACAGC
TCCAGTGGGAAGGCCACTGGAGAAGCTGATGTGCACTTTGAGACCCATGAGGATGCTGTTGCAGCGATGCTCAAGGATCGGTCCCACGTT
CATCATAGGTATATTGAACTGTTCCTGAATTCATGTCCAAAAGGAAAATAAGACTCTAGGGGCTCCAGATAATAAGGGTGAAGCAAGAAG
CATTTCATTTGCACATCTTTCTTGGACTTGGGATATACAGTTCCAGTTTATTAGCAGCAACTGCTAGGGAAATGATTTTGGTGTTTTGGG
TTAATTGCTTCTAAGAAAAGTTTCATAGTGGACTGTTTAGAAGAAGAAATGAAAGATCCAGTTTGGGATTATGAAATAAACCACAAATTA
AAATTTTTGTTTAAACTGTCCAGGATCTGATTTAAAAATATGGTCTTTGTTTTATATGATTAAATGGTTTGTTTTCATAGATGATATGTT
ACTCATTGTAAAGACCACATATTTTTATTCAGCAGTGTTCTTTAAACGGTTTCATTTAAAAAGTAACTTTTTTTTTTTGCCTGTGAATTG
AGTGCTCTGATGTAAAACTTCTCATGGAGTGAAACAGTGATTTATTTTAACCAAACATTCACCAAAGCAAAGAACGGTTTCAGACCTTTG
AACTGGTATGGTTTGGCAGAATAGTTTTAAATTTTGCTGTATTTGATTACTTAGAGATAGGAATTTTTAAAAATCAAAACAAAAAATACC
ACAGCTTAGTGTAAATGACAATTTGGCGGTTTTATGTCTTTAGAAATGTTTTGCCTTTCTAAGCCTTGTGCTAAAGGCGTATAACGGTGG
TGCCTATCTACTTAAGGGGGCATTCTAGTCTTAACTTAAAAGTTGTCTAAACTGTCCCTCCCTGGCTTTTTTTGGTTTGGGGTAGACCTA
AGGGTGTTTGTTAGTCTCAAAACTGTGAAGTGACATGTCAGAACAGTCCAGACTGGTAAGAAAATTAATGGCTTCACTTGAATTTAAACC
AGCTCTAGATAGGAAAAAAATCAGTCTCCTCATTTGCTTTTTAAATGGAGTAGTACATCCCATATTTTAGAACAAGTAGGGGTGCCTTGC
TTAAATAAAAATAGCATTTAATGTATAATTGTGTGAAGGGTTTATGGATAAAGCTGTACTTCTGTCACAATGTGGCAGTACTTTCTGCTT
TAATATTAAACAGCTTGTTATTTAAATATTGGACAAAATGGCTGGCTTCAAAATATAGTCATTAATAAACTAACTTTATGTGCACCTGTG
TAGGAGAATCAAAATCCTGTATGCTTTCTTTGCCTTGTTCCTGTTCTCAGGGTGACGACTGCCACCAGGAGATGCAGTTCTAGTTCTTAA
AATTAAATTTGCCCAGGTTTCTGACAGGTGATACCTGGAAGAGAGACTATGTCTTCTCTTACTTAATACATAACCATCTTTGATTACCAG
CTAAGATGCGAAATCACTGTACTGTAGTCAATAAATGAAGACTTGTTTCAGGCTGAAGATTACCTAAGAGTATTTATTATTGGAGTCTGT
GAGTCAACTGAATATATTATTACCTCAAGTCCTGCTATATTAATATAAGTAGTAAGGGTTAATTTTCGTGTGTGTGTTCTCTAAAATCCT
GTGAACATGACTTAACCAGCTTAACATCATCAGTAGTACTGCCTAGATGGAAATGCGTTTTCATATATGGTTGAATATGCCAAGCTATGA
GAACTGGTATCTGTAGTTGTACGAACTATTAGAATGTGATCTTTGTTGCTCTTTCACATTTGGTATCTGATTTGCTGTGGAAAAGATCTG
TGGGGCCTACTGTGAGGAATTCATCTGCAATTGATTTAAGCTAATGAGTTTTATTTGCACATCTCTGGAAAAAGAATGCAAGCAAAGCAT
TAAAATGCTATATGATGGATGGGTAAGGTTGAAAGGATATATCTTCTTGGCACGCTACAGGCTGAGTTTTCTGTACAAAATGTGGCCATT
