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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHX9-PRELID1 (FusionGDB2 ID:HG1660TG27166)

Fusion Gene Summary for DHX9-PRELID1

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX9-PRELID1
Fusion gene ID: hg1660tg27166
HgeneTgene
Gene symbol

DHX9

PRELID1

Gene ID

1660

27166

Gene nameDExH-box helicase 9PRELI domain containing 1
SynonymsDDX9|LKP|NDH2|NDHII|RHACGI-106|PRELI|PX19|SBBI12
Cytomap('DHX9')('PRELID1')

1q25.3

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase ADEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9DEAH (Asp-Glu-Ala-His) box helicase 9DEAH (Asp-Glu-Ala-His) box polypeptide 9DEAH box protein 9DEAH-box helicase 9RNA helicase Aleukophysinnuclear DNA helicase IIPRELI domain-containing protein 1, mitochondrial25 kDa protein of relevant evolutionary and lymphoid interestpx19-like protein
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000485081, ENST00000367549, 
Fusion gene scores* DoF score14 X 10 X 7=9803 X 4 X 2=24
# samples 154
** MAII scorelog2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHX9 [Title/Abstract] AND PRELID1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX9(182850782)-PRELID1(176733423), # samples:3
Anticipated loss of major functional domain due to fusion event.DHX9-PRELID1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-PRELID1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-PRELID1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHX9-PRELID1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX9

GO:0010501

RNA secondary structure unwinding

1537828|9111062

HgeneDHX9

GO:0032508

DNA duplex unwinding

9111062|21561811

HgeneDHX9

GO:0034622

cellular protein-containing complex assembly

23361462

HgeneDHX9

GO:0039695

DNA-templated viral transcription

11096080

HgeneDHX9

GO:0044806

G-quadruplex DNA unwinding

21561811

HgeneDHX9

GO:0046833

positive regulation of RNA export from nucleus

11402034

HgeneDHX9

GO:0050434

positive regulation of viral transcription

11096080

HgeneDHX9

GO:0050684

regulation of mRNA processing

28355180

HgeneDHX9

GO:2000765

regulation of cytoplasmic translation

28355180

TgenePRELID1

GO:0010917

negative regulation of mitochondrial membrane potential

18945965

TgenePRELID1

GO:0010950

positive regulation of endopeptidase activity

18945965

TgenePRELID1

GO:0043066

negative regulation of apoptotic process

21364629

TgenePRELID1

GO:0045580

regulation of T cell differentiation

18945965

TgenePRELID1

GO:0051881

regulation of mitochondrial membrane potential

21364629

TgenePRELID1

GO:0070234

positive regulation of T cell apoptotic process

18945965

TgenePRELID1

GO:0090201

negative regulation of release of cytochrome c from mitochondria

23931759

TgenePRELID1

GO:0097035

regulation of membrane lipid distribution

23931759

TgenePRELID1

GO:1901857

positive regulation of cellular respiration

21364629|23931759

TgenePRELID1

GO:2001140

positive regulation of phospholipid transport

23931759


check buttonFusion gene breakpoints across DHX9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PRELID1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-TK-A8OK-01ADHX9chr1

182850782

-PRELID1chr5

176733423

+
ChimerDB4PRADTCGA-TK-A8OK-01ADHX9chr1

182850782

+PRELID1chr5

176733423

+
ChimerDB4PRADTCGA-TK-A8OKDHX9chr1

182850782

+PRELID1chr5

176733422

+
ChimerDB4PRADTCGA-TK-A8OKDHX9chr1

182850782

+PRELID1chr5

176733423

+


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Fusion Gene ORF analysis for DHX9-PRELID1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000485081ENST00000303204DHX9chr1

182850782

+PRELID1chr5

176733423

+
3UTR-3CDSENST00000485081ENST00000303204DHX9chr1

182850782

+PRELID1chr5

176733422

+
3UTR-intronENST00000485081ENST00000502670DHX9chr1

182850782

+PRELID1chr5

176733423

+
3UTR-intronENST00000485081ENST00000502670DHX9chr1

182850782

+PRELID1chr5

176733422

+
3UTR-intronENST00000485081ENST00000503216DHX9chr1

182850782

+PRELID1chr5

176733423

+
3UTR-intronENST00000485081ENST00000503216DHX9chr1

182850782

+PRELID1chr5

176733422

+
5CDS-intronENST00000367549ENST00000502670DHX9chr1

182850782

+PRELID1chr5

176733423

+
5CDS-intronENST00000367549ENST00000502670DHX9chr1

182850782

+PRELID1chr5

176733422

+
5CDS-intronENST00000367549ENST00000503216DHX9chr1

182850782

+PRELID1chr5

176733423

+
5CDS-intronENST00000367549ENST00000503216DHX9chr1

182850782

+PRELID1chr5

176733422

+
In-frameENST00000367549ENST00000303204DHX9chr1

182850782

+PRELID1chr5

176733423

+
In-frameENST00000367549ENST00000303204DHX9chr1

182850782

+PRELID1chr5

176733422

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000367549DHX9chr1182850782+ENST00000303204PRELID1chr5176733423+3562302411031721020
ENST00000367549DHX9chr1182850782+ENST00000303204PRELID1chr5176733422+3562302411031721020

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367549ENST00000303204DHX9chr1182850782+PRELID1chr5176733423+0.0012444060.9987556
ENST00000367549ENST00000303204DHX9chr1182850782+PRELID1chr5176733422+0.0012444060.9987556

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Fusion Genomic Features for DHX9-PRELID1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHX9chr1182850782+PRELID1chr5176733422+2.28E-070.99999976
DHX9chr1182850782+PRELID1chr5176733422+2.28E-070.99999976
DHX9chr1182850782+PRELID1chr5176733422+2.28E-070.99999976
DHX9chr1182850782+PRELID1chr5176733422+2.28E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHX9-PRELID1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:182850782/chr5:176733423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428180_2529711271.0DomainDRBM 2
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428398_5649711271.0DomainHelicase ATP-binding
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+24283_719711271.0DomainDRBM 1
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428636_8099711271.0DomainHelicase C-terminal
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428180_2529711271.0DomainDRBM 2
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428398_5649711271.0DomainHelicase ATP-binding
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+24283_719711271.0DomainDRBM 1
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428636_8099711271.0DomainHelicase C-terminal
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428511_5149711271.0MotifNote=DEIH box
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428586_5959711271.0MotifNuclear localization signal (NLS1)
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428511_5149711271.0MotifNote=DEIH box
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428586_5959711271.0MotifNuclear localization signal (NLS1)
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428411_4199711271.0Nucleotide bindingATP
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428411_4199711271.0Nucleotide bindingATP
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428182_1869711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428234_2369711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428331_3809711271.0RegionMTAD
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428398_8099711271.0RegionCore helicase
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+242853_559711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+24285_99711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428831_9199711271.0RegionHA2
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428182_1869711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428234_2369711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428331_3809711271.0RegionMTAD
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428398_8099711271.0RegionCore helicase
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+242853_559711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+24285_99711271.0RegionsiRNA-binding
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428831_9199711271.0RegionHA2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+24281155_11739711271.0MotifNuclear localization signal (NLS2)
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+24281155_11739711271.0MotifNuclear localization signal (NLS2)
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+24281150_12709711271.0RegionRGG
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428958_10749711271.0RegionOB-fold
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+24281150_12709711271.0RegionRGG
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428958_10749711271.0RegionOB-fold
TgenePRELID1chr1:182850782chr5:176733422ENST000003032043536_174170220.0DomainPRELI/MSF1
TgenePRELID1chr1:182850782chr5:176733423ENST000003032043536_174170220.0DomainPRELI/MSF1


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Fusion Gene Sequence for DHX9-PRELID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22730_22730_1_DHX9-PRELID1_DHX9_chr1_182850782_ENST00000367549_PRELID1_chr5_176733422_ENST00000303204_length(transcript)=3562nt_BP=3024nt
GCGAGTTGCTGTGCGTTTCTCTGTTGTCTCGGTAGAAGGCCAGAGTCACACACGGTCCTAAGAGCTGGGCACCAGGAAGCGAAGGCTGAT
CTGAAGAAGACACTTGAATCATGGGTGACGTTAAAAATTTTCTGTATGCCTGGTGTGGCAAAAGGAAGATGACCCCATCCTATGAAATTA
GAGCAGTGGGGAACAAAAACAGGCAGAAATTCATGTGTGAGGTTCAGGTGGAAGGTTATAATTACACTGGCATGGGAAATTCCACCAATA
AAAAAGATGCACAAAGCAATGCTGCCAGAGACTTTGTTAACTATTTGGTTCGAATAAATGAAATAAAGAGTGAAGAAGTTCCAGCTTTTG
GGGTAGCATCTCCGCCCCCACTTACTGATACTCCTGACACTACAGCAAATGCTGAAGGAGATTTACCAACAACCATGGGAGGACCTCTTC
CTCCACATCTGGCTCTCAAAGCAGAAAATAATTCTGAGGTAGGGGCCTCTGGCTATGGTGTTCCTGGGCCCACCTGGGACCGAGGAGCCA
ACTTGAAGGATTACTACTCAAGAAAGGAAGAACAAGAAGTGCAAGCGACTCTAGAATCAGAAGAAGTGGATTTAAATGCTGGGCTTCATG
GAAACTGGACCTTGGAAAATGCTAAAGCTCGTCTAAACCAATATTTTCAGAAAGAAAAGATCCAAGGAGAATATAAGTACACCCAAGTGG
GTCCTGATCACAACAGGAGCTTTATTGCAGAAATGACCATTTATATCAAGCAGCTGGGCAGAAGGATTTTTGCACGAGAACATGGATCAA
ATAAGAAATTGGCAGCACAGTCCTGTGCCCTGTCACTTGTCAGACAACTGTACCATCTTGGAGTGGTTGAAGCTTACTCCGGACTTACAA
AGAAGAAGGAAGGAGAGACAGTGGAGCCTTACAAAGTAAACCTCTCTCAAGATTTAGAGCATCAGCTGCAAAACATCATTCAAGAGCTAA
ATCTTGAGATTTTGCCCCCGCCTGAAGATCCTTCTGTGCCAGTTGCACTCAACATTGGCAAATTGGCTCAGTTCGAACCATCTCAGCGAC
AAAACCAAGTGGGTGTGGTTCCTTGGTCACCTCCACAATCCAACTGGAATCCTTGGACTAGTAGCAACATTGATGAGGGGCCTCTGGCTT
TTGCTACTCCAGAGCAAATAAGCATGGACCTCAAGAATGAATTGATGTACCAGTTGGAACAGGATCATGATTTGCAAGCAATCTTGCAGG
AGAGAGAGTTACTGCCTGTGAAGAAATTTGAAAGTGAGATTCTGGAAGCAATCAGCCAAAATTCAGTTGTCATTATTAGAGGGGCTACTG
GATGTGGGAAAACCACACAGGTTCCCCAGTTCATTCTAGATGACTTTATCCAGAATGACCGAGCAGCAGAGTGTAACATCGTAGTAACTC
AGCCCAGAAGAATCAGTGCGGTTTCTGTGGCAGAGCGAGTTGCATTTGAAAGAGGAGAAGAGCCTGGAAAAAGCTGTGGCTACAGCGTTC
GATTTGAGTCTATACTTCCTCGTCCTCATGCCAGTATAATGTTTTGTACTGTAGGTGTGCTCCTGAGAAAATTAGAAGCAGGCATTCGAG
GAATCAGTCATGTAATTGTAGATGAAATACATGAAAGAGATATTAATACTGACTTCCTTTTGGTAGTACTGCGTGATGTTGTTCAGGCTT
ATCCTGAAGTTCGCATTGTTCTTATGTCTGCTACTATTGATACCAGCATGTTTTGTGAATATTTCTTCAATTGCCCCATCATTGAAGTTT
ATGGGAGGACTTACCCAGTTCAAGAATATTTTCTGGAAGACTGCATTCAGATGACCCACTTTGTTCCTCCACCAAAAGACAAAAAGAAGA
AGGATAAGGATGATGATGGTGGTGAGGATGATGATGCAAATTGCAACTTGATCTGTGGTGATGAATATGGTCCAGAAACAAGGTTGAGCA
TGTCTCAATTGAACGAAAAGGAAACTCCTTTTGAACTCATCGAGGCTCTACTTAAGTACATTGAAACCCTTAATGTTCCTGGAGCTGTGT
TGGTTTTTTTGCCTGGCTGGAATCTGATTTATACTATGCAGAAGCATTTGGAAATGAATCCACATTTTGGAAGCCATCGGTATCAGATTC
TACCCCTGCATTCTCAGATTCCTCGAGAGGAACAGCGCAAAGTGTTTGATCCAGTACCAGTTGGAGTAACCAAGGTTATTTTGTCCACAA
ATATTGCTGAAACAAGCATTACCATAAACGATGTTGTTTATGTCATTGACTCCTGCAAGCAGAAAGTGAAACTCTTCACTGCTCACAACA
ATATGACCAACTATGCTACCGTATGGGCATCAAAAACAAACCTTGAGCAACGGAAAGGGCGAGCTGGCCGAGTACGGCCTGGATTCTGCT
TTCACCTGTGCAGCCGAGCTCGTTTTGAGAGACTTGAAACCCACATGACACCAGAGATGTTCCGAACACCATTGCATGAAATTGCTCTTA
GCATAAAACTTCTGCGTCTAGGAGGAATTGGCCAATTTCTGGCCAAAGCAATTGAACCTCCCCCTTTGGATGCTGTGATTGAAGCAGAAC
ACACTCTTAGAGAGCTTGATGCATTAGATGCCAATGATGAGTTGACTCCTTTGGGACGAATCCTGGCTAAACTCCCCATTGAGCCTCGTT
TTGGCAAAATGATGATAATGGGGTGTATTTTCTACGTGGGAGATGCTATCTGTACCATTGCTGCTGCTACCTGCTTTCCAGAGCCTTTCA
TCAATGAAGGAAAGCGGCTGGGCTATATCCATCGAAATTTTGCTGGAAACAGATTTTCTGATCACGTAGCCCTTTTATCAGTATTCCAAG
CCTGGGATGATGCTAGAATGGGTGGAGAAGAAGCAGAGATACGTTTTTGTGAGCACAAAAGACTTAATATGGCTACACTAAGAATGACTT
GGGAAGCCAAAGTTCAGCTCAAAGAGATTTTGATTAATTCTGGGTTTCCAGAAGGCGAGGCCCCTTCCAAAACACTTGTTGAGACAGCCA
AGGAAGCCAAGGAGAAGGCAAAGGAGACGGCACTGGCAGCTACAGAGAAGGCCAAGGACCTCGCCAGCAAGGCGGCCACCAAGAAGCAGC
AGCAGCAGCAACAGTTTGTGTAGCCAGTCTACCACCACCACAGCACCCCAGACAGCTAGGCTTAGCCTCTCTGCCCTCCCTTCATTGTAC
TTTATCATTAAAAATCAACTTCCAGCCCTGTCTGCTGTCTACGTGGTGGGTTGTGGGGATGCAGTTTGGCATCTGCAGTACACCAAGCAC
ATGATTCATGTCTGAGCCAGGTCTGCTTATTCTCCCATTGGGCAGCTGAGGACCGAGGCACAGAGGTGCGGTGACTTGCCCGGGGCTCCA
GGTAGCCTGCAGGTTAACTGGCGGTAAGTGCTAGACTGTAAGCCCGACAAGGGCAGGGCTTTTGGTTTTGTTCTCTGATGTGTCTCAGTA

>22730_22730_1_DHX9-PRELID1_DHX9_chr1_182850782_ENST00000367549_PRELID1_chr5_176733422_ENST00000303204_length(amino acids)=1020AA_BP=971
MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPP
LTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLEN
AKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGET
VEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQI
SMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISA
VSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIV
LMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEK
ETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSI
TINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRL
GGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRL
GYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEGEAPSKTLVETAKEAKEKA

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>22730_22730_2_DHX9-PRELID1_DHX9_chr1_182850782_ENST00000367549_PRELID1_chr5_176733423_ENST00000303204_length(transcript)=3562nt_BP=3024nt
GCGAGTTGCTGTGCGTTTCTCTGTTGTCTCGGTAGAAGGCCAGAGTCACACACGGTCCTAAGAGCTGGGCACCAGGAAGCGAAGGCTGAT
CTGAAGAAGACACTTGAATCATGGGTGACGTTAAAAATTTTCTGTATGCCTGGTGTGGCAAAAGGAAGATGACCCCATCCTATGAAATTA
GAGCAGTGGGGAACAAAAACAGGCAGAAATTCATGTGTGAGGTTCAGGTGGAAGGTTATAATTACACTGGCATGGGAAATTCCACCAATA
AAAAAGATGCACAAAGCAATGCTGCCAGAGACTTTGTTAACTATTTGGTTCGAATAAATGAAATAAAGAGTGAAGAAGTTCCAGCTTTTG
GGGTAGCATCTCCGCCCCCACTTACTGATACTCCTGACACTACAGCAAATGCTGAAGGAGATTTACCAACAACCATGGGAGGACCTCTTC
CTCCACATCTGGCTCTCAAAGCAGAAAATAATTCTGAGGTAGGGGCCTCTGGCTATGGTGTTCCTGGGCCCACCTGGGACCGAGGAGCCA
ACTTGAAGGATTACTACTCAAGAAAGGAAGAACAAGAAGTGCAAGCGACTCTAGAATCAGAAGAAGTGGATTTAAATGCTGGGCTTCATG
GAAACTGGACCTTGGAAAATGCTAAAGCTCGTCTAAACCAATATTTTCAGAAAGAAAAGATCCAAGGAGAATATAAGTACACCCAAGTGG
GTCCTGATCACAACAGGAGCTTTATTGCAGAAATGACCATTTATATCAAGCAGCTGGGCAGAAGGATTTTTGCACGAGAACATGGATCAA
ATAAGAAATTGGCAGCACAGTCCTGTGCCCTGTCACTTGTCAGACAACTGTACCATCTTGGAGTGGTTGAAGCTTACTCCGGACTTACAA
AGAAGAAGGAAGGAGAGACAGTGGAGCCTTACAAAGTAAACCTCTCTCAAGATTTAGAGCATCAGCTGCAAAACATCATTCAAGAGCTAA
ATCTTGAGATTTTGCCCCCGCCTGAAGATCCTTCTGTGCCAGTTGCACTCAACATTGGCAAATTGGCTCAGTTCGAACCATCTCAGCGAC
AAAACCAAGTGGGTGTGGTTCCTTGGTCACCTCCACAATCCAACTGGAATCCTTGGACTAGTAGCAACATTGATGAGGGGCCTCTGGCTT
TTGCTACTCCAGAGCAAATAAGCATGGACCTCAAGAATGAATTGATGTACCAGTTGGAACAGGATCATGATTTGCAAGCAATCTTGCAGG
AGAGAGAGTTACTGCCTGTGAAGAAATTTGAAAGTGAGATTCTGGAAGCAATCAGCCAAAATTCAGTTGTCATTATTAGAGGGGCTACTG
GATGTGGGAAAACCACACAGGTTCCCCAGTTCATTCTAGATGACTTTATCCAGAATGACCGAGCAGCAGAGTGTAACATCGTAGTAACTC
AGCCCAGAAGAATCAGTGCGGTTTCTGTGGCAGAGCGAGTTGCATTTGAAAGAGGAGAAGAGCCTGGAAAAAGCTGTGGCTACAGCGTTC
GATTTGAGTCTATACTTCCTCGTCCTCATGCCAGTATAATGTTTTGTACTGTAGGTGTGCTCCTGAGAAAATTAGAAGCAGGCATTCGAG
GAATCAGTCATGTAATTGTAGATGAAATACATGAAAGAGATATTAATACTGACTTCCTTTTGGTAGTACTGCGTGATGTTGTTCAGGCTT
ATCCTGAAGTTCGCATTGTTCTTATGTCTGCTACTATTGATACCAGCATGTTTTGTGAATATTTCTTCAATTGCCCCATCATTGAAGTTT
ATGGGAGGACTTACCCAGTTCAAGAATATTTTCTGGAAGACTGCATTCAGATGACCCACTTTGTTCCTCCACCAAAAGACAAAAAGAAGA
AGGATAAGGATGATGATGGTGGTGAGGATGATGATGCAAATTGCAACTTGATCTGTGGTGATGAATATGGTCCAGAAACAAGGTTGAGCA
TGTCTCAATTGAACGAAAAGGAAACTCCTTTTGAACTCATCGAGGCTCTACTTAAGTACATTGAAACCCTTAATGTTCCTGGAGCTGTGT
TGGTTTTTTTGCCTGGCTGGAATCTGATTTATACTATGCAGAAGCATTTGGAAATGAATCCACATTTTGGAAGCCATCGGTATCAGATTC
TACCCCTGCATTCTCAGATTCCTCGAGAGGAACAGCGCAAAGTGTTTGATCCAGTACCAGTTGGAGTAACCAAGGTTATTTTGTCCACAA
ATATTGCTGAAACAAGCATTACCATAAACGATGTTGTTTATGTCATTGACTCCTGCAAGCAGAAAGTGAAACTCTTCACTGCTCACAACA
ATATGACCAACTATGCTACCGTATGGGCATCAAAAACAAACCTTGAGCAACGGAAAGGGCGAGCTGGCCGAGTACGGCCTGGATTCTGCT
TTCACCTGTGCAGCCGAGCTCGTTTTGAGAGACTTGAAACCCACATGACACCAGAGATGTTCCGAACACCATTGCATGAAATTGCTCTTA
GCATAAAACTTCTGCGTCTAGGAGGAATTGGCCAATTTCTGGCCAAAGCAATTGAACCTCCCCCTTTGGATGCTGTGATTGAAGCAGAAC
ACACTCTTAGAGAGCTTGATGCATTAGATGCCAATGATGAGTTGACTCCTTTGGGACGAATCCTGGCTAAACTCCCCATTGAGCCTCGTT
TTGGCAAAATGATGATAATGGGGTGTATTTTCTACGTGGGAGATGCTATCTGTACCATTGCTGCTGCTACCTGCTTTCCAGAGCCTTTCA
TCAATGAAGGAAAGCGGCTGGGCTATATCCATCGAAATTTTGCTGGAAACAGATTTTCTGATCACGTAGCCCTTTTATCAGTATTCCAAG
CCTGGGATGATGCTAGAATGGGTGGAGAAGAAGCAGAGATACGTTTTTGTGAGCACAAAAGACTTAATATGGCTACACTAAGAATGACTT
GGGAAGCCAAAGTTCAGCTCAAAGAGATTTTGATTAATTCTGGGTTTCCAGAAGGCGAGGCCCCTTCCAAAACACTTGTTGAGACAGCCA
AGGAAGCCAAGGAGAAGGCAAAGGAGACGGCACTGGCAGCTACAGAGAAGGCCAAGGACCTCGCCAGCAAGGCGGCCACCAAGAAGCAGC
AGCAGCAGCAACAGTTTGTGTAGCCAGTCTACCACCACCACAGCACCCCAGACAGCTAGGCTTAGCCTCTCTGCCCTCCCTTCATTGTAC
TTTATCATTAAAAATCAACTTCCAGCCCTGTCTGCTGTCTACGTGGTGGGTTGTGGGGATGCAGTTTGGCATCTGCAGTACACCAAGCAC
ATGATTCATGTCTGAGCCAGGTCTGCTTATTCTCCCATTGGGCAGCTGAGGACCGAGGCACAGAGGTGCGGTGACTTGCCCGGGGCTCCA
GGTAGCCTGCAGGTTAACTGGCGGTAAGTGCTAGACTGTAAGCCCGACAAGGGCAGGGCTTTTGGTTTTGTTCTCTGATGTGTCTCAGTA

>22730_22730_2_DHX9-PRELID1_DHX9_chr1_182850782_ENST00000367549_PRELID1_chr5_176733423_ENST00000303204_length(amino acids)=1020AA_BP=971
MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPP
LTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLEN
AKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGET
VEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQI
SMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISA
VSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIV
LMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEK
ETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSI
TINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRL
GGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRL
GYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEGEAPSKTLVETAKEAKEKA

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Fusion Gene PPI Analysis for DHX9-PRELID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+2428230_325971.33333333333341271.0BRCA1
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+2428230_325971.33333333333341271.0BRCA1
HgeneDHX9chr1:182850782chr5:176733422ENST00000367549+24281_250971.33333333333341271.0CREBBP
HgeneDHX9chr1:182850782chr5:176733423ENST00000367549+24281_250971.33333333333341271.0CREBBP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHX9-PRELID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHX9-PRELID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource