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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1B-CD55 (FusionGDB2 ID:HG163486TG1604)

Fusion Gene Summary for DENND1B-CD55

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B-CD55
Fusion gene ID: hg163486tg1604
HgeneTgene
Gene symbol

DENND1B

CD55

Gene ID

163486

1604

Gene nameDENN domain containing 1BCD55 molecule (Cromer blood group)
SynonymsC1ORF18|C1orf218|FAM31BCHAPLE|CR|CROM|DAF|TC
Cytomap('DENND1B')('CD55')

1q31.3

1q32.2

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member Bcomplement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367396, ENST00000235453, 
ENST00000477581, ENST00000400967, 
Fusion gene scores* DoF score13 X 7 X 7=63710 X 8 X 4=320
# samples 1610
** MAII scorelog2(16/637*10)=-1.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1B [Title/Abstract] AND CD55 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1B(197741998)-CD55(207532891), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD55

GO:0007204

positive regulation of cytosolic calcium ion concentration

8223854

TgeneCD55

GO:0030449

regulation of complement activation

25284781

TgeneCD55

GO:0031664

regulation of lipopolysaccharide-mediated signaling pathway

12731067

TgeneCD55

GO:0035743

CD4-positive, alpha-beta T cell cytokine production

16818763

TgeneCD55

GO:0045916

negative regulation of complement activation

6211481

TgeneCD55

GO:1903659

regulation of complement-dependent cytotoxicity

25284781

TgeneCD55

GO:2000516

positive regulation of CD4-positive, alpha-beta T cell activation

16818763

TgeneCD55

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

16818763



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01ADENND1Bchr1

197741998

-CD55chr1

207532891

+


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Fusion Gene ORF analysis for DENND1B-CD55

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367396ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-3UTRENST00000367396ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-intronENST00000367396ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5CDS-intronENST00000367396ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3CDSENST00000235453ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3CDSENST00000477581ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000235453ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-3UTRENST00000477581ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000235453ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000235453ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000477581ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
5UTR-intronENST00000477581ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+
Frame-shiftENST00000367396ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3CDSENST00000400967ENST00000367064DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000314754DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367062DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367065DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000367067DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000391920DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-3UTRENST00000400967ENST00000465534DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-intronENST00000400967ENST00000367063DENND1Bchr1

197741998

-CD55chr1

207532891

+
intron-intronENST00000400967ENST00000391921DENND1Bchr1

197741998

-CD55chr1

207532891

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DENND1B-CD55


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND1Bchr1197741997-CD55chr1207532890+0.0078569450.99214303
DENND1Bchr1197741997-CD55chr1207532890+0.0078569450.99214303


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DENND1B-CD55


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:197741998/:207532891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DENND1B-CD55


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DENND1B-CD55


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1B-CD55


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1B-CD55


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND1BC0008312Primary biliary cirrhosis1CTD_human
HgeneDENND1BC0010346Crohn Disease1CTD_human
HgeneDENND1BC0023892Biliary cirrhosis1CTD_human
HgeneDENND1BC0156147Crohn's disease of large bowel1CTD_human
HgeneDENND1BC0238065Secondary Biliary Cholangitis1CTD_human
HgeneDENND1BC0267380Crohn's disease of the ileum1CTD_human
HgeneDENND1BC0678202Regional enteritis1CTD_human
HgeneDENND1BC0949272IIeocolitis1CTD_human
HgeneDENND1BC4551595Biliary Cirrhosis, Primary, 11CTD_human
TgeneC4538570COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY2UNIPROT
TgeneC0014175Endometriosis1CTD_human
TgeneC0033680Protein-Losing Enteropathies1CTD_human;GENOMICS_ENGLAND
TgeneC0086438Hypogammaglobulinemia1GENOMICS_ENGLAND
TgeneC0236733Amphetamine-Related Disorders1CTD_human
TgeneC0236804Amphetamine Addiction1CTD_human
TgeneC0236807Amphetamine Abuse1CTD_human
TgeneC0267372Primary intestinal lymphangiectasia1GENOMICS_ENGLAND
TgeneC0269102Endometrioma1CTD_human
TgeneC0272242Complement deficiency disease1GENOMICS_ENGLAND