|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DHX8-MSI2 (FusionGDB2 ID:HG1659TG124540) |
Fusion Gene Summary for DHX8-MSI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX8-MSI2 | Fusion gene ID: hg1659tg124540 | Hgene | Tgene | Gene symbol | DHX8 | MSI2 | Gene ID | 1659 | 124540 |
| Gene name | DEAH-box helicase 8 | musashi RNA binding protein 2 | |
| Synonyms | DDX8|Dhr2|HRH1|PRP22|PRPF22 | MSI2H | |
| Cytomap | ('DHX8')('MSI2') 17q21.31 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1 | RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2 | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | . | Q96DH6 | |
| Ensembl transtripts involved in fusion gene | ENST00000262415, ENST00000540306, | ||
| Fusion gene scores | * DoF score | 17 X 12 X 11=2244 | 26 X 18 X 10=4680 |
| # samples | 18 | 30 | |
| ** MAII score | log2(18/2244*10)=-3.64000386427912 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/4680*10)=-3.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHX8 [Title/Abstract] AND MSI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DHX8(41567831)-MSI2(55674229), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | DHX8-MSI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-MSI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-MSI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-MSI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHX8 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Fusion gene breakpoints across DHX8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across MSI2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PAAD | TCGA-HZ-A4BK-01A | DHX8 | chr17 | 41567831 | - | MSI2 | chr17 | 55674229 | + |
| ChimerDB4 | PAAD | TCGA-HZ-A4BK-01A | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| ChimerDB4 | PAAD | TCGA-HZ-A4BK | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
Top |
Fusion Gene ORF analysis for DHX8-MSI2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000262415 | ENST00000579505 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| 5CDS-3UTR | ENST00000540306 | ENST00000579505 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000262415 | ENST00000284073 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000262415 | ENST00000322684 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000262415 | ENST00000416426 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000262415 | ENST00000442934 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000262415 | ENST00000579180 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000540306 | ENST00000284073 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000540306 | ENST00000322684 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000540306 | ENST00000416426 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000540306 | ENST00000442934 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| In-frame | ENST00000540306 | ENST00000579180 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000540306 | DHX8 | chr17 | 41567831 | + | ENST00000416426 | MSI2 | chr17 | 55674229 | + | 1573 | 382 | 30 | 968 | 312 |
| ENST00000540306 | DHX8 | chr17 | 41567831 | + | ENST00000284073 | MSI2 | chr17 | 55674229 | + | 6083 | 382 | 30 | 914 | 294 |
| ENST00000540306 | DHX8 | chr17 | 41567831 | + | ENST00000322684 | MSI2 | chr17 | 55674229 | + | 1765 | 382 | 30 | 695 | 221 |
| ENST00000540306 | DHX8 | chr17 | 41567831 | + | ENST00000442934 | MSI2 | chr17 | 55674229 | + | 1695 | 382 | 30 | 914 | 294 |
| ENST00000540306 | DHX8 | chr17 | 41567831 | + | ENST00000579180 | MSI2 | chr17 | 55674229 | + | 1770 | 382 | 30 | 695 | 221 |
| ENST00000262415 | DHX8 | chr17 | 41567831 | + | ENST00000416426 | MSI2 | chr17 | 55674229 | + | 1570 | 379 | 27 | 965 | 312 |
| ENST00000262415 | DHX8 | chr17 | 41567831 | + | ENST00000284073 | MSI2 | chr17 | 55674229 | + | 6080 | 379 | 27 | 911 | 294 |
| ENST00000262415 | DHX8 | chr17 | 41567831 | + | ENST00000322684 | MSI2 | chr17 | 55674229 | + | 1762 | 379 | 27 | 692 | 221 |
| ENST00000262415 | DHX8 | chr17 | 41567831 | + | ENST00000442934 | MSI2 | chr17 | 55674229 | + | 1692 | 379 | 27 | 911 | 294 |
| ENST00000262415 | DHX8 | chr17 | 41567831 | + | ENST00000579180 | MSI2 | chr17 | 55674229 | + | 1767 | 379 | 27 | 692 | 221 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000540306 | ENST00000416426 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001112486 | 0.9988875 |
| ENST00000540306 | ENST00000284073 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.000194794 | 0.9998053 |
| ENST00000540306 | ENST00000322684 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001338773 | 0.9986613 |
| ENST00000540306 | ENST00000442934 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.000672558 | 0.9993274 |
| ENST00000540306 | ENST00000579180 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001338295 | 0.99866176 |
| ENST00000262415 | ENST00000416426 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001123259 | 0.99887675 |
| ENST00000262415 | ENST00000284073 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.000194908 | 0.99980515 |
| ENST00000262415 | ENST00000322684 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001185701 | 0.99881434 |
| ENST00000262415 | ENST00000442934 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.000675244 | 0.9993248 |
| ENST00000262415 | ENST00000579180 | DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674229 | + | 0.001185809 | 0.9988142 |
Top |
Fusion Genomic Features for DHX8-MSI2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674228 | + | 4.59E-06 | 0.99999547 |
| DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674228 | + | 4.59E-06 | 0.99999547 |
| DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674228 | + | 4.59E-06 | 0.99999547 |
| DHX8 | chr17 | 41567831 | + | MSI2 | chr17 | 55674228 | + | 4.59E-06 | 0.99999547 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for DHX8-MSI2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41567831/chr17:55674229) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MSI2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000284073 | 6 | 14 | 253_260 | 151 | 1951.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000322684 | 5 | 10 | 253_260 | 147 | 252.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000579180 | 2 | 7 | 253_260 | 47 | 152.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000579180 | 2 | 7 | 110_187 | 47 | 152.0 | Domain | RRM 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 172_175 | 102 | 1221.0 | Compositional bias | Note=Poly-Lys |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 176_228 | 102 | 1221.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 265_336 | 102 | 1221.0 | Domain | S1 motif |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 575_738 | 102 | 1221.0 | Domain | Helicase ATP-binding |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 756_936 | 102 | 1221.0 | Domain | Helicase C-terminal |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 685_688 | 102 | 1221.0 | Motif | Note=DEAH box |
| Hgene | DHX8 | chr17:41567831 | chr17:55674229 | ENST00000262415 | + | 3 | 23 | 588_595 | 102 | 1221.0 | Nucleotide binding | ATP |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000284073 | 6 | 14 | 110_187 | 151 | 1951.0 | Domain | RRM 2 | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000284073 | 6 | 14 | 21_111 | 151 | 1951.0 | Domain | RRM 1 | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000322684 | 5 | 10 | 110_187 | 147 | 252.0 | Domain | RRM 2 | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000322684 | 5 | 10 | 21_111 | 147 | 252.0 | Domain | RRM 1 | |
| Tgene | MSI2 | chr17:41567831 | chr17:55674229 | ENST00000579180 | 2 | 7 | 21_111 | 47 | 152.0 | Domain | RRM 1 |
Top |
Fusion Gene Sequence for DHX8-MSI2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22712_22712_1_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000284073_length(transcript)=6080nt_BP=379nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATC AATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTAC ACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCA AGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCC AACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTG GGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAAT GGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGC CCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTG ACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTT TTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTT AGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTT TTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTG TATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTT GTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTT TCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCTGTTGAAAGAGGTGATATTATAAGGTT TTTTGAAATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACATAGAAACTATTAAGAAAGAGAGAATCAAAAATA TTTTTGTGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAGGGAACGTTGGCCAAGTCAGTTACTGAGATGAAG ATCGCCCAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTGTCTGTGTGATAGACCTAAGAACTGTATTAGTGT TGTACCAGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTAGATTTTTATTTAAAATATGAAAAACTGCTTTTC CCAAGATGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTTCAAAGCACACCTGTTTGGCTTGGGTGGGGGTGG GGTGGGGGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATTGTCCAATCATTTCAGCACCTCCAAAGGTCCCTA GGACACTTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCCCATGGGCCAGGAGTGGATAAGCCTGCATTAATA CAACCTTTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTATATATATTTTTTTTAATACCTCAGTGCTGCAAGT ATCACCAGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAATTTTAAAAATAAAAAGTATAAACATCACTGCAC TGTGACTGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTGTTATAATATATGGTCCTCGGTTGGGGAAAGATA CTTATGATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCGGCAACAGCAACTATAGAAGTACAACTCAATAGA TGGCATTAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATATTGACGTTTTATTAATATTTTTTAAATTGTTAC GTTTATAAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTATTATAAAGAGCTGCTGCACTCCTATTTTTATAA ATTTTACTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCATCTTCAAACTAAAGACTCCAAAATGCTAACTCA GAAAGAAAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTAATTAAAAAAAAAATCATGTTCTTTGTTTTTCTA ATAAAATGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTTCTTTTCTTTTCCCCCAAACAACCAGATTAAATG CTGAGCGCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGTTTTATTTAAAAAAAAAAAAAGAAAGAAAAAATA GTAAATTCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCATGTTGGTGATGTACTGTACTTCCCTTCCTTTTCT CTGCATCCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATGTATAAAATGGCTATCTTGTAAGCGTGCTGTCCT GGTACTAGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTATAACATAATTAAGGTTTAAAAAAAATTAGACATA GTTATTCAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAATGCTAATAATTTTGGGGCAGTTTTTTCCTTTAAT TATTTTTTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACTAACCCAAGGTCTCACCATGTTAAAATGCCGGCG GACTCTACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATACTACCTTAAATGCTAATGCTAGATATGCAAAAC TGGATTTTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTTACTAAGAGAAAAAATATTTTTTTAAGAATGCTC AGAAGAAATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGAGACCCAGTAGCCCATAGCACAAATCTTGTGGAA ATCCGATATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATTCCATCTAGAAGTCCATTTTGAAAGATTTTTGTA AATTCTTTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCGAACATGGGAACCACCTTTCGCCTTCCCTGGGGG AGAAACCCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGACTTTCTGGCTTCCAGATCCATCTGCCTGAGACCC CCGAACTCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCATTCCCGGTCCTAGCTGGGCATGGGGCTGACGGAG ATGACCAAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTCCTTATATCCACTGGGAACAAACAGCCTCGCGCT CTATACCAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAAGCCCCAGCAGGCCTTTGCGTTTTTATCCTTCAT AACCTTCATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTGCTGTCAATTTACTGTTTCACTGCACAGCAATCA CAGCCAGTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATTGTTGGTTCTAATGACCTGAAAGGTGTTCAGTTT TTGTTCTTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTCCTTTTCATTTGGGGGTTTTTGGGGAAAAAATTT ATTTTTGGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGGCTAGGGACTTAGCCTCCTCCACCACCTCCACAC TGCTTCATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTTACTACATTTTTTATTGAAGGTCAGCCATGCTTT CTGTATTATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCTTTATTGGTTGCAAGTGGCACGCAGGAACAGAGG GAGAGTGGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCTTCGCAAGCCAGGCTATCTTCCAAGGAAGGCAGA CAGTGGGAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCGGGTTTCCCCACCCTCACCCCAAAGCAGAAAACT AGCAGACGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGAAGTTAAGCAATACTTTAATACTGTAATATGTTT GTTTTCTTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAAAAACATATAAATAAAATCCATCCCTCTTGTCGG GGACCTGCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGTATTGTCTCAGACAGGATTTCAGTTCCGGGAGGC AGGGGCATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCCTCGAAGGTTCTCTACTACTGTATTCTGTACATA ATGTACCATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAATCTGCCGTTCATGGTGTATTGTAAACTCCGAAT TCCATATGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAATAAAACTTTCCCTAGCACTGTGGCTGACCTCAC CCTTACTTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTTTTATATATATACATATATATGTACTATCTATAT ATATATCTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTAAAAAATTACTATGTGGATGGCAGTCTCTCACAT CACAGATGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAAAGGTTTCCATCCTCTACTGTGGTCCAGAAATCA >22712_22712_1_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000284073_length(amino acids)=294AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASP -------------------------------------------------------------- >22712_22712_2_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000322684_length(transcript)=1762nt_BP=379nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATC AATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTAC ACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCA AGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGG GGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTG CCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAG TCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTC GTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTG AGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACA CAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGC CAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGG CACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGG GGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGC TTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTT GTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTC >22712_22712_2_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000322684_length(amino acids)=221AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM -------------------------------------------------------------- >22712_22712_3_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000416426_length(transcript)=1570nt_BP=379nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATC AATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTAC ACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCA AGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGTCCTG AATAGCTACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAAC AGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGC TCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCA CTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCC ACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAATAT AAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTC TTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAA AGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAA GGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAA >22712_22712_3_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000416426_length(amino acids)=312AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLY -------------------------------------------------------------- >22712_22712_4_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000442934_length(transcript)=1692nt_BP=379nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATC AATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTAC ACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCA AGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCC AACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTG GGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAAT GGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGC CCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTG ACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTT TTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTT AGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTT TTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTG TATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGCGTT GTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTATTT >22712_22712_4_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000442934_length(amino acids)=294AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASP -------------------------------------------------------------- >22712_22712_5_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000579180_length(transcript)=1767nt_BP=379nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAAATC AATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCTTAC ACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCA AGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGTGGG GGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAGCTG CCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTCCAG TCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAACTTC GTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGGGTG AGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAACACA CAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGGGGC CAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGTGGG CACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGGAGG GGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCATGGC TTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGCTTT GTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATTGTC >22712_22712_5_DHX8-MSI2_DHX8_chr17_41567831_ENST00000262415_MSI2_chr17_55674229_ENST00000579180_length(amino acids)=221AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM -------------------------------------------------------------- >22712_22712_6_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000284073_length(transcript)=6083nt_BP=382nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAA ATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCT TACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCT CCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGC TCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGA GTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACA AATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGT GGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGG TTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTT GTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGA CTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACA TTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGA CTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGC GTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTA TTTTCGGCAATAAGGTAAGGACGACAGTGTTTTGAGTGTCCTCCTTTTCTATAAGTGCTTTTTTTCTGTTGAAAGAGGTGATATTATAAG GTTTTTTGAAATTGTGAATTCTAAAAAAGAAATGTTGTAAATACAATTCCATTAACTACATAGAAACTATTAAGAAAGAGAGAATCAAAA ATATTTTTGTGAGGGAGTCGGTCCCAGGCAGTTTGATGCTCTGTGGAAGGAGGCGGGAAGGGAACGTTGGCCAAGTCAGTTACTGAGATG AAGATCGCCCAGCTGCCAGGACCACCCCAGGACAAGTTAGAGCACTGTTTAGCTCCTTTGTCTGTGTGATAGACCTAAGAACTGTATTAG TGTTGTACCAGCCTATTAACCTCTTGTCTGTGCACAGCTTCAAATGTTACCGTCTAGTTAGATTTTTATTTAAAATATGAAAAACTGCTT TTCCCAAGATGTTTTTTAAAAACAAAGCTACAATTTTAATATTTAACATATTTAAAGTTTCAAAGCACACCTGTTTGGCTTGGGTGGGGG TGGGGTGGGGGGGACATTCTTTTTCAGTCTTAATTTTTAAATATTTGATCATTTTCTATTGTCCAATCATTTCAGCACCTCCAAAGGTCC CTAGGACACTTTGCCTCTCTTCTCCCCCTGCCCCCCACCCTGCTCCCACATCTGGGGGCCCATGGGCCAGGAGTGGATAAGCCTGCATTA ATACAACCTTTCTCCATTCACTTTCTATTTACAAATTAGGAAAGCAACCTTTTGGTTTATATATATTTTTTTTAATACCTCAGTGCTGCA AGTATCACCAGAGAGGCTATGGAAGAATTTTTTTTTAATTTATTGTAGATGTAAACAGAATTTTAAAAATAAAAAGTATAAACATCACTG CACTGTGACTGGTGGGAAAAACTGACAGTTTCCTCTTTGCACATGTTTAACATTTGGCTGTTATAATATATGGTCCTCGGTTGGGGAAAG ATACTTATGATGAAGGATATTTTTTAATTTAACTTTTTTTTAAATATTGGTAATAGGTCGGCAACAGCAACTATAGAAGTACAACTCAAT AGATGGCATTAAAACATATTGTAGTGTGGATATATATTTTTTCTTTTTTAAAATGTGATATTGACGTTTTATTAATATTTTTTAAATTGT TACGTTTATAAATTTGGTACTTAAGGCACAGCCAGTATGAGACACTGAATGCGACATTTATTATAAAGAGCTGCTGCACTCCTATTTTTA TAAATTTTACTAACAAAGTAGACTAATGTAGACATTCACAGACATGGTAGGGCAAAAGCATCTTCAAACTAAAGACTCCAAAATGCTAAC TCAGAAAGAAAGAAAAAACCCGTTTTCAATTCTAATGAAACAGCAACAACATTTTTTTTAATTAAAAAAAAAATCATGTTCTTTGTTTTT CTAATAAAATGTTAGGTTGTTTGGTGAGGTTTTTTTGTTGTTTTTTTCCTTTCTTTGTTTCTTTTCTTTTCCCCCAAACAACCAGATTAA ATGCTGAGCGCTTTTAAAATATCAAAACTTGTTCAAGTCATAAAACAACAAAACATAAGTTTTATTTAAAAAAAAAAAAAGAAAGAAAAA ATAGTAAATTCCCAGAAATTCAGTGTTTAGACGAGGGAATTTAATTCCTATTTTGTCCATGTTGGTGATGTACTGTACTTCCCTTCCTTT TCTCTGCATCCCCCATCACCTCATAGAAGACTCTTTGTTGATCATTGTATGTTAATAATGTATAAAATGGCTATCTTGTAAGCGTGCTGT CCTGGTACTAGTGTAGCGACTTTTTTTCTCCTCTTTCTTCTAGTACATATTGATAGGTATAACATAATTAAGGTTTAAAAAAAATTAGAC ATAGTTATTCAGATTTAGGACCAGTAAGGATAGAACTTTCTCTTATTTATGAAAAAAAATGCTAATAATTTTGGGGCAGTTTTTTCCTTT AATTATTTTTTTCAATTTCAAGTTTAATTTTATTTTAGCTGATCTGATGTGGTTTCAACTAACCCAAGGTCTCACCATGTTAAAATGCCG GCGGACTCTACGGCGTTTTGTAGATCCCCCCCCCCCCACCCACTGTGAAGGGGTGCCATACTACCTTAAATGCTAATGCTAGATATGCAA AACTGGATTTTTTTAATTTATTTTTTAAAAGAGGGAGGCATGGTATATTAAAATGATTTTACTAAGAGAAAAAATATTTTTTTAAGAATG CTCAGAAGAAATTGATAATCTGTGTGAATATGTTTTAGATGTTTATATACCTTTTGAAGAGACCCAGTAGCCCATAGCACAAATCTTGTG GAAATCCGATATGTTTTAATGTGGCTACCTAGGTTTAAGGTTCACGTTAGTCCCCCCATTCCATCTAGAAGTCCATTTTGAAAGATTTTT GTAAATTCTTTTAACACTGATGTTTCAGCCTCGTCTTTGTTTCAGTTAAGCTCAATGGCGAACATGGGAACCACCTTTCGCCTTCCCTGG GGGAGAAACCCTCTTGGCTGATGGCTTTTCCCCGGAATTATCAAACAGCCACCGGGTGACTTTCTGGCTTCCAGATCCATCTGCCTGAGA CCCCCGAACTCCTCTCCTCCCAAGCAGAGGCGAGTGAGTGGCATTAGCTCCCGGACCCATTCCCGGTCCTAGCTGGGCATGGGGCTGACG GAGATGACCAAGCCTTGGTCTGCTCTCTAGCAGCTTCCACAGACTTGGCTCGTGGCCTTCCTTATATCCACTGGGAACAAACAGCCTCGC GCTCTATACCAAACAGCCTCGCGCTCTATCCCAGTCGCCCATTAGCTTGATTCAAACAAAGCCCCAGCAGGCCTTTGCGTTTTTATCCTT CATAACCTTCATCTTAATTTGAACTTGTAGCTTGGACTTTAAGGTAGCATGGCTCTATTGCTGTCAATTTACTGTTTCACTGCACAGCAA TCACAGCCAGTGAATGTTACACACATCTTGCTAGACTAGTATAAAAATCATTGGGTAATTGTTGGTTCTAATGACCTGAAAGGTGTTCAG TTTTTGTTCTTGGTTTTGTTTTGTTTTTGATTTCTTGGGGGTGGGTTTTGCTTGTTGTTCCTTTTCATTTGGGGGTTTTTGGGGAAAAAA TTTATTTTTGGTTCCAAATAGAAAAACAAAACCTATTTTGATCTTTAGTGCAAACGAGGGCTAGGGACTTAGCCTCCTCCACCACCTCCA CACTGCTTCATTCTGCCATTCACTCACTGCAGCATATTCAAGAATAAAGCAATATCGTTTACTACATTTTTTATTGAAGGTCAGCCATGC TTTCTGTATTATATTGCATATGAAATTGTTTACAAAAGAAACACTAACTCATACTTCTCTTTATTGGTTGCAAGTGGCACGCAGGAACAG AGGGAGAGTGGGGGGCTGGTGGGGGAGGGGAGATTTTTTTTTTTTTTTCTTGAATGTGCTTCGCAAGCCAGGCTATCTTCCAAGGAAGGC AGACAGTGGGAGAGCAGAGGGACTGACTGCAGGCAAGCACATTGAAGAAAGACACTGGCGGGTTTCCCCACCCTCACCCCAAAGCAGAAA ACTAGCAGACGTCAGCTCAGCCCCGTCCTGGGCACAGACACTACACAAGGAGACGCTGGAAGTTAAGCAATACTTTAATACTGTAATATG TTTGTTTTCTTTTTCTTTCTTTTTTTTCTACCAAAAAAAAGTAAGTAAACTAAAACACAAAAACATATAAATAAAATCCATCCCTCTTGT CGGGGACCTGCAGGGGGGCAACCTTAATCCAAACACCTGGCTATCAAATAATCAGAATGTATTGTCTCAGACAGGATTTCAGTTCCGGGA GGCAGGGGCATGATGGGGGAGGGGGCCGGAGGCTGAGAGACAAAAGTTCCAGAGCCTCCCTCGAAGGTTCTCTACTACTGTATTCTGTAC ATAATGTACCATCCCATGTGGAATCTGTGAGTGTCCTCTTAAGTAGCGTGGGCTAGCCAATCTGCCGTTCATGGTGTATTGTAAACTCCG AATTCCATATGTAATAGGATGCAAGTCTAAGCGTTTCATGTGGACATAAATGTATCTAAATAAAACTTTCCCTAGCACTGTGGCTGACCT CACCCTTACTTTTATACTTTAGTATGAAACTGATGAGAACTTTGGTAGTGAGTATTTTTTTTATATATATACATATATATGTACTATCTA TATATATATCTCAAGCATCTTTCAGGTCTTTGTGTGTGGCTTTCTTAAAGCCCTGTTGTAAAAAATTACTATGTGGATGGCAGTCTCTCA CATCACAGATGTGGAAAGTATAATTTTATATTTGTATTTTCAAATAAATAAGTTTGTGAAAGGTTTCCATCCTCTACTGTGGTCCAGAAA >22712_22712_6_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000284073_length(amino acids)=294AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASP -------------------------------------------------------------- >22712_22712_7_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000322684_length(transcript)=1765nt_BP=382nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAA ATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCT TACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCT CCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGT GGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAG CTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTC CAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAAC TTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGG GTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAAC ACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGG GGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGT GGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGG AGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCAT GGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGC TTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATT >22712_22712_7_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000322684_length(amino acids)=221AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM -------------------------------------------------------------- >22712_22712_8_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000416426_length(transcript)=1573nt_BP=382nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAA ATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCT TACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCT CCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGTC CTGAATAGCTACAGTGCTCAACCGAATTTTGGCGCGCCCGCTTCCCCGGCAGGCTCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCC AACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCG GGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACAAATGGATACCATTGAGCAGGTGCTTTCGTTGCCATC TCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGTGGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACC CCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGGTTGACTACATCTCATCATCTCACGAATCTGCTGTAA TATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTTGTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCT CTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGACTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTT CAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACATTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTT AAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGACTGTATGAATTTTCAGGTGGAACTTTAGCACACACT >22712_22712_8_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000416426_length(amino acids)=312AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLY -------------------------------------------------------------- >22712_22712_9_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000442934_length(transcript)=1695nt_BP=382nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAA ATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCT TACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCT CCAAGCTATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCAGCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGC TCCAACCCGGCGCGGCCCGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGGCCCTGCCAGCCAGGACTCCGGA GTGGGGAATTACATAAGTGCGGCCAGCCCACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAACGGCCTTTACA AATGGATACCATTGAGCAGGTGCTTTCGTTGCCATCTCACTCTGAGAGCATACCTGGATGTCCAGGCAAGACTGGGCGAAGTTTCTGAGT GGCCCTTTGTTTAGGTGATGTCCTCAGACCTGGACCCCCACCAGCCTCACTCCCCATCCCAACCAGAGATGGCTCACTTCGGATCGAGGG TTGACTACATCTCATCATCTCACGAATCTGCTGTAATATAAGACAACAGCTTTTAAATGTGTATATAACCCATGATTTCGGTTTTGTTTT GTTTTGTTTTTCTTGATGGTTTCCCTCTCCCTCCCTCTCTTCCCATTCTCCTTTTAAATCTCTTTGAATCACATTTGGTAGTGATTTTGA CTTAGTCCAGTAGTCACATAGCTTTAATATCTAGTTCAAAGCTAACCATAGTATAATTGTTATATTAAGGAGTTATTTTTTCTTAAAACA TTTTTTTTTGCTTGTTTTGGTTCTGTTCTCACTTTTAAAGGATGCTGAGATGGTAATATGACTCTCCATATTTTGGTACCAATTCTGAGA CTGTATGAATTTTCAGGTGGAACTTTAGCACACACTGAAGCAAAGTTGTGAAGTGCAGGGCGGGAGGTGGGCGTGAGCTTTCTATTTTGC GTTGTAGAAGAAGTGAGATGTAGTAAGCTAATTAACAGACTTTCTAGCAGTTCTTTTTGTGATGTCTCTTTGTTAATCTGAGTCTATCTA >22712_22712_9_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000442934_length(amino acids)=294AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM GMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASP -------------------------------------------------------------- >22712_22712_10_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000579180_length(transcript)=1770nt_BP=382nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGTGAGATTCATTTCCATGAA ATCAATAATAAAATGGTAGAATGTAAGAAAGCTCAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGGACTGCCT TACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATATCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCT CCAAGCTATGGCTATCAGTTCCCAGACTATTTGCCGGTTTCACAAGACATAATTTTTATCAACTAGCTCTTAAGAGAGGCATAGCAAAGT GGGGGTTGCTACCATTTCTAGAGAGAGAGGACACAGTCCCGGCCTGGGCTGCCCCCGCTCCAGTCAATGCTCACTGAAAGTCTGTCTTAG CTGCCTGTTTGAATGACTGTTCTTTTTCTCATTTTTAATTCTTGGACTCATGTCCTCATTGCTTCACTCAATTAAAAAAAAATTATTCTC CAGTCCCCTCCCACTTTGCTTCTTGTATGCATTGTGACCGACCCCACTTCCTCAGAATGTAACGGGGCCAGAGGGAAACTTCTCACAAAC TTCGTAGAGCCTCCTCAGGGGAAGCTAGGAAGAAGACATCAAATGTTTTTAAGTCATGACCAAACAGGCTTGTTGGGGACATATCATGGG GTGAGCTTTGAAGTGCTGGTGGTCCAGAGGGGTTGCAGATACGTGACTTGGAGCACCCGTGTCTTACGATGGACAGTGATAAAGGTGAAC ACACAGAGACAGACTATTCTCTAAGAATGTGAGAAACCTGATCTGGAAGAGGAGCTATATAAACACTATCTGACTATCTTTGTCTTTTGG GGCCAGTGGCTGTTGGCATAATCACAAGCCTGTCTGTCTTCGAGAAGGGACAGTGGAGTCATCCAGGTGCTGCCACATGACAGGCACGGT GGGCACCGATCCACAGTGGGCCCCGCCTTCCCCAGCTCGCCTCCCTGCCTGTGCTGGCCTGGCCTTGCCTGCTGGCACCATTGGAGTAGG AGGGGGTGGAACACAGGGGGCCCATCCTGATCAGGCCCCATCTCAAGGTTGGCACTCCTGCCCATCACCCTTAGAAGGATCTTTTCCCAT GGCTTGACTTCCTTCATTTCCCTAACTGAAATACACCCACTCTCTTGGAATAATGACGTACCACTCAGTTGGACCCTCAAGAGTCACTGC TTTGTCTGTGCTGGTAGTTTGTGAGAAGTGACCCGCACGCTTCCATTTGATGCATTTGATGTGAGTGAATCCATACATTTGAATGTCATT >22712_22712_10_DHX8-MSI2_DHX8_chr17_41567831_ENST00000540306_MSI2_chr17_55674229_ENST00000579180_length(amino acids)=221AA_BP=117 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGM -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for DHX8-MSI2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for DHX8-MSI2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for DHX8-MSI2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies