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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AARS-COG4 (FusionGDB2 ID:HG16TG25839)

Fusion Gene Summary for AARS-COG4

check button Fusion gene summary
Fusion gene informationFusion gene name: AARS-COG4
Fusion gene ID: hg16tg25839
HgeneTgene
Gene symbol

AARS

COG4

Gene ID

16

25839

Gene namealanyl-tRNA synthetase 1component of oligomeric golgi complex 4
SynonymsAARS|CMT2N|EIEE29CDG2J|COD1|SWILS
Cytomap('AARS')('COG4')

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionalanine--tRNA ligase, cytoplasmicalaRSalanine tRNA ligase 1, cytoplasmicalanyl-tRNA synthetase, cytoplasmicrenal carcinoma antigen NY-REN-42conserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4
Modification date2020032820200320
UniProtAcc.

Q9H9E3

Ensembl transtripts involved in fusion geneENST00000261772, ENST00000564359, 
ENST00000564359, ENST00000261772, 
Fusion gene scores* DoF score13 X 16 X 8=166412 X 11 X 12=1584
# samples 1623
** MAII scorelog2(16/1664*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/1584*10)=-2.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AARS [Title/Abstract] AND COG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAARS(70316523)-COG4(70553634), # samples:3
Anticipated loss of major functional domain due to fusion event.AARS-COG4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AARS-COG4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AARS-COG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AARS-COG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COG4-AARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COG4-AARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AARS-COG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AARS-COG4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAARS

GO:0006419

alanyl-tRNA aminoacylation

27622773|28493438


check buttonFusion gene breakpoints across AARS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across COG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B9-01AAARSchr16

70316523

-COG4chr16

70553634

-
ChimerDB4BRCATCGA-BH-A0B9AARSchr16

70316522

-COG4chr16

70553634

-
ChimerDB4GBMTCGA-12-1597-01BAARSchr16

70301562

-COG4chr16

70524295

-
ChimerDB4LUADTCGA-44-2668-01AAARSchr16

70288524

-COG4chr16

70553634

-


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Fusion Gene ORF analysis for AARS-COG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261772ENST00000393612AARSchr16

70301562

-COG4chr16

70524295

-
5CDS-intronENST00000261772ENST00000564653AARSchr16

70301562

-COG4chr16

70524295

-
Frame-shiftENST00000261772ENST00000323786AARSchr16

70301562

-COG4chr16

70524295

-
In-frameENST00000261772ENST00000323786AARSchr16

70316523

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000323786AARSchr16

70316522

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000323786AARSchr16

70288524

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000393612AARSchr16

70316523

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000393612AARSchr16

70316522

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000393612AARSchr16

70288524

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000564653AARSchr16

70316523

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000564653AARSchr16

70316522

-COG4chr16

70553634

-
In-frameENST00000261772ENST00000564653AARSchr16

70288524

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000323786AARSchr16

70316523

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000323786AARSchr16

70316522

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000323786AARSchr16

70301562

-COG4chr16

70524295

-
intron-3CDSENST00000564359ENST00000323786AARSchr16

70288524

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000393612AARSchr16

70316523

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000393612AARSchr16

70316522

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000393612AARSchr16

70288524

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000564653AARSchr16

70316523

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000564653AARSchr16

70316522

-COG4chr16

70553634

-
intron-3CDSENST00000564359ENST00000564653AARSchr16

70288524

-COG4chr16

70553634

-
intron-intronENST00000564359ENST00000393612AARSchr16

70301562

-COG4chr16

70524295

-
intron-intronENST00000564359ENST00000564653AARSchr16

70301562

-COG4chr16

70524295

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261772AARSchr1670316523-ENST00000323786COG4chr1670553634-2928288872486799
ENST00000261772AARSchr1670316523-ENST00000393612COG4chr1670553634-1143288871142351
ENST00000261772AARSchr1670316523-ENST00000564653COG4chr1670553634-70028887698203
ENST00000261772AARSchr1670288524-ENST00000323786COG4chr1670553634-518425448747421551
ENST00000261772AARSchr1670288524-ENST00000393612COG4chr1670553634-339925448733981103
ENST00000261772AARSchr1670288524-ENST00000564653COG4chr1670553634-29562544872954955
ENST00000261772AARSchr1670316522-ENST00000323786COG4chr1670553634-2928288872486799
ENST00000261772AARSchr1670316522-ENST00000393612COG4chr1670553634-1143288871142351
ENST00000261772AARSchr1670316522-ENST00000564653COG4chr1670553634-70028887698203

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261772ENST00000323786AARSchr1670316523-COG4chr1670553634-0.0069238490.9930762
ENST00000261772ENST00000393612AARSchr1670316523-COG4chr1670553634-0.0018597880.9981402
ENST00000261772ENST00000564653AARSchr1670316523-COG4chr1670553634-0.008548540.99145144
ENST00000261772ENST00000323786AARSchr1670288524-COG4chr1670553634-0.0029707850.99702924
ENST00000261772ENST00000393612AARSchr1670288524-COG4chr1670553634-0.0011868230.99881315
ENST00000261772ENST00000564653AARSchr1670288524-COG4chr1670553634-0.0012909910.99870896
ENST00000261772ENST00000323786AARSchr1670316522-COG4chr1670553634-0.0069238490.9930762
ENST00000261772ENST00000393612AARSchr1670316522-COG4chr1670553634-0.0018597880.9981402
ENST00000261772ENST00000564653AARSchr1670316522-COG4chr1670553634-0.008548540.99145144

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Fusion Genomic Features for AARS-COG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AARS-COG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70316523/chr16:70553634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COG4

Q9H9E3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAARSchr16:70288524chr16:70553634ENST00000261772-1721214_216800969.0Nucleotide bindingATP
TgeneCOG4chr16:70288524chr16:70553634ENST0000039361208618_74053338.0RegionD domain
TgeneCOG4chr16:70288524chr16:70553634ENST0000039361208741_78553338.0RegionE domain%3B essential for proper cell surface glycosylation
TgeneCOG4chr16:70316522chr16:70553634ENST0000039361208618_74053338.0RegionD domain
TgeneCOG4chr16:70316522chr16:70553634ENST0000039361208741_78553338.0RegionE domain%3B essential for proper cell surface glycosylation
TgeneCOG4chr16:70316523chr16:70553634ENST0000039361208618_74053338.0RegionD domain
TgeneCOG4chr16:70316523chr16:70553634ENST0000039361208741_78553338.0RegionE domain%3B essential for proper cell surface glycosylation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAARSchr16:70316522chr16:70553634ENST00000261772-221214_21648969.0Nucleotide bindingATP
HgeneAARSchr16:70316523chr16:70553634ENST00000261772-221214_21648969.0Nucleotide bindingATP


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Fusion Gene Sequence for AARS-COG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91_91_1_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(transcript)=5184nt_BP=2544nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCTCACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACC
CAGAAGTGCATCCGGGCTGGGGGCAAACATAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATGCTGGGC
TCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAACTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGA
CTTTATGTTACTTACTTTGGCGGGGATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGGCTGGAT
GACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGACACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTAC
GACCGGATTGGTGGTCGGGACGCCGCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATCCAGTAT
AACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACAGGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAG
AATAAGATGTCCAACTATGACACTGACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACTGGGAAA
GTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGACCACGCTCGGACCATCACTGTGGCACTGGCTGATGGT
GGCCGGCCTGACAACACAGGGCGTGGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAATGCCAGC
AGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCATTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAG
GACATCATTAATGAAGAAGAGGTGCAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTGGGAGAC
AGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTTCCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAG
GGCCTGGTGGTAGACATGGATGGCTTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAAGACCTC
ATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTCACAGATGATTCCCCAAAGTACAATTACCATTTGGAC
TCCAGTGGTAGCTATGTATTTGAGAACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCCACAGGC
CAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGCCAGATCTATGACGAAGGCTACCTGGTGAAGGTGGAT
GACAGCAGTGAAGATAAAACAGAGTTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTACGGTGAC
CTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCCATCATGAGCAACCACACAGCTACGCACATTCTGAAC
TTCGCCCTGCGCTCAGTGCTTGGGGAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCCAAGGGA
GCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATTGAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCC
CTGGCAGCAGCGAAAGCCATCCAGGGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGGGTCCCG
GTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTTGAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGT
CATGCAGGAGCTTTTGTGATCGTGACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCCCAGAAG
GCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAAGTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAG
AGGGAGATCGCTGACCTTGGAGAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTC
ACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCT
GAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTG
AAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGAC
AAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTC
AAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTG
GGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTG
GGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACC
CACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAG
AAGGTGGTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAA
AAAATCGAACCAAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAG
AGGATTAGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAAT
AACTGCCTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCT
GTGGCTCTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCT
CTGTCCAGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAAT
AAGCTGCGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAG
CAAGGCAAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGT
GAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAG
TTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCC
ATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAAC
GACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTA
ACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGAC
AAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACC
ATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTG
CGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGGCTCAT
CACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTT
CTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCC
CCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCT
CTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTTGACTT

>91_91_1_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(amino acids)=1551AA_BP=819
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAAN
TQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGL
DDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVL
QNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNA
SRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEE
KGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVST
GQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRPIMSNHTATHIL
NFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGV
PVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDV
QREIADLGEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILD
LKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPL
LGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQV
EKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLL
NNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLC
NKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQA
KFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDS
LTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAE

--------------------------------------------------------------
>91_91_2_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(transcript)=3399nt_BP=2544nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCTCACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACC
CAGAAGTGCATCCGGGCTGGGGGCAAACATAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATGCTGGGC
TCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAACTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGA
CTTTATGTTACTTACTTTGGCGGGGATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGGCTGGAT
GACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGACACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTAC
GACCGGATTGGTGGTCGGGACGCCGCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATCCAGTAT
AACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACAGGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAG
AATAAGATGTCCAACTATGACACTGACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACTGGGAAA
GTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGACCACGCTCGGACCATCACTGTGGCACTGGCTGATGGT
GGCCGGCCTGACAACACAGGGCGTGGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAATGCCAGC
AGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCATTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAG
GACATCATTAATGAAGAAGAGGTGCAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTGGGAGAC
AGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTTCCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAG
GGCCTGGTGGTAGACATGGATGGCTTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAAGACCTC
ATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTCACAGATGATTCCCCAAAGTACAATTACCATTTGGAC
TCCAGTGGTAGCTATGTATTTGAGAACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCCACAGGC
CAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGCCAGATCTATGACGAAGGCTACCTGGTGAAGGTGGAT
GACAGCAGTGAAGATAAAACAGAGTTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTACGGTGAC
CTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCCATCATGAGCAACCACACAGCTACGCACATTCTGAAC
TTCGCCCTGCGCTCAGTGCTTGGGGAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCCAAGGGA
GCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATTGAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCC
CTGGCAGCAGCGAAAGCCATCCAGGGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGGGTCCCG
GTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTTGAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGT
CATGCAGGAGCTTTTGTGATCGTGACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCCCAGAAG
GCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAAGTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAG
AGGGAGATCGCTGACCTTGGAGAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTC
ACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCT
GAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTG
AAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGAC
AAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTC
AAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTG
GGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTG
GGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACC
CACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAG

>91_91_2_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(amino acids)=1103AA_BP=819
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAAN
TQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGL
DDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVL
QNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNA
SRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEE
KGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVST
GQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRPIMSNHTATHIL
NFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGV
PVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDV
QREIADLGEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILD
LKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPL
LGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQV

--------------------------------------------------------------
>91_91_3_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(transcript)=2956nt_BP=2544nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCTCACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACC
CAGAAGTGCATCCGGGCTGGGGGCAAACATAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATGCTGGGC
TCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAACTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGA
CTTTATGTTACTTACTTTGGCGGGGATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGGCTGGAT
GACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGACACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTAC
GACCGGATTGGTGGTCGGGACGCCGCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATCCAGTAT
AACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACAGGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAG
AATAAGATGTCCAACTATGACACTGACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACTGGGAAA
GTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGACCACGCTCGGACCATCACTGTGGCACTGGCTGATGGT
GGCCGGCCTGACAACACAGGGCGTGGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAATGCCAGC
AGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCATTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAG
GACATCATTAATGAAGAAGAGGTGCAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTGGGAGAC
AGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTTCCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAG
GGCCTGGTGGTAGACATGGATGGCTTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAAGACCTC
ATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTCACAGATGATTCCCCAAAGTACAATTACCATTTGGAC
TCCAGTGGTAGCTATGTATTTGAGAACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCCACAGGC
CAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGCCAGATCTATGACGAAGGCTACCTGGTGAAGGTGGAT
GACAGCAGTGAAGATAAAACAGAGTTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTACGGTGAC
CTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCCATCATGAGCAACCACACAGCTACGCACATTCTGAAC
TTCGCCCTGCGCTCAGTGCTTGGGGAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCCAAGGGA
GCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATTGAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCC
CTGGCAGCAGCGAAAGCCATCCAGGGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGGGTCCCG
GTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTTGAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGT
CATGCAGGAGCTTTTGTGATCGTGACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCCCAGAAG
GCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAAGTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAG
AGGGAGATCGCTGACCTTGGAGAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTC
ACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCT
GAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTG
AAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGAC

>91_91_3_AARS-COG4_AARS_chr16_70288524_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(amino acids)=955AA_BP=819
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAAN
TQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGL
DDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVL
QNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNA
SRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEE
KGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVST
GQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRPIMSNHTATHIL
NFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGV
PVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAKVKAQTAPNKDV
QREIADLGEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILD

--------------------------------------------------------------
>91_91_4_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(transcript)=2928nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG
GTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCC
ATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTG
CATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACA
GACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAG
CCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTG
GTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATC
GAACCAAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATT
AGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGC
CTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCT
CTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCC
AGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTG
CGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGC
AAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAAC
ATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGAC
AGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAG
CCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCT
TGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGC
CTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAG
CTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTC
AATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAG
GTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGGCTCATCACACT
TGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTTCTACGG
CTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCCCCACCG
AGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCTCTTGCC
CTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTTGACTTTGAGGA

>91_91_4_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(amino acids)=799AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG
TDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEK
IEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAV
ALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQ
GKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAI
KPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDK

--------------------------------------------------------------
>91_91_5_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(transcript)=1143nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG
GTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCC
ATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTG
CATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACA
GACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAG
CCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTG

>91_91_5_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(amino acids)=351AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG

--------------------------------------------------------------
>91_91_6_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(transcript)=700nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG

>91_91_6_AARS-COG4_AARS_chr16_70316522_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(amino acids)=203AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK

--------------------------------------------------------------
>91_91_7_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(transcript)=2928nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG
GTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCC
ATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTG
CATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACA
GACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAG
CCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTG
GTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATC
GAACCAAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATT
AGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGC
CTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCT
CTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCC
AGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTG
CGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGC
AAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAAC
ATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGAC
AGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAG
CCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCT
TGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGC
CTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAG
CTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTC
AATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAG
GTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGGCTCATCACACT
TGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTTCTACGG
CTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCCCCACCG
AGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCTCTTGCC
CTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTTGACTTTGAGGA

>91_91_7_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000323786_length(amino acids)=799AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG
TDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEK
IEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAV
ALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQ
GKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAI
KPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDK

--------------------------------------------------------------
>91_91_8_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(transcript)=1143nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG
GTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCC
ATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTG
CATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACA
GACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAG
CCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTG

>91_91_8_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000393612_length(amino acids)=351AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG

--------------------------------------------------------------
>91_91_9_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(transcript)=700nt_BP=288nt
CGTGGCGGGTTGTGGTAGGTCGTGGTCTGAGGCCGGTACAGCTGCGCGTCTGCGGGAATAGGTGCAGCGGGCCCTTGGCGGGGGACTCTG
AGGGAGGAGCTGGGGACGGCGACCCTAGGAGAGTTCTTTGGGGTGACTTTCAAGATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAG
CGATTTATAGATTTCTTCAAGAGGAACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTCTTTGCC
AATGCAGGCATGAACCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTC
CACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAAT
GTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTC
TGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCG

>91_91_9_AARS-COG4_AARS_chr16_70316523_ENST00000261772_COG4_chr16_70553634_ENST00000564653_length(amino acids)=203AA_BP=66
MREELGTATLGEFFGVTFKMDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AARS-COG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCOG4chr16:70288524chr16:70553634ENST000003936120885_15353.0338.0STX5
TgeneCOG4chr16:70316522chr16:70553634ENST000003936120885_15353.0338.0STX5
TgeneCOG4chr16:70316523chr16:70553634ENST000003936120885_15353.0338.0STX5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCOG4chr16:70288524chr16:70553634ENST00000393612082_8453.0338.0SCFD1
TgeneCOG4chr16:70316522chr16:70553634ENST00000393612082_8453.0338.0SCFD1
TgeneCOG4chr16:70316523chr16:70553634ENST00000393612082_8453.0338.0SCFD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AARS-COG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AARS-COG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3150736CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC1300285SAUL-WILSON SYNDROME1GENOMICS_ENGLAND;ORPHANET;UNIPROT