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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNST-LNX1 (FusionGDB2 ID:HG163882TG84708)

Fusion Gene Summary for CNST-LNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: CNST-LNX1
Fusion gene ID: hg163882tg84708
HgeneTgene
Gene symbol

CNST

LNX1

Gene ID

163882

84708

Gene nameconsortin, connexin sorting proteinligand of numb-protein X 1
SynonymsC1orf71|PPP1R64LNX|MPDZ|PDZRN2
Cytomap('CNST')('LNX1')

1q44

4q12

Type of geneprotein-codingprotein-coding
Descriptionconsortinprotein phosphatase 1, regulatory subunit 64E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000483271, ENST00000366512, 
ENST00000366513, 
Fusion gene scores* DoF score8 X 6 X 8=3847 X 10 X 6=420
# samples 117
** MAII scorelog2(11/384*10)=-1.8036027871965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/420*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNST [Title/Abstract] AND LNX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNST(246755243)-LNX1(54373636), # samples:3
Anticipated loss of major functional domain due to fusion event.CNST-LNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNST-LNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNST-LNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CNST-LNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNST

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across CNST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LNX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A197-06ACNSTchr1

246755243

-LNX1chr4

54373636

-
ChimerDB4SKCMTCGA-ER-A197-06ACNSTchr1

246755243

+LNX1chr4

54373636

-


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Fusion Gene ORF analysis for CNST-LNX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000483271ENST00000263925CNSTchr1

246755243

+LNX1chr4

54373636

-
3UTR-3CDSENST00000483271ENST00000306888CNSTchr1

246755243

+LNX1chr4

54373636

-
3UTR-intronENST00000483271ENST00000504605CNSTchr1

246755243

+LNX1chr4

54373636

-
5CDS-intronENST00000366512ENST00000504605CNSTchr1

246755243

+LNX1chr4

54373636

-
5CDS-intronENST00000366513ENST00000504605CNSTchr1

246755243

+LNX1chr4

54373636

-
In-frameENST00000366512ENST00000263925CNSTchr1

246755243

+LNX1chr4

54373636

-
In-frameENST00000366512ENST00000306888CNSTchr1

246755243

+LNX1chr4

54373636

-
In-frameENST00000366513ENST00000263925CNSTchr1

246755243

+LNX1chr4

54373636

-
In-frameENST00000366513ENST00000306888CNSTchr1

246755243

+LNX1chr4

54373636

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366513CNSTchr1246755243+ENST00000306888LNX1chr454373636-38196481642212682
ENST00000366513CNSTchr1246755243+ENST00000263925LNX1chr454373636-26646481642212682
ENST00000366512CNSTchr1246755243+ENST00000306888LNX1chr454373636-39307591492323724
ENST00000366512CNSTchr1246755243+ENST00000263925LNX1chr454373636-27757591492323724

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366513ENST00000306888CNSTchr1246755243+LNX1chr454373636-0.0009106590.99908936
ENST00000366513ENST00000263925CNSTchr1246755243+LNX1chr454373636-0.0030004990.9969995
ENST00000366512ENST00000306888CNSTchr1246755243+LNX1chr454373636-0.0010137210.9989863
ENST00000366512ENST00000263925CNSTchr1246755243+LNX1chr454373636-0.0034445320.99655545

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Fusion Genomic Features for CNST-LNX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CNST-LNX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246755243/chr4:54373636)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211274_359207729.0DomainPDZ 1
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211381_464207729.0DomainPDZ 2
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211507_593207729.0DomainPDZ 3
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211638_724207729.0DomainPDZ 4
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110274_359111633.0DomainPDZ 1
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110381_464111633.0DomainPDZ 2
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110507_593111633.0DomainPDZ 3
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110638_724111633.0DomainPDZ 4
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110181_184111633.0MotifNote=NPXY motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNSTchr1:246755243chr4:54373636ENST00000366512+291_664126617.0Topological domainCytoplasmic
HgeneCNSTchr1:246755243chr4:54373636ENST00000366512+29686_725126617.0Topological domainExtracellular
HgeneCNSTchr1:246755243chr4:54373636ENST00000366513+2111_664126726.0Topological domainCytoplasmic
HgeneCNSTchr1:246755243chr4:54373636ENST00000366513+211686_725126726.0Topological domainExtracellular
HgeneCNSTchr1:246755243chr4:54373636ENST00000366512+29665_685126617.0TransmembraneHelical
HgeneCNSTchr1:246755243chr4:54373636ENST00000366513+211665_685126726.0TransmembraneHelical
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211181_184207729.0MotifNote=NPXY motif
TgeneLNX1chr1:246755243chr4:54373636ENST0000026392521141_79207729.0Zinc fingerRING-type
TgeneLNX1chr1:246755243chr4:54373636ENST0000030688811041_79111633.0Zinc fingerRING-type


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Fusion Gene Sequence for CNST-LNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17851_17851_1_CNST-LNX1_CNST_chr1_246755243_ENST00000366512_LNX1_chr4_54373636_ENST00000263925_length(transcript)=2775nt_BP=759nt
CGCGGGCCGCCAGCCTCCAGCCGGCCAGCCGCGAGGGGTGCGCAGAGGGAGGCGGGGCGGAAAGGCGAGAGGTGTCTCCTCCACCGGAGC
CAGGGGAGACCCGAGCAAGCTCCGTGACAGCACGTCGGCCGCCATGTCGCCGAGTGGGGCTGGAAACAGACCCGGCGCCCAGCGGTAGCC
CTCCTTGCGCCTCCGATTCCCAGGTGAGGAGAGGAGGAGCGGGATGCAGGGGACCCGCCGGCTCGCGGCCGGGATGGAAAGCCTTTCGGA
AGCCTCTCGCTCCTCCCCCTGCGCTGTCCTCCTCCAGCCGCGCAGCCTCTGCCCTCCGGACATGGAAGGTCTTTAATGTAACTTTAAATG
GTTCACCAAAGGATGCTCTAATGGATGACAGCGATACTCCTACATATTATCTGCAAATAGAACCACAAGATGGATGTCATCCTGGTGACA
GCGTGGAAAGGAGTGTGACCTGTCTGCCTTCTGCATCAGATGAAAATGAAAATCAGCTTGACGGGGACGGGCATGAGCATCTGACCAGCA
GTGACAGTGCGATGGGAAAGCCCCAAGTGTCTGAGCAGGACAGTCTCAATAATAATGAAAGCTGCACATTGAGCTGCGAGGTGGCTGCAG
GTGAGAACTTGCAAAACACCCTTTGTGAAGCCTCCAGAGATGAACAGGCCTTCTTGGGAAAGGACAAAAAAATTCCTGGAAAAAGAAGTC
CAAGAAGCAAAAAAGGGACTGCTAAGAAGATACCACCAGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAA
ATCGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCA
CTGCCCCTGAAGTCTTTCCAAGGTTGTACCACCTGATTCCAGATGGTGAAATTACCAGCATCAAGATCAATCGAGTAGATCCCAGTGAAA
GCCTCTCTATTAGGCTGGTGGGAGGTAGCGAAACCCCACTGGTCCATATCATTATCCAACACATTTATCGTGATGGGGTGATCGCCAGAG
ACGGCCGGCTACTGCCAGGAGACATCATTCTAAAGGTCAACGGGATGGACATCAGCAATGTCCCTCACAACTACGCTGTGCGTCTCCTGC
GGCAGCCCTGCCAGGTGCTGTGGCTGACTGTGATGCGTGAACAGAAGTTCCGCAGCAGGAACAATGGACAGGCCCCGGATGCCTACAGAC
CCCGAGATGACAGCTTTCATGTGATTCTCAACAAAAGTAGCCCCGAGGAGCAGCTTGGAATAAAACTGGTGCGCAAGGTGGATGAGCCTG
GGGTTTTCATCTTCAATGTGCTGGATGGCGGTGTGGCATATCGACATGGTCAGCTTGAGGAGAATGACCGTGTGTTAGCCATCAATGGAC
ATGATCTTCGATATGGCAGCCCAGAAAGTGCGGCTCATCTGATTCAGGCCAGTGAAAGACGTGTTCACCTCGTCGTGTCCCGCCAGGTTC
GGCAGCGGAGCCCTGACATCTTTCAGGAAGCCGGCTGGAACAGCAATGGCAGCTGGTCCCCAGGGCCAGGGGAGAGGAGCAACACTCCCA
AGCCCCTCCATCCTACAATTACTTGTCATGAGAAGGTGGTAAATATCCAAAAAGACCCCGGTGAATCTCTCGGCATGACCGTCGCAGGGG
GAGCATCACATAGAGAATGGGATTTGCCTATCTATGTCATCAGTGTTGAGCCCGGAGGAGTCATAAGCAGAGATGGAAGAATAAAAACAG
GTGACATTTTGTTGAATGTGGATGGGGTCGAACTGACAGAGGTCAGCCGGAGTGAGGCAGTGGCATTATTGAAAAGAACATCATCCTCGA
TAGTACTCAAAGCTTTGGAAGTCAAAGAGTATGAGCCCCAGGAAGACTGCAGCAGCCCAGCAGCCCTGGACTCCAACCACAACATGGCCC
CACCCAGTGACTGGTCCCCATCCTGGGTCATGTGGCTGGAATTACCACGGTGCTTGTATAACTGTAAAGATATTGTATTACGAAGAAACA
CAGCTGGAAGTCTGGGCTTCTGCATTGTAGGAGGTTATGAAGAATACAATGGAAACAAACCTTTTTTCATCAAATCCATTGTTGAAGGAA
CACCAGCATACAATGATGGAAGAATTAGATGTGGTGATATTCTTCTTGCTGTCAATGGTAGAAGTACATCAGGAATGATACATGCTTGCT
TGGCAAGACTGCTGAAAGAACTTAAAGGAAGAATTACTCTAACTATTGTTTCTTGGCCTGGCACTTTTTTATAGAATCAATGATGGGTCA
GAGGAAAACAGAAAAATCACAAATAGGCTAAGAAGTTGAAACACTATATTTATCTTGTCAGTTTTTATATTTAAAGAAAGAATACATTGT
AAAAATGTCAGGAAAAGTATGATCATCTAATGAAAGCCAGTTACACCTCAGAAAATATGATTCCAAAAAAATTAAAACTACTAGTTTTTT
TTCAGTGTGGAGGATTTCTCATTACTCTACAACATTGTTTATATTTTTTCTATTCAATAAAAAGCCCTAAAACAACTAAAATGATTTGTA
TACCCCACTGAATTCAAGCTGATTTAAATTTAAAATTTGGTATATGCTGAAGTCTGCCAAGGGTACATTATGGCCATTTTTAATTTACAG
CTAAAATATTTTTTAAAATGCATTGCTGAGAAACGTTGCTTTCATCAAACAAGAATAAATATTTTTCAGAAGTTA

>17851_17851_1_CNST-LNX1_CNST_chr1_246755243_ENST00000366512_LNX1_chr4_54373636_ENST00000263925_length(amino acids)=724AA_BP=203
METDPAPSGSPPCASDSQVRRGGAGCRGPAGSRPGWKAFRKPLAPPPALSSSSRAASALRTWKVFNVTLNGSPKDALMDDSDTPTYYLQI
EPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLG
KDKKIPGKRSPRSKKGTAKKIPPARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITS
IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR
NNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER
RVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG
VISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLY
NCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP
GTFL

--------------------------------------------------------------
>17851_17851_2_CNST-LNX1_CNST_chr1_246755243_ENST00000366512_LNX1_chr4_54373636_ENST00000306888_length(transcript)=3930nt_BP=759nt
CGCGGGCCGCCAGCCTCCAGCCGGCCAGCCGCGAGGGGTGCGCAGAGGGAGGCGGGGCGGAAAGGCGAGAGGTGTCTCCTCCACCGGAGC
CAGGGGAGACCCGAGCAAGCTCCGTGACAGCACGTCGGCCGCCATGTCGCCGAGTGGGGCTGGAAACAGACCCGGCGCCCAGCGGTAGCC
CTCCTTGCGCCTCCGATTCCCAGGTGAGGAGAGGAGGAGCGGGATGCAGGGGACCCGCCGGCTCGCGGCCGGGATGGAAAGCCTTTCGGA
AGCCTCTCGCTCCTCCCCCTGCGCTGTCCTCCTCCAGCCGCGCAGCCTCTGCCCTCCGGACATGGAAGGTCTTTAATGTAACTTTAAATG
GTTCACCAAAGGATGCTCTAATGGATGACAGCGATACTCCTACATATTATCTGCAAATAGAACCACAAGATGGATGTCATCCTGGTGACA
GCGTGGAAAGGAGTGTGACCTGTCTGCCTTCTGCATCAGATGAAAATGAAAATCAGCTTGACGGGGACGGGCATGAGCATCTGACCAGCA
GTGACAGTGCGATGGGAAAGCCCCAAGTGTCTGAGCAGGACAGTCTCAATAATAATGAAAGCTGCACATTGAGCTGCGAGGTGGCTGCAG
GTGAGAACTTGCAAAACACCCTTTGTGAAGCCTCCAGAGATGAACAGGCCTTCTTGGGAAAGGACAAAAAAATTCCTGGAAAAAGAAGTC
CAAGAAGCAAAAAAGGGACTGCTAAGAAGATACCACCAGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAA
ATCGAGCTTTGAGTGTTCTTCGAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCA
CTGCCCCTGAAGTCTTTCCAAGGTTGTACCACCTGATTCCAGATGGTGAAATTACCAGCATCAAGATCAATCGAGTAGATCCCAGTGAAA
GCCTCTCTATTAGGCTGGTGGGAGGTAGCGAAACCCCACTGGTCCATATCATTATCCAACACATTTATCGTGATGGGGTGATCGCCAGAG
ACGGCCGGCTACTGCCAGGAGACATCATTCTAAAGGTCAACGGGATGGACATCAGCAATGTCCCTCACAACTACGCTGTGCGTCTCCTGC
GGCAGCCCTGCCAGGTGCTGTGGCTGACTGTGATGCGTGAACAGAAGTTCCGCAGCAGGAACAATGGACAGGCCCCGGATGCCTACAGAC
CCCGAGATGACAGCTTTCATGTGATTCTCAACAAAAGTAGCCCCGAGGAGCAGCTTGGAATAAAACTGGTGCGCAAGGTGGATGAGCCTG
GGGTTTTCATCTTCAATGTGCTGGATGGCGGTGTGGCATATCGACATGGTCAGCTTGAGGAGAATGACCGTGTGTTAGCCATCAATGGAC
ATGATCTTCGATATGGCAGCCCAGAAAGTGCGGCTCATCTGATTCAGGCCAGTGAAAGACGTGTTCACCTCGTCGTGTCCCGCCAGGTTC
GGCAGCGGAGCCCTGACATCTTTCAGGAAGCCGGCTGGAACAGCAATGGCAGCTGGTCCCCAGGGCCAGGGGAGAGGAGCAACACTCCCA
AGCCCCTCCATCCTACAATTACTTGTCATGAGAAGGTGGTAAATATCCAAAAAGACCCCGGTGAATCTCTCGGCATGACCGTCGCAGGGG
GAGCATCACATAGAGAATGGGATTTGCCTATCTATGTCATCAGTGTTGAGCCCGGAGGAGTCATAAGCAGAGATGGAAGAATAAAAACAG
GTGACATTTTGTTGAATGTGGATGGGGTCGAACTGACAGAGGTCAGCCGGAGTGAGGCAGTGGCATTATTGAAAAGAACATCATCCTCGA
TAGTACTCAAAGCTTTGGAAGTCAAAGAGTATGAGCCCCAGGAAGACTGCAGCAGCCCAGCAGCCCTGGACTCCAACCACAACATGGCCC
CACCCAGTGACTGGTCCCCATCCTGGGTCATGTGGCTGGAATTACCACGGTGCTTGTATAACTGTAAAGATATTGTATTACGAAGAAACA
CAGCTGGAAGTCTGGGCTTCTGCATTGTAGGAGGTTATGAAGAATACAATGGAAACAAACCTTTTTTCATCAAATCCATTGTTGAAGGAA
CACCAGCATACAATGATGGAAGAATTAGATGTGGTGATATTCTTCTTGCTGTCAATGGTAGAAGTACATCAGGAATGATACATGCTTGCT
TGGCAAGACTGCTGAAAGAACTTAAAGGAAGAATTACTCTAACTATTGTTTCTTGGCCTGGCACTTTTTTATAGAATCAATGATGGGTCA
GAGGAAAACAGAAAAATCACAAATAGGCTAAGAAGTTGAAACACTATATTTATCTTGTCAGTTTTTATATTTAAAGAAAGAATACATTGT
AAAAATGTCAGGAAAAGTATGATCATCTAATGAAAGCCAGTTACACCTCAGAAAATATGATTCCAAAAAAATTAAAACTACTAGTTTTTT
TTCAGTGTGGAGGATTTCTCATTACTCTACAACATTGTTTATATTTTTTCTATTCAATAAAAAGCCCTAAAACAACTAAAATGATTTGTA
TACCCCACTGAATTCAAGCTGATTTAAATTTAAAATTTGGTATATGCTGAAGTCTGCCAAGGGTACATTATGGCCATTTTTAATTTACAG
CTAAAATATTTTTTAAAATGCATTGCTGAGAAACGTTGCTTTCATCAAACAAGAATAAATATTTTTCAGAAGTTATAGTTGTCTTTTAGT
ATGTGATACTAATTAAGATTACTTTTGTATTATCACTATTTAAAAGATCCTAGTAATTTATTCTTTCAAATACCATGTTATTTGTTACCA
TCACCGATGAATACCTCCTAGGCTTATCCCTAAAAATGCTCGCTCAGAGAATTAATTATAAACTTGTTTTGTTTTTAGTAAGAAATGGCT
AAAGCTCTTTTTTTCCACAATCGTTAGTAACTGTATAAAAACTCATGCTGCTCCACCAGTGGGCCTTGGAAAATGCATCAAGAAGGCCAA
ACCAGCTTGACCCTGGCTCACAGACATGGTCATGAGGCGATTTAAATTTGTGCCACAATGAAGAGTGTGTGTACACATGCCTCCTAGAAA
CTACACTATGGGTAATTAATTAATTTATTTCATAGAGGCCACCCAGATGCCTTATAGGTTTTATTAATTTGGATATGAAAGTGTACCCCA
TTTGGTTTCACCAGGAACCCAAATTTAGAATATTGAAAAGCCATCAAAAAGTTGTGATATCAAAAATGTATGAGTCTCTTAATATACTAA
GCAAGAGTGTCACAGCAGTAATGATAAAGACTAGTTTTAATCTCAAGCCTTAGAGGGGCCCTTTGTTGCCTTTTGTGATGCAGCCTCTTA
AGAGAGTGGTGTTTGATTAACAAAAAAACTGTGGCCCAAGTGGAACCCTTGACCTTTTCTCAGATAATCTGTGTATGTACACAGCTAACA
CAGCTCTTTAGATTCCCTGTTAAGTGACTCATTCACATTCCTTTCTTGGATATAAAGTCATTGCTGTCTTTTTATTTTTGAAATAGTACA
AGACAAAGATTTTTAACTTAACATGAAAAATTCACTCTTTTATTTTGGAAAAAAAGTTAACTTTTCATACTAACAAACAGAACAAGATTT
AAGGTAAATTTCTTAAACATTATCCAGAAAAATAACAAGATTTATAGTATCTACTTCTGGTACTAATATACACAAAAGGCCAAAACCATG
CCTATTCTGCAGGTGTAGCTTCGGTGCTCTCCTGTTCAGGGGCAGGCTCACTGCCCGCTTCTTTTCCTTCTTTGCTTCTTTTAGATTTTT
TGTGTTTGTGTCTCCTGTGACTATCTCCTTCTTCACTTTCATGGCGACGTCTACTATTAC

>17851_17851_2_CNST-LNX1_CNST_chr1_246755243_ENST00000366512_LNX1_chr4_54373636_ENST00000306888_length(amino acids)=724AA_BP=203
METDPAPSGSPPCASDSQVRRGGAGCRGPAGSRPGWKAFRKPLAPPPALSSSSRAASALRTWKVFNVTLNGSPKDALMDDSDTPTYYLQI
EPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSDSAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLG
KDKKIPGKRSPRSKKGTAKKIPPARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITS
IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR
NNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER
RVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG
VISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLY
NCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP
GTFL

--------------------------------------------------------------
>17851_17851_3_CNST-LNX1_CNST_chr1_246755243_ENST00000366513_LNX1_chr4_54373636_ENST00000263925_length(transcript)=2664nt_BP=648nt
TCTATGCTCCGCGGTCGCGGGCCGCCAGCCTCCAGCCGGCCAGCCGCGAGGGGTGCGCAGAGGGAGGCGGGGCGGAAAGGCGAGAGGTGT
CTCCTCCACCGGAGCCAGGGGAGACCCGAGCAAGCTCCGTGACAGCACGTCGGCCGCCATGTCGCCGAGTGGGGCTGGAAACAGACCCGG
CGCCCAGCGGTAGCCCTCCTTGCGCCTCCGATTCCCAGACATGGAAGGTCTTTAATGTAACTTTAAATGGTTCACCAAAGGATGCTCTAA
TGGATGACAGCGATACTCCTACATATTATCTGCAAATAGAACCACAAGATGGATGTCATCCTGGTGACAGCGTGGAAAGGAGTGTGACCT
GTCTGCCTTCTGCATCAGATGAAAATGAAAATCAGCTTGACGGGGACGGGCATGAGCATCTGACCAGCAGTGACAGTGCGATGGGAAAGC
CCCAAGTGTCTGAGCAGGACAGTCTCAATAATAATGAAAGCTGCACATTGAGCTGCGAGGTGGCTGCAGGTGAGAACTTGCAAAACACCC
TTTGTGAAGCCTCCAGAGATGAACAGGCCTTCTTGGGAAAGGACAAAAAAATTCCTGGAAAAAGAAGTCCAAGAAGCAAAAAAGGGACTG
CTAAGAAGATACCACCAGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAATCGAGCTTTGAGTGTTCTTC
GAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACTGCCCCTGAAGTCTTTCCAA
GGTTGTACCACCTGATTCCAGATGGTGAAATTACCAGCATCAAGATCAATCGAGTAGATCCCAGTGAAAGCCTCTCTATTAGGCTGGTGG
GAGGTAGCGAAACCCCACTGGTCCATATCATTATCCAACACATTTATCGTGATGGGGTGATCGCCAGAGACGGCCGGCTACTGCCAGGAG
ACATCATTCTAAAGGTCAACGGGATGGACATCAGCAATGTCCCTCACAACTACGCTGTGCGTCTCCTGCGGCAGCCCTGCCAGGTGCTGT
GGCTGACTGTGATGCGTGAACAGAAGTTCCGCAGCAGGAACAATGGACAGGCCCCGGATGCCTACAGACCCCGAGATGACAGCTTTCATG
TGATTCTCAACAAAAGTAGCCCCGAGGAGCAGCTTGGAATAAAACTGGTGCGCAAGGTGGATGAGCCTGGGGTTTTCATCTTCAATGTGC
TGGATGGCGGTGTGGCATATCGACATGGTCAGCTTGAGGAGAATGACCGTGTGTTAGCCATCAATGGACATGATCTTCGATATGGCAGCC
CAGAAAGTGCGGCTCATCTGATTCAGGCCAGTGAAAGACGTGTTCACCTCGTCGTGTCCCGCCAGGTTCGGCAGCGGAGCCCTGACATCT
TTCAGGAAGCCGGCTGGAACAGCAATGGCAGCTGGTCCCCAGGGCCAGGGGAGAGGAGCAACACTCCCAAGCCCCTCCATCCTACAATTA
CTTGTCATGAGAAGGTGGTAAATATCCAAAAAGACCCCGGTGAATCTCTCGGCATGACCGTCGCAGGGGGAGCATCACATAGAGAATGGG
ATTTGCCTATCTATGTCATCAGTGTTGAGCCCGGAGGAGTCATAAGCAGAGATGGAAGAATAAAAACAGGTGACATTTTGTTGAATGTGG
ATGGGGTCGAACTGACAGAGGTCAGCCGGAGTGAGGCAGTGGCATTATTGAAAAGAACATCATCCTCGATAGTACTCAAAGCTTTGGAAG
TCAAAGAGTATGAGCCCCAGGAAGACTGCAGCAGCCCAGCAGCCCTGGACTCCAACCACAACATGGCCCCACCCAGTGACTGGTCCCCAT
CCTGGGTCATGTGGCTGGAATTACCACGGTGCTTGTATAACTGTAAAGATATTGTATTACGAAGAAACACAGCTGGAAGTCTGGGCTTCT
GCATTGTAGGAGGTTATGAAGAATACAATGGAAACAAACCTTTTTTCATCAAATCCATTGTTGAAGGAACACCAGCATACAATGATGGAA
GAATTAGATGTGGTGATATTCTTCTTGCTGTCAATGGTAGAAGTACATCAGGAATGATACATGCTTGCTTGGCAAGACTGCTGAAAGAAC
TTAAAGGAAGAATTACTCTAACTATTGTTTCTTGGCCTGGCACTTTTTTATAGAATCAATGATGGGTCAGAGGAAAACAGAAAAATCACA
AATAGGCTAAGAAGTTGAAACACTATATTTATCTTGTCAGTTTTTATATTTAAAGAAAGAATACATTGTAAAAATGTCAGGAAAAGTATG
ATCATCTAATGAAAGCCAGTTACACCTCAGAAAATATGATTCCAAAAAAATTAAAACTACTAGTTTTTTTTCAGTGTGGAGGATTTCTCA
TTACTCTACAACATTGTTTATATTTTTTCTATTCAATAAAAAGCCCTAAAACAACTAAAATGATTTGTATACCCCACTGAATTCAAGCTG
ATTTAAATTTAAAATTTGGTATATGCTGAAGTCTGCCAAGGGTACATTATGGCCATTTTTAATTTACAGCTAAAATATTTTTTAAAATGC
ATTGCTGAGAAACGTTGCTTTCATCAAACAAGAATAAATATTTTTCAGAAGTTA

>17851_17851_3_CNST-LNX1_CNST_chr1_246755243_ENST00000366513_LNX1_chr4_54373636_ENST00000263925_length(amino acids)=682AA_BP=161
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPARPFERSTIRSRSFKKINR
ALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDG
RLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGV
FIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKP
LHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV
LKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP
AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL

--------------------------------------------------------------
>17851_17851_4_CNST-LNX1_CNST_chr1_246755243_ENST00000366513_LNX1_chr4_54373636_ENST00000306888_length(transcript)=3819nt_BP=648nt
TCTATGCTCCGCGGTCGCGGGCCGCCAGCCTCCAGCCGGCCAGCCGCGAGGGGTGCGCAGAGGGAGGCGGGGCGGAAAGGCGAGAGGTGT
CTCCTCCACCGGAGCCAGGGGAGACCCGAGCAAGCTCCGTGACAGCACGTCGGCCGCCATGTCGCCGAGTGGGGCTGGAAACAGACCCGG
CGCCCAGCGGTAGCCCTCCTTGCGCCTCCGATTCCCAGACATGGAAGGTCTTTAATGTAACTTTAAATGGTTCACCAAAGGATGCTCTAA
TGGATGACAGCGATACTCCTACATATTATCTGCAAATAGAACCACAAGATGGATGTCATCCTGGTGACAGCGTGGAAAGGAGTGTGACCT
GTCTGCCTTCTGCATCAGATGAAAATGAAAATCAGCTTGACGGGGACGGGCATGAGCATCTGACCAGCAGTGACAGTGCGATGGGAAAGC
CCCAAGTGTCTGAGCAGGACAGTCTCAATAATAATGAAAGCTGCACATTGAGCTGCGAGGTGGCTGCAGGTGAGAACTTGCAAAACACCC
TTTGTGAAGCCTCCAGAGATGAACAGGCCTTCTTGGGAAAGGACAAAAAAATTCCTGGAAAAAGAAGTCCAAGAAGCAAAAAAGGGACTG
CTAAGAAGATACCACCAGCACGGCCCTTTGAGAGATCCACTATTAGAAGCAGATCATTTAAAAAAATAAATCGAGCTTTGAGTGTTCTTC
GAAGGACAAAGAGCGGGAGTGCAGTTGCCAACCATGCCGACCAGGGCAGGGAAAATTCTGAAAACACCACTGCCCCTGAAGTCTTTCCAA
GGTTGTACCACCTGATTCCAGATGGTGAAATTACCAGCATCAAGATCAATCGAGTAGATCCCAGTGAAAGCCTCTCTATTAGGCTGGTGG
GAGGTAGCGAAACCCCACTGGTCCATATCATTATCCAACACATTTATCGTGATGGGGTGATCGCCAGAGACGGCCGGCTACTGCCAGGAG
ACATCATTCTAAAGGTCAACGGGATGGACATCAGCAATGTCCCTCACAACTACGCTGTGCGTCTCCTGCGGCAGCCCTGCCAGGTGCTGT
GGCTGACTGTGATGCGTGAACAGAAGTTCCGCAGCAGGAACAATGGACAGGCCCCGGATGCCTACAGACCCCGAGATGACAGCTTTCATG
TGATTCTCAACAAAAGTAGCCCCGAGGAGCAGCTTGGAATAAAACTGGTGCGCAAGGTGGATGAGCCTGGGGTTTTCATCTTCAATGTGC
TGGATGGCGGTGTGGCATATCGACATGGTCAGCTTGAGGAGAATGACCGTGTGTTAGCCATCAATGGACATGATCTTCGATATGGCAGCC
CAGAAAGTGCGGCTCATCTGATTCAGGCCAGTGAAAGACGTGTTCACCTCGTCGTGTCCCGCCAGGTTCGGCAGCGGAGCCCTGACATCT
TTCAGGAAGCCGGCTGGAACAGCAATGGCAGCTGGTCCCCAGGGCCAGGGGAGAGGAGCAACACTCCCAAGCCCCTCCATCCTACAATTA
CTTGTCATGAGAAGGTGGTAAATATCCAAAAAGACCCCGGTGAATCTCTCGGCATGACCGTCGCAGGGGGAGCATCACATAGAGAATGGG
ATTTGCCTATCTATGTCATCAGTGTTGAGCCCGGAGGAGTCATAAGCAGAGATGGAAGAATAAAAACAGGTGACATTTTGTTGAATGTGG
ATGGGGTCGAACTGACAGAGGTCAGCCGGAGTGAGGCAGTGGCATTATTGAAAAGAACATCATCCTCGATAGTACTCAAAGCTTTGGAAG
TCAAAGAGTATGAGCCCCAGGAAGACTGCAGCAGCCCAGCAGCCCTGGACTCCAACCACAACATGGCCCCACCCAGTGACTGGTCCCCAT
CCTGGGTCATGTGGCTGGAATTACCACGGTGCTTGTATAACTGTAAAGATATTGTATTACGAAGAAACACAGCTGGAAGTCTGGGCTTCT
GCATTGTAGGAGGTTATGAAGAATACAATGGAAACAAACCTTTTTTCATCAAATCCATTGTTGAAGGAACACCAGCATACAATGATGGAA
GAATTAGATGTGGTGATATTCTTCTTGCTGTCAATGGTAGAAGTACATCAGGAATGATACATGCTTGCTTGGCAAGACTGCTGAAAGAAC
TTAAAGGAAGAATTACTCTAACTATTGTTTCTTGGCCTGGCACTTTTTTATAGAATCAATGATGGGTCAGAGGAAAACAGAAAAATCACA
AATAGGCTAAGAAGTTGAAACACTATATTTATCTTGTCAGTTTTTATATTTAAAGAAAGAATACATTGTAAAAATGTCAGGAAAAGTATG
ATCATCTAATGAAAGCCAGTTACACCTCAGAAAATATGATTCCAAAAAAATTAAAACTACTAGTTTTTTTTCAGTGTGGAGGATTTCTCA
TTACTCTACAACATTGTTTATATTTTTTCTATTCAATAAAAAGCCCTAAAACAACTAAAATGATTTGTATACCCCACTGAATTCAAGCTG
ATTTAAATTTAAAATTTGGTATATGCTGAAGTCTGCCAAGGGTACATTATGGCCATTTTTAATTTACAGCTAAAATATTTTTTAAAATGC
ATTGCTGAGAAACGTTGCTTTCATCAAACAAGAATAAATATTTTTCAGAAGTTATAGTTGTCTTTTAGTATGTGATACTAATTAAGATTA
CTTTTGTATTATCACTATTTAAAAGATCCTAGTAATTTATTCTTTCAAATACCATGTTATTTGTTACCATCACCGATGAATACCTCCTAG
GCTTATCCCTAAAAATGCTCGCTCAGAGAATTAATTATAAACTTGTTTTGTTTTTAGTAAGAAATGGCTAAAGCTCTTTTTTTCCACAAT
CGTTAGTAACTGTATAAAAACTCATGCTGCTCCACCAGTGGGCCTTGGAAAATGCATCAAGAAGGCCAAACCAGCTTGACCCTGGCTCAC
AGACATGGTCATGAGGCGATTTAAATTTGTGCCACAATGAAGAGTGTGTGTACACATGCCTCCTAGAAACTACACTATGGGTAATTAATT
AATTTATTTCATAGAGGCCACCCAGATGCCTTATAGGTTTTATTAATTTGGATATGAAAGTGTACCCCATTTGGTTTCACCAGGAACCCA
AATTTAGAATATTGAAAAGCCATCAAAAAGTTGTGATATCAAAAATGTATGAGTCTCTTAATATACTAAGCAAGAGTGTCACAGCAGTAA
TGATAAAGACTAGTTTTAATCTCAAGCCTTAGAGGGGCCCTTTGTTGCCTTTTGTGATGCAGCCTCTTAAGAGAGTGGTGTTTGATTAAC
AAAAAAACTGTGGCCCAAGTGGAACCCTTGACCTTTTCTCAGATAATCTGTGTATGTACACAGCTAACACAGCTCTTTAGATTCCCTGTT
AAGTGACTCATTCACATTCCTTTCTTGGATATAAAGTCATTGCTGTCTTTTTATTTTTGAAATAGTACAAGACAAAGATTTTTAACTTAA
CATGAAAAATTCACTCTTTTATTTTGGAAAAAAAGTTAACTTTTCATACTAACAAACAGAACAAGATTTAAGGTAAATTTCTTAAACATT
ATCCAGAAAAATAACAAGATTTATAGTATCTACTTCTGGTACTAATATACACAAAAGGCCAAAACCATGCCTATTCTGCAGGTGTAGCTT
CGGTGCTCTCCTGTTCAGGGGCAGGCTCACTGCCCGCTTCTTTTCCTTCTTTGCTTCTTTTAGATTTTTTGTGTTTGTGTCTCCTGTGAC
TATCTCCTTCTTCACTTTCATGGCGACGTCTACTATTAC

>17851_17851_4_CNST-LNX1_CNST_chr1_246755243_ENST00000366513_LNX1_chr4_54373636_ENST00000306888_length(amino acids)=682AA_BP=161
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPARPFERSTIRSRSFKKINR
ALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDG
RLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGV
FIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKP
LHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV
LKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP
AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CNST-LNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLNX1chr1:246755243chr4:54373636ENST00000306888110186_244111.33333333333333633.0MAGEB18


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneLNX1chr1:246755243chr4:54373636ENST00000263925211186_244207.33333333333334729.0MAGEB18


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNST-LNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNST-LNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNSTC0040128Thyroid Diseases1CTD_human