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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:AP2B1-RAB20 (FusionGDB2 ID:HG163TG55647)

Fusion Gene Summary for AP2B1-RAB20

check button Fusion gene summary
Fusion gene informationFusion gene name: AP2B1-RAB20
Fusion gene ID: hg163tg55647
HgeneTgene
Gene symbol

AP2B1

RAB20

Gene ID

163

55647

Gene nameadaptor related protein complex 2 subunit beta 1RAB20, member RAS oncogene family
SynonymsADTB2|AP105B|AP2-BETA|CLAPB1-
Cytomap('AP2B1')('RAB20')

17q12

13q34

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit betaadapter-related protein complex 2 beta subunitadapter-related protein complex 2 subunit betaadaptin, beta 2 (beta)adaptor protein complex AP-2 subunit betaadaptor related protein complex 2 beta 1 subunitadaptor-related proteras-related protein Rab-20
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000538556, ENST00000262325, 
ENST00000312678, ENST00000537622, 
ENST00000589344, ENST00000592545, 
ENST00000545922, 
Fusion gene scores* DoF score10 X 9 X 5=4504 X 1 X 4=16
# samples 94
** MAII scorelog2(9/450*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AP2B1 [Title/Abstract] AND RAB20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP2B1(33921086)-RAB20(111176544), # samples:1
Anticipated loss of major functional domain due to fusion event.AP2B1-RAB20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2B1-RAB20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2B1

GO:0072583

clathrin-dependent endocytosis

23676497


check buttonFusion gene breakpoints across AP2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RAB20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-6225-01AAP2B1chr17

33921086

+RAB20chr13

111176544

-


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Fusion Gene ORF analysis for AP2B1-RAB20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000538556ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000262325ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000312678ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000537622ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000589344ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
In-frameENST00000592545ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-
intron-3CDSENST00000545922ENST00000267328AP2B1chr17

33921086

+RAB20chr13

111176544

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262325AP2B1chr1733921086+ENST00000267328RAB20chr13111176544-17185901492902196
ENST00000592545AP2B1chr1733921086+ENST00000267328RAB20chr13111176544-13031751077487196
ENST00000312678AP2B1chr1733921086+ENST00000267328RAB20chr13111176544-12951671069479196
ENST00000589344AP2B1chr1733921086+ENST00000267328RAB20chr13111176544-14192911193603196
ENST00000537622AP2B1chr1733921086+ENST00000267328RAB20chr13111176544-14002721174584196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262325ENST00000267328AP2B1chr1733921086+RAB20chr13111176544-0.0057504130.9942496
ENST00000592545ENST00000267328AP2B1chr1733921086+RAB20chr13111176544-0.005372940.99462706
ENST00000312678ENST00000267328AP2B1chr1733921086+RAB20chr13111176544-0.0057215410.99427843
ENST00000589344ENST00000267328AP2B1chr1733921086+RAB20chr13111176544-0.0045035530.9954965
ENST00000537622ENST00000267328AP2B1chr1733921086+RAB20chr13111176544-0.0033055330.99669445

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Fusion Genomic Features for AP2B1-RAB20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AP2B1-RAB20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:33921086/chr13:111176544)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB20chr17:33921086chr13:111176544ENST0000026732802113_11657235.0Nucleotide bindingGTP
TgeneRAB20chr17:33921086chr13:111176544ENST000002673280255_5957235.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2B1chr17:33921086chr13:111176544ENST00000262325+221576_71612938.0Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000312678+222576_71612952.0Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000537622+222576_71612952.0Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000538556+222576_7160881.0Compositional biasNote=Pro-rich (stalk region)
HgeneAP2B1chr17:33921086chr13:111176544ENST00000589344+222576_71612952.0Compositional biasNote=Pro-rich (stalk region)
TgeneRAB20chr17:33921086chr13:111176544ENST000002673280233_4157235.0MotifEffector region
TgeneRAB20chr17:33921086chr13:111176544ENST000002673280212_1957235.0Nucleotide bindingGTP


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Fusion Gene Sequence for AP2B1-RAB20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5246_5246_1_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000262325_RAB20_chr13_111176544_ENST00000267328_length(transcript)=1718nt_BP=590nt
TTTTACGTGCAGCACTATCCTCTAGCCCCACTGCCCGTATATAGGCCTGGGCTATATCACCATTGTCCGCCCTTGAGCCTGGAAGGAAAA
TGAGCTGAGGGGTTTTGTTTTTTCAGAAAGGAACAGGATATTTCATCATCTCTATGTTTACGTTTTTCAGAGAATTTCTGTGCGAGGAAA
CAAATCCATTGTCAGCTTTTTAAAATATATCCCTTTGGAGTAGCCACTTAACATCCTCTGAGGCCCAGATGGGCTAGCTTGCCGGGACCA
AAGGAAATCTTTGGGTCTGGAAGGCGACAAGAGATCACAGGCTTTCTAGGTCTACCGCGCACCCCGATGACGTCACGCGGCGACGTTCTC
TGACGTCAGAGTTTCCTGCCCACCATCTTTGTCCCTGGCAAAGTGGGTTTTGCGCAGTGGCTTAGACCTAGAAAAGAATCGTGACGGGCA
GGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGCCTTCGCCTCCGCCTCCGGTGCACATTA
AAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCG
GGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACAC
AGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTG
CAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGAT
CCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGA
CCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAG
TCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTC
TGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAA
TGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGC
AAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTT
GCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACAT
TTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCT
CGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTGGCTACATGTATTATTAAAGAGGATTTT

>5246_5246_1_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000262325_RAB20_chr13_111176544_ENST00000267328_length(amino acids)=196AA_BP=
MKRSEVQVQTQASASARARGPLVAGCKGPVPGSGAESTRGLDSADWALQRIPVSHLPTPLTETEETTHVDLLFIASHHFHSNILLRVSFW
KIIPCCSLLLSDHSLPGQTPSQHAQSESRRPSKVRHNTQIWSSWVAYDWIYPLCVTASQLSAVRSLAPPGQRGSQTGGPHCSRSWRWSQS

--------------------------------------------------------------
>5246_5246_2_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000312678_RAB20_chr13_111176544_ENST00000267328_length(transcript)=1295nt_BP=167nt
AGACCTAGAAAAGAATCGTGACGGGCAGGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGC
CTTCGCCTCCGCCTCCGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGGGAGCAGTT
CCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGA
GGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAGGAGGGGGC
CTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGA
GGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGAC
CAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGAGCTGAGAG
GCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGAC
TCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCCAGAATGAC
ACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTG
GGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCT
TTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCACCCTGGGT
TGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGT
ATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAGCAATGTTG

>5246_5246_2_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000312678_RAB20_chr13_111176544_ENST00000267328_length(amino acids)=196AA_BP=
MKRSEVQVQTQASASARARGPLVAGCKGPVPGSGAESTRGLDSADWALQRIPVSHLPTPLTETEETTHVDLLFIASHHFHSNILLRVSFW
KIIPCCSLLLSDHSLPGQTPSQHAQSESRRPSKVRHNTQIWSSWVAYDWIYPLCVTASQLSAVRSLAPPGQRGSQTGGPHCSRSWRWSQS

--------------------------------------------------------------
>5246_5246_3_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000537622_RAB20_chr13_111176544_ENST00000267328_length(transcript)=1400nt_BP=272nt
AGGGTGTGTCCCTAATTGACGGGGTCGGGGACGGAGAGAAGGGTAACACCAGGCTGGGTCGGAGACCGGCGGAGGCGAGGAAATCCTAAG
AGCGTGACCGTTGATGATGCAGGGAACCGTCGGGTGTGACCATTGAGAGGGAAAAGGTTGGAGAAAGGGTCTCTACCATGATGCCTGTGG
TGCGGTGAGGGAATCCTCGGGTGTGGCAGCAGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAA
AGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAG
CCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCT
CACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAA
GCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCA
AATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACA
GCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTC
GAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATT
ATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTC
TCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTG
CCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGT
TTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTC
CCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTG

>5246_5246_3_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000537622_RAB20_chr13_111176544_ENST00000267328_length(amino acids)=196AA_BP=
MKRSEVQVQTQASASARARGPLVAGCKGPVPGSGAESTRGLDSADWALQRIPVSHLPTPLTETEETTHVDLLFIASHHFHSNILLRVSFW
KIIPCCSLLLSDHSLPGQTPSQHAQSESRRPSKVRHNTQIWSSWVAYDWIYPLCVTASQLSAVRSLAPPGQRGSQTGGPHCSRSWRWSQS

--------------------------------------------------------------
>5246_5246_4_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000589344_RAB20_chr13_111176544_ENST00000267328_length(transcript)=1419nt_BP=291nt
ACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCCGCCCTCGCCTTCGCCTCCGCCTCCGGTGAGTTCAGGGCGGTTGCCTTTAGGGT
GTGTCCCTAATTGACGGGGTCGGGGACGGAGAGAAGGGTAACACCAGGCTGGGTCGGAGACCGGCGGAGGCGAGGAAATCCTAAGAGCGT
GACCGTTGATGATGCAGGGAACCGTCGGGTGTGACCATTGAGAGGGAAAAGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGT
ATTTCACAACCAATAAAAAAGGGCGGGAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATG
ATGTGAATCACCGGCAGAGCCTGGTGGAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCG
TGGGGAACAAAGTGGACCTCACTGAGGAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTG
TCTCCCCAAGGGCACCTAAGCAGGTGCAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGG
ATGTGCCGGCCGCTGAGCAAATGTGCTTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGG
TGGTGCCAATGATCTTACAGCAGAGAGCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTG
GGTGTTGTGCCTGACTTTCGAGGGCCTCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAG
CAAGGAACAGCAAGGAATTATTTTCCAGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAAC
GTGTGTGGTCTCCTCAGTCTCTGTCAGAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCT
GGTGCTCTCTGCCCCGCTGCCTGGCACTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTG
CACCTGCACCTCTGACCGTTTCAGCACCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTG
TGAGTTGTCTTTGGTCCTCCCACTTGGTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAA

>5246_5246_4_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000589344_RAB20_chr13_111176544_ENST00000267328_length(amino acids)=196AA_BP=
MKRSEVQVQTQASASARARGPLVAGCKGPVPGSGAESTRGLDSADWALQRIPVSHLPTPLTETEETTHVDLLFIASHHFHSNILLRVSFW
KIIPCCSLLLSDHSLPGQTPSQHAQSESRRPSKVRHNTQIWSSWVAYDWIYPLCVTASQLSAVRSLAPPGQRGSQTGGPHCSRSWRWSQS

--------------------------------------------------------------
>5246_5246_5_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000592545_RAB20_chr13_111176544_ENST00000267328_length(transcript)=1303nt_BP=175nt
AGTGGCTTAGACCTAGAAAAGAATCGTGACGGGCAGGAAACCATTACACCACCACCTGGGCTGTGCTCTCCGGCTCCCGCCGCCACCCCC
GCCCTCGCCTTCGCCTCCGCCTCCGGTGCACATTAAAGATCCAAAGTCATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGGCGG
GAGCAGTTCCACGGCCTGGGCTCCATGTACTGCCGGGGGGCGGCCGCCATCATCCTCACCTATGATGTGAATCACCGGCAGAGCCTGGTG
GAGCTGGAGGACCGGTTCCTGGGCCTGACAGACACAGCCAGCAAAGACTGCCTCTTTGCCATCGTGGGGAACAAAGTGGACCTCACTGAG
GAGGGGGCCTTGGCGGGCCAGGAGAAGGAAGAGTGCAGTCCCAATATGGACGCTGGGGACCGTGTCTCCCCAAGGGCACCTAAGCAGGTG
CAGCTGGAGGATGCGGTGGCCCTTTATAAAAAGATCCTCAAGTACAAGATGCTGGATGAGCAGGATGTGCCGGCCGCTGAGCAAATGTGC
TTTGAGACCAGCGCCAAGACCGGCTACAATGTGGACCTCCTGTTTGAGACCCTCTTTGACCTGGTGGTGCCAATGATCTTACAGCAGAGA
GCTGAGAGGCCGTCACACACAGTGGATATATCCAGTCATAAGCCACCCAAGAGGACCAGATCTGGGTGTTGTGCCTGACTTTCGAGGGCC
TCCTGGACTCAGACTGTGCATGTTGGGAAGGGGTCTGACCAGGCAAGCTGTGATCTGAAAGGAGCAAGGAACAGCAAGGAATTATTTTCC
AGAATGACACCCGCAGCAGAATGTTGGAGTGGAAATGATGGCTGGCTATGAAGAGGAGGTCAACGTGTGTGGTCTCCTCAGTCTCTGTCA
GAGGGGTGGGGAGGTGGGAAACAGGAATCCTCTGCAAAGCCCAATCTGCAGAGTCGAGACCCCTGGTGCTCTCTGCCCCGCTGCCTGGCA
CTGGTCCTTTGCAGCCAGCCACCAACGGCCCCCTTGCCCTTGCAGAGGCAGAAGCCTGCGTCTGCACCTGCACCTCTGACCGTTTCAGCA
CCCTGGGTTGTTACCACGTCCTACAACTCTGACATTTCTTGTTCTCAAGCGTTTCTCTTCACTGTGAGTTGTCTTTGGTCCTCCCACTTG
GTACTTGTATCTTGATGCTTTATAATCCTGACTCTCGACGTGTTCATTTATACAAAATCAGGAATAACTTTGTTTTTATACTGATTGCAG

>5246_5246_5_AP2B1-RAB20_AP2B1_chr17_33921086_ENST00000592545_RAB20_chr13_111176544_ENST00000267328_length(amino acids)=196AA_BP=
MKRSEVQVQTQASASARARGPLVAGCKGPVPGSGAESTRGLDSADWALQRIPVSHLPTPLTETEETTHVDLLFIASHHFHSNILLRVSFW
KIIPCCSLLLSDHSLPGQTPSQHAQSESRRPSKVRHNTQIWSSWVAYDWIYPLCVTASQLSAVRSLAPPGQRGSQTGGPHCSRSWRWSQS

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Fusion Gene PPI Analysis for AP2B1-RAB20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAP2B1chr17:33921086chr13:111176544ENST00000262325+221841_93712.333333333333334938.0ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000312678+222841_93712.333333333333334952.0ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000537622+222841_93712.333333333333334952.0ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000538556+222841_9370881.0ARRB1
HgeneAP2B1chr17:33921086chr13:111176544ENST00000589344+222841_93712.333333333333334952.0ARRB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AP2B1-RAB20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AP2B1-RAB20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAP2B1C0086132Depressive Symptoms1PSYGENET