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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DHX8-TRPM7 (FusionGDB2 ID:HG1659TG54822) |
Fusion Gene Summary for DHX8-TRPM7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX8-TRPM7 | Fusion gene ID: hg1659tg54822 | Hgene | Tgene | Gene symbol | DHX8 | TRPM7 | Gene ID | 1659 | 54822 |
| Gene name | DEAH-box helicase 8 | transient receptor potential cation channel subfamily M member 7 | |
| Synonyms | DDX8|Dhr2|HRH1|PRP22|PRPF22 | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | |
| Cytomap | ('DHX8')('TRPM7') 17q21.31 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1 | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000262415, ENST00000540306, | ||
| Fusion gene scores | * DoF score | 17 X 12 X 11=2244 | 13 X 16 X 5=1040 |
| # samples | 18 | 15 | |
| ** MAII score | log2(18/2244*10)=-3.64000386427912 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1040*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DHX8 [Title/Abstract] AND TRPM7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DHX8(41585888)-TRPM7(50906460), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DHX8-TRPM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-TRPM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-TRPM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DHX8-TRPM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHX8 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Fusion gene breakpoints across DHX8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TRPM7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A8NI | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
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Fusion Gene ORF analysis for DHX8-TRPM7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262415 | ENST00000561443 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| 5CDS-intron | ENST00000540306 | ENST00000561443 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| In-frame | ENST00000262415 | ENST00000313478 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| In-frame | ENST00000262415 | ENST00000560955 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| In-frame | ENST00000540306 | ENST00000313478 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| In-frame | ENST00000540306 | ENST00000560955 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000540306 | DHX8 | chr17 | 41585888 | + | ENST00000560955 | TRPM7 | chr15 | 50906460 | - | 8063 | 2577 | 30 | 6677 | 2215 |
| ENST00000540306 | DHX8 | chr17 | 41585888 | + | ENST00000313478 | TRPM7 | chr15 | 50906460 | - | 8064 | 2577 | 30 | 6680 | 2216 |
| ENST00000262415 | DHX8 | chr17 | 41585888 | + | ENST00000560955 | TRPM7 | chr15 | 50906460 | - | 8060 | 2574 | 27 | 6674 | 2215 |
| ENST00000262415 | DHX8 | chr17 | 41585888 | + | ENST00000313478 | TRPM7 | chr15 | 50906460 | - | 8061 | 2574 | 27 | 6677 | 2216 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000540306 | ENST00000560955 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - | 0.000222852 | 0.99977714 |
| ENST00000540306 | ENST00000313478 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - | 0.000170563 | 0.9998294 |
| ENST00000262415 | ENST00000560955 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - | 0.000222557 | 0.9997775 |
| ENST00000262415 | ENST00000313478 | DHX8 | chr17 | 41585888 | + | TRPM7 | chr15 | 50906460 | - | 0.000170384 | 0.99982953 |
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Fusion Genomic Features for DHX8-TRPM7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for DHX8-TRPM7 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41585888/chr15:50906460) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 172_175 | 834 | 1221.0 | Compositional bias | Note=Poly-Lys |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 176_228 | 834 | 1221.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 265_336 | 834 | 1221.0 | Domain | S1 motif |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 575_738 | 834 | 1221.0 | Domain | Helicase ATP-binding |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 685_688 | 834 | 1221.0 | Motif | Note=DEAH box |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 588_595 | 834 | 1221.0 | Nucleotide binding | ATP |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1198_1250 | 498 | 1866.0 | Coiled coil | Ontology_term=ECO:0000250 | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1594_1824 | 498 | 1866.0 | Domain | Alpha-type protein kinase | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1036_1056 | 498 | 1866.0 | Intramembrane | Pore-forming | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1794_1800 | 498 | 1866.0 | Nucleotide binding | ATP | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1017_1035 | 498 | 1866.0 | Topological domain | Extracellular | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1057_1074 | 498 | 1866.0 | Topological domain | Extracellular | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1096_1865 | 498 | 1866.0 | Topological domain | Cytoplasmic | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 777_855 | 498 | 1866.0 | Topological domain | Extracellular | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 877_918 | 498 | 1866.0 | Topological domain | Cytoplasmic | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 940_962 | 498 | 1866.0 | Topological domain | Extracellular | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 984_995 | 498 | 1866.0 | Topological domain | Cytoplasmic | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1075_1095 | 498 | 1866.0 | Transmembrane | Helical | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 756_776 | 498 | 1866.0 | Transmembrane | Helical | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 856_876 | 498 | 1866.0 | Transmembrane | Helical | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 919_939 | 498 | 1866.0 | Transmembrane | Helical | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 963_983 | 498 | 1866.0 | Transmembrane | Helical | |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 996_1016 | 498 | 1866.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHX8 | chr17:41585888 | chr15:50906460 | ENST00000262415 | + | 16 | 23 | 756_936 | 834 | 1221.0 | Domain | Helicase C-terminal |
| Tgene | TRPM7 | chr17:41585888 | chr15:50906460 | ENST00000313478 | 12 | 39 | 1_755 | 498 | 1866.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for DHX8-TRPM7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >22722_22722_1_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000262415_TRPM7_chr15_50906460_ENST00000313478_length(transcript)=8061nt_BP=2574nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCGGAC AACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGCGCA GCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGATCGA GACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGGAAT AAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAATCTG GATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATCATG CAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGTGTG GCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATGAAG GATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGGAAT CCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCTGAC CCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATTCTC CCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAAAGC ATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAAAGG CGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGATGCG GAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGCAAC AAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTCCAG GCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCAGGC TACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGTTGT TGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATGTTG CTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGATGTG CTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTTTCT CAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGATTAT CTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAAATT GATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCTCTT CCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGGGAAATCTTCCTCCAGGATATAAGATCACTCTGATT GATATAGGACTTGTTATTGAATATCTCATGGGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGTCTT GGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAGAGTCATGAATCTTTTGGCAATAGGGCAGAT AAAAAGGAAAAAATGAGGCATAACCATTTCATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAGAAG AAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTATCCACTTAATGAACTTTTAATTTGGGCTTGC CTTATGAAGAGGCAGGTCATGGCCCGTTTTTTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTATCGT TCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAACAGTATTCCAATGATTTTGGTCAGTTGGCC GTTGAATTATTAGAACAGTCCTTCAGACAAGATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCAACC TGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAAATGTTGTTATCTGATATGTGGATGGGAAGG CTGAATATGAGGAAAAATTCCTGGTACAAGGTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAGGCT GAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAAAACAACTTTCAGAACATAACAGAAGAGATC CCCATGGAAGTGTTTAAAGAAGTACGGATTTTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTTCCA ATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACGTTGGCATATTTAGGATTTCTGATGCTTTAT ACATTTGTGGTTCTTGTACAAATGGAACAGTTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAGAAA GTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTTAGTGATTACTTCAACATCAGTGATACAATT GCCATAATTTCTTTCTTCATTGGATTTGGACTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTGGCT GGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTAGCTGTAAATCAACAGGCAGGACCTTATGTA ATGATGATTGGAAAAATGGTGGCCAATATGTTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAGGCA ATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCATACTGGATGATTTTTGGTGAAGTTTATGCA TACGAAATTGATGTGTGTGCAAATGATTCTGTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTCTAC CTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTATTTACAAGTGAAGGCAATTTCCAATATTGTA TGGAAGTACCAGCGTTATCATTTTATTATGGCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTTTCT CTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTTTTCTTAACAGAAGAAGATCAAAAGAAACTT CATGATTTTGAAGAGCAGTGTGTTGAAATGTATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTCACT TTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTACATAAAAAGATCATTACAATCATTAGATTCT CAAATTGGCCATTTGCAAGATCTTTCAGCCCTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAAGTT CATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGATGATGGTCCTGTAAGACCTTCTGTATGGAAA AAGCATGGTGTTGTAAATACACTTAGCTCCTCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATGAAA GATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGAAAAGAATTTAATTTTCCAGAGGCTGGTTCC TCTTCTGGTGCCTTATTCCCAAGTGCTGTTTCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAATAAA AATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAATTTTTTGTTAGTACACCATCTCAGCCAAGT TGCAAAAGCCACTTGGAAACTGGAACCAAAGATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCATTT GTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAAATACTATCCAATAACAATACTTCTGAAAAC ACTTTGAAACGAGTGAGTTCTCTTGCTGGATTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGCAGAAAAAATCAGT AGAAGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGATTGGTTACAAGATAGACCATCAAACAGAGAA ATGCCATCTGAAGAAGGAACATTAAATGGTCTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAAAGA AATAACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAGCCTGTCACAGTGTATCGTTTGGAAGAGAGT TCACCCAACATACTAAATAACAGCATGTCTTCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATGGGA GGAGGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAATCAGGGCATCTTTATATTATCAAATCTTTT CTTCCAGAGGTGGTTAATACATGGTCAAGTATTTACAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGAGCA GCACAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCAAGGTTCCTTGAAGTTTTCCTGCTGTATTGC CATTCAGCAGGACAGTGGTTTGCTGTGGAAGAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATTCCA ACTAATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGAGGGGAGTTACTGGTACTTGATTTGCAAGGT GTTGGTGAAAATTTGACTGACCCATCTGTGATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGAGAA GATGCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAACTTCCAGATCTGAAGAGGAATGATTATACG CCTGATAAAATTATATTTCCTCAGGATGAGCCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAATTCT GTTCGTCTGATGTTATAATATTAATATTACTGAATCATTGGTTTTGCCTGCACCTCACAGAAATGTTACTGTGTCACTTTTCCCTCGGGA GGAAATTGTTTGGTAATATAGAAAGGTGTATGCAAGTTGAATTTGCTGACTCCAGCACAGTTAAAAGGTCAATATTCTTTTGACCTGATT AATCAGTCAGAAAGTCCCTATAGGATAGAGCTGGCAGCTGAGAAATTTTAAAGGTAATTGATAATTAGTATTTATAACTTTTTAAAGGGC TCTTTGTATAGCAGAGGATCTCATTTGACTTTGTTTTGATGAGGGTGATGCTCTCTCTTATGTGGTACAATACCATTAACCAAAGGTAGG TGTCCATGCAGATTTTATTGGCAGCTGTTTTATTGCCATTCAACTAGGGAAATGAAGAAATCACGCAGCCTTTTGGTTAAATGGCAGTCA AAATTTTCCTCAGTGTATTTAGTGTGTTCAGTGATGATATCACTGGTTCCCAACTAGATGCTTGTTGGCCACGGGAAGGGAAATGACTTG TTCTAATTCTAGGTTCACAGAGGTATGAGAAGCCTGAACTGAAGACCATTTTCAAGAGGGACGGTATTTATGAATCAGGGTTAGGCTCCA TATTTAAAGATAGAGCCAGTTTTTTTTTTTAAATAGAACCCAAATTGTGTAAAAATGTTAATTGGGTTTTTTAAACATTGTTTTATCAAG TCACTGTTAAGTAGAAGAAAGCCATGGTAAACTGATACATAACCTAAATTATAAAAGCAGAAACCTAACTCACTCGTCAAGGGAAGTTAC CTTTTGAGGAAAGTTAAAGTACTTTTTTCCCTATCTGTATCTATAGCAACAACCCAGAACTTACAAACTTCTCCAAAGATTTTATTGATT GTTATATCAAATCAGAATGTAAACATGAACTCTTGCATATATTTAAAATTGTGTTGGAACATTTGAACATGAATGCTGTTTGTGGTACTT AAGAAATTAATTCAGTTGGATTATCATTATGTGATACTGGCAGATTGCAGTGCAACCTTATGCCAATAAAATGTAATTTAACAGCCCCAG ATATTGTTGAATATTCAACAATAACAAGAAAAGCTTTTCATCTAAGTTTTATGCTTTAATTTTTTTTCTTTTTTTTTCTTTTTCTTTTGT TTCCTTGGTACTAATTTTAATTTTTATTTGGAAGGGAGCAGTATAAAGCTTATTTGTATTTAGTAGTGTATCTCATAGATACAGACAAGG CAAGAGATGATAAGCTGTTTAAATAGTGTTTAATATTGATTGGGGGTGGGGAGAAAGAAAAAGTGTATTACTTAAAGATACTATATACGT >22722_22722_1_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000262415_TRPM7_chr15_50906460_ENST00000313478_length(amino acids)=2216AA_BP=849 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLN GLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKV QCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAV EECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAK -------------------------------------------------------------- >22722_22722_2_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000262415_TRPM7_chr15_50906460_ENST00000560955_length(transcript)=8060nt_BP=2574nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCGGAC AACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGCGCA GCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGATCGA GACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGGAAT AAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAATCTG GATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATCATG CAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGTGTG GCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATGAAG GATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGGAAT CCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCTGAC CCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATTCTC CCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAAAGC ATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAAAGG CGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGATGCG GAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGCAAC AAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTCCAG GCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCAGGC TACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGTTGT TGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATGTTG CTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGATGTG CTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTTTCT CAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGATTAT CTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAAATT GATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCTCTT CCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGGGAAATCTTCCTCCAGGATATAAGATCACTCTGATT GATATAGGACTTGTTATTGAATATCTCATGGGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGTCTT GGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAGAGTCATGAATCTTTTGGCAATAGGGCAGAT AAAAAGGAAAAAATGAGGCATAACCATTTCATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAGAAG AAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTATCCACTTAATGAACTTTTAATTTGGGCTTGC CTTATGAAGAGGCAGGTCATGGCCCGTTTTTTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTATCGT TCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAACAGTATTCCAATGATTTTGGTCAGTTGGCC GTTGAATTATTAGAACAGTCCTTCAGACAAGATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCAACC TGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAAATGTTGTTATCTGATATGTGGATGGGAAGG CTGAATATGAGGAAAAATTCCTGGTACAAGGTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAGGCT GAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAAAACAACTTTCAGAACATAACAGAAGAGATC CCCATGGAAGTGTTTAAAGAAGTACGGATTTTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTTCCA ATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACGTTGGCATATTTAGGATTTCTGATGCTTTAT ACATTTGTGGTTCTTGTACAAATGGAACAGTTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAGAAA GTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTTAGTGATTACTTCAACATCAGTGATACAATT GCCATAATTTCTTTCTTCATTGGATTTGGACTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTGGCT GGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTAGCTGTAAATCAACAGGCAGGACCTTATGTA ATGATGATTGGAAAAATGGTGGCCAATATGTTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAGGCA ATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCATACTGGATGATTTTTGGTGAAGTTTATGCA TACGAAATTGATGTGTGTGCAAATGATTCTGTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTCTAC CTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTATTTACAAGTGAAGGCAATTTCCAATATTGTA TGGAAGTACCAGCGTTATCATTTTATTATGGCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTTTCT CTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTTTTCTTAACAGAAGAAGATCAAAAGAAACTT CATGATTTTGAAGAGCAGTGTGTTGAAATGTATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTCACT TTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTACATAAAAAGATCATTACAATCATTAGATTCT CAAATTGGCCATTTGCAAGATCTTTCAGCCCTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAAGTT CATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGATGATGGTCCTGTAAGACCTTCTGTATGGAAA AAGCATGGTGTTGTAAATACACTTAGCTCCTCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATGAAA GATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGAAAAGAATTTAATTTTCCAGAGGCTGGTTCC TCTTCTGGTGCCTTATTCCCAAGTGCTGTTTCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAATAAA AATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAATTTTTTGTTAGTACACCATCTCAGCCAAGT TGCAAAAGCCACTTGGAAACTGGAACCAAAGATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCATTT GTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAAATACTATCCAATAACAATACTTCTGAAAAC ACTTTGAAACGAGTGAGTTCTCTTGCTGGATTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGAAAAAATCAGTAGA AGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGATTGGTTACAAGATAGACCATCAAACAGAGAAATG CCATCTGAAGAAGGAACATTAAATGGTCTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAAAGAAAT AACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAGCCTGTCACAGTGTATCGTTTGGAAGAGAGTTCA CCCAACATACTAAATAACAGCATGTCTTCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATGGGAGGA GGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAATCAGGGCATCTTTATATTATCAAATCTTTTCTT CCAGAGGTGGTTAATACATGGTCAAGTATTTACAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGAGCAGCA CAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCAAGGTTCCTTGAAGTTTTCCTGCTGTATTGCCAT TCAGCAGGACAGTGGTTTGCTGTGGAAGAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATTCCAACT AATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGAGGGGAGTTACTGGTACTTGATTTGCAAGGTGTT GGTGAAAATTTGACTGACCCATCTGTGATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGAGAAGAT GCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAACTTCCAGATCTGAAGAGGAATGATTATACGCCT GATAAAATTATATTTCCTCAGGATGAGCCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAATTCTGTT CGTCTGATGTTATAATATTAATATTACTGAATCATTGGTTTTGCCTGCACCTCACAGAAATGTTACTGTGTCACTTTTCCCTCGGGAGGA AATTGTTTGGTAATATAGAAAGGTGTATGCAAGTTGAATTTGCTGACTCCAGCACAGTTAAAAGGTCAATATTCTTTTGACCTGATTAAT CAGTCAGAAAGTCCCTATAGGATAGAGCTGGCAGCTGAGAAATTTTAAAGGTAATTGATAATTAGTATTTATAACTTTTTAAAGGGCTCT TTGTATAGCAGAGGATCTCATTTGACTTTGTTTTGATGAGGGTGATGCTCTCTCTTATGTGGTACAATACCATTAACCAAAGGTAGGTGT CCATGCAGATTTTATTGGCAGCTGTTTTATTGCCATTCAACTAGGGAAATGAAGAAATCACGCAGCCTTTTGGTTAAATGGCAGTCAAAA TTTTCCTCAGTGTATTTAGTGTGTTCAGTGATGATATCACTGGTTCCCAACTAGATGCTTGTTGGCCACGGGAAGGGAAATGACTTGTTC TAATTCTAGGTTCACAGAGGTATGAGAAGCCTGAACTGAAGACCATTTTCAAGAGGGACGGTATTTATGAATCAGGGTTAGGCTCCATAT TTAAAGATAGAGCCAGTTTTTTTTTTTAAATAGAACCCAAATTGTGTAAAAATGTTAATTGGGTTTTTTAAACATTGTTTTATCAAGTCA CTGTTAAGTAGAAGAAAGCCATGGTAAACTGATACATAACCTAAATTATAAAAGCAGAAACCTAACTCACTCGTCAAGGGAAGTTACCTT TTGAGGAAAGTTAAAGTACTTTTTTCCCTATCTGTATCTATAGCAACAACCCAGAACTTACAAACTTCTCCAAAGATTTTATTGATTGTT ATATCAAATCAGAATGTAAACATGAACTCTTGCATATATTTAAAATTGTGTTGGAACATTTGAACATGAATGCTGTTTGTGGTACTTAAG AAATTAATTCAGTTGGATTATCATTATGTGATACTGGCAGATTGCAGTGCAACCTTATGCCAATAAAATGTAATTTAACAGCCCCAGATA TTGTTGAATATTCAACAATAACAAGAAAAGCTTTTCATCTAAGTTTTATGCTTTAATTTTTTTTCTTTTTTTTTCTTTTTCTTTTGTTTC CTTGGTACTAATTTTAATTTTTATTTGGAAGGGAGCAGTATAAAGCTTATTTGTATTTAGTAGTGTATCTCATAGATACAGACAAGGCAA GAGATGATAAGCTGTTTAAATAGTGTTTAATATTGATTGGGGGTGGGGAGAAAGAAAAAGTGTATTACTTAAAGATACTATATACGTTTT >22722_22722_2_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000262415_TRPM7_chr15_50906460_ENST00000560955_length(amino acids)=2215AA_BP=849 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQ CTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVE ECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKH -------------------------------------------------------------- >22722_22722_3_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000540306_TRPM7_chr15_50906460_ENST00000313478_length(transcript)=8064nt_BP=2577nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCG GACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGC GCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGAT CGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGG AATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAAT CTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATC ATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGT GTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATG AAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGG AATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCT GACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATT CTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAA AGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAA AGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGAT GCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGC AACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTC CAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCA GGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGT TGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATG TTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGAT GTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTT TCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGAT TATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAA ATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCT CTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGGGAAATCTTCCTCCAGGATATAAGATCACTCTG ATTGATATAGGACTTGTTATTGAATATCTCATGGGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGT CTTGGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAGAGTCATGAATCTTTTGGCAATAGGGCA GATAAAAAGGAAAAAATGAGGCATAACCATTTCATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAG AAGAAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTATCCACTTAATGAACTTTTAATTTGGGCT TGCCTTATGAAGAGGCAGGTCATGGCCCGTTTTTTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTAT CGTTCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAACAGTATTCCAATGATTTTGGTCAGTTG GCCGTTGAATTATTAGAACAGTCCTTCAGACAAGATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCA ACCTGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAAATGTTGTTATCTGATATGTGGATGGGA AGGCTGAATATGAGGAAAAATTCCTGGTACAAGGTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAG GCTGAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAAAACAACTTTCAGAACATAACAGAAGAG ATCCCCATGGAAGTGTTTAAAGAAGTACGGATTTTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTT CCAATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACGTTGGCATATTTAGGATTTCTGATGCTT TATACATTTGTGGTTCTTGTACAAATGGAACAGTTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAG AAAGTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTTAGTGATTACTTCAACATCAGTGATACA ATTGCCATAATTTCTTTCTTCATTGGATTTGGACTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTG GCTGGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTAGCTGTAAATCAACAGGCAGGACCTTAT GTAATGATGATTGGAAAAATGGTGGCCAATATGTTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAG GCAATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCATACTGGATGATTTTTGGTGAAGTTTAT GCATACGAAATTGATGTGTGTGCAAATGATTCTGTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTC TACCTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTATTTACAAGTGAAGGCAATTTCCAATATT GTATGGAAGTACCAGCGTTATCATTTTATTATGGCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTT TCTCTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTTTTCTTAACAGAAGAAGATCAAAAGAAA CTTCATGATTTTGAAGAGCAGTGTGTTGAAATGTATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTC ACTTTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTACATAAAAAGATCATTACAATCATTAGAT TCTCAAATTGGCCATTTGCAAGATCTTTCAGCCCTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAA GTTCATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGATGATGGTCCTGTAAGACCTTCTGTATGG AAAAAGCATGGTGTTGTAAATACACTTAGCTCCTCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATG AAAGATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGAAAAGAATTTAATTTTCCAGAGGCTGGT TCCTCTTCTGGTGCCTTATTCCCAAGTGCTGTTTCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAAT AAAAATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAATTTTTTGTTAGTACACCATCTCAGCCA AGTTGCAAAAGCCACTTGGAAACTGGAACCAAAGATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCA TTTGTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAAATACTATCCAATAACAATACTTCTGAA AACACTTTGAAACGAGTGAGTTCTCTTGCTGGATTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGCAGAAAAAATC AGTAGAAGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGATTGGTTACAAGATAGACCATCAAACAGA GAAATGCCATCTGAAGAAGGAACATTAAATGGTCTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAA AGAAATAACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAGCCTGTCACAGTGTATCGTTTGGAAGAG AGTTCACCCAACATACTAAATAACAGCATGTCTTCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATG GGAGGAGGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAATCAGGGCATCTTTATATTATCAAATCT TTTCTTCCAGAGGTGGTTAATACATGGTCAAGTATTTACAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGA GCAGCACAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCAAGGTTCCTTGAAGTTTTCCTGCTGTAT TGCCATTCAGCAGGACAGTGGTTTGCTGTGGAAGAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATT CCAACTAATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGAGGGGAGTTACTGGTACTTGATTTGCAA GGTGTTGGTGAAAATTTGACTGACCCATCTGTGATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGA GAAGATGCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAACTTCCAGATCTGAAGAGGAATGATTAT ACGCCTGATAAAATTATATTTCCTCAGGATGAGCCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAAT TCTGTTCGTCTGATGTTATAATATTAATATTACTGAATCATTGGTTTTGCCTGCACCTCACAGAAATGTTACTGTGTCACTTTTCCCTCG GGAGGAAATTGTTTGGTAATATAGAAAGGTGTATGCAAGTTGAATTTGCTGACTCCAGCACAGTTAAAAGGTCAATATTCTTTTGACCTG ATTAATCAGTCAGAAAGTCCCTATAGGATAGAGCTGGCAGCTGAGAAATTTTAAAGGTAATTGATAATTAGTATTTATAACTTTTTAAAG GGCTCTTTGTATAGCAGAGGATCTCATTTGACTTTGTTTTGATGAGGGTGATGCTCTCTCTTATGTGGTACAATACCATTAACCAAAGGT AGGTGTCCATGCAGATTTTATTGGCAGCTGTTTTATTGCCATTCAACTAGGGAAATGAAGAAATCACGCAGCCTTTTGGTTAAATGGCAG TCAAAATTTTCCTCAGTGTATTTAGTGTGTTCAGTGATGATATCACTGGTTCCCAACTAGATGCTTGTTGGCCACGGGAAGGGAAATGAC TTGTTCTAATTCTAGGTTCACAGAGGTATGAGAAGCCTGAACTGAAGACCATTTTCAAGAGGGACGGTATTTATGAATCAGGGTTAGGCT CCATATTTAAAGATAGAGCCAGTTTTTTTTTTTAAATAGAACCCAAATTGTGTAAAAATGTTAATTGGGTTTTTTAAACATTGTTTTATC AAGTCACTGTTAAGTAGAAGAAAGCCATGGTAAACTGATACATAACCTAAATTATAAAAGCAGAAACCTAACTCACTCGTCAAGGGAAGT TACCTTTTGAGGAAAGTTAAAGTACTTTTTTCCCTATCTGTATCTATAGCAACAACCCAGAACTTACAAACTTCTCCAAAGATTTTATTG ATTGTTATATCAAATCAGAATGTAAACATGAACTCTTGCATATATTTAAAATTGTGTTGGAACATTTGAACATGAATGCTGTTTGTGGTA CTTAAGAAATTAATTCAGTTGGATTATCATTATGTGATACTGGCAGATTGCAGTGCAACCTTATGCCAATAAAATGTAATTTAACAGCCC CAGATATTGTTGAATATTCAACAATAACAAGAAAAGCTTTTCATCTAAGTTTTATGCTTTAATTTTTTTTCTTTTTTTTTCTTTTTCTTT TGTTTCCTTGGTACTAATTTTAATTTTTATTTGGAAGGGAGCAGTATAAAGCTTATTTGTATTTAGTAGTGTATCTCATAGATACAGACA AGGCAAGAGATGATAAGCTGTTTAAATAGTGTTTAATATTGATTGGGGGTGGGGAGAAAGAAAAAGTGTATTACTTAAAGATACTATATA >22722_22722_3_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000540306_TRPM7_chr15_50906460_ENST00000313478_length(amino acids)=2216AA_BP=849 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLN GLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKV QCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAV EECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAK -------------------------------------------------------------- >22722_22722_4_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000540306_TRPM7_chr15_50906460_ENST00000560955_length(transcript)=8063nt_BP=2577nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCG GACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGC GCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGAT CGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGG AATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAAT CTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATC ATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGT GTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATG AAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGG AATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCT GACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATT CTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAA AGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAA AGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGAT GCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGC AACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTC CAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCA GGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGT TGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATG TTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGAT GTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTT TCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGAT TATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAA ATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCT CTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGGGAAATCTTCCTCCAGGATATAAGATCACTCTG ATTGATATAGGACTTGTTATTGAATATCTCATGGGAGGAACCTACAGATGCACCTATACTAGGAAACGTTTTCGATTAATATATAATAGT CTTGGTGGAAATAATCGGAGGTCTGGCCGAAATACCTCCAGCAGCACTCCTCAGTTGCGAAAGAGTCATGAATCTTTTGGCAATAGGGCA GATAAAAAGGAAAAAATGAGGCATAACCATTTCATTAAGACAGCACAGCCCTACCGACCAAAGATTGATACAGTTATGGAAGAAGGAAAG AAGAAAAGAACCAAAGATGAAATTGTAGACATTGATGATCCAGAAACCAAGCGCTTTCCTTATCCACTTAATGAACTTTTAATTTGGGCT TGCCTTATGAAGAGGCAGGTCATGGCCCGTTTTTTATGGCAACATGGTGAAGAATCAATGGCTAAAGCATTAGTTGCCTGTAAGATCTAT CGTTCAATGGCATATGAAGCAAAGCAGAGTGACCTGGTAGATGATACTTCAGAAGAACTAAAACAGTATTCCAATGATTTTGGTCAGTTG GCCGTTGAATTATTAGAACAGTCCTTCAGACAAGATGAAACCATGGCTATGAAATTGCTCACTTATGAACTGAAGAACTGGAGTAATTCA ACCTGCCTTAAGTTAGCAGTTTCTTCAAGACTTAGACCTTTTGTAGCTCACACCTGTACACAAATGTTGTTATCTGATATGTGGATGGGA AGGCTGAATATGAGGAAAAATTCCTGGTACAAGGTCATACTAAGCATTTTAGTTCCACCTGCCATATTGCTGTTAGAGTATAAAACTAAG GCTGAAATGTCCCATATCCCACAATCTCAAGATGCTCATCAGATGACAATGGATGACAGCGAAAACAACTTTCAGAACATAACAGAAGAG ATCCCCATGGAAGTGTTTAAAGAAGTACGGATTTTGGATAGTAATGAAGGAAAGAATGAGATGGAGATACAAATGAAATCAAAAAAGCTT CCAATTACGCGAAAGTTTTATGCCTTTTATCATGCACCAATTGTAAAATTCTGGTTTAACACGTTGGCATATTTAGGATTTCTGATGCTT TATACATTTGTGGTTCTTGTACAAATGGAACAGTTACCTTCAGTTCAAGAATGGATTGTTATTGCTTATATTTTTACTTATGCCATTGAG AAAGTCCGTGAGATCTTTATGTCTGAAGCTGGGAAAGTAAACCAGAAGATTAAAGTATGGTTTAGTGATTACTTCAACATCAGTGATACA ATTGCCATAATTTCTTTCTTCATTGGATTTGGACTAAGATTTGGAGCAAAATGGAACTTTGCAAATGCATATGATAATCATGTTTTTGTG GCTGGAAGATTAATTTACTGTCTTAACATAATATTTTGGTATGTGCGTTTGCTAGATTTTCTAGCTGTAAATCAACAGGCAGGACCTTAT GTAATGATGATTGGAAAAATGGTGGCCAATATGTTCTACATTGTAGTGATTATGGCTCTTGTATTACTTAGTTTTGGTGTTCCCAGAAAG GCAATACTTTATCCTCATGAAGCACCATCTTGGACTCTTGCTAAAGATATAGTTTTTCACCCATACTGGATGATTTTTGGTGAAGTTTAT GCATACGAAATTGATGTGTGTGCAAATGATTCTGTTATCCCTCAAATCTGTGGTCCTGGGACGTGGTTGACTCCATTTCTTCAAGCAGTC TACCTCTTTGTACAGTATATCATTATGGTTAATCTTCTTATTGCATTTTTCAACAATGTGTATTTACAAGTGAAGGCAATTTCCAATATT GTATGGAAGTACCAGCGTTATCATTTTATTATGGCTTATCATGAGAAACCAGTTCTGCCTCCTCCACTTATCATTCTTAGCCATATAGTT TCTCTGTTTTGCTGCATATGTAAGAGAAGAAAGAAAGATAAGACTTCCGATGGACCAAAACTTTTCTTAACAGAAGAAGATCAAAAGAAA CTTCATGATTTTGAAGAGCAGTGTGTTGAAATGTATTTCAATGAAAAAGATGACAAATTTCATTCTGGGAGTGAAGAGAGAATTCGTGTC ACTTTTGAAAGAGTGGAACAGATGTGCATTCAGATTAAAGAAGTTGGAGATCGTGTCAACTACATAAAAAGATCATTACAATCATTAGAT TCTCAAATTGGCCATTTGCAAGATCTTTCAGCCCTGACGGTAGATACATTAAAAACACTCACTGCCCAGAAAGCGTCGGAAGCTAGCAAA GTTCATAATGAAATCACACGAGAACTGAGCATTTCCAAACACTTGGCTCAAAACCTTATTGATGATGGTCCTGTAAGACCTTCTGTATGG AAAAAGCATGGTGTTGTAAATACACTTAGCTCCTCTCTTCCTCAAGGTGATCTTGAAAGTAATAATCCTTTTCATTGTAATATTTTAATG AAAGATGACAAAGATCCCCAGTGTAATATATTTGGTCAAGACTTACCTGCAGTACCCCAGAGAAAAGAATTTAATTTTCCAGAGGCTGGT TCCTCTTCTGGTGCCTTATTCCCAAGTGCTGTTTCCCCTCCAGAACTGCGACAGAGACTACATGGGGTAGAACTCTTAAAAATATTTAAT AAAAATCAAAAATTAGGCAGTTCATCTACTAGCATACCACATCTGTCATCCCCACCAACCAAATTTTTTGTTAGTACACCATCTCAGCCA AGTTGCAAAAGCCACTTGGAAACTGGAACCAAAGATCAAGAAACTGTTTGCTCTAAAGCTACAGAAGGAGATAATACAGAATTTGGAGCA TTTGTAGGACACAGAGATAGCATGGATTTACAGAGGTTTAAAGAAACATCAAACAAGATAAAAATACTATCCAATAACAATACTTCTGAA AACACTTTGAAACGAGTGAGTTCTCTTGCTGGATTTACTGACTGTCACAGAACTTCCATTCCTGTTCATTCAAAACAAGAAAAAATCAGT AGAAGGCCATCTACCGAAGACACTCATGAAGTAGATTCCAAAGCAGCTTTAATACCGGATTGGTTACAAGATAGACCATCAAACAGAGAA ATGCCATCTGAAGAAGGAACATTAAATGGTCTCACTTCTCCATTTAAGCCAGCTATGGATACAAATTACTATTATTCAGCTGTGGAAAGA AATAACTTGATGAGGTTATCACAGAGCATTCCATTTACACCTGTGCCTCCAAGAGGGGAGCCTGTCACAGTGTATCGTTTGGAAGAGAGT TCACCCAACATACTAAATAACAGCATGTCTTCTTGGTCACAACTAGGCCTCTGTGCCAAAATAGAGTTTTTAAGCAAAGAGGAGATGGGA GGAGGTTTACGAAGAGCTGTCAAAGTACAGTGTACCTGGTCAGAACATGATATCCTCAAATCAGGGCATCTTTATATTATCAAATCTTTT CTTCCAGAGGTGGTTAATACATGGTCAAGTATTTACAAAGAAGATACAGTTCTGCATCTCTGTCTGAGAGAAATTCAACAACAGAGAGCA GCACAAAAGCTTACGTTTGCCTTTAATCAAATGAAACCCAAATCCATACCATATTCTCCAAGGTTCCTTGAAGTTTTCCTGCTGTATTGC CATTCAGCAGGACAGTGGTTTGCTGTGGAAGAATGTATGACTGGAGAATTTAGAAAATACAACAATAATAATGGAGATGAGATTATTCCA ACTAATACTCTGGAAGAGATCATGCTAGCCTTTAGCCACTGGACTTACGAATATACAAGAGGGGAGTTACTGGTACTTGATTTGCAAGGT GTTGGTGAAAATTTGACTGACCCATCTGTGATAAAAGCAGAAGAAAAGAGATCCTGTGATATGGTTTTTGGCCCAGCAAATCTAGGAGAA GATGCAATTAAAAACTTCAGAGCAAAACATCACTGTAATTCTTGCTGTAGAAAGCTTAAACTTCCAGATCTGAAGAGGAATGATTATACG CCTGATAAAATTATATTTCCTCAGGATGAGCCTTCAGATTTGAATCTTCAGCCTGGAAATTCCACCAAAGAATCAGAATCAACTAATTCT GTTCGTCTGATGTTATAATATTAATATTACTGAATCATTGGTTTTGCCTGCACCTCACAGAAATGTTACTGTGTCACTTTTCCCTCGGGA GGAAATTGTTTGGTAATATAGAAAGGTGTATGCAAGTTGAATTTGCTGACTCCAGCACAGTTAAAAGGTCAATATTCTTTTGACCTGATT AATCAGTCAGAAAGTCCCTATAGGATAGAGCTGGCAGCTGAGAAATTTTAAAGGTAATTGATAATTAGTATTTATAACTTTTTAAAGGGC TCTTTGTATAGCAGAGGATCTCATTTGACTTTGTTTTGATGAGGGTGATGCTCTCTCTTATGTGGTACAATACCATTAACCAAAGGTAGG TGTCCATGCAGATTTTATTGGCAGCTGTTTTATTGCCATTCAACTAGGGAAATGAAGAAATCACGCAGCCTTTTGGTTAAATGGCAGTCA AAATTTTCCTCAGTGTATTTAGTGTGTTCAGTGATGATATCACTGGTTCCCAACTAGATGCTTGTTGGCCACGGGAAGGGAAATGACTTG TTCTAATTCTAGGTTCACAGAGGTATGAGAAGCCTGAACTGAAGACCATTTTCAAGAGGGACGGTATTTATGAATCAGGGTTAGGCTCCA TATTTAAAGATAGAGCCAGTTTTTTTTTTTAAATAGAACCCAAATTGTGTAAAAATGTTAATTGGGTTTTTTAAACATTGTTTTATCAAG TCACTGTTAAGTAGAAGAAAGCCATGGTAAACTGATACATAACCTAAATTATAAAAGCAGAAACCTAACTCACTCGTCAAGGGAAGTTAC CTTTTGAGGAAAGTTAAAGTACTTTTTTCCCTATCTGTATCTATAGCAACAACCCAGAACTTACAAACTTCTCCAAAGATTTTATTGATT GTTATATCAAATCAGAATGTAAACATGAACTCTTGCATATATTTAAAATTGTGTTGGAACATTTGAACATGAATGCTGTTTGTGGTACTT AAGAAATTAATTCAGTTGGATTATCATTATGTGATACTGGCAGATTGCAGTGCAACCTTATGCCAATAAAATGTAATTTAACAGCCCCAG ATATTGTTGAATATTCAACAATAACAAGAAAAGCTTTTCATCTAAGTTTTATGCTTTAATTTTTTTTCTTTTTTTTTCTTTTTCTTTTGT TTCCTTGGTACTAATTTTAATTTTTATTTGGAAGGGAGCAGTATAAAGCTTATTTGTATTTAGTAGTGTATCTCATAGATACAGACAAGG CAAGAGATGATAAGCTGTTTAAATAGTGTTTAATATTGATTGGGGGTGGGGAGAAAGAAAAAGTGTATTACTTAAAGATACTATATACGT >22722_22722_4_DHX8-TRPM7_DHX8_chr17_41585888_ENST00000540306_TRPM7_chr15_50906460_ENST00000560955_length(amino acids)=2215AA_BP=849 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQ CTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVE ECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DHX8-TRPM7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DHX8-TRPM7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DHX8-TRPM7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0001430 | Adenoma | 1 | CTD_human | |
| Tgene | C0009376 | Colonic Polyps | 1 | CTD_human | |
| Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
| Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
| Tgene | C0021053 | Immune System Diseases | 1 | CTD_human | |
| Tgene | C0022650 | Kidney Calculi | 1 | CTD_human | |
| Tgene | C0023890 | Liver Cirrhosis | 1 | CTD_human | |
| Tgene | C0027626 | Neoplasm Invasiveness | 1 | CTD_human | |
| Tgene | C0205646 | Adenoma, Basal Cell | 1 | CTD_human | |
| Tgene | C0205647 | Follicular adenoma | 1 | CTD_human | |
| Tgene | C0205648 | Adenoma, Microcystic | 1 | CTD_human | |
| Tgene | C0205649 | Adenoma, Monomorphic | 1 | CTD_human | |
| Tgene | C0205650 | Papillary adenoma | 1 | CTD_human | |
| Tgene | C0205651 | Adenoma, Trabecular | 1 | CTD_human | |
| Tgene | C0234544 | Todd Paralysis | 1 | CTD_human | |
| Tgene | C0239946 | Fibrosis, Liver | 1 | CTD_human | |
| Tgene | C0522224 | Paralysed | 1 | CTD_human | |
| Tgene | C0549159 | Infant Death | 1 | CTD_human | |
| Tgene | C2751260 | Macrothrombocytopenia | 1 | GENOMICS_ENGLAND |
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