ATTGGGAAATCATTTTATGTATTTGAATGCTCCCTTTTGTTTTTGTTCATGATCTAGGCTAGTACGTAAGTGATTGCTAAGGTGGATGTA
GTTATGGGAAAGGAAGAGAAGCACATAATACAGTAAAAGTAATCTTATTTCCATGCAAGTGGAAGACGGTACCGTCTCCCCACATTTGAG
AAGACTGTTTTGCATCACTCTTTGCTATTGAAGGAAGCAGTGATGGTGAATTTCCTTCTGTTTGGGTTCCTTGTGTCTATAACTTCCTTT
GTGGTAAAGCCATCAGGAAGAATAGTGGGAGTGGGGCATATGGTCAGGGTGCTCATATCCTGCTTTAGCCTAGCTGCTGCTTACGGAGTG
CAAGGGAGAACTCTGAGAAGCAGTATGTAAATACCAGGGAGCTGATTGCTGAATATTGTGGTCTCATCTGAATATTGTGGTCTCATCTAA
ATATTGACACCAGGCAATGAAGCAGAAATAGAGTATGTGTCCCTTTATGCGTGGGTAACTTAAGCTTCTGTCATGTGGGAAGGGGGACCG
AATCTTCCCTGGGAGGAAGGCTCCAAATTCTCACTACTTCTGTGTTACTTGAAGGGGGAAGCATAAGGAACCCAGTTTGAAGGCAACATT
GTGTGCCATGAATCTGCTTATTAATCAACATGCCTTGTTAATGTCCTCTGCCCTGAACAGCCCTTACTCAGTTCTCATTTGGAAAGTTAT
TTTTTGGGGTTACATCCTGTTTGTTTCAGAATTTAAAACCCTCCATGGTGGGTCACTTGAGGTCAGGAGTTCAAGATTAGCCTGGCCAAC
TTAGTGAAACTCCGGCTCTACTGAAAATGCAAAAATTAGCCAGGTGTGGCACACGCCTGTAATCCCAGTTACTTGGGAGGCCAAGGCAGG
AGAATCGCTTGAACCTGGGAGGCAGAGGTTGTAGCGAGCCAAGATCACACCATTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCA
AAATCAAAAAAACCAAAATACAAAAAACTCCATTGTTCTGAGAGTTTCCCCTAAATTATCGGAAGACACTCACATTGAATTGGTAGGACC
TATAGTATAGAGGAGAATGGTATGTATGTCAGCAGTAGAGTTCCAATCCAAATTGCGCTATCGCATTAGAAATACATTACCCTCCCACTC
CCCAAGTTCAGCAAATTAGAAGAGAATCTGAAGTTTGTAGGAAGGGAATAAAGCTGCTATAAACATTTATGTGCAGGTTTTTGTGTAGAC
TCGTTTTCAGCTCCTTTGGGTAAATACCAAGGAACCAGGTTGCTGGATTGTAAGTTAAGAGTATGTTTAGTTTTGGAAGAAACTGCCAAA
CTGTTCCAACATGACTATTTTGAATTCCCATTGACAATGAATAAGAGTTCCTGTAGCTCCTCACCCTCATTAGTATTTGGTGATGTCACT
CTTGCATTTTAGCTAATGGGTGAATAGTGGTCTCATCGTTTTAATTCCCAATCCCATAGTGATGTGGAGCACCTTTTCATATACTTAATC
TGCCATCCTTATATCATCATTGGTGAGGTGTCTGGATTTTCTGTCCAGAATTTTAGTTCTAGTGGTTTTCTTATTTTTAGAAAGGAAGTA
TAGGAAGGAAGGTTTAATCTGTCTTAAGCCTGATTATATGAAAATCAAGAATAGGCTAGGTGTGGTGGCTGACATCTGTAATCCCCGCAC
TTTGTGAGGCTGAAGTGGGAGGACTGCTTGAGCCTGGGAAGTCAAGCCTGCAGTGAGCCATGACTGTTGCTGCACTCCAGCCTGAGTGAC
AGAGTGAGACCCTGTCTCAGAAAAAAAAAAAGCAGGCTCATTTTAAAGTTGTTTATATTTTATTTTTTGAAGGAAATAAACTTGAAGAGA
TACAAACGGTAGTGAAGATTCTCCTTCCCCTCCTGTAATTCAGCTGTTTAGTTTCTATTCTCGCACAGCCCTGTTATCAGTTTCTAGTGT
AAGCTTGCAGTGACTTTTACTTTATTTATAAGCAAGTGTTAGTGGGTGTTGTCATTTCTTTTAAAAATATAAATTATACTGTACATGCTA
TTTTGTATTTTGGCTTTTCTCCCACCTAAACACCCTAAAGATCATTTTCTGTCAGTATATAAAATCTTGGTGATGCCAATACCCATCCCT
TAGATTGTACAAGCAGCATTTTGCCATGCTTTATCCCATAGCCTGCCTCCTGCAGTCTCATCTTTTTTTCTATATGCATGTCCAAGTAAG
TTGTAGACATTTTTCACTTTTAATCCTTTCAGCATACATGTCATGGGAATTTGTTTTTGTTTTTGTTTTTTGTGTTTGAGACAGTCGCTC
TGTCACCCAGGCTGGAGTTATAGTGACGTGATCCCAGCTCATTACAGCCTCCACCTCCCAGTTTCAAGCAATTCTCATGCCTCAGATTCC
CGAGTAGCTGGGATTACAGATGTGCACCACCACGCCTGACTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCATCATGTTGGCCAGGCT
GGTCTGGAACTCCTGGCCTCCAGTCATTTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCACACCCAGCCGTCA
TTGGAGTTTTTTTGAGGGAGATTTGCAGTAAGGTGAATAAATGTTAAGTGTATCATTTGATGAGGTTTTTTCTTTTTTTTTTTTTTTTTT
TGAGATGGAGTCTTGTATCGCCCAGGCTAGAGTGCAGTGGCCTGGTCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGGGAGTCTC
CTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGAGCCACCATACCCAGACTCATTTGATGAGTTTTGATGTAAAAGCATGTAACT
CAAACCCCTATGTCTGGAACATCTGTATTACATCTGAATTTTTTCACCTAGTCAATTCCTGCACCTCTCTCTCCTGTCCCTTCTTCCCTC
CCCTGGCAGTCAGCTACTGTTAGGATTTTGTTCACTGTAGATTAATTTTGCCTATTCTAGAACTTCATATAACGGACTCACTTATGCAGT
ATGTATTCTGTAAGTTCCTTTTACTCAGCATGTTTGTATGTTCATCAGTGTGTTTAAGCTTTGTTCCTTTTTATGGCTGAGCAGTGTTCT
ATGTATGAATGCCACATTTTAACGTTTCACCTGTTAGGTGAACAACTAACTGGTGAACAATGGGCTGTTTCTAGTTTGGGGCTATCATGA

>21609_21609_3_DCK-GRSF1_DCK_chr4_71863899_ENST00000504952_GRSF1_chr4_71702031_ENST00000254799_length(amino acids)=430AA_BP=69
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEESKTTYLEDLPPPPEYELAPS
KLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNE
DVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIE
IFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCK-GRSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCK-GRSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDCKP27707DB01073FludarabineAgonistSmall moleculeApproved

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Related Diseases for DCK-GRSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource