Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DENND1B-RRP15 (FusionGDB2 ID:HG163486TG51018)

Fusion Gene Summary for DENND1B-RRP15

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B-RRP15
Fusion gene ID: hg163486tg51018
HgeneTgene
Gene symbol

DENND1B

RRP15

Gene ID

163486

51018

Gene nameDENN domain containing 1Bribosomal RNA processing 15 homolog
SynonymsC1ORF18|C1orf218|FAM31BCGI-115|KIAA0507
Cytomap('DENND1B')('RRP15')

1q31.3

1q41

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member BRRP15-like proteinribosomal RNA-processing protein 15
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367396, ENST00000235453, 
ENST00000477581, ENST00000400967, 
Fusion gene scores* DoF score13 X 7 X 7=6377 X 5 X 6=210
# samples 169
** MAII scorelog2(16/637*10)=-1.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND1B [Title/Abstract] AND RRP15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1B(197741998)-RRP15(218475636), # samples:2
Anticipated loss of major functional domain due to fusion event.DENND1B-RRP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1B-RRP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DENND1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RRP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OK-A5Q2-01ADENND1Bchr1

197741998

-RRP15chr1

218475636

+
ChimerDB4BRCATCGA-OK-A5Q2DENND1Bchr1

197741997

-RRP15chr1

218475635

+


Top

Fusion Gene ORF analysis for DENND1B-RRP15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000367396ENST00000491428DENND1Bchr1

197741998

-RRP15chr1

218475636

+
5CDS-3UTRENST00000367396ENST00000491428DENND1Bchr1

197741997

-RRP15chr1

218475635

+
5UTR-3CDSENST00000235453ENST00000366932DENND1Bchr1

197741998

-RRP15chr1

218475636

+
5UTR-3CDSENST00000235453ENST00000366932DENND1Bchr1

197741997

-RRP15chr1

218475635

+
5UTR-3CDSENST00000477581ENST00000366932DENND1Bchr1

197741998

-RRP15chr1

218475636

+
5UTR-3CDSENST00000477581ENST00000366932DENND1Bchr1

197741997

-RRP15chr1

218475635

+
5UTR-3UTRENST00000235453ENST00000491428DENND1Bchr1

197741998

-RRP15chr1

218475636

+
5UTR-3UTRENST00000235453ENST00000491428DENND1Bchr1

197741997

-RRP15chr1

218475635

+
5UTR-3UTRENST00000477581ENST00000491428DENND1Bchr1

197741998

-RRP15chr1

218475636

+
5UTR-3UTRENST00000477581ENST00000491428DENND1Bchr1

197741997

-RRP15chr1

218475635

+
In-frameENST00000367396ENST00000366932DENND1Bchr1

197741998

-RRP15chr1

218475636

+
In-frameENST00000367396ENST00000366932DENND1Bchr1

197741997

-RRP15chr1

218475635

+
intron-3CDSENST00000400967ENST00000366932DENND1Bchr1

197741998

-RRP15chr1

218475636

+
intron-3CDSENST00000400967ENST00000366932DENND1Bchr1

197741997

-RRP15chr1

218475635

+
intron-3UTRENST00000400967ENST00000491428DENND1Bchr1

197741998

-RRP15chr1

218475636

+
intron-3UTRENST00000400967ENST00000491428DENND1Bchr1

197741997

-RRP15chr1

218475635

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367396DENND1Bchr1197741998-ENST00000366932RRP15chr1218475636+7854252170961263
ENST00000367396DENND1Bchr1197741997-ENST00000366932RRP15chr1218475635+7854252170961263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367396ENST00000366932DENND1Bchr1197741998-RRP15chr1218475636+0.0003523520.9996476
ENST00000367396ENST00000366932DENND1Bchr1197741997-RRP15chr1218475635+0.0003523520.9996476

Top

Fusion Genomic Features for DENND1B-RRP15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND1Bchr1197741997-RRP15chr1218475635+3.25E-050.9999676
DENND1Bchr1197741997-RRP15chr1218475635+3.25E-050.9999676
DENND1Bchr1197741997-RRP15chr1218475635+3.25E-050.9999676
DENND1Bchr1197741997-RRP15chr1218475635+3.25E-050.9999676

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DENND1B-RRP15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:197741998/chr1:218475636)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRRP15chr1:197741997chr1:218475635ENST0000036693205108_14446283.0Coiled coilOntology_term=ECO:0000255
TgeneRRP15chr1:197741998chr1:218475636ENST0000036693205108_14446283.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000235453-21614_1430397.0DomainuDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000235453-216180_3160397.0DomaincDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000235453-216318_3950397.0DomaindDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000367396-21614_14327427.0DomainuDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000367396-216180_31627427.0DomaincDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000367396-216318_39527427.0DomaindDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000400967-11414_1430397.0DomainuDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000400967-114180_3160397.0DomaincDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000400967-114318_3950397.0DomaindDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000235453-21614_1430397.0DomainuDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000235453-216180_3160397.0DomaincDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000235453-216318_3950397.0DomaindDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000367396-21614_14327427.0DomainuDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000367396-216180_31627427.0DomaincDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000367396-216318_39527427.0DomaindDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000400967-11414_1430397.0DomainuDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000400967-114180_3160397.0DomaincDENN
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000400967-114318_3950397.0DomaindDENN
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000235453-216398_4020397.0MotifFXDXF motif
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000235453-216566_5750397.0MotifClathrin box
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000367396-216398_40227427.0MotifFXDXF motif
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000367396-216566_57527427.0MotifClathrin box
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000400967-114398_4020397.0MotifFXDXF motif
HgeneDENND1Bchr1:197741997chr1:218475635ENST00000400967-114566_5750397.0MotifClathrin box
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000235453-216398_4020397.0MotifFXDXF motif
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000235453-216566_5750397.0MotifClathrin box
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000367396-216398_40227427.0MotifFXDXF motif
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000367396-216566_57527427.0MotifClathrin box
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000400967-114398_4020397.0MotifFXDXF motif
HgeneDENND1Bchr1:197741998chr1:218475636ENST00000400967-114566_5750397.0MotifClathrin box


Top

Fusion Gene Sequence for DENND1B-RRP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22224_22224_1_DENND1B-RRP15_DENND1B_chr1_197741997_ENST00000367396_RRP15_chr1_218475635_ENST00000366932_length(transcript)=7854nt_BP=252nt
GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG
CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA
GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGGAAGCTGTGGATCGGAAA
AGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAATGATGGAG
AATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACTATTCTGG
TCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGCGTGATAAGAGGCTGGAGTGGG
AAATGATGTGCAGAGTAAAGCCAGATGTTGTCCAAGACAAAGAGACAGAGAGAAATCTTCAGAGAATTGCAACAAGGGGTGTGGTGCAAT
TATTTAATGCTGTTCAGAAACATCAAAAGAATGTTGATGAAAAGGTTAAGGAAGCTGGAAGTTCTATGAGAAAGCGTGCTAAGTTGATAT
CAACTGTTTCCAAGAAAGATTTCATCAGTGTTTTGAGAGGGATGGATGGAAGTACAAATGAGACTGCTTCAAGCAGGAAGAAACCAAAAG
CCAAACAGACTGAAGTGAAATCAGAAGAAGGCCCAGGTTGGACGATCCTACGTGATGATTTCATGATGGGAGCATCTATGAAAGACTGGG
ACAAGGAAAGTGATGGGCCAGATGACAGCAGACCAGAATCTGCAAGTGACTCTGATACATAAAGCATCATAGGAAATACAATTGCAGTCG
TTTTATTTTTTCTAGAAAAATATGTCATCCTCTGATAGTTGGGGAATTATAAGGATACCATTTGTAAGAAAGCCAAAAGACTTTTGCCAG
ATTTCATATTTCCCCTTTTCATGTACACTTTATATATACTTCATTAAAATTATATTTTAAACCCTTGTATAATTTTAAGCATTGTTCCTC
AGAACATTTGTAAAAGGATATATTTCTGCTTGACCAGCGAGATGTGCATTTTGCCAGGATCATATTGGTCATGTCTATTGGTGTATTATT
TCAGTATCACCAATGTTTTCAGAAATACAGTACTAATTCATCATTAAACTCTTTGAAGTTAATATTTTTCTGCCTTCTAACTTATAGACT
CAACTATGTATCTGTAGTTTTTGGGAATGGTTGGTGTTTTTTGCTTTGTGTTGGGAAGTTATTGAGAAAACCTATATAATAAAATTTAAA
ATTATAGTTTTTCAGATTTTGGGTCGTGATTTTAGTTTTAGGTAATCTGGAAGATATGATTTAAGAAACAACAGATTTCAACTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTGGCCCCGGATGGAATGCAGTGGCGTGATCTCGGCTCACT
GCAAGCACCGCCTCCCAGGTTCACGCCATTCTCCCACCTCAACCTCTCAAGTAGCTGGGACTACAGGTGCCTGCCACCACGCCCAGCTAA
TTTTTTGTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTC
GGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCCAGATTTCAACTTTTATTTTATTTCCTTTCATTTATTAAATA
ATATAAATAATGACAGATTTATTTTAGGTGTTAGCCTATTTTTGCATGAGAGATTTACAGAGGTGGAAATTCTCATGCTTAACTTATGCA
ATGAGACAATTTCTCAGGAAGCAAGTTTGACATGCTTTAGTCTCTCTCTTCTTTTTTTTCCTCCCAAATATTTGAGTTAGCTTAAATTCT
TTTTTATGGACTGCCCAACCAGTGAATTGATGCACTTAGACAACAAGTAATCTGCAGCAGAATATTGCATCCAATTTGAGACTTGATTCC
ATATTATTGCCTTAAAGGCTATTAAATTGGGTGACTTTTAGTATCCAGCTGTTAAAAAGAGGAAAGACTGTTTAATATCATTCCAAAATT
TTTGTGAAATGTGGCCCAAGATCTAAAGTTTTTAAGGGAATTATTTTTAATAAATATGATCTGTCCCTTTTTGAAAAGGATCCATCCCTT
TTCATAATAAAAATAATTCCCTCCTACCACCCAGTTGCACATACTTGCATCTGTTATGTATTGAAGGATAATCCCCCCCAAAAAAACTAT
CCAAGAGCAGAGATGTTTATATTTTGAAACCCATTTGAGTGTTACAGTATTATATGACTAAAGCTGAATCAGTCTGTGGCCTGGTATTTG
TTATCATAAAGGAAGATGTACACCTAAGGTATCAAGTGGTTAAAACAGCAAAGTACAAGATGCATTTTTGTATTTATTCTAACTTTTGAA
CATTAGTGTCTTTCAGTATAAATAAATGTGAACAAATATACCTCAGTAGTAATACAGGAGAACTAAATATCCTGCTATAACTTAATACAG
ATACATATTTCAATATGACTTAACAAACACACAATTTTGAAAAAAAAAAAAAAAAAGTGCAGCAACTTAAACACATTTTTCTCCCCAGAA
CTAAGATTACACTTAATTTAATTTAATGTGTTTCTGCGTTATACTAGAGTTTTGCAGGAATTTTTCTGAATAGTACATTCACATGATAGA
TACGGATAAATACCTTATTTACTAAAATGTTTTGAAACATATTTTATAGTCCCTCATTTGATTTGAAAAAATTTGACAAGATCTTCACAT
TGAAAGTAAGGACGAGAATATTTGCAGATTTCCTTCGTTCCAAAATTATTTTATTCCAAAGAAAAATTGAGTTGCCACTATCAGGAAAAA
AAAAATGTATCACTTCTGTTAGAAGGCTATGAAGTATATATAAATTATATGACAATTTTTATCATATAGATTTGATATCTTCTATGTATT
CGTATTTTTGCATCTTGGGTATTAAGCAAAATACCATATGTATAAATATGAAACCAGGAATGTGCATATTTTAGAAACTAATTGTGTATC
TTAAGTGAATGTTTTGAGTAGTTCTGTCACCCCTATTCTAAATATTTTACCTACAACATTTAAATTATTCTGATATCAATCAGATAAATA
ATCCGAGTGTATTTCATCTTTCTACATTGTCTTTGTGGTTTTTGTTTGTTTGTTTTTGAGACGGTCTCACACTGTCACCCAGGCTGGAGT
GCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCCAGCTATCCTCCCACCTCAGCCTCCCAAGTAGCTAGGACTACAG
GTGTGCACCACCATGCCCAGCTAATTTTTTGTCTTTTTGATGTAGATGGGGTTACCCCATGTTGCCCAGGCTGGTTGTGAACTCCTGAGC
TCAAGGGATCCCCCCGCCTCTTGCCTCCCAAAGTGCTTGGATTACAGGTGTGAGCCACCATACCACCTGTCTTTGAATTTTTTAACGAGG
GGAAAGAAAACTGCAATTCCTGCCTCCCCATTTATTTAAACATAACACCTAGGATTTTATTTTTGGTAACTACTTAGAATAATATAGTAG
GTTACTTATCTTCGGTTAGAAAGAACTATGGAAAATAGGAACCAATAATTTGGAAGTATTATTTCCTTATTTCATATATAGAAATAATTA
TCTTATTTCCTTATTTCATATATAGAATATTCTAGATACTTGGATGGCTGGGGTTGATGTTCTTAGTATTTATCATAGTTTAGCATTGGT
TGTTATTTTTAAGCATCAGAATTTGAAAGCCAATGATAATACCTGATTAGGACTGAAAATAGAATTATCTTAGTAGTTTAGCACTTTTTA
TAATGGAGTTGGAGCACTGAATTTATTTTCAAATTACCTAGAATTCTGCATTGCTCAAACATTATTCAATTGATTGCAAAATATACCTTG
GAAACCCTTTGGATAGAACAGTTCAGAGGGTTACCACTAGTACTTAGAGCCTAAAGTCACTCAGTAGGAGGTTCTCAAAGGTCTATTTGA
AGGCAATCCAATTTCTTTAAAATAAAATATTTTTTGCCTTTTAAAACAGATGGGTGAAGAAAGGGACGTATAAATTCTGGGAAACCTCTT
ATGTTTTCCTCCCATTTCCTTCTATGTCTCCATTAATGTGCTAACTTGAAGGAATTTAACTTCAAGGAAAGTTGACTGATGAAGTTTATG
TAGAGCTGTGAATATTATAATTTGTCAATACTTTATTGATAATGTTAACTTTGTTTTTATTTGGAAACATTTTTTCCAGTTGACCAAAGC
AGAATTCATTCTGTTCTTCCCTCAAATTCATCTATTAGGATCAATGTGATTGACATTTATCTCCACTCTGCATGTCACTGATATGGTATA
GACGCTATAAGCCCTGTAGATATTATGGGTATGAAGACTATTTGAGGTGAATTGGCAGTGAGAGCAAATTTTGGAAACAGGAGAGAGAAC
TACTTCGTGCCTATAAAAAGCTCTCTCACTCCTTCCCCAAGAAAACAGGAGTCTGAATTTTGGCCAGCTGGGTATTTGAATCTTACTGAC
TGTTGCAGCACTGGTAGTCCTGGTAAATTTTTTCAGTGGGCGAGCTTTTCTGAAATTTGATTAAACATATTAGTCAAGGGAATCTGTGAA
TAGATTTAGAAGTAGAATGTTTGAGGTGGTTGACAAGACATTTAGAATTGTGATTAATGTTTTAATAAAATGCTAAGTTAGAATGAATAA
TCATAATTATATAGATGGAAGATATATTCTAACAGTTCTTAAATAATTTTAGATTCTCTAAATTTAGAGTGTTTTCTAGCTTAGAGAGCA
ATATTAATATTTTTTACCTAGTCTACTGAACATAATTTCAGGGAGTTAGTATTTAGGACTTTTTACCTAGAGATGCGGTAAACCTTTTAA
ATTTAAATTTGCTTTCTTAAAATACCTGTTCCAACATTGCTCACCTTTCTTCTCCCTCCTTTTTGCCCTCTCCTTCAGTGGGAGGAGCAC
ATATTCAGCTTTCTGTTAAACACTCTTTGGTTTTCAACTGAGTAAGGCAAGCAAGGATATATGTTAGAAGAGTGGGCATAATACTTTATA
TTAAAATTATAGGGACTAAAAGTCTAAATCATTGCTGTCAATAGGACTTTTTTTGATGATGGAAATAATTTATGTCTGTGCTGTTCAATA
TGGTAGCCACTCGCAGAGGTGACTACTGAGCATTTCACGTGTGGCTTGTGATACAGAGGAACTAAATTTTTAATTTTACTTAATTACTTT
AAATTTTAAAAGTTACACGTGGCTAGTGGGTCTATCCCAACTATGAAGAGAATAAAGCTACAGAGCATCTATCTAGTCTAATGAAACAAC
AGTGAATTTGGGAATTGTAAATCTGTCTTAAGCTTTTTCCATAAACTTTTATTGATATAATTTAGGCATATACAAATACTGGTGAAATTT
TATTGATTGAATTATTGTTGACTTTTTTTTCAGTATTTATATTTTTAAAAAGATATGTTTCTTTATAATTAACTTGTATTGTAGGGTAAC
CATTGTCCTTAAATGTTAAGCCACTTAGTTAATAACAAATAGCATTTGGTTTTTTAGCATTATTTATCATCTGAGGCTTTCAGAATTAAT
GCACCAAACCTTAAATATTTTTGTTGTTCTCTAAAAGAATGGGTTTATGATGCACCAAAAGGACATTTTGAGAACTGCCGGAGCAACAGA
TACCACCATGTAAGGAGTGAATTCCCATGTTTTTCACTTATATCTAGAGGCCTACTTATTTAGGAGGTTTCCTAAGTAAGTGTATTTAGT
TGTAGGACCTTAGAGTTGCCTAGGTCCATTCTATTCTAGCATATACTCAACATACTGCCAGAGCAAATGTAGGTTGCAGATTCAGGCAAA
ACACACACACACACACACACAAAACCCTGAAGAGCACAATGAGCATTATTAGCACAGCCAATTTAAAATGATGAGGTGTTAACCACATTT
GTATAAATAATAGTTTCTCTAACCCTGAATCATTATCCTGCATTTTTAATGCAATCGGTTCATAAACATCAAAGTGAAAACACCAAATTT
GTAAGAGGTCAGGACCAACTGGGGCTCTAAATGGAGAGACAGCTGAGAGCTGTGTCCCTATGCGTGGGTGGCCTTGCAGCTGTTGATTCA
CCCTCAGGCTACCAGACAGTTGCCTCTTTGCATTTGCAGAACCAGACTTCAATCTTAGGTAAAAATGTATCCCTCCCATGGACAGGACAT
AAACAATAGATTGACATCAGCTCTGAAAACAGTGCAGCAGCCAGACTCAGCAGTTGCCCTGAAATACTGAGAAGTACCAAGCATAACATC
AAGACTGTTTCTACACAATAATATTTGTCTTTGTACAGCAACACTGGGTTCTCTTAAGTATATTATAAATATAAAAGCTCAAAGTCCAAA
AGGTTCAATGTGATGATATCCTTCTCTACAAATGCCAGGAACACCAGGGTAGATTGCATGAGACATGACTGCCGTATCTTGGTCCTTACT
AGGATTCCCAAATATACTCCTTAATAACCAGTAAAGTTATATTTACACTGGACATTTTAAGAAATACCAGTGTTCGTTGTTAGATGAGAG
ACAGCATAATTTTGGAATCACAACTGAGTTCAGAGTTCAGTTTTGAGTCCTACTAGTTTTGTTTCCTTGTGTAAGTTTCTTAACCTTTGT
AAGGCTAGCATGTAAATCAGATACAATAATATATAGTTCAGGGTGTAAAGATTGGATTAATGTATGCAGTGTCTATCTAGCACAGTGCCT
GTTATGTAGTAGCGTGTCAAGAGATGTTCTCTCTTATGCATTTGGAGGATTAGGTGCTGCACCTATAGGTTTCCATTCATTTCTCATCTA
TGTAATTCTGAGTCTTCCTTTTCTAGATAGAATTCCCCCCAACAAAAATTTAAAGTCTAACAGGTGGTAGGTGCTTATTGAGGCCCAGCA
ATTCTACTTCTGGAAACCTTCCTCAGGAAAAGATTCTGATGACAGAAAATGCTGTGTGAACAGTATTATATAGAATTGTTTTTAATAGCA
AGAAATTTTTTAAAACTTACAAGTTCAGTGATATGAGGACATTTACATAAACTATCGAACCACCAGTCTTCTGTCAATTCCTTTTAAAAT
GATGGTTGTGAAGACTGATGAAAACACAGTGTCAATGATATGTTAACTGAAAAAGTAAGATTAAAAACATTATGGATAGTATAAGTTTCT
TAAATGCCAACAATGCATGAGGTGAATAGAATAAGACTTTTTTTTAAAGAATGTAATTTTTGACAGTCTGAAAAGACAGGCCTTATATTT
ATATTGAGAAAAATGATCCTGACATTTAATGAGACACTAAAACAGTTTTTATTTTTTGCTTACTTATTCTGTTCTAGAATCCAAACTCTA
CATACTGTTTAATAGAGCATTATTGATATTAGCTGTATTAGATGACTGTATGAAGAGTCCTGTTTGCTAGAATCCTACTTTATCTTTTAA
GTTTTGCTAATTACCCTGCAATGAATGTTGAACATAAAAAATTTGACTCCCTTTCCATGTGTCCACTGTTTCCTTGTGCCTTTTGATTAA
TAAAACTTTATTTTTAAGTGAGAA

>22224_22224_1_DENND1B-RRP15_DENND1B_chr1_197741997_ENST00000367396_RRP15_chr1_218475635_ENST00000366932_length(amino acids)=263AA_BP=27
MDCRTKANPDRTFDLVLKVKCHASENEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNMGWADAMAKVLNKKTPESKP
TILVKNKKLEKEKEKLKQERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGSSMRKRA
KLISTVSKKDFISVLRGMDGSTNETASSRKKPKAKQTEVKSEEGPGWTILRDDFMMGASMKDWDKESDGPDDSRPESASDSDT

--------------------------------------------------------------
>22224_22224_2_DENND1B-RRP15_DENND1B_chr1_197741998_ENST00000367396_RRP15_chr1_218475636_ENST00000366932_length(transcript)=7854nt_BP=252nt
GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG
CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA
GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGGAAGCTGTGGATCGGAAA
AGGACCACTTTTATTCTGATGATGACGCAATAGAAGCTGACAGTGAGGGTGATGCTGAGCCCTGTGACAAAGAAAATGAAAATGATGGAG
AATCAAGTGTTGGGACTAATATGGGCTGGGCAGATGCTATGGCTAAAGTCCTCAACAAGAAAACTCCTGAAAGTAAACCTACTATTCTGG
TCAAAAATAAGAAGCTGGAAAAGGAAAAAGAAAAGTTAAAGCAAGAAAGACTAGAGAAAATAAAACAGCGTGATAAGAGGCTGGAGTGGG
AAATGATGTGCAGAGTAAAGCCAGATGTTGTCCAAGACAAAGAGACAGAGAGAAATCTTCAGAGAATTGCAACAAGGGGTGTGGTGCAAT
TATTTAATGCTGTTCAGAAACATCAAAAGAATGTTGATGAAAAGGTTAAGGAAGCTGGAAGTTCTATGAGAAAGCGTGCTAAGTTGATAT
CAACTGTTTCCAAGAAAGATTTCATCAGTGTTTTGAGAGGGATGGATGGAAGTACAAATGAGACTGCTTCAAGCAGGAAGAAACCAAAAG
CCAAACAGACTGAAGTGAAATCAGAAGAAGGCCCAGGTTGGACGATCCTACGTGATGATTTCATGATGGGAGCATCTATGAAAGACTGGG
ACAAGGAAAGTGATGGGCCAGATGACAGCAGACCAGAATCTGCAAGTGACTCTGATACATAAAGCATCATAGGAAATACAATTGCAGTCG
TTTTATTTTTTCTAGAAAAATATGTCATCCTCTGATAGTTGGGGAATTATAAGGATACCATTTGTAAGAAAGCCAAAAGACTTTTGCCAG
ATTTCATATTTCCCCTTTTCATGTACACTTTATATATACTTCATTAAAATTATATTTTAAACCCTTGTATAATTTTAAGCATTGTTCCTC
AGAACATTTGTAAAAGGATATATTTCTGCTTGACCAGCGAGATGTGCATTTTGCCAGGATCATATTGGTCATGTCTATTGGTGTATTATT
TCAGTATCACCAATGTTTTCAGAAATACAGTACTAATTCATCATTAAACTCTTTGAAGTTAATATTTTTCTGCCTTCTAACTTATAGACT
CAACTATGTATCTGTAGTTTTTGGGAATGGTTGGTGTTTTTTGCTTTGTGTTGGGAAGTTATTGAGAAAACCTATATAATAAAATTTAAA
ATTATAGTTTTTCAGATTTTGGGTCGTGATTTTAGTTTTAGGTAATCTGGAAGATATGATTTAAGAAACAACAGATTTCAACTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTGGCCCCGGATGGAATGCAGTGGCGTGATCTCGGCTCACT
GCAAGCACCGCCTCCCAGGTTCACGCCATTCTCCCACCTCAACCTCTCAAGTAGCTGGGACTACAGGTGCCTGCCACCACGCCCAGCTAA
TTTTTTGTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCCGCCTC
GGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCCAGATTTCAACTTTTATTTTATTTCCTTTCATTTATTAAATA
ATATAAATAATGACAGATTTATTTTAGGTGTTAGCCTATTTTTGCATGAGAGATTTACAGAGGTGGAAATTCTCATGCTTAACTTATGCA
ATGAGACAATTTCTCAGGAAGCAAGTTTGACATGCTTTAGTCTCTCTCTTCTTTTTTTTCCTCCCAAATATTTGAGTTAGCTTAAATTCT
TTTTTATGGACTGCCCAACCAGTGAATTGATGCACTTAGACAACAAGTAATCTGCAGCAGAATATTGCATCCAATTTGAGACTTGATTCC
ATATTATTGCCTTAAAGGCTATTAAATTGGGTGACTTTTAGTATCCAGCTGTTAAAAAGAGGAAAGACTGTTTAATATCATTCCAAAATT
TTTGTGAAATGTGGCCCAAGATCTAAAGTTTTTAAGGGAATTATTTTTAATAAATATGATCTGTCCCTTTTTGAAAAGGATCCATCCCTT
TTCATAATAAAAATAATTCCCTCCTACCACCCAGTTGCACATACTTGCATCTGTTATGTATTGAAGGATAATCCCCCCCAAAAAAACTAT
CCAAGAGCAGAGATGTTTATATTTTGAAACCCATTTGAGTGTTACAGTATTATATGACTAAAGCTGAATCAGTCTGTGGCCTGGTATTTG
TTATCATAAAGGAAGATGTACACCTAAGGTATCAAGTGGTTAAAACAGCAAAGTACAAGATGCATTTTTGTATTTATTCTAACTTTTGAA
CATTAGTGTCTTTCAGTATAAATAAATGTGAACAAATATACCTCAGTAGTAATACAGGAGAACTAAATATCCTGCTATAACTTAATACAG
ATACATATTTCAATATGACTTAACAAACACACAATTTTGAAAAAAAAAAAAAAAAAGTGCAGCAACTTAAACACATTTTTCTCCCCAGAA
CTAAGATTACACTTAATTTAATTTAATGTGTTTCTGCGTTATACTAGAGTTTTGCAGGAATTTTTCTGAATAGTACATTCACATGATAGA
TACGGATAAATACCTTATTTACTAAAATGTTTTGAAACATATTTTATAGTCCCTCATTTGATTTGAAAAAATTTGACAAGATCTTCACAT
TGAAAGTAAGGACGAGAATATTTGCAGATTTCCTTCGTTCCAAAATTATTTTATTCCAAAGAAAAATTGAGTTGCCACTATCAGGAAAAA
AAAAATGTATCACTTCTGTTAGAAGGCTATGAAGTATATATAAATTATATGACAATTTTTATCATATAGATTTGATATCTTCTATGTATT
CGTATTTTTGCATCTTGGGTATTAAGCAAAATACCATATGTATAAATATGAAACCAGGAATGTGCATATTTTAGAAACTAATTGTGTATC
TTAAGTGAATGTTTTGAGTAGTTCTGTCACCCCTATTCTAAATATTTTACCTACAACATTTAAATTATTCTGATATCAATCAGATAAATA
ATCCGAGTGTATTTCATCTTTCTACATTGTCTTTGTGGTTTTTGTTTGTTTGTTTTTGAGACGGTCTCACACTGTCACCCAGGCTGGAGT
GCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCCAGCTATCCTCCCACCTCAGCCTCCCAAGTAGCTAGGACTACAG
GTGTGCACCACCATGCCCAGCTAATTTTTTGTCTTTTTGATGTAGATGGGGTTACCCCATGTTGCCCAGGCTGGTTGTGAACTCCTGAGC
TCAAGGGATCCCCCCGCCTCTTGCCTCCCAAAGTGCTTGGATTACAGGTGTGAGCCACCATACCACCTGTCTTTGAATTTTTTAACGAGG
GGAAAGAAAACTGCAATTCCTGCCTCCCCATTTATTTAAACATAACACCTAGGATTTTATTTTTGGTAACTACTTAGAATAATATAGTAG
GTTACTTATCTTCGGTTAGAAAGAACTATGGAAAATAGGAACCAATAATTTGGAAGTATTATTTCCTTATTTCATATATAGAAATAATTA
TCTTATTTCCTTATTTCATATATAGAATATTCTAGATACTTGGATGGCTGGGGTTGATGTTCTTAGTATTTATCATAGTTTAGCATTGGT
TGTTATTTTTAAGCATCAGAATTTGAAAGCCAATGATAATACCTGATTAGGACTGAAAATAGAATTATCTTAGTAGTTTAGCACTTTTTA
TAATGGAGTTGGAGCACTGAATTTATTTTCAAATTACCTAGAATTCTGCATTGCTCAAACATTATTCAATTGATTGCAAAATATACCTTG
GAAACCCTTTGGATAGAACAGTTCAGAGGGTTACCACTAGTACTTAGAGCCTAAAGTCACTCAGTAGGAGGTTCTCAAAGGTCTATTTGA
AGGCAATCCAATTTCTTTAAAATAAAATATTTTTTGCCTTTTAAAACAGATGGGTGAAGAAAGGGACGTATAAATTCTGGGAAACCTCTT
ATGTTTTCCTCCCATTTCCTTCTATGTCTCCATTAATGTGCTAACTTGAAGGAATTTAACTTCAAGGAAAGTTGACTGATGAAGTTTATG
TAGAGCTGTGAATATTATAATTTGTCAATACTTTATTGATAATGTTAACTTTGTTTTTATTTGGAAACATTTTTTCCAGTTGACCAAAGC
AGAATTCATTCTGTTCTTCCCTCAAATTCATCTATTAGGATCAATGTGATTGACATTTATCTCCACTCTGCATGTCACTGATATGGTATA
GACGCTATAAGCCCTGTAGATATTATGGGTATGAAGACTATTTGAGGTGAATTGGCAGTGAGAGCAAATTTTGGAAACAGGAGAGAGAAC
TACTTCGTGCCTATAAAAAGCTCTCTCACTCCTTCCCCAAGAAAACAGGAGTCTGAATTTTGGCCAGCTGGGTATTTGAATCTTACTGAC
TGTTGCAGCACTGGTAGTCCTGGTAAATTTTTTCAGTGGGCGAGCTTTTCTGAAATTTGATTAAACATATTAGTCAAGGGAATCTGTGAA
TAGATTTAGAAGTAGAATGTTTGAGGTGGTTGACAAGACATTTAGAATTGTGATTAATGTTTTAATAAAATGCTAAGTTAGAATGAATAA
TCATAATTATATAGATGGAAGATATATTCTAACAGTTCTTAAATAATTTTAGATTCTCTAAATTTAGAGTGTTTTCTAGCTTAGAGAGCA
ATATTAATATTTTTTACCTAGTCTACTGAACATAATTTCAGGGAGTTAGTATTTAGGACTTTTTACCTAGAGATGCGGTAAACCTTTTAA
ATTTAAATTTGCTTTCTTAAAATACCTGTTCCAACATTGCTCACCTTTCTTCTCCCTCCTTTTTGCCCTCTCCTTCAGTGGGAGGAGCAC
ATATTCAGCTTTCTGTTAAACACTCTTTGGTTTTCAACTGAGTAAGGCAAGCAAGGATATATGTTAGAAGAGTGGGCATAATACTTTATA
TTAAAATTATAGGGACTAAAAGTCTAAATCATTGCTGTCAATAGGACTTTTTTTGATGATGGAAATAATTTATGTCTGTGCTGTTCAATA
TGGTAGCCACTCGCAGAGGTGACTACTGAGCATTTCACGTGTGGCTTGTGATACAGAGGAACTAAATTTTTAATTTTACTTAATTACTTT
AAATTTTAAAAGTTACACGTGGCTAGTGGGTCTATCCCAACTATGAAGAGAATAAAGCTACAGAGCATCTATCTAGTCTAATGAAACAAC
AGTGAATTTGGGAATTGTAAATCTGTCTTAAGCTTTTTCCATAAACTTTTATTGATATAATTTAGGCATATACAAATACTGGTGAAATTT
TATTGATTGAATTATTGTTGACTTTTTTTTCAGTATTTATATTTTTAAAAAGATATGTTTCTTTATAATTAACTTGTATTGTAGGGTAAC
CATTGTCCTTAAATGTTAAGCCACTTAGTTAATAACAAATAGCATTTGGTTTTTTAGCATTATTTATCATCTGAGGCTTTCAGAATTAAT
GCACCAAACCTTAAATATTTTTGTTGTTCTCTAAAAGAATGGGTTTATGATGCACCAAAAGGACATTTTGAGAACTGCCGGAGCAACAGA
TACCACCATGTAAGGAGTGAATTCCCATGTTTTTCACTTATATCTAGAGGCCTACTTATTTAGGAGGTTTCCTAAGTAAGTGTATTTAGT
TGTAGGACCTTAGAGTTGCCTAGGTCCATTCTATTCTAGCATATACTCAACATACTGCCAGAGCAAATGTAGGTTGCAGATTCAGGCAAA
ACACACACACACACACACACAAAACCCTGAAGAGCACAATGAGCATTATTAGCACAGCCAATTTAAAATGATGAGGTGTTAACCACATTT
GTATAAATAATAGTTTCTCTAACCCTGAATCATTATCCTGCATTTTTAATGCAATCGGTTCATAAACATCAAAGTGAAAACACCAAATTT
GTAAGAGGTCAGGACCAACTGGGGCTCTAAATGGAGAGACAGCTGAGAGCTGTGTCCCTATGCGTGGGTGGCCTTGCAGCTGTTGATTCA
CCCTCAGGCTACCAGACAGTTGCCTCTTTGCATTTGCAGAACCAGACTTCAATCTTAGGTAAAAATGTATCCCTCCCATGGACAGGACAT
AAACAATAGATTGACATCAGCTCTGAAAACAGTGCAGCAGCCAGACTCAGCAGTTGCCCTGAAATACTGAGAAGTACCAAGCATAACATC
AAGACTGTTTCTACACAATAATATTTGTCTTTGTACAGCAACACTGGGTTCTCTTAAGTATATTATAAATATAAAAGCTCAAAGTCCAAA
AGGTTCAATGTGATGATATCCTTCTCTACAAATGCCAGGAACACCAGGGTAGATTGCATGAGACATGACTGCCGTATCTTGGTCCTTACT
AGGATTCCCAAATATACTCCTTAATAACCAGTAAAGTTATATTTACACTGGACATTTTAAGAAATACCAGTGTTCGTTGTTAGATGAGAG
ACAGCATAATTTTGGAATCACAACTGAGTTCAGAGTTCAGTTTTGAGTCCTACTAGTTTTGTTTCCTTGTGTAAGTTTCTTAACCTTTGT
AAGGCTAGCATGTAAATCAGATACAATAATATATAGTTCAGGGTGTAAAGATTGGATTAATGTATGCAGTGTCTATCTAGCACAGTGCCT
GTTATGTAGTAGCGTGTCAAGAGATGTTCTCTCTTATGCATTTGGAGGATTAGGTGCTGCACCTATAGGTTTCCATTCATTTCTCATCTA
TGTAATTCTGAGTCTTCCTTTTCTAGATAGAATTCCCCCCAACAAAAATTTAAAGTCTAACAGGTGGTAGGTGCTTATTGAGGCCCAGCA
ATTCTACTTCTGGAAACCTTCCTCAGGAAAAGATTCTGATGACAGAAAATGCTGTGTGAACAGTATTATATAGAATTGTTTTTAATAGCA
AGAAATTTTTTAAAACTTACAAGTTCAGTGATATGAGGACATTTACATAAACTATCGAACCACCAGTCTTCTGTCAATTCCTTTTAAAAT
GATGGTTGTGAAGACTGATGAAAACACAGTGTCAATGATATGTTAACTGAAAAAGTAAGATTAAAAACATTATGGATAGTATAAGTTTCT
TAAATGCCAACAATGCATGAGGTGAATAGAATAAGACTTTTTTTTAAAGAATGTAATTTTTGACAGTCTGAAAAGACAGGCCTTATATTT
ATATTGAGAAAAATGATCCTGACATTTAATGAGACACTAAAACAGTTTTTATTTTTTGCTTACTTATTCTGTTCTAGAATCCAAACTCTA
CATACTGTTTAATAGAGCATTATTGATATTAGCTGTATTAGATGACTGTATGAAGAGTCCTGTTTGCTAGAATCCTACTTTATCTTTTAA
GTTTTGCTAATTACCCTGCAATGAATGTTGAACATAAAAAATTTGACTCCCTTTCCATGTGTCCACTGTTTCCTTGTGCCTTTTGATTAA
TAAAACTTTATTTTTAAGTGAGAA

>22224_22224_2_DENND1B-RRP15_DENND1B_chr1_197741998_ENST00000367396_RRP15_chr1_218475636_ENST00000366932_length(amino acids)=263AA_BP=27
MDCRTKANPDRTFDLVLKVKCHASENEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNMGWADAMAKVLNKKTPESKP
TILVKNKKLEKEKEKLKQERLEKIKQRDKRLEWEMMCRVKPDVVQDKETERNLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGSSMRKRA
KLISTVSKKDFISVLRGMDGSTNETASSRKKPKAKQTEVKSEEGPGWTILRDDFMMGASMKDWDKESDGPDDSRPESASDSDT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DENND1B-RRP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DENND1B-RRP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DENND1B-RRP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND1BC0008312Primary biliary cirrhosis1CTD_human
HgeneDENND1BC0010346Crohn Disease1CTD_human
HgeneDENND1BC0023892Biliary cirrhosis1CTD_human
HgeneDENND1BC0156147Crohn's disease of large bowel1CTD_human
HgeneDENND1BC0238065Secondary Biliary Cholangitis1CTD_human
HgeneDENND1BC0267380Crohn's disease of the ileum1CTD_human
HgeneDENND1BC0678202Regional enteritis1CTD_human
HgeneDENND1BC0949272IIeocolitis1CTD_human
HgeneDENND1BC4551595Biliary Cirrhosis, Primary, 11CTD_human