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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DDT-C21orf33 (FusionGDB2 ID:HG1652TG8209)

Fusion Gene Summary for DDT-C21orf33

Fusion gene summary

Fusion gene information	Fusion gene name: DDT-C21orf33
	Fusion gene ID: hg1652tg8209
		Hgene	Tgene
	Gene symbol	DDT	C21orf33
	Gene ID	1652	8209
	Gene name	D-dopachrome tautomerase	glutamine amidotransferase like class 1 domain containing 3A
	Synonyms	D-DT\|DDCT\|MIF-2\|MIF2	C21orf33\|ES1\|GATD3\|GT335\|HES1\|KNPH\|KNPI
	Cytomap	('DDT')('C21orf33') 22q11.23	21q22.3
	Type of gene	protein-coding	protein-coding
	Description	D-dopachrome decarboxylasephenylpyruvate tautomerase II	glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrialES1 protein homolog, mitochondrialKeio novel protein Ihuman HES1 protein, homolog to E.coli and zebrafish ES1 proteintestis secretory sperm-binding protein Li 237E
	Modification date	20200313	20200328
	UniProtAcc	P30046	.
	Ensembl transtripts involved in fusion gene	ENST00000350608, ENST00000398344, ENST00000403754, ENST00000404092, ENST00000430101,
Fusion gene scores	* DoF score	10 X 3 X 6=180	5 X 5 X 3=75
	# samples	10	5
	** MAII score	log2(10/180*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DDT [Title/Abstract] AND C21orf33 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DDT(24315957)-C21orf33(45555942), # samples:1
Anticipated loss of major functional domain due to fusion event.	DDT-C21orf33 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DDT	GO:0010760	negative regulation of macrophage chemotaxis	21817065
Hgene	DDT	GO:0032760	positive regulation of tumor necrosis factor production	21817065

Fusion gene breakpoints across DDT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C21orf33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0797-01A	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+

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Fusion Gene ORF analysis for DDT-C21orf33

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000350608	ENST00000348499	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000350608	ENST00000493883	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000398344	ENST00000348499	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000398344	ENST00000493883	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000403754	ENST00000348499	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000403754	ENST00000493883	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000404092	ENST00000348499	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000404092	ENST00000493883	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000430101	ENST00000348499	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
5CDS-3UTR	ENST00000430101	ENST00000493883	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
Frame-shift	ENST00000350608	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
Frame-shift	ENST00000350608	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
Frame-shift	ENST00000404092	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
Frame-shift	ENST00000404092	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000398344	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000398344	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000403754	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000403754	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000430101	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+
In-frame	ENST00000430101	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398344	DDT	chr22	24315957	-	ENST00000291577	C21orf33	chr21	45555942	+	1841	454	116	1066	316
ENST00000398344	DDT	chr22	24315957	-	ENST00000427803	C21orf33	chr21	45555942	+	1257	454	116	913	265
ENST00000403754	DDT	chr22	24315957	-	ENST00000291577	C21orf33	chr21	45555942	+	1716	329	36	941	301
ENST00000403754	DDT	chr22	24315957	-	ENST00000427803	C21orf33	chr21	45555942	+	1132	329	36	788	250
ENST00000430101	DDT	chr22	24315957	-	ENST00000291577	C21orf33	chr21	45555942	+	1716	329	36	941	301
ENST00000430101	DDT	chr22	24315957	-	ENST00000427803	C21orf33	chr21	45555942	+	1132	329	36	788	250

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398344	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.005670551	0.9943295
ENST00000398344	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.06892903	0.931071
ENST00000403754	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.004563955	0.995436
ENST00000403754	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.06819506	0.9318049
ENST00000430101	ENST00000291577	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.004563955	0.995436
ENST00000430101	ENST00000427803	DDT	chr22	24315957	-	C21orf33	chr21	45555942	+	0.06819506	0.9318049

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Fusion Genomic Features for DDT-C21orf33

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DDT	chr22	24315956	-	C21orf33	chr21	45555941	+	6.35E-07	0.9999994
DDT	chr22	24315956	-	C21orf33	chr21	45555941	+	6.35E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DDT-C21orf33

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24315957/chr21:45555942)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DDT P30046	.
FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for DDT-C21orf33

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>21856_21856_1_DDT-C21orf33_DDT_chr22_24315957_ENST00000398344_C21orf33_chr21_45555942_ENST00000291577_length(transcript)=1841nt_BP=454nt
GTTTGCAGAAGCGGGAGGTACCCTAGGCAGCCAATCGGGGAGCGCCGAGTCTCTGTCCAGCCAATGAGAAGCCAGGTTGCTGTGGCGCCT
CGCCCCTCCTCCCTGGTCCGCGAGCCTTGGGTACCCCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCC
TGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAAC
CTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCT
CCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGG
ACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCTGAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCA
AGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTTTTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCA
GTGCAGCCAACCATGATGCTGCCATCTTTCCAGGAGGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCA
AGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAGTTCCACCAGGCCGGGAAGCCCATCGGCTTGTGCTGCATTGCACCTGTCCTCGCGG
CCAAGGTGCTCAGAGGCGTCGAGGTGACTGTGGGCCACGAGCAGGAGGAAGGTGGCAAGTGGCCTTATGCCGGGACCGCAGAGGCCATCA
AGGCCCTGGGTGCCAAGCACTGCGTGAAGGAAGTGGTCGAAGCTCACGTGGACCAGAAAAACAAGGTGGTCACGACCCCAGCCTTCATGT
GCGAGACGGCACTCCACTACATCCATGATGGGATCGGAGCCATGGTGAGGAAGGTGCTGGAACTCACTGGAAAGTGACGCGCATGGACGG
GGCCCAGCTAGGCGCCAGGACTTGGCCTCACCCTCTGGCTGAGGAGCTGTCGGCTGCTTTCCATCCAGCTGGGAGTCTGGCAGGCCCTTT
TTTTTTTTTCTTTGCCGAAACCTGCAGGCGTTCTCTCTCTAAGGAGGATGTGCTGCAGTGCATGGGGGATGTTTCTTCCTGGGTGTGGCT
GGGCTGCTCTCACATACAGAGGCCGAGGGGCCAATTCGTTCTCTGCCACAGGGACTTGCCTCACTGTGTCCCAAAAACAAATCGCAGCCA
GCTTTTCCAGAAATAGAAAATTCTGCCGTCTGAGGTTTTATACTTCAGGTTAGTTAGTTTTTGGAAGGAAGAACATTTTTAGGTTTGCAA
GCCTCCTGATCAGGAAACCAGAAATACCACATTTATGGACCATGAAAGGTTGGTTCTTGACTCTGAAGGGACTTTTGAGTTAATCAGCGT
AAGGGGATTTCTAAAGCAGGCAATCCCTGTAGCCGCAGAGAATAAACGCCTTCCCAAAATGGCAACTTCCCACAGCCACATTTCAGACCT
GCTGAGACTGCTGAGTGAGGAATGGCAGTGAGGTTTCTTCAATTAGTCTCAGTTCTCTTAATTTTCAGGAAGAAAGGGAAATTGCAGCCC
CTCAGCCCCCAGGATTGACCTCTGGGGAGTGATGGTAGCGTTGGTGCCAGGCCGTGGGTTCAGGTGTGGCAGAAGCTTGCAGATGCGTCC
GAAGGGAAATAAAGTGTGTTGGCGTTAGACTTTGTGCTGCA

>21856_21856_1_DDT-C21orf33_DDT_chr22_24315957_ENST00000398344_C21orf33_chr21_45555942_ENST00000291577_length(amino acids)=316AA_BP=112
MGTPSFSSARAVSVPLPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAE
DNRSHSAHFFEFLTKELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAI
FPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCV
KEVVEAHVDQKNKVVTTPAFMCETALHYIHDGIGAMVRKVLELTGK

--------------------------------------------------------------
>21856_21856_2_DDT-C21orf33_DDT_chr22_24315957_ENST00000398344_C21orf33_chr21_45555942_ENST00000427803_length(transcript)=1257nt_BP=454nt
GTTTGCAGAAGCGGGAGGTACCCTAGGCAGCCAATCGGGGAGCGCCGAGTCTCTGTCCAGCCAATGAGAAGCCAGGTTGCTGTGGCGCCT
CGCCCCTCCTCCCTGGTCCGCGAGCCTTGGGTACCCCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCC
TGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAAC
CTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCT
CCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGG
ACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCTGAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCA
AGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTTTTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCA
GTGCAGCCAACCATGATGCTGCCATCTTTCCAGGAGGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCA
AGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAGTTCCACCAGGCCGGGAAGCCCATCGGGTGTGATGCTTCCACGAGCCTCCCGGCAC
CTGCTCCTTGGTGGTCCTGGAACGCGGCGCTGTGCTGTCCAGGTCTCAGCTGCGTCTGGTGCTGGCAGGGCGAGAGCCGCACTTGCGTGG
GTGAACATCAGTGAGGCGCACTCGCGATGGCCGCTCACTACCGAGTTCTGTCAGCCGAACAAGGATGAGGATCTATCGGAATCCTCTGTC
TCCCCATCCACAGTCACTCACTTAAGGACCTGCCTGGTCACTGTCCAGGGAGGCCCCTAAAGTGGAGCCTCAGGAAGAGGTGCAGGCTCA
GAGCTCCTGAAGGAGGTCCCTGCTGCAGCCGTGTCACAGCCGGGGTGAAGGTTTCGCCCATGGTCTCCACCTCGGGATCCCGTCCTTGTC
AGAGAAGTGTTCCTTGGATGAGCGCCCAGAGGGAGGAGCCCATGGCCCTTTCTTCTGTGACTGATTAAAAATCTCGATGAAACAAGA

>21856_21856_2_DDT-C21orf33_DDT_chr22_24315957_ENST00000398344_C21orf33_chr21_45555942_ENST00000427803_length(amino acids)=265AA_BP=112
MGTPSFSSARAVSVPLPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAE
DNRSHSAHFFEFLTKELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAI
FPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHQAGKPIGCDASTSLPAPAPWWSWNAALCCPGLSCVWCWQGESRTCVGEHQ

--------------------------------------------------------------
>21856_21856_3_DDT-C21orf33_DDT_chr22_24315957_ENST00000403754_C21orf33_chr21_45555942_ENST00000291577_length(transcript)=1716nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCT
GAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCAAGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTT
TTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCAGTGCAGCCAACCATGATGCTGCCATCTTTCCAGGA
GGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCAAGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAG
TTCCACCAGGCCGGGAAGCCCATCGGCTTGTGCTGCATTGCACCTGTCCTCGCGGCCAAGGTGCTCAGAGGCGTCGAGGTGACTGTGGGC
CACGAGCAGGAGGAAGGTGGCAAGTGGCCTTATGCCGGGACCGCAGAGGCCATCAAGGCCCTGGGTGCCAAGCACTGCGTGAAGGAAGTG
GTCGAAGCTCACGTGGACCAGAAAAACAAGGTGGTCACGACCCCAGCCTTCATGTGCGAGACGGCACTCCACTACATCCATGATGGGATC
GGAGCCATGGTGAGGAAGGTGCTGGAACTCACTGGAAAGTGACGCGCATGGACGGGGCCCAGCTAGGCGCCAGGACTTGGCCTCACCCTC
TGGCTGAGGAGCTGTCGGCTGCTTTCCATCCAGCTGGGAGTCTGGCAGGCCCTTTTTTTTTTTTCTTTGCCGAAACCTGCAGGCGTTCTC
TCTCTAAGGAGGATGTGCTGCAGTGCATGGGGGATGTTTCTTCCTGGGTGTGGCTGGGCTGCTCTCACATACAGAGGCCGAGGGGCCAAT
TCGTTCTCTGCCACAGGGACTTGCCTCACTGTGTCCCAAAAACAAATCGCAGCCAGCTTTTCCAGAAATAGAAAATTCTGCCGTCTGAGG
TTTTATACTTCAGGTTAGTTAGTTTTTGGAAGGAAGAACATTTTTAGGTTTGCAAGCCTCCTGATCAGGAAACCAGAAATACCACATTTA
TGGACCATGAAAGGTTGGTTCTTGACTCTGAAGGGACTTTTGAGTTAATCAGCGTAAGGGGATTTCTAAAGCAGGCAATCCCTGTAGCCG
CAGAGAATAAACGCCTTCCCAAAATGGCAACTTCCCACAGCCACATTTCAGACCTGCTGAGACTGCTGAGTGAGGAATGGCAGTGAGGTT
TCTTCAATTAGTCTCAGTTCTCTTAATTTTCAGGAAGAAAGGGAAATTGCAGCCCCTCAGCCCCCAGGATTGACCTCTGGGGAGTGATGG
TAGCGTTGGTGCCAGGCCGTGGGTTCAGGTGTGGCAGAAGCTTGCAGATGCGTCCGAAGGGAAATAAAGTGTGTTGGCGTTAGACTTTGT
GCTGCA

>21856_21856_3_DDT-C21orf33_DDT_chr22_24315957_ENST00000403754_C21orf33_chr21_45555942_ENST00000291577_length(amino acids)=301AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFA
VDGKDCKVNKEVERVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKEVVEAHVDQKNKVV
TTPAFMCETALHYIHDGIGAMVRKVLELTGK

--------------------------------------------------------------
>21856_21856_4_DDT-C21orf33_DDT_chr22_24315957_ENST00000403754_C21orf33_chr21_45555942_ENST00000427803_length(transcript)=1132nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCT
GAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCAAGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTT
TTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCAGTGCAGCCAACCATGATGCTGCCATCTTTCCAGGA
GGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCAAGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAG
TTCCACCAGGCCGGGAAGCCCATCGGGTGTGATGCTTCCACGAGCCTCCCGGCACCTGCTCCTTGGTGGTCCTGGAACGCGGCGCTGTGC
TGTCCAGGTCTCAGCTGCGTCTGGTGCTGGCAGGGCGAGAGCCGCACTTGCGTGGGTGAACATCAGTGAGGCGCACTCGCGATGGCCGCT
CACTACCGAGTTCTGTCAGCCGAACAAGGATGAGGATCTATCGGAATCCTCTGTCTCCCCATCCACAGTCACTCACTTAAGGACCTGCCT
GGTCACTGTCCAGGGAGGCCCCTAAAGTGGAGCCTCAGGAAGAGGTGCAGGCTCAGAGCTCCTGAAGGAGGTCCCTGCTGCAGCCGTGTC
ACAGCCGGGGTGAAGGTTTCGCCCATGGTCTCCACCTCGGGATCCCGTCCTTGTCAGAGAAGTGTTCCTTGGATGAGCGCCCAGAGGGAG
GAGCCCATGGCCCTTTCTTCTGTGACTGATTAAAAATCTCGATGAAACAAGA

>21856_21856_4_DDT-C21orf33_DDT_chr22_24315957_ENST00000403754_C21orf33_chr21_45555942_ENST00000427803_length(amino acids)=250AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFA
VDGKDCKVNKEVERVLKEFHQAGKPIGCDASTSLPAPAPWWSWNAALCCPGLSCVWCWQGESRTCVGEHQ

--------------------------------------------------------------
>21856_21856_5_DDT-C21orf33_DDT_chr22_24315957_ENST00000430101_C21orf33_chr21_45555942_ENST00000291577_length(transcript)=1716nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCT
GAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCAAGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTT
TTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCAGTGCAGCCAACCATGATGCTGCCATCTTTCCAGGA
GGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCAAGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAG
TTCCACCAGGCCGGGAAGCCCATCGGCTTGTGCTGCATTGCACCTGTCCTCGCGGCCAAGGTGCTCAGAGGCGTCGAGGTGACTGTGGGC
CACGAGCAGGAGGAAGGTGGCAAGTGGCCTTATGCCGGGACCGCAGAGGCCATCAAGGCCCTGGGTGCCAAGCACTGCGTGAAGGAAGTG
GTCGAAGCTCACGTGGACCAGAAAAACAAGGTGGTCACGACCCCAGCCTTCATGTGCGAGACGGCACTCCACTACATCCATGATGGGATC
GGAGCCATGGTGAGGAAGGTGCTGGAACTCACTGGAAAGTGACGCGCATGGACGGGGCCCAGCTAGGCGCCAGGACTTGGCCTCACCCTC
TGGCTGAGGAGCTGTCGGCTGCTTTCCATCCAGCTGGGAGTCTGGCAGGCCCTTTTTTTTTTTTCTTTGCCGAAACCTGCAGGCGTTCTC
TCTCTAAGGAGGATGTGCTGCAGTGCATGGGGGATGTTTCTTCCTGGGTGTGGCTGGGCTGCTCTCACATACAGAGGCCGAGGGGCCAAT
TCGTTCTCTGCCACAGGGACTTGCCTCACTGTGTCCCAAAAACAAATCGCAGCCAGCTTTTCCAGAAATAGAAAATTCTGCCGTCTGAGG
TTTTATACTTCAGGTTAGTTAGTTTTTGGAAGGAAGAACATTTTTAGGTTTGCAAGCCTCCTGATCAGGAAACCAGAAATACCACATTTA
TGGACCATGAAAGGTTGGTTCTTGACTCTGAAGGGACTTTTGAGTTAATCAGCGTAAGGGGATTTCTAAAGCAGGCAATCCCTGTAGCCG
CAGAGAATAAACGCCTTCCCAAAATGGCAACTTCCCACAGCCACATTTCAGACCTGCTGAGACTGCTGAGTGAGGAATGGCAGTGAGGTT
TCTTCAATTAGTCTCAGTTCTCTTAATTTTCAGGAAGAAAGGGAAATTGCAGCCCCTCAGCCCCCAGGATTGACCTCTGGGGAGTGATGG
TAGCGTTGGTGCCAGGCCGTGGGTTCAGGTGTGGCAGAAGCTTGCAGATGCGTCCGAAGGGAAATAAAGTGTGTTGGCGTTAGACTTTGT
GCTGCA

>21856_21856_5_DDT-C21orf33_DDT_chr22_24315957_ENST00000430101_C21orf33_chr21_45555942_ENST00000291577_length(amino acids)=301AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFA
VDGKDCKVNKEVERVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKEVVEAHVDQKNKVV
TTPAFMCETALHYIHDGIGAMVRKVLELTGK

--------------------------------------------------------------
>21856_21856_6_DDT-C21orf33_DDT_chr22_24315957_ENST00000430101_C21orf33_chr21_45555942_ENST00000427803_length(transcript)=1132nt_BP=329nt
CCCAGCTTTTCTTCCGCCAGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTG
CCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGC
CTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGC
AGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATCCTGGTGCACCTGAGCCGTGGAGGGGCT
GAAGTCCAGATCTTTGCTCCTGACGTCCCTCAGATGCACGTGATTGACCACACCAAGGGGCAGCCGTCCGAAGGCGAGAGCAGGAATGTT
TTGACCGAGTCTGCGAGGATCGCCCGTGGCAAAATCACAGACCTGGCCAACCTCAGTGCAGCCAACCATGATGCTGCCATCTTTCCAGGA
GGCTTTGGAGCGGCTAAAAACCTGAGCACGTTTGCCGTGGACGGGAAAGATTGCAAGGTGAATAAAGAAGTGGAGCGTGTCCTGAAGGAG
TTCCACCAGGCCGGGAAGCCCATCGGGTGTGATGCTTCCACGAGCCTCCCGGCACCTGCTCCTTGGTGGTCCTGGAACGCGGCGCTGTGC
TGTCCAGGTCTCAGCTGCGTCTGGTGCTGGCAGGGCGAGAGCCGCACTTGCGTGGGTGAACATCAGTGAGGCGCACTCGCGATGGCCGCT
CACTACCGAGTTCTGTCAGCCGAACAAGGATGAGGATCTATCGGAATCCTCTGTCTCCCCATCCACAGTCACTCACTTAAGGACCTGCCT
GGTCACTGTCCAGGGAGGCCCCTAAAGTGGAGCCTCAGGAAGAGGTGCAGGCTCAGAGCTCCTGAAGGAGGTCCCTGCTGCAGCCGTGTC
ACAGCCGGGGTGAAGGTTTCGCCCATGGTCTCCACCTCGGGATCCCGTCCTTGTCAGAGAAGTGTTCCTTGGATGAGCGCCCAGAGGGAG
GAGCCCATGGCCCTTTCTTCTGTGACTGATTAAAAATCTCGATGAAACAAGA

>21856_21856_6_DDT-C21orf33_DDT_chr22_24315957_ENST00000430101_C21orf33_chr21_45555942_ENST00000427803_length(amino acids)=250AA_BP=97
MPAMPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQLSISSIGVVGTAEDNRSHSAHFFEFLTK
ELALGQDRILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFA
VDGKDCKVNKEVERVLKEFHQAGKPIGCDASTSLPAPAPWWSWNAALCCPGLSCVWCWQGESRTCVGEHQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDT-C21orf33

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DDT-C21orf33

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DDT-C21orf33

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Fusion Gene Studies in Kim Lab

Fusion gene:DDT-C21orf33 (FusionGDB2 ID:HG1652TG8209)

Fusion Gene Summary for DDT-C21orf33

Fusion Gene ORF analysis for DDT-C21orf33

Fusion Genomic Features for DDT-C21orf33

Fusion Protein Features for DDT-C21orf33

Fusion Gene Sequence for DDT-C21orf33

Fusion Gene PPI Analysis for DDT-C21orf33

Related Drugs for DDT-C21orf33

Related Diseases for DDT-C21orf33

Fusion Gene Studies
in Kim Lab