Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DHX8-PCTP (FusionGDB2 ID:HG1659TG58488)

Fusion Gene Summary for DHX8-PCTP

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX8-PCTP
Fusion gene ID: hg1659tg58488
HgeneTgene
Gene symbol

DHX8

PCTP

Gene ID

1659

58488

Gene nameDEAH-box helicase 8phosphatidylcholine transfer protein
SynonymsDDX8|Dhr2|HRH1|PRP22|PRPF22PC-TP|STARD2
Cytomap('DHX8')('PCTP')

17q21.31

17q22

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1phosphatidylcholine transfer proteinSTART domain-containing protein 2StAR-related lipid transfer (START) domain containing 2stAR-related lipid transfer protein 2
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262415, ENST00000540306, 
Fusion gene scores* DoF score17 X 12 X 11=22449 X 7 X 5=315
# samples 1814
** MAII scorelog2(18/2244*10)=-3.64000386427912
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/315*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX8 [Title/Abstract] AND PCTP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX8(41585888)-PCTP(53900122), # samples:1
Anticipated loss of major functional domain due to fusion event.DHX8-PCTP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX8-PCTP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX8-PCTP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX8-PCTP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX8

GO:0000398

mRNA splicing, via spliceosome

28076346

TgenePCTP

GO:0015914

phospholipid transport

12055623


check buttonFusion gene breakpoints across DHX8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PCTP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-5425-01ADHX8chr17

41585888

+PCTPchr17

53900122

+


Top

Fusion Gene ORF analysis for DHX8-PCTP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262415ENST00000576221DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-3UTRENST00000540306ENST00000576221DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000262415ENST00000268896DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000262415ENST00000325214DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000262415ENST00000576183DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000540306ENST00000268896DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000540306ENST00000325214DHX8chr17

41585888

+PCTPchr17

53900122

+
5CDS-intronENST00000540306ENST00000576183DHX8chr17

41585888

+PCTPchr17

53900122

+
In-frameENST00000262415ENST00000573500DHX8chr17

41585888

+PCTPchr17

53900122

+
In-frameENST00000540306ENST00000573500DHX8chr17

41585888

+PCTPchr17

53900122

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000540306DHX8chr1741585888+ENST00000573500PCTPchr1753900122+29072577302657875
ENST00000262415DHX8chr1741585888+ENST00000573500PCTPchr1753900122+29042574272654875

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540306ENST00000573500DHX8chr1741585888+PCTPchr1753900122+0.0012778670.99872214
ENST00000262415ENST00000573500DHX8chr1741585888+PCTPchr1753900122+0.0012931420.9987068

Top

Fusion Genomic Features for DHX8-PCTP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX8chr1741585888+PCTPchr1753900121+0.0001189830.999881
DHX8chr1741585888+PCTPchr1753900121+0.0001189830.999881

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for DHX8-PCTP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41585888/chr17:53900122)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623172_1758341221.0Compositional biasNote=Poly-Lys
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623176_2288341221.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623265_3368341221.0DomainS1 motif
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623575_7388341221.0DomainHelicase ATP-binding
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623685_6888341221.0MotifNote=DEAH box
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623588_5958341221.0Nucleotide bindingATP
TgenePCTPchr17:41585888chr17:53900122ENST00000268896061_2120215.0DomainSTART
TgenePCTPchr17:41585888chr17:53900122ENST00000325214061_2120143.0DomainSTART

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX8chr17:41585888chr17:53900122ENST00000262415+1623756_9368341221.0DomainHelicase C-terminal


Top

Fusion Gene Sequence for DHX8-PCTP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22715_22715_1_DHX8-PCTP_DHX8_chr17_41585888_ENST00000262415_PCTP_chr17_53900122_ENST00000573500_length(transcript)=2904nt_BP=2574nt
GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC
ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT
GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT
AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG
AAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCGGAC
AACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGCGCA
GCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGATCGA
GACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGGAAT
AAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAATCTG
GATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATCATG
CAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGTGTG
GCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATGAAG
GATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGGAAT
CCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCTGAC
CCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATTCTC
CCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAAAGC
ATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAAAGG
CGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGATGCG
GAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGCAAC
AAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTCCAG
GCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCAGGC
TACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGTTGT
TGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATGTTG
CTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGATGTG
CTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTTTCT
CAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGATTAT
CTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAAATT
GATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCTCTT
CCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAG
AGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATGAGA
AAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAATTC
ATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATATTATTCACAGATGTGTTCACTATCATCTATGTACTGGAAAGATAGCAGTGA

>22715_22715_1_DHX8-PCTP_DHX8_chr17_41585888_ENST00000262415_PCTP_chr17_53900122_ENST00000573500_length(amino acids)=875AA_BP=849
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA
EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA
EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD
RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED
LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE
DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM
RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC
TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV
QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE

--------------------------------------------------------------
>22715_22715_2_DHX8-PCTP_DHX8_chr17_41585888_ENST00000540306_PCTP_chr17_53900122_ENST00000573500_length(transcript)=2907nt_BP=2577nt
AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA
GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC
ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT
TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA
GCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCG
GACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGC
GCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGAT
CGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGG
AATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAAT
CTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATC
ATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGT
GTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATG
AAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGG
AATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCT
GACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATT
CTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAA
AGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAA
AGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGAT
GCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGC
AACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTC
CAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCA
GGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGT
TGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATG
TTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGAT
GTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTT
TCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGAT
TATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAA
ATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCT
CTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAAT
CAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATG
AGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAA
TTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATATTATTCACAGATGTGTTCACTATCATCTATGTACTGGAAAGATAGCAG

>22715_22715_2_DHX8-PCTP_DHX8_chr17_41585888_ENST00000540306_PCTP_chr17_53900122_ENST00000573500_length(amino acids)=875AA_BP=849
MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA
EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA
EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD
RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED
LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE
DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM
RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC
TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV
QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DHX8-PCTP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DHX8-PCTP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DHX8-PCTP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource