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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABHD3-ANKRD29 (FusionGDB2 ID:HG171586TG147463)

Fusion Gene Summary for ABHD3-ANKRD29

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD3-ANKRD29
Fusion gene ID: hg171586tg147463
HgeneTgene
Gene symbol

ABHD3

ANKRD29

Gene ID

171586

147463

Gene nameabhydrolase domain containing 3, phospholipaseankyrin repeat domain 29
SynonymsLABH3-
Cytomap('ABHD3')('ANKRD29')

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipase ABHD3abhydrolase domain containing 3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3ankyrin repeat domain-containing protein 29
Modification date2020031320200313
UniProtAcc

Q8WU67

Q8N6D5

Ensembl transtripts involved in fusion geneENST00000289119, ENST00000578270, 
ENST00000579875, ENST00000580981, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 6 X 8=384
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/384*10)=-1.8036027871965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABHD3 [Title/Abstract] AND ANKRD29 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABHD3(19244079)-ANKRD29(21214113), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A893-01AABHD3chr18

19244079

-ANKRD29chr18

21214113

-


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Fusion Gene ORF analysis for ABHD3-ANKRD29

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000289119ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
5CDS-intronENST00000289119ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
5CDS-intronENST00000289119ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
Frame-shiftENST00000289119ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
Frame-shiftENST00000289119ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000578270ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000578270ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000579875ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000579875ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000580981ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000580981ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABHD3-ANKRD29


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ABHD3-ANKRD29


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19244079/:21214113)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD3

Q8WU67

ANKRD29

Q8N6D5

FUNCTION: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. {ECO:0000250|UniProtKB:Q91ZH7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABHD3-ANKRD29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABHD3-ANKRD29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABHD3-ANKRD29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABHD3-ANKRD29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